Clinical Trials Sponsored by Astra USA

Total 4892 results

OnQuality Pharmaceuticals (USA) LLC

Active, not recruiting

A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients (NOVA-II)

Hand-Foot Skin Reaction (HFSR)

United States, China, India
Haisco-USA Pharmaceuticals, Inc.

Completed

Dose-Finding and Human Abuse Potential Study Of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users

General Anesthesia

United States
Legend Biotech USA Inc

Active, not recruiting

Study of CD4-Targeted Chimeric Antigen Receptor T-Cells (CD4- CAR-T) in Subjects With Relapsed or Refractory T-Cell Lymphoma

T-Cell Lymphoma | Peripheral T-Cell Lymphoma Refractory | Cutaneous T-Cell Lymphoma Refractory | Cutaneous T-Cell Lymphoma Recurrent | Peripheral T-Cell Lymphoma Recurrent

United States
Induce Biologics USA Inc.

Enrolling by invitation

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

Degenerative Disc Disease

United States
BeiGene USA, Inc.

Completed

A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma

Brain and Central Nervous System Tumors

United States, Netherlands, Switzerland
Horizon Pharma USA, Inc.

Completed

Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study (OPTIC)

Thyroid Eye Disease | Graves' Orbitopathy

United States, Italy, Germany
Horizon Pharma USA, Inc.

Completed

Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study (OPTIC-X)

Thyroid Eye Disease

Italy, United States, Germany
Canon Medical Systems, USA

Completed

Verification of Imaging System PCD-1000A

Cancer Patients

United States
Knight Therapeutics (USA) Inc

Completed

Miltefosine to Treat Mucocutaneous Leishmaniasis

Cutaneous Leishmaniasis | Mucosal Leishmaniasis

United States
Knight Therapeutics (USA) Inc

Withdrawn

Treatment of Leishmaniasis With Impavido® (Miltefosine): Higher-Weight Patient Registry

Leishmaniasis

United States
Teikoku Pharma USA, Inc.

Unknown

Evaluating Efficacy of the Dexmedetomidine Transdermal System for Postoperative Analgesia Following Abdominoplasty

Pain, Postoperative

United States
Fidia Pharma USA Inc.

Completed

2 Weekly Intra-articular Hyaluronan Knee Injections, Given 1 wk. Apart, of HYMOVIS Combined With Physical Exercise Program (PEP) Compared to PEP Alone, in Relatively Young, Active Population of Subjects With Patellofemoral Osteoarthritis (PFOA) and/or Tibiofemoral Osteoarthritis (TFOA)

Knee Osteoarthritis | Osteoarthritis, Knee | Patellofemoral Osteoarthritis

United States
Tsumura USA
Cato Research

Completed

Effect of TU-100 in Patients Undergoing Laparoscopic Colectomy (TU100P2T3)

Postoperative Ileus

United States
Horizon Pharma USA, Inc.

Approved for marketing

Expanded Access Protocol of Teprotumumab (HZN-001) for Patients With Active Thyroid Eye Disease (EAP)

Thyroid Eye Disease | Graves' Orbitopathy

United States
Mimetogen Pharmaceuticals USA, Inc.

Completed

A Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye

Dry Eye Syndromes

United States
Horizon Pharma USA, Inc.

Completed

Open-Label, Safety and Superior Effectiveness Study of Cysteamine Bitartrate Delayed-Release Capsules (RP103) in Cystinosis

Cystinosis

France, United States, United Kingdom, Belgium, Italy, Netherlands
Horizon Pharma USA, Inc.

Completed

Long-Term Safety Follow-up Study of Cysteamine Bitartrate Delayed-release Capsules (RP103)

Cystinosis

France, United States, Netherlands
Horizon Pharma USA, Inc.

Terminated

A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease

Mitochondrial Diseases

United States
Horizon Pharma USA, Inc.

Completed

"Safety, Tolerability and Pharmacokinetics of MP-376 Administered for 14 Days to Stable Pediatric (CF) Patients"

Cystic Fibrosis

United States
Horizon Pharma USA, Inc.

Completed

A Phase 2 Study of MP-376 to Prevent Acute Exacerbations in Chronic Obstructive Pulmonary Disease (COPD) Patients

Chronic Obstructive Pulmonary Disease

United States
Synthes USA HQ, Inc.

Completed

Lumbar Degenerative Disc Disease Treated With Anterior Tension Band System (ATB) With ALIF/FRA Spacer (ATB)

Lumbar Degenerative Disc Disease
Horizon Pharma USA, Inc.

Completed

Phase 3 Study of Cysteamine Bitartrate Delayed-release (RP103) Compared to Cystagon® in Patients With Cystinosis

Cystinosis

France, United States, Netherlands
Horizon Pharma USA, Inc.

Completed

Pilot Study of Safety, Tolerability, Pharmacokinetics/Pharmacodynamics of RP103 Compared to Cystagon® in Patients With Cystinosis

Cystinosis

United States
Sorin Group USA, Inc.

Completed

Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair (MEMO3D)

Mitral Valve Regurgitation

United States, Canada
Synthes USA HQ, Inc.

Completed

Safety and Effectiveness Study of Prodisc to Spinal Fusion Surgery (PDL)

Spinal Diseases
Alza Corporation, DE, USA

Withdrawn

An Evaluation of Safety of the Fentanyl Transdermal System for Management of Acute Post-Operative Pain in Pediatric Patients

Pain, Postoperative | Pediatrics
Synthes USA HQ, Inc.

Terminated

A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis (In-Space)

Spinal Stenosis

United States
Sorin Group USA, Inc.

Terminated

CarboMedics Top Hat vs St. Jude Medical Regent Valve Comparing Sizing and Hemodynamics

Aortic Valve Disease

United States
Sorin Group USA, Inc.

Completed

Clinical Investigation Of The Mitroflow Aortic Pericardial Heart Valve

Heart Valve Diseases

United States, Canada
Alza Corporation, DE, USA

Completed

Pharmacokinetics of Fentanyl Following Intravenous and Oral Routes of Administration in Healthy Volunteers

Biological Availability
Alza Corporation, DE, USA

Completed

An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation

Sexual Dysfunction | Erectile Dysfunction | Ejaculation
Alza Corporation, DE, USA

Completed

Efficacy of the Fentanyl Transdermal Therapeutic System (TTS) in the Management of Pain in Patients With Cancer

Pain | Cancer
Alza Corporation, DE, USA

Completed

Clinical Use and Safety of the Fentanyl Transdermal Therapeutic System (TTS) in the Management of Pain in Patients With Cancer

Pain | Cancer
Alza Corporation, DE, USA

Completed

Efficacy and Safety of OROS Oybutynin and TTS Oxybutynin in Middle-Aged and Elderly Women With Urinary Incontinence

Urinary Incontinence
Osprey Pharmaceuticals USA, Inc.

Terminated

Safety Study of of Intravenous CCL2-LPM in Patients With IgA Nephropathy

Proteinuria | IGA Nephropathy

Canada
Alza Corporation, DE, USA

Completed

Study of the Effectiveness and Tolerability of OROS Hydromorphone HCI SR(Slow-release) Tablets and Immediate-Release Hydromorphone Tablets in Patients With Chronic Pain

Pain
Alza Corporation, DE, USA

Completed

An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release)

Osteoarthritis, Knee | Osteoarthritis, Hip
Alza Corporation, DE, USA

Completed

Safety and Tolerability of Long-Term Administration of Hydromorphone HCI CR (Controlled Release)

Pain | Analgesics, Opioid
Alza Corporation, DE, USA

Completed

Safety, Effectiveness, and Impact on Quality of Life on Long-Term Administration of OROS Hydromorphone Slow-Release in Patients With Chronic Low Back Pain

Low Back Pain
Alza Corporation, DE, USA

Completed

A Randomized, Open-Label, Single-Dose, Small Study to Evaluate the Safety and Effectiveness of Hydromorphone in Patients With Short Term, Moderate to Severe Postoperative Pain

Pain, Postoperative | Analgesia | Orthopedic Procedures
Teikoku Pharma USA, Inc.

Not yet recruiting

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

Agitation
Zenas BioPharma (USA), LLC

Recruiting

A Phase 3 Study of Obexelimab in Patients With IgG4-Related Disease (INDIGO)

IgG4 Related Disease

United States, Korea, Republic of, Spain, China, Japan, France, Mexico, Poland, Taiwan, Hungary, Italy, Germany, United Kingdom, Argentina, Netherlands, Turkey, Hong Kong, Sweden, Canada
Orum Therapeutics USA, Inc.

Recruiting

Study of ORM-5029 in Subjects With HER2-Expressing Advanced Solid Tumors

HER2-positive Breast Cancer | HER-2 Gene Amplification | HER2 Gene Mutation | HER-2 Protein Overexpression

United States
Haisco-USA Pharmaceuticals, Inc.

Recruiting

Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery

General Anesthesia

United States, Spain, Poland
Hinova Pharmaceuticals USA, Inc.

Active, not recruiting

HC-1119 Versus Enzalutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Castration-resistant Prostate Cancer | Prostate Cancer Metastatic

Germany, Spain, Denmark, France, United Kingdom, Russian Federation, Poland, Australia, Italy, Netherlands, United States, Finland, Canada, Austria
Mimetogen Pharmaceuticals USA, Inc.

Completed

Efficacy and Safety Evaluation of Tavilermide Ophthalmic Solution for the Treatment of Dry Eye

Dry Eye Syndromes | Dry Eye Disease | Kerato Conjunctivitis Sicca

United States
Zenas BioPharma (USA), LLC

Active, not recruiting

Study of ZB001 in Chinese Patients With Thyroid Eye Disease

Thyroid Eye Disease

China
Haisco-USA Pharmaceuticals, Inc.

Completed

Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery

Anesthesia

United States
Zenas BioPharma (USA), LLC

Completed

A Safety, Tolerability and Pharmacokinetics Study of ZB001 in Healthy Subjects

Healthy Volunteers

China
Mimetogen Pharmaceuticals USA, Inc.

Completed

Tavilermide Ophthalmic Solution for the Treatment of Dry Eye

Dry Eye | Keratoconjunctivitis Sicca

United States

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