Search clinical trials for: MTHFR genotype

Total 1431 results

Hospital de Clinicas de Porto Alegre

Unknown

Natural History of Oculomotor Neurophysiology in Ataxic and Pre-ataxic Carriers of SCA3/MJD (BIGPRO)

Spinocerebellar Ataxia Type 3 | Machado-Joseph Disease

Brazil
Instituto de Investigación Hospital Universitario...

Unknown

Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.

HIV-1-infection

Spain
Rigshospitalet, Denmark
Steno Diabetes Center Copenhagen

Completed

Glycaemic Markers in Persons With Type 2 Diabetes on Haemodialysis (GLYCOHEMO)

Type2 Diabetes | Diabetic Nephropathy Type 2

Denmark
University of Texas Southwestern Medical Center

Completed

Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial (PAH)

Pulmonary Arterial Hypertension

United States
Mayo Clinic

Completed

A PK/PD Genetic Variation Treatment Algorithm Versus Treatment As Usual for Adolescent Management Of Depression (AMOD)

Depression

United States
National Cancer Institute (NCI)

Completed

Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)

Nasopharyngeal Carcinoma

China
AbbVie

Completed

Drug Use-Results Survey in Participants Infected With Hepatitis C Virus Genotype 2

Chronic Hepatitis C Virus

Japan
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Elbasvir (MK-8742) + Grazoprevir (MK-5172) in Treatment-Naïve/Treatment-Experienced (TN/TE) French Participants With Hepatitis C Virus (HCV) Genotype 4 (GT4) Infection (MK-5172-096)

Hepatitis C Virus (HCV) Infection

France
University of Texas Southwestern Medical Center
National Center for Research Resources (NCRR)

Completed

Safety and Efficacy of Fluoxetine in Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

United States
Beni-Suef University

Completed

Sofosbuvir/Ombitasvir/Paritaprevir/ Ritonavir and Ribavirin for Hepatitis C Virus Genotype 4 Patients

Chronic Hepatitis C Virus Infection

Egypt
Beni-Suef University

Completed

Sofosbuvir Plus Daclatasvir With or Without Ribavirin and Chronic HCV Genotype (GT) 4

Chronic Hepatitis C Virus Infection
Beni-Suef University

Completed

ٍٍSofosbuvir/Simeprevir/Daclatasvir/Ribavirin and HCV Genotype 4-infected Egyptian Experienced Participants

Chronic Hepatitis C Virus Infection

Egypt
Beni-Suef University

Completed

Ombitasvir /Paritaprevir/Ritonavir Plus Ribavirin on HCV GT4

Hepatitis C Virus Infection
Beni-Suef University

Completed

Sofosbuvir/Pegylated-interferon Plus Ribavirin With HCV Genotype 4 (HCV)

Hepatitis C Virus Infection
University of Chicago
National Cancer Institute (NCI)

Completed

Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Stage IIIA Rectal Cancer | Stage IIIB Rectal Cancer | Stage IIIC Rectal Cancer | Acinar Cell Adenocarcinoma of the Pancreas | Duct Cell Adenocarcinoma of the Pancreas | Stage III Pancreatic Cancer | Stage IV Pancreatic... and other conditions

United States
Mental Health Services in the Capital Region, Denmark
Copenhagen University Hospital, Denmark

Completed

The Relationship Between CES1 Genotype and Methylphenidate Response in Children With ADHD - INDICES Work Package 6

ADHD
International Vaccine Institute
Ministry of Health, Thailand

Enrolling by invitation

Effectiveness of Single Dose or Two Doses of Bivalent HPV Vaccine in Thailand (IVIHPV1)

Healthy

Thailand
University of Maryland, Baltimore
Merck Sharp & Dohme LLC; Cairo University

Withdrawn

Clinical Trial to eLiminate HCV-infection in Treatment-naïve, Renally Impaired EgyptiAn Patients on Renal Dialysis, With Chronic Hepatitis C Genotype 4 (CLEAR-C4)

Hepatitis C Virus Infection, Response to Therapy of

Egypt
Icahn School of Medicine at Mount Sinai
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Rare... and other collaborators

Completed

Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact

Erythropoietic Protoporphyria | EPP | XLP | X-Linked Protoporphyria | XLPP | X-Linked Dominant Erythropoietic Protoporphyria | XLEPP | XLDP

United States
Chang Gung Memorial Hospital
Dr. Chip Biotechnology Incorporation

Completed

HPV Genotyping by DR. HPV Genotyping in Vitro Diagnostic Device (IVD) Kit in Exfoliated Cells of the Uterine Cervix

Cervical Intraepithelial Neoplasia | HPV Infection | Human Papillomavirus Infection

Taiwan
Universidad de Costa Rica
Universitat Autonoma de Barcelona

Unknown

C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine Effectiveness in Metastatic Colon Cancer

Colon Cancer | Chemotherapy Effect | Chemotherapeutic Toxicity | MTHFR Gene Mutation

Costa Rica
National Institute of Diabetes and Digestive and...

Completed

Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected With Different Hepatitis C Virus Genotypes During Therapy With Sofosbuvir and GS-5816

Chronic Hepatitis C

United States
Sunshine Lake Pharma Co., Ltd.

Completed

Phase 2 Study of Yimitasvir Phosphate Capsules

Chronic HCV Infection

China
Sunshine Lake Pharma Co., Ltd.

Completed

Phase 3 Study of Yimitasvir Phosphate Capsules

Chronic HCV Infection

China
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment-Naive Adults in Brazil With Chronic Hepatitis C Virus (HCV) Genotype 1 - 6 Infection

Hepatitis C Virus (HCV)

Brazil
Eisai Inc.

Completed

Exploratory Study, Evaluating the Treatment Effect of Surgery Plus GLIADEL® Wafer in Patients With Metastatic Brain Cancer

Metastatic Brain Cancer

United States
National Human Genome Research Institute (NHGRI)

Completed

Genetic Analysis of Hereditary Prostate Cancer

Prostate Cancer

United States, Finland
National Human Genome Research Institute (NHGRI)

Completed

Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

Hereditary Oral Clefts

Syrian Arab Republic
Leiden University Medical Center
Erasmus Medical Center; The Netherlands Cancer Institute; Medical Center Haaglanden and other collaborators

Unknown

Identifying Novel Variants in the DPYD Gene in Patients of Non-Western Descent (DPYD-NOW)

Neoplasms
Gilead Sciences

Completed

Safety and Efficacy of Voxilaprevir Plus Sofosbuvir/Velpatasvir Fixed Dose Combination in Adults With Chronic Genotype 1 HCV Infection

Hepatitis C Virus Infection

United States, Puerto Rico, New Zealand
Gilead Sciences

Completed

Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination in Participants With Chronic Genotype 1 HCV Infection

Chronic HCV Infection

China, Korea, Republic of, Taiwan
Gilead Sciences

Completed

Safety and Efficacy of Voxilaprevir Plus Sofosbuvir/Velpatasvir Fixed Dose Combination in Adults With Chronic Non-Genotype 1 HCV Infection

Hepatitis C Virus Infection

United States, Puerto Rico, New Zealand
Gilead Sciences

Completed

Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed Dose Combination in the Treatment of Hepatitis C Virus (HCV) Infection in Pediatric Participants Undergoing Cancer Chemotherapy

Hepatitis C Virus Infection

Egypt
Istanbul Medeniyet University

Completed

Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke

Epilepsy | Ischemic Stroke | Hyperhomocysteinemia, Thrombotic, Cbs-Related

Turkey
Sun Yat-sen University

Completed

A Retrospective Cohort Study: The Influence of MTHFR C677T and A1298C on the High-dose Methotrexate-Related Toxicities in Pediatric Patients With Non-Hodgkin Lymphoma

Pediatric NHL

China
AbbVie

Completed

Drug Use-results Survey in Patients Infected With Hepatitis C Virus Genotype 1

Chronic Hepatitis C Virus

Japan
The HIV Netherlands Australia Thailand Research...
Merck Sharp & Dohme LLC; Chulalongkorn University

Unknown

Safety and Efficacy of Grazoprevir and Elbasvir for GT1ang GT6 With and Without HIV

Compensated Cirrhosis

Thailand
University Medical Center Groningen

Unknown

An Integrative Genomic Approach to Solve tHe Puzzle of sevERe earLy-Onset COPD (SHERLOCk)

Chronic Obstructive Pulmonary Disease | COPD | Severe Early-Onset COPD | SEO-COPD

Netherlands
Chang Gung Memorial Hospital

Unknown

Clinical Trial for GALNT14 Genotype - Guided, Sorafenib in Combination With TACE in Hepatocellular Carcinoma

Hepatocellular Carcinoma

Taiwan
Centre Hospitalier Universitaire de Besancon

Unknown

Assessment of Cardiac Output With EtCO2 (COCO2)

Cardiac Output

France
Institut de Médecine et d'Epidémiologie Appliquée...
Merck Sharp & Dohme LLC; Institut National de la Santé Et de la Recherche Médicale...

Completed

Short Duration Therapy of Acute Hepatitis C Genotypes 1 or 4 (SAHIV)

HIV | Acute Hepatitis C

France
University of Monastir

Completed

Clinical and Genetic Influencing Factors on Clozapine Pharmacokinetics

Schizophrenia | Clozapine | CYP1A2 Polymorphism | CYP2C19 Polymorphism

Tunisia
Vertex Pharmaceuticals Incorporated

Completed

A Study of VX-445 Combination Therapy in CF Subjects Homozygous for F508del (F/F)

Cystic Fibrosis

United States, Belgium, Netherlands, United Kingdom
Instituto de Investigación Hospital Universitario...

Unknown

Effectiveness and Efficiency of a Voriconazole Preemptive Genotyping Strategy (VORIGENPHARM)

Invasive Fungal Infections

Spain
Nemours Children's Clinic
Merck Sharp & Dohme LLC

Completed

Genotype Stratified Pharmacokinetic Study of Montelukast (GSPOM)

Asthma

United States
The Netherlands Cancer Institute
Leiden University Medical Center

Unknown

Improving the Safety of Fluoropyrimidine-based Chemotherapy (Alpe2U)

Neoplasms

Netherlands
National Cancer Institute (NCI)

Terminated

Host Genetic Factors Influencing HIV1 and HCV Viral Loads and AIDS Clinical Progression in a Hemophilia Cohort (HGDS-3)

Hemophilia | AIDS

United States
Norwegian University of Science and Technology

Completed

Treatment of Latent Autoimmune Diabetes of the Adult (LADA)

Diabetes

Norway
M.D. Anderson Cancer Center

Terminated

Metformin in Non Small Cell Lung Cancer (NSCLC)

Lung Cancer

United States
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced, Non-Cirrhotic Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With or Without Human Immunodeficiency Virus Co-Infection (VOYAGE-1)

Hepatitis C Virus (HCV)

China, Korea, Republic of, Singapore

Search clinical trials for: MTHFR genotype

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