Search clinical trials for: Locoregional therapies

Total 2083 results

Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)

Esophageal Squamous Cell Carcinoma (ESCC)

Japan, Italy, Brazil, Chile, France, Germany, Korea, Republic of, Norway, Singapore, Switzerland, Taiwan, Thailand, Turkey
Boston Scientific Corporation

Active, not recruiting

Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing (MODULAR ATP)

Tachycardia, Ventricular | Arrhythmia, Ventricular

United States, Spain, Italy, United Kingdom, Netherlands, France, Czechia, Austria, Canada
Genmab
AbbVie

Active, not recruiting

A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab As Monotherapy or Combined With Standard of Care Therapies in Adult Participants in China With B-Cell Non-Hodgkin Lymphoma

B-Cell Non-Hodgkin Lymphoma

China
University of Gaziantep

Completed

Effect of Non-invasive Photobiomodulation Therapies in Patients With Trigeminal Neuralgia

Trigeminal Neuralgia

Turkey
Centre for Addiction and Mental Health
University of British Columbia; Brain Canada; Ontario Shores Centre for Mental...

Active, not recruiting

Efficacy of Convulsive Therapies for Bipolar Depression (CORRECT-BD)

Bipolar Disorder | Bipolar Depression | Bipolar I Disorder | Bipolar II Disorder

Canada
St. Jude Children's Research Hospital
Novartis Pharmaceuticals

Completed

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Glioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditions

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); University of Pittsburgh; AIM ImmunoTech Inc.

Suspended

Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines

Ovarian Cancer | Cancer of the Ovary | Ovary Cancer | Neoplasms, Ovarian | Ovary Neoplasms | Cancer of Ovary

United States
Centre Hospitalier de Valenciennes

Completed

Evaluation of the Use of the RELAX® Glasses on the Anxiety of Patients Undergoing Emergency Hand Surgery Under Locoregional Anesthesia (RELAX)

Surgery

France
Bristol-Myers Squibb

Active, not recruiting

A Study of BMS-986406 as Monotherapy and Combination Therapies in Participants With Advanced Tumors

Advanced Cancer

United States, Spain, Argentina, Belgium, Korea, Republic of, Japan
Boehringer Ingelheim

Active, not recruiting

Platform Trial Evaluating Safety and Efficacy of BI 754091 Anti- PD-1 Based Combination Therapies in PD-(L)1 naïve and PD- (L)1 Pretreated Patient Populations With Advanced/Metastatic Solid Tumours

Neoplasm Metastasis

United States, United Kingdom, Canada
Marmara University

Completed

Adding Core Stabilization Training to Manuel Therapy in Temporomandibular Disorders

Temporomandibular Disorders | Temporomandibular Joint Disorders

Turkey
Genentech, Inc.

Active, not recruiting

Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors

Advanced/Metastatic Tumors

Spain, United States, Korea, Republic of, Australia, France, Japan, Canada
Gulhane Training and Research Hospital

Completed

Effect of Different Dietary Therapies on Intestinal Barrier Integrity in Patients With Irritable Bowel Syndrome

Irritable Bowel Syndrome-IBS

Turkey
AstraZeneca

Active, not recruiting

A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma (EMERALD-1)

Hepatocellular Carcinoma

United States, Canada, France, Taiwan, Thailand, Vietnam, Italy, Korea, Republic of, Brazil, India, Japan, Mexico, Russian Federation, China, Hong Kong, Australia, Spain, Singapore
UMC Utrecht

Withdrawn

Efficacy of MR-HIFU Ablation of Breast Cancer

Breast Cancer

Netherlands
Strata Oncology
Merck Sharp & Dohme LLC; Pfizer; Gilead Sciences

Active, not recruiting

Strata PATH™ (Precision Indications for Approved Therapies) (Strata PATH)

Cancer | Advanced Solid Tumor

United States
Centre Hospitalier Universitaire de Saint Etienne

Completed

Analgesic Territory Assessment of the Spinal Erector Block Using Pupillometry (TEASER)

Anesthesia, Local

France
National Cancer Institute (NCI)

Active, not recruiting

Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer

Recurrent Gallbladder Carcinoma | Metastatic Gallbladder Carcinoma | Stage IV Gallbladder Cancer AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IV Distal Bile Duct Cancer AJCC v8 | Metastatic Intrahepatic Cholangiocarcinoma | Recurrent Intrahepatic Cholangiocarcinoma | Metastatic... and other conditions

United States
Hoffmann-La Roche

Completed

A Study of Atezolizumab in Combination With Bevacizumab in Spanish Patients With Unresectable or Unsuitable for Locoregional Treatments Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy

Carcinoma, Hepatocellular

Spain
Women's College Hospital
University of Toronto

Withdrawn

Rhythmic Sensory Stimulation on Fibromyalgia

Chronic Pain, Widespread
Pfizer

Completed

Comparative Effectiveness of Targeted Therapies in BRAF Positive Metastatic Melanoma in the US (OCEANMIST)

Melanoma

United States
University of Alcala

Withdrawn

Spinal Manipulation and Neuromuscular Performance on Amateur Cyclists

Manual Therapies

Spain
Ipsen

Active, not recruiting

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) (ELATIVE)

Primary Biliary Cirrhosis

United States, France, Spain, Belgium, Germany, Switzerland, Brazil, United Kingdom, Argentina, Canada, Chile, Italy, South Africa, Turkey
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

New and Emerging Therapies for the Treatment of Resectable, Borderline Resectable, or Locally Advanced Pancreatic Cancer, PIONEER-Panc Study

Borderline Resectable Pancreatic Adenocarcinoma | Resectable Pancreatic Ductal Adenocarcinoma | Locally Advanced Pancreatic Ductal Adenocarcinoma

United States
Spanish Foundation for Neurometrics Development
Fundacion para la Salud Materno Infantil

Enrolling by invitation

Result of tDCS in ASD Children With Comorbidities Like PANDAS, Rare Genetic Diseases or Autoimmune Disorders (tDCS&ASD)

Social Behavior | Attention | EEG With Periodic Abnormalities | Visual Perceptual Weakness | Fluency Disorder

United Kingdom
Centre Hospitalier Universitaire Saint Pierre

Terminated

Comparison of 2 Different Positional Therapies for Positional Obstructive Sleep Apnea Syndrome

Positional Obstructive Sleep Apnea

Belgium
Centers for Disease Control and Prevention
Ministry of Health, Liberia

Completed

Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia

Malaria | Plasmodium Falciparum | Uncomplicated Malaria

Liberia
Zhejiang Cancer Hospital

Completed

Radiation Plus Concurrent Nimotuzumab in Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

China
McMaster University
St. Joseph's Healthcare Hamilton; Canadian Institutes of Health Research (CIHR) and other collaborators

Active, not recruiting

CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients (CYCLE)

Respiratory Failure | Critical Care | Mechanical Ventilation | Intensive Care Unit Acquired Weakness

Canada, United States, Australia
Thomas Martin, MD
University of California, Davis; Actavis Inc.; Eugia Pharma Specialities Limited

Active, not recruiting

Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple Myeloma

Refractory Multiple Myeloma | Relapsed Multiple Myeloma

United States
Chinese University of Hong Kong

Active, not recruiting

Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD

Meibomian Gland Dysfunction

Hong Kong
University of California, Los Angeles
NYU Langone Health; Olive View-UCLA Education & Research Institute

Enrolling by invitation

Financial Incentives for Smoking Treatment II (FIESTA II)

Smoking Cessation | Tobacco Use Cessation

United States
Allegheny Singer Research Institute (also known...
ElectroCore INC

Terminated

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms (SAVIORII)

Respiratory Failure | COVID | Corona Virus Infection | Respiratory Distress Syndrome, Adult | SARS (Severe Acute Respiratory Syndrome) | ARDS, Human

United States
The Cleveland Clinic
University of Nottingham

Active, not recruiting

Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS (DELIVER-MS)

Multiple Sclerosis, Relapsing-Remitting

United States, United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Onalespib in Treating Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Radiation Therapy and Cisplatin

Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7 | Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 | Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IVB Laryngeal Squamous Cell Carcinoma AJCC... and other conditions

United States, Canada
Merck Sharp & Dohme LLC

Terminated

A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001)

Nonalcoholic Steatohepatitis

Korea, Republic of, United States, Argentina, Australia, Canada, Chile, China, Colombia, France, Germany, Greece, Hong Kong, Israel, Italy, Japan, Malaysia, Mexico, New Zealand, Puerto Rico, Russian Federation, Spain, Sweden, Taiwan, ...
Indiana University
National Center for Advancing Translational Sciences (NCATS); Indiana Clinical... and other collaborators

Completed

Efficacy of Psychological Therapies in Patients With Functional Bowel Disorders (PTSD)

Constipation | IBS - Irritable Bowel Syndrome

United States
Brigham and Women's Hospital
National Institute on Aging (NIA)

Active, not recruiting

Addressing Diffusion of Responsibility and Prescribing Burden to Improve Use of Diabetes Medications

Diabetes | SGLT-2i and GLP-1RA Therapies | Diffusion of Responsibility | Prescribing Burden

United States
Karolinska University Hospital
Medical University of Graz; Aarhus University Hospital; Centre Hospitalier Universitaire... and other collaborators

Enrolling by invitation

GUIDING MULTI-MODAL THERAPIES AGAINST MINIMAL RESIDUAL DISEASE BY LIQUID BIOPSIES (GUIDEMRD)

Pancreatic Adenocarcinoma

Sweden
Intra-Cellular Therapies, Inc.

Completed

Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

Major Depressive Disorder

United States, Bulgaria, Czechia, Slovakia, Hungary, India
Inova Health Care Services
University of Houston; University of Louisville; Howard University; Tigerlily Foundation and other collaborators

Active, not recruiting

Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention (MOM)

Melanoma | Cancer | Breast Cancer | Head and Neck Cancer | Gynecologic Cancer | Colorectal Cancer | Esophageal Cancer | Lung Cancer | Brain Cancer | Gastrointestinal Cancer | Central Nervous System Cancer | Acceptance and Commitment Therapy | Blood Cancer | Genitourinary Cancer | Psychosocial Intervention | Mind-Body Therapies

United States
University of Florida

Suspended

Investigating Integrative Therapies for Symptom Management in Adults With Acute Leukemia

Acute Myeloid Leukemia

United States
Novartis Pharmaceuticals

Active, not recruiting

An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumab (ARTIOS)

Relapsing Multiple Sclerosis

United States, Poland, Austria, Belgium, Czechia, Germany, Australia, Switzerland, Lebanon, Argentina, Canada, Slovenia, Bulgaria, Latvia, Russian Federation, Spain, Italy, Turkey, Slovakia, Portugal, Greece, Saudi Arabia, Hungary, No... and more
University Medical Center Groningen
AstraZeneca

Completed

Decentralized N=1 Study: A Feasible Approach to Evaluate Individual Therapy Response to Dapagliflozin. (@HOME)

Diabetes Mellitus, Type 2 | Diabetes Mellitus | Diabetes | Diabetes Complications | Chronic Kidney Diseases | Proteinuria | Albuminuria | CKD | Chronic Kidney Disease Due to Type 2 Diabetes Mellitus | Diabetes Mellitus Type 2 With Proteinuria

Netherlands
VA Office of Research and Development
Veterans Health Administration Office of Patient Centered Care & Cultural...

Completed

Assessing Pain, Patient Reported Outcomes and Complementary and Integrative Health (APPROACH)

Chronic Musculoskeletal Pain

United States
Merck Sharp & Dohme LLC

Active, not recruiting

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Carcinoma, Renal Cell

Spain, United States, Australia, Canada, Chile, Colombia, France, Hungary, Israel, Korea, Republic of, Netherlands, New Zealand, Poland, United Kingdom
University of Michigan
National Heart, Lung, and Blood Institute (NHLBI); Nationwide Children's Hospital and other collaborators

Completed

Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension

Pulmonary Hypertension | Congenital Heart Disease | Pediatric Congenital Heart Disease

United States
Amgen
Innovative Therapies For Children with Cancer Consortium; Therapeutic Advances...

Active, not recruiting

Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL)

Spain, United Kingdom, United States, Korea, Republic of, Czechia, France, Russian Federation, Saudi Arabia, Thailand, Canada, Italy, Singapore, Turkey, Taiwan, Portugal, Poland, Romania, Brazil, Australia, Greece, Argentina, Mexico, Austr... and more
Indiana University
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies Trial (SOCIAL HF)

Implementation Science | Decision Making | Bias, Racial | Heart Transplant | Health Equity | Bias, Sex

United States
Centre Hospitalier Departemental Vendee

Completed

Chronic Pain and Functional Prognosis After Total Knee Replacement: Continuous Locoregional Analgesia by Catheter to the Femoral Triangle Versus Tissue Infiltration as Part of an Improved Rehabilitation After Surgery Approach (TKAFTER)

Knee Pain Chronic

France

Search clinical trials for: Locoregional therapies

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