Clinical Trials Sponsored by CRL

Total 1130 results

ikfe-CRO GmbH
IKFE Institute for Clinical Research and Development

Unknown

Establishing Cardiovascular Biomarkers to Define Preferred Lantus® Use

Insulin-requiring Type 2 Diabetes Mellitus

Germany
Medical University of Graz
Novo Nordisk A/S; CSL Behring

Completed

Reversibility of Dual Antiplatelet Therapy by Platelets

Bleeding

Austria
Center for Epidemiology and Health Research, Germany
Estetra SRL

Recruiting

International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety Study (INAS-NEES)

Contraception | Birth Control

Germany
Signorini Medicale S.r.l.
Opera CRO, a TIGERMED Group Company

Not yet recruiting

Study to Evaluate the Performance and Safety of the Medical Device Argogen

Burn Wound | Pressure Ulcers Stage II | Pressure Ulcers Stage III

Romania
Artcline GmbH
Zentrum für Klinische Studien Jena; CRO Kottmann

Recruiting

Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy (ReActiF-ICE)

Sepsis, Severe

Germany
GMG Grand Medical
Gama CRO Tıbbi İlaç Araştırma Org.Tic.Ltd.Şti

Not yet recruiting

Retrospective Chart Review of Treataprost Added to Antibiotic Treatment in Patients With Chronic Prostatitis (Treataprost)

Quality of Life | Infection, Bacterial | Prostatitis | PSA

Turkey
Enlivex Therapeutics Ltd.
Cato Research; Accelsiors CRO & Consultancy Services

Active, not recruiting

A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients

Sepsis | Intraabdominal Infections | Cholecystitis, Acute | Urinary Tract Infections | Community-acquired Pneumonia | Cholangitis Acute

Netherlands, Israel, France, Belgium, Spain
Ludwig Institute for Cancer Research
Cancer Research Institute (CRI)

Completed

NY-ESO-1 Protein Vaccine With Imiquimod in Melanoma (Adjuvant Setting)

Malignant Melanoma

United States
CRG UZ Brussel
KU Leuven; Abbott; Universitätsklinikum Hamburg-Eppendorf

Completed

Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI

Infertility | Infertility, Female | Dydrogesterone | Genital Diseases, Female | Progesterone | Hormones | Physiological Effects of Drugs | Genital Diseases, Male | Hormones, Hormone Substitutes, and Hormone Antagonists | Progestins

Belgium
Effik Italia S.p.A.
Opera CRO, a TIGERMED Group Company

Completed

A Study of the New Medical Device Polybactum® (POLARIS)

Bacterial Vaginosis

Romania
Stanley Jordan, MD
CSL Behring

Completed

Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection

Kidney Transplantation

United States
Carl Ade, M.S., Ph.D.
California Strawberry Commission

Recruiting

Strawberry Consumption in Overweight and Obese Individuals

Obesity | Metabolic Syndrome

United States
Teikoku Seiyaku Co., Ltd.
ClinSearch; Clinigen, Inc.; CRM Biometrics GmbH

Completed

Efficacy and Safety of Esflurbiprofen Hydrogel Patch in the Treatment of Local Acute Pain

Soft Tissue Injuries | Sprains | Contusions | Strains | Bruises

Germany
ReiThera Srl
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Completed

Phase I Study to Assess the Safety and Immunology of a COVID-19 Vaccine With GRAd-COV2 Vaccine

COVID-19

Italy
COL George Peoples, MD, FACS

Completed

Phase I/IIa Trial of Folate Binding Protein Vaccine in Ovarian Cancer

Ovarian Cancer | Endometrial Cancer | Peritoneal Cancer | Fallopian Cancer

United States
German CLL Study Group
Hoffmann-La Roche; Janssen-Cilag Ltd.

Completed

Sequential Regimen of Bendamustin [B] Followed by GA101 and Ibrutinib [I] in CLL Patients

Chronic Lymphocytic Leucemia

Germany
Radboud University Medical Center
ABX CRO; Telix International Pty Ltd

Completed

89Zr-girentuximab ) Dosimetry in CCRC Study - ZIR-DOSE

Clear Cell Renal Carcinoma

Netherlands
MDM S.p.A.
Opera CRO, a TIGERMED Group Company; Latis S.r.l.

Completed

Study to Assess the Efficacy and Safety of Tizaspray® Versus Sirdalud®, in Patients With Acute Low Back Pain

Low Back Pain

Romania
IRCCS Policlinico S. Matteo
Nestlé Health Science Spain; Akern Srl

Completed

Intensive Nutritional Counseling in Head-neck Cancer Patients Undergoing Radiotherapy

Head-neck Cancer

Italy
Kanto CML Study Group
Epidemiological and Clinical Research Information Network

Completed

A Study of Complete Molecular Response for Chronic Myeloid Leukemia in Chronic Phase Patients, Treated With Dasatinib (CMR-CML)

Chronic Myeloid Leukemia

Japan
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Sintesi Research Srl

Unknown

Safety/Efficacy Study to Assess Whether FVIII/VWF Concentrate Can Induce Immune Tolerance in Haemophilia A Patients (ITI)

Hemophilia A

India, Egypt
German CLL Study Group
AbbVie; Hoffmann-La Roche; Swiss Group for Clinical Cancer Research; Stichting... and other collaborators

Completed

Standard Chemoimmunotherapy (FCR/BR) Versus Rituximab + Venetoclax (RVe) Versus Obinutuzumab (GA101) + Venetoclax (GVe) Versus Obinutuzumab + Ibrutinib + Venetoclax (GIVe) in Fit Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without Del(17p) or TP53 Mutation (GAIA)

Chronic Lymphocytic Leukemia

Ireland, Germany, Israel, Austria, Belgium, Denmark, Switzerland, Finland, Sweden, Netherlands
Farmacia La Regina s.r.l.
Federfarma Campania; Federfarma Salerno; HTN - Health Telematic Network srl; BSI... and other collaborators

Completed

New Patient Support Program in Type 2 Diabetes

Diabetes Mellitus, Type 2

Italy
Centre Leon Berard
Centre de Recherche en Cancérologie de Lyon (CRCL)

Recruiting

Prospective Study of Immune Alterations in Operable Breast and Ovarian Carcinoma (GYNECO-IMM&CO)

Breast Carcinoma | Ovarian Carcinoma

France
United States Naval Medical Center, San Diego
Carl Zeiss Meditec, Inc.

Recruiting

SMILE (Small Incision Lenticule Extraction) in the DoD (Department of Defense)

Astigmatism | Myopia

United States
Universitätsmedizin Mannheim
University of California, Los Angeles; Carl Zeiss Meditec AG

Recruiting

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme (INTRAGO-II)

Glioblastoma

Korea, Republic of, Germany, Canada, Spain, United States, Brazil, China, United Kingdom
Kuros Biosurgery AG
Factory CRO; Kuros BioSciences B.V.; The London Clinic

Withdrawn

Post Marketing Clinical Follow up Study for MagnetOs Putty in Patients With Degenerative Disc Disease (PROGRESS)

Degenerative Disc Disease

United Kingdom
I.R.A. Istituto Ricerche Applicate S.p.A.
Opera CRO, a TIGERMED Group Company

Completed

Evaluating the Performance and Safety of the Medical Device Janesse in the Treatment of Facial Dermal Tissue Defects

Cicatrix | Plaque | Lipodystrophy

Romania
Implandata Ophthalmic Products GmbH
CRO Dr. med. Kottmann GmbH & Co. KG

Active, not recruiting

Long-term Safety and Performance of the ARGOS-SC Suprachoroidal Pressure Sensor System in Patients With Glaucoma Underwent Non-penetrating Glaucoma Surgery

Glaucoma | Open Angle Glaucoma

Germany, Switzerland
Swisse Wellness Pty Ltd
Commonwealth Scientific & Industrial Research Organisation; BIONAP SRL

Completed

Investigating Effects of a Novel Nutraceutical on Hypercholesterolaemia in Australian Adults (CLoNE)

Hypercholesterolemia

Australia
German CLL Study Group
Genzyme, a Sanofi Company; University of Cologne

Completed

Combined Immunochemotherapy in Patients With T-Prolymphocytic Leukemia (T-PLL)

T-cell-prolymphocytic Leukemia

Germany
Implandata Ophthalmic Products GmbH
CRO Dr. med. Kottmann GmbH & Co. KG

Completed

Performance and Safety of the ARGOS-SC01 Suprachoroidal Pressure Sensor in Patients With Glaucoma Undergoing Non-penetrating Glaucoma Surgery (ARGOS-SC01)

Glaucoma | Open Angle Glaucoma

Germany, Switzerland
I.R.A. Istituto Ricerche Applicate S.p.A.
Opera CRO, a TIGERMED Group Company

Completed

Study to Evaluate the Performance and Safety of the Medical Device Plenhyage® (Plenhyage)

Wrinkle

Romania
I.R.A. Istituto Ricerche Applicate S.p.A.
Opera CRO, a TIGERMED Group Company

Completed

Study To Assess The Efficacy And Safety Of The Medical Device Iracross Versus Iraline Administered Intra-Articular To Patients With Knee Osteoarthritis

Osteoarthritis, Knee

Romania
I.R.A. Istituto Ricerche Applicate S.p.A.
Opera CRO, a TIGERMED Group Company

Completed

Open, Non-Comparative Study To Evaluate The Performance Of The Medical Device JANESSE®

Wrinkle

Romania
Gruppo Italiano Malattie EMatologiche dell'Adulto
European Leukemia Net; CML Advocates Network

Unknown

LEONIDAS: Quality of Life Study in Chronic Myeloid Leukemia Patients (QoL-CML0713)

Chronic Myeloid Leukemia

Italy, France, Germany, Spain
Weill Medical College of Cornell University
University of Pennsylvania; CSL Behring

Completed

Females With Severe or Moderate Hemophilia A or B: A Multi-Center Study

Hemophilia A | Hemophilia B

United States, Puerto Rico
Mayo Clinic
University of Florence; Olivi Agri Team Srl- Grosetto, Italy

Completed

Effects of EGCG-Enhanced Extra Virgin Olive Oil on Endothelial Function

Atherosclerosis

United States
ikfe-CRO GmbH
Sanofi; IKFE Institute for Clinical Research and Development

Completed

Beta Cell Relieving and Cardiovascular Protective Effects of LANTUS Treatment in Type 2 Diabetes Patients

Diabetes Mellitus, Type 2

Germany
Entos Pharmaceuticals Inc.
Q2 Solutions; Calian CRO; PCI Pharma Services

Not yet recruiting

To Evaluate Safety and Immunogenicity of a Prophylactic Plasmid DNA (VAX-002-01)

COVID-19

Canada
Yooyoung Pharmaceutical Co., Ltd.
Opera CRO, a TIGERMED Group Company

Not yet recruiting

Post Marketing Clinical Follow up Study to Evaluate the Performance and Safety of ORTHIX PLUS

Osteoarthritis, Knee | Degenerative Joint Disease of Knee
Yooyoung Pharmaceutical Co., Ltd.
Opera CRO, a TIGERMED Group Company

Not yet recruiting

Post Marketing Clinical Follow up Study to Evaluate the Performance and Safety of HYALEXO

Osteoarthritis | Degenerative Joint Disease
ResMed
CRI-The Clinical Research Institute GmbH; University Hospital Regensburg

Completed

Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation (READ-ASV)

Obstructive Sleep Apnea | Central Sleep Apnea | Mixed Sleep Apnea | Complex Sleep Apnea

Switzerland, Spain, Denmark, Portugal, France, Germany
MODAG GmbH
Quotient Sciences; Aptuit (Verona) Srl, an Evotec Company

Completed

A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects

Healthy Volunteers

United Kingdom
Ricerfarma S.r.l
Opera CRO, a TIGERMED Group Company; Latis S.r.l.

Completed

Study of a New Medical Device in Gel Formulation Versus Calgel® for the Topical Treatment of Teething in Infants

Pain Teeth

Romania
Mesoestetic Pharma Group S.L.
Opera CRO, a TIGERMED Group Company

Completed

Pilot Trial to Assess the Performance and Tolerance of mRDX-02-17 Dermal Filler in the Facial Rejuvenation

Facial Rejuvenation

Romania
Fondazione Italiana Sclerosi Multipla
Opera CRO, a TIGERMED Group Company

Unknown

Understanding Evaluation of Patient Information Sheets by User Testing Method

MS (Multiple Sclerosis)

Italy, Romania
Fondazione Italiana Sclerosi Multipla
Opera CRO, a TIGERMED Group Company

Completed

Observational Study of the Prevalence of CCSVI in Multiple Sclerosis and in Other Neurodegenerative Diseases (COSMO)

Multiple Sclerosis | Neurodegenerative Diseases

Italy, Romania
Cytonet GmbH & Co. KG
CRS Clinical Research Services Mannheim GmbH

Completed

Study in Healthy Subjects, Patients With Urea Cycle Disorders (UCD) and Carriers of UCD Mutations to Evaluate Urea Cycle Function

Urea Cycle Disorders

Germany
ikfe-CRO GmbH
IKFE Institute for Clinical Research and Development

Completed

Beta-Cell Function of Insulin Glargine Compared to Neutral Protamine Hagedorn (NPH) Insuline and to Insulin Detemir in Combination With Metformin

Type 2 Diabetic Patients | Insufficient Metabolic Control | OAD Treatment

Germany

Clinical Trials Sponsored by CRL

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in Australia

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Drug Interventions

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