Search clinical trials for: Protease Inhibitors

Total 64218 results

Cephalon

Terminated

Study to Determine the Maximum Tolerated Dose and Evaluate the Efficacy and Safety of CEP-18770 (Delanzomib) in Patients With Relapsed Multiple Myeloma Refractory to the Most Recent Therapy

Multiple Myeloma

United States
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Terminated

Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency

Chronic Obstructive Pulmonary Disease | Alpha1-antitrypsin Deficiency

United States, Canada, Australia
Cytonics Corporation
Southern Star Research Pty Ltd.

Not yet recruiting

Evaluation of CYT-108, a Recombinant Protease Inhibitor, for Treatment of Mild to Moderate Primary Osteoarthritis of the Knee

Osteoarthritis | Osteoarthritis, Knee

Australia
Eli Lilly and Company

Completed

A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury

Acute Lung Injury | Respiratory Distress Syndrome, Adult

United States, Belgium, Spain, Canada, Australia, New Zealand
John Levine
National Cancer Institute (NCI)

Completed

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

GVHD | Graft-versus-host-disease

United States
RenJi Hospital

Recruiting

Exploratory Research of PCSK9 Inhibitor on Patency of aAVF After PTA With PCB

Hemodialysis Access Failure

China
Janssen Research & Development, LLC

Completed

A Study of Darunavir in Combination With Cobicistat or Ritonavir, and Dabigatran Etexilate in Healthy Participants

Healthy

Belgium
ANRS, Emerging Infectious Diseases
Janssen-Cilag Ltd.

Terminated

Management of Participants With Low-level Persistent Viremia (ANRS 161 L-VIR)

Viremia | HIV-1 Infection | Treatment Resistant Disorders

France
Pfizer

Completed

PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy Participants

Healthy Participants

United States
Centre Hospitalier Universitaire de la Réunion

Completed

Use of Public Health Surveillance Models in the French National Health System Database (DABI-SURV)

Atrial Fibrillation | Anticoagulants | Pharmacoepidemiology

France
Techpool Bio-Pharma Co., Ltd.
The First Affiliated Hospital with Nanjing Medical University; Peking Union... and other collaborators

Suspended

Ulinastatin in Severe Acute Pancreatitis

Pancreatitis

China
Boehringer Ingelheim

Completed

ReAHEAD: A Study to Find Out Whether Education Improves Adherence to Dabigatran in People With Atrial Fibrillation Who Are Younger Than 75 Years

Atrial Fibrillation

Taiwan
Jinnah Postgraduate Medical Centre

Recruiting

Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality (MUNI-SEP)

Septic Shock | Severe Sepsis | MODS

Pakistan
Nanfang Hospital of Southern Medical University
Dongguan People's Hospital; Foshan Hospital of Traditional Chinese Medicine; Shenzhen... and other collaborators

Recruiting

Effects of Ulinastatin on Inflammatory Response During ECMO Support (Uli-ECMO)

Inflammatory Response | ECMO

China
Shanghai Zhongshan Hospital

Unknown

Protective Effect in Cardiac Surgery Patients

Cardiac Surgery
Yonsei University

Completed

Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement

Abnormal Aortic Valve

Korea, Republic of
Nemours Children's Clinic

Completed

Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery

Pancreatitis

United States
Grifols Therapeutics LLC

Completed

The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency (STAMP)

Alpha 1-Antitrypsin Deficiency

United States, United Kingdom
Qin Zhang

Completed

Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction

Cardiac Complication

China
Grifols Therapeutics LLC

Completed

Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic Fibrosis

Cystic Fibrosis

United States
Fundación FLS de Lucha Contra el Sida, las Enfermedades...

Completed

Multicentre Study To Assess Changes In Bone Mineral Density Of The Switch From Protease Inhibitors To Dolutegravir In HIV-1-Infected Subjects With Low Bone Mineral Density

HIV-1 Infection

Spain
BioCryst Pharmaceuticals

Completed

A Long Term Safety Study of BCX7353 in Hereditary Angioedema (APeX-S)

Hereditary Angioedema | Prophylaxis | HAE

Austria, Denmark, France, Germany, Hungary, Israel, Italy, North Macedonia, Poland, Switzerland, United Kingdom, United States, Australia, Hong Kong, Korea, Republic of, New Zealand, Serbia, Slovakia, South Africa, Spain
HaEmek Medical Center, Israel

Completed

ACRIPAB- Trial: Anti Coagulation Regimen In High Risk PAtients for Bleeding (ACRIPAB)

Hematologic Diseases

Israel
Boston Children's Hospital

Recruiting

Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

Drug Effect

United States
Assiut University

Unknown

Acute Kidney Injury in Newborns With Perinatal Asphyxia

Acute Kidney Injury
Boehringer Ingelheim

Completed

Randomized Evaluation of Strategic Intervention in Multidrug Resistant Patients With Tipranavir (RESIST)

HIV Infections

United States, Australia, Canada, Puerto Rico
Nanjing First Hospital, Nanjing Medical University

Recruiting

Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome (sICASBLM)

Intracranial Artery Stenosis

China
Techpool Bio-Pharma Co., Ltd.
Children's Hospital of Fudan University; Shanghai Children's Medical Center; Guangzhou... and other collaborators

Unknown

Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery

Congenital Heart Diseases

China
Maastricht University

Not yet recruiting

In Vivo Effects of Amylase Trypsin Inhibitors (ATI)

Irritable Bowel Syndrome | Non-Coeliac Wheat Sensitivity (NCWS)
KU Leuven
University Ghent; Vrije Universiteit Brussel; Universiteit Antwerpen; Université...

Terminated

The DAWN Antivirals Trial for Ambulatory COVID-19 Patients (DAWN)

Covid19 | SARS-CoV Infection

Belgium
Institute of Liver and Biliary Sciences, India

Recruiting

Efficacy and Safety of Dabigatran in Patients With Cirrhosis and Portal Vein Thrombosis

Liver Cirrhosis | Portal Vein Thrombosis

India
Boehringer Ingelheim

Completed

Tolerability , PK/PD and Safety of Dabigatran Etexilate Oral Liquid Formulation in Children < 1 Year of Age

Venous Thromboembolism

Canada, France, Russian Federation
S. Andrea Hospital

Unknown

Safety Study of Dabigatran in CADASIL (SONICA)

CADASIL

Italy
Cancer Institute and Hospital, Chinese Academy...

Not yet recruiting

Evaluate the Efficacy and Safety of Edoxaban on Prevention of Catheter-related Thrombosis (CRT) in Cancer Patients (Thrombosis)

Cancer | Catheter Complications | Thrombosis, Venous

China
Daiichi Sankyo, Inc.
Daiichi Sankyo Korea Co., Ltd.

Recruiting

A Study to Evaluate Effectiveness and Safety of Edoxaban in Patients 80 Years of Age or Older With Nonvalvular Atrial Fibrillation

Atrial Fibrillation

Korea, Republic of
University Hospital, Tours

Not yet recruiting

Chronic Anticoagulation With a Reduced Dose Regimen of Rivaroxaban in End-stage Renal Disease Patients (CARD-AXA)

Chronic Hemodialysis Patients
Mayo Clinic
Ottawa Heart Institute Research Corporation

Recruiting

Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion (CAPITAL-RAPTOR)

Radial Artery Occlusion

United States
Norwegian University of Science and Technology
St. Olavs Hospital; Alesund Hospital; Namsos Hospital; Volvat Medisinsk Senter...

Recruiting

Bariatric Surgery and Pharmacokinetics of Apixaban

Obesity, Morbid

Norway
Bayer

Completed

An Observational Study (Called RETAF-PS) Using a Patient Survey to Learn More About Treatment Outcomes in Patients With Irregular and Often Rapid Heartbeat (Atrial Fibrillation) Treated With Apixaban in a Real World Setting

Atrial Fibrillation | Prevention of Thromboembolic Events

United States
Daiichi Sankyo, Inc.
Daiichi Sankyo (China) Holdings Co., Ltd.

Active, not recruiting

Real-world Study on Edoxaban Treatment for Patients With Non-valvular Atrial Fibrillation in China (ETNA-AF-CHINA)

Non-valvular Atrial Fibrillation

China
LiuZhou People's Hospital

Unknown

Rivaroxaban for Thromboprophylaxis in High-risk Cancer Patients With Totally Implantable Access Ports

Cancer | Rivaroxaban | Thromboprophylaxis
J.P.S Henriques

Not yet recruiting

Rivaroxaban Monotherapy After CYP2C19 Genotype Testing in Patients With Atrial Fibrillation and Percutaneous Coronary Intervention (IMPACT AF-PCI)

Coronary Artery Disease | Atrial Fibrillation
China National Center for Cardiovascular Diseases
Chinese Academy of Medical Sciences, Fuwai Hospital

Recruiting

Population Pharmacokinetics of Edoxaban in Chinese Patients With Non-Valvular Atrial Fibrillation

Non-Valvular Atrial Fibrillation

China
Shanghai Zhongshan Hospital

Recruiting

Prophylactic vs Therapeutic Anticoagulation in Symptomatic Isolated Distal Deep Vein Thrombosis

Venous Thrombosis

China
University Hospital, Ghent

Recruiting

The Potential of Oral Camostat in Early COVID-19 Disease in an Ambulatory Setting to Reduce Viral Load and Disease Burden

Covid19

Belgium
Second Affiliated Hospital, School of Medicine,...
Bayer; The Central Hospital of Lishui City; Shaoxing People's Hospital; Wenzhou... and other collaborators

Recruiting

Predictive Value of Infarction Volume on Hemorrhagic Transformation in Ischemic Stroke/TIA With Non-valve Atrial Fibrillation(NVAF) Patients Using Rivaroxaban

Intracranial Hemorrhages | Anticoagulant | Cerebrovascular Stroke | Matrix Metalloproteinases

China
Portola Pharmaceuticals
Merck Sharp & Dohme LLC

Completed

A Study to Determine the Pharmacokinetics, Pharmacodynamics, and Tolerabiltiy of Betrixaban in Patients With Mild, Moderate, and Severe Renal Impairment

Renal Impairment

Germany
Daiichi Sankyo, Inc.
Daiichi Sankyo Deutschland GmbH

Completed

Edoxaban in Patients With Non-valvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention (ENCOURAGE-AF)

Non-valvular Atrial Fibrillation

Germany
Daiichi Sankyo Turkey, a Daiichi Sankyo Company
Daiichi Sankyo, Inc.

Completed

Evaluation of Treatment Safety in Patients With Atrial Fibrillation on Edoxaban Therapy in Real-Life in Turkey (ETAF-TR)

Atrial Fibrillation

Turkey
Daiichi Sankyo, Inc.
Quintiles, Inc.

Completed

Comparison of Two Doses of Edoxaban Using Different Tests (Assays) and Clinical Outcomes

Atrial Fibrillation

Denmark, Hungary, Croatia, Serbia, Spain, Russian Federation, Bulgaria, Latvia, Czechia, Poland, Estonia, Belgium, Lithuania, Slovakia, Ukraine

Search clinical trials for: Protease Inhibitors

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