Clinical Trials Sponsored by Apotex Inc.

Total 35657 results

Astex Pharmaceuticals, Inc.

Terminated

A Study of Oral Decitabine/Cedazuridine in Combination With Magrolimab in Participants With Intermediate- to Very High-Risk Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndromes

United States
Astex Pharmaceuticals, Inc.

Terminated

A Study of TAS1553 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia (AML) and Other Myeloid Neoplasms

Acute Myeloid Leukemia | Myeloproliferative Neoplasm | Myelodysplastic/Myeloproliferative Neoplasm

United States, Canada
Astex Pharmaceuticals, Inc.

Completed

SGI-110 in Combination With Carboplatin in Ovarian Cancer (SGI-110)

Ovarian Cancer

Canada, United States, United Kingdom
Astex Pharmaceuticals, Inc.

Completed

SGI-110 in Patients With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)

AML | MDS | CMML

United States, Canada
Astex Pharmaceuticals, Inc.

Completed

Pharmacokinetic Guided Dose Escalation and Dose Confirmation With Oral Decitabine and Oral Cytidine Deaminase Inhibitor (CDAi) in Patients With Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndrome | MDS

United States, Canada
Astex Pharmaceuticals, Inc.

Completed

A Phase 1 Study to Evaluate the Effect of Food on Pharmacokinetics of ASTX029

Healthy Volunteers

United States
Astex Pharmaceuticals, Inc.

Completed

Safety of MP470 in Combination With Standard-of-Care Chemotherapy Regimens to Treat Solid Tumors (SGI-0470-02)

Malignant Disease

United States
Astex Pharmaceuticals, Inc.

Terminated

Safety of SGI-1776, A PIM Kinase Inhibitor in Refractory Prostate Cancer and Relapsed/Refractory Non Hodgkin's Lymphoma

Prostate Cancer | Non-Hodgkins Lymphoma

United Kingdom, United States
Astex Pharmaceuticals, Inc.

Completed

SGI-110 in the Treatment of Advanced Hepatocellular Carcinoma (HCC)

Hepatocellular Carcinoma

United States, United Kingdom, Canada
Astex Pharmaceuticals, Inc.

Terminated

Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Myelofibrosis | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia

United States
Apnex Medical, Inc.

Terminated

Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea

Obstructive Sleep Apnea

United States, Australia
Astex Pharmaceuticals, Inc.
Eisai Inc.

Completed

Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Blast Phase Who Are Refractory to Imatinib Mesylate (Gleevec)

Chronic Myelogenous Leukemia

United States, Canada
Astex Pharmaceuticals, Inc.
Eisai Inc.

Completed

Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Accelerated Phase Who Are Refractory to Imatinib Mesylate (Gleevec)

Chronic Myelogenous Leukemia

United States, Canada
BioTex, Inc.
Endocrinoloogy Associates Houston

Completed

A Feasibility Study to Assess Critical Aspects of Fluorescence Affinity Sensor (FAS) Performance and Safety Over Several Hours (FAS)

Diabetes

United States
BioTex, Inc.
Rhode Island Hospital

Completed

Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses

Thyroid Neoplasms | Nodular Goiter | Thyroid Cancer | Thyroid Nodule

United States
M.D. Anderson Cancer Center
BioTex, Inc.

Completed

Correlation of MR Thermal Imaging to Actual Size of Ablation During Laser Ablation Therapy

Bone Metastases | Advanced Cancer

United States
M.D. Anderson Cancer Center
BioTex, Inc.

Terminated

Magnetic Resonance Temperature Imaging & Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors

Brain Tumor

United States
Emory University
Astex Pharmaceuticals, Inc.

Recruiting

Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer

Head and Neck Carcinoma of Unknown Primary | Locally Advanced Head and Neck Squamous Cell Carcinoma | Locally Advanced Hypopharyngeal Squamous Cell Carcinoma | Locally Advanced Laryngeal Squamous Cell Carcinoma | Locally Advanced Nasopharyngeal Squamous Cell Carcinoma | Locally Advanced Oropharyngeal...

United States
Massachusetts General Hospital
Astex Pharmaceuticals, Inc.

Recruiting

ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas

Neurological Cancer

United States
Race Oncology Ltd
Astex Pharmaceuticals, Inc.

Withdrawn

A Study of Bisantrene Combined With Cytarabine or With Decitabine for Adult Subjects With Extramedullary AML and MDS (BISECT)

Acute Myeloid Leukemia | Chronic Myelomonocytic Leukemia | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Higher Risk Myelodysplastic Syndrome

Australia
US Oncology Research
Astex Pharmaceuticals, Inc.

Completed

Fludarabine, Cyclophosphamide, and Rituximab Versus Pentostatin, Cyclophosphamide, and Rituximab in Previously Untreated or Treated B-Cell Chronic Lymphocytic Leukemia Patients

B-Cell Chronic Lymphocytic Leukemia

United States
University of Nebraska
Astex Pharmaceuticals, Inc.

Completed

Safety and Efficacy of Pentostatin and Low Dose TBI With Allogenic Peripheral Blood Stem Cell Transplant

Myelodysplastic Syndromes | Multiple Myeloma | Chronic Lymphocytic Leukemia | Peripheral T-cell Lymphoma | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Non-Hodgkins Lymphoma | Hodgkins Disease

United States
Aronex Pharmaceuticals

Unknown

Aroplatin and Gemcitabine in Patients With Advanced Pancreatic Cancer Resistant to Standard Therapies

Pancreatic Neoplasms
Aronex Pharmaceuticals

Unknown

A Safety and Effectiveness Study of Aroplatin in Patients With Advanced Colorectal Cancer Resistant to Standard Therapies

Colorectal Neoplasms

United States
M.D. Anderson Cancer Center
Genentech, Inc.; Astex Pharmaceuticals, Inc.

Recruiting

Venetoclax in Combination With ASTX727 for the Treatment of Treatment-Naive High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome

United States
Apothyx, Co.

Not yet recruiting

Topical CBD for Musculoskeletal Pain

Pain
Aronex Pharmaceuticals

Unknown

A Safety and Effectiveness Study of Aroplatin in Patients With Advanced Solid Malignancies

Neoplasms | Colorectal Neoplasms | Hepatocellular Carcinoma | Pancreatic Neoplasms | Esophageal Neoplasms | Ovarian Neoplasms

United States
Aronex Pharmaceuticals

Unknown

Aroplatin and Capecitabine in Patients With Advanced Colorectal Cancer Resistant to Standard Therapies

Colorectal Neoplasms
Sunnybrook Health Sciences Centre
University of British Columbia; AbbVie; World Health Organization; Apotex Inc.; Arch...

Active, not recruiting

Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial (CATCO)

COVID-19

Canada
University of Aarhus
Skanderbog Apotek

Completed

Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease (MORPHILD)

Interstitial Lung Disease | Dyspnea | Morphine

Denmark
M.D. Anderson Cancer Center
Astex Pharmaceuticals, Inc.

Suspended

A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia

United States
Astex Pharmaceuticals, Inc.

Unknown

Nitrocamptothecin Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer

Pancreatic Cancer

United States
Astex Pharmaceuticals, Inc.

Completed

Nitrocamptothecin in Treating Patients With Metastatic Melanoma

Melanoma (Skin)

United States
Astex Pharmaceuticals, Inc.

Terminated

MP470 in Treating Patients With Unresectable or Metastatic Solid Tumor or Lymphoma

Lymphoma | Unspecified Adult Solid Tumor, Protocol Specific

United States
M.D. Anderson Cancer Center
Astex Pharmaceuticals, Inc.

Not yet recruiting

A Phase I/II Trial to Assess the Efficacy and Toxicity of ASTX727 (Oral Decitabine/Cedazuridine) for the Treatment of Hematological Neoplasms After Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation

United States
Groupe Francophone des Myelodysplasies
Astex Pharmaceuticals, Inc.

Active, not recruiting

ASTX727 and Donor Lymphocyte Infusions After Allogenic Stem Cell Transplantation in Very High Risk MDS or AML Patients

AML | MDS

France
Astex Pharmaceuticals, Inc.

Unknown

Nitrocamptothecin or Fluorouracil in Treating Patients With Recurrent or Refractory Pancreatic Cancer

Pancreatic Cancer

United States
Astex Pharmaceuticals, Inc.

Completed

Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas

Sarcoma | Small Intestine Cancer | Gastrointestinal Stromal Tumor

United States
Massachusetts General Hospital
AstraZeneca; Astex Pharmaceuticals, Inc.

Active, not recruiting

Oral Decitabine (ASTX727) and Durvalumab in Recurrent and/or Metastatic Head and Neck Cancer Patients

Head and Neck Cancer

United States
Astex Pharmaceuticals, Inc.
Multiple Myeloma Research Consortium

Completed

Effect of AT7519M Alone and AT7519M Plus Bortezomib in Patients With Previously Treated Multiple Myeloma

Multiple Myeloma

United States
Groupe Francophone des Myelodysplasies
Astex Pharmaceuticals, Inc.

Completed

A Phase II Trial of SGI-110 in Patients With IPSS High and Int 2 Myelodysplastic Syndrome, Acute Myeloid Leukemia With 20-30% Marrow Blasts or Chronic Myelomonocytic Leukemia Type 2 Not Responding to Azacitidine or Decitabine After at Least 6 Courses or Relapsing After a Response

MDS

France
M.D. Anderson Cancer Center
Astex Pharmaceuticals, Inc.

Completed

Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT

Lymphoma | Leukemia

United States
Astex Pharmaceuticals, Inc.

Completed

Nitrocamptothecin in Treating Patients With Recurrent Non-small Cell Lung Cancer

Lung Cancer

United States
Astex Pharmaceuticals, Inc.

Completed

Nitrocamptothecin in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

Breast Cancer

United States
Astex Pharmaceuticals, Inc.

Unknown

Nitrocamptothecin in Treating Patients With Advanced or Recurrent Colorectal Cancer

Colorectal Cancer

United States
Astex Pharmaceuticals, Inc.

Unknown

Nitrocamptothecin Compared With Other Chemotherapy in Treating Patients With Recurrent or Refractory Cancer of the Pancreas

Pancreatic Cancer

United States
Astex Pharmaceuticals, Inc.

Unknown

Nitrocamptothecin in Treating Patients With Locally Advanced or Metastatic Stomach Cancer That Cannot Be Removed During Surgery

Gastric Cancer | Esophageal Cancer

United States
Vanderbilt-Ingram Cancer Center
Astex Pharmaceuticals, Inc.; Forma Therapeutics, Inc.

Withdrawn

ASTX727 and FT-2102 in Treating IDH1-Mutated Recurrent/Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome
M.D. Anderson Cancer Center
Astex Pharmaceuticals, Inc.; Pharmatech

Completed

Evaluation of the Safety and Efficacy of Nipent, Cytoxan, and Rituxan

Lymphoma

United States
M.D. Anderson Cancer Center
Bayer; Astex Pharmaceuticals, Inc.

Terminated

Alemtuzumab and Pentostatin In T-cell Neoplasms

Lymphoma | Leukemia

United States

Clinical Trials Sponsored by Apotex Inc.

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