Search clinical trials for: Double blind randomised sham-controlled

Total 7964 results

Mundipharma Research GmbH & Co KG

Completed

Oxycodone-naloxone in Relieving Opioid-related Constipation

Pain
Mundipharma Research GmbH & Co KG

Completed

OXN PR Compared to OxyPR to Demonstrate Non-inferiority in Pain & Locomotor Function & Improvement in Symptoms of Constipation in OA Subjects

Chronic Osteoarthritis

Spain, Belgium, Finland, Czechia, Germany, Hungary
University of Melbourne
The University of Queensland; Swinburne University of Technology

Completed

Kava for the Treatment of Generalised Anxiety Disorder: A Double-Blind Randomised Placebo-Controlled Trial (KGAD)

Generalized Anxiety Disorder

Australia
GlaxoSmithKline

Completed

A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel Group Study of Six Months Treatment With Ropinirole PR as Adjunctive Therapy in Patients With Parkinson's Disease Who Are Not Optimally Controlled on L-Dopa

Parkinson Disease

China
Instituto de Investigación Hospital Universitario...

Completed

Reparative Therapy in Acute Ischemic Stroke With Allogenic Mesenchymal Stem Cells From Adipose Tissue, Safety Assessment, a Randomised, Double Blind Placebo Controlled Single Center Pilot Clinical Trial (AMASCIS-01)

Ischemic Stroke

Spain
GlaxoSmithKline

Completed

Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-centre, Dose Ranging Study to Evaluate the Efficacy and Safety of Losmapimod Tablets Administered Twice Daily Compared With Placebo for 24 Weeks in Adult Subjects With Chronic Obstructive Pulmonary Disease (COPD).

Pulmonary Disease, Chronic Obstructive

United States, Argentina, Germany, Estonia, Ukraine, Korea, Republic of, Norway, Czechia
Boehringer Ingelheim

Completed

Randomised, Double-blind Study to Investigate the Safety and Efficacy of Brotizolam in Insomnia Outpatients.

Sleep Initiation and Maintenance Disorders

China
Novo Nordisk A/S

Completed

A Multi-centre, Comparative, Double Blind, Randomised Cross-over Trial Investigating Single Dose Pharmacokinetics and Safety of Turoctocog Alfa Pegol From the Pivotal Process and Turoctocog Alfa Pegol From the Commercial Process in Patients With Severe Haemophilia A (pathfinder™7)

Congenital Bleeding Disorder | Haemophilia A

United States, Netherlands, Spain, Germany, France, Denmark
GlaxoSmithKline

Completed

Randomised, Double-blind, Placebo-controlled Study of Topical Clobetasone Butyrate 0.05% Cream in Subjects With Eczema for Two Weeks to Evaluate the Efficacy and Safety

Eczema

China
Shanghai University of Traditional Chinese Medicine
Liaoning University of Traditional Chinese Medicine; Hubei Hospital of Traditional... and other collaborators

Unknown

Tong-Luo-Qu-Tong Plaster for KOA: a Randomised, Double-blind, Parallel Positive Control, Multi-center Clinical Trial

Knee Osteoarthritis | Chronic Musculoskeletal Disease

China
GlaxoSmithKline

Completed

Study to Evaluate the Efficacy and Safety of GSK239512 in Schizophrenia

Schizophrenia

United States
University Hospital Inselspital, Berne
Bern University of Applied Sciences

Terminated

Whole-body Vibration Physiotherapy in Kidney Transplantation

Kidney Transplantation

Switzerland
GlaxoSmithKline

Terminated

A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder (Orvepitant MDD)

Depressive Disorder

United States, Canada
Mater Misericordiae University Hospital

Completed

Single-shot Pectoral Plane(PECs) Block Versus Continuous Local Anaesthetic Infusion Analgesia or Both PECS Block and Local Anaesthetic Infusion After Breast Surgery: A Prospective Randomised, Double-blind Trial

Breast Diseases | Anesthesia | Block

Ireland
Pfizer

Completed

A Single-centre, Randomised, Double-blind, Placebo-controlled, Four Way Crossover Phase I Study to Investigate the Effect on QT/QTc Interval of Ceftazidime NXL104 or Ceftaroline Fosamil NXL104, Compared With Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male Volunteers

Healthy Male Volunteers

United States
Adocia

Completed

A Double-blinded, Randomised, Two -Period Crossover Euglycemic Clamp Trial Investigating the Pharmacokinetics, Glucodynamics and Safety of BioChaperone Insulin Lispro and Insulin Lispro (Humalog®) in Subjects With Type 1 Diabetes

Diabetes Mellitus Type 1

Germany
Adocia

Completed

A Double-blinded, Randomised, Three-period Crossover Euglycaemic Clamp Trial Investigating the Pharmacokinetics, Glucodynamics and Safety of BioChaperone Human Insulin, Human Insulin (Huminsulin® Normal) and Insulin Lispro (Humalog®) in Subjects With Type 1 Diabetes

Diabetes Mellitus Type 1

Germany
GlaxoSmithKline

Completed

Study to Evaluate the Efficacy and Safety of GSK239512 in Alzheimer's Disease

Alzheimer's Disease

Bulgaria, Germany, Korea, Republic of, Russian Federation, United Kingdom, Chile, Czech Republic, Slovakia
Novo Nordisk A/S

Completed

A Randomised, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy and Safety of NNC0114-0006 in Subjects With Active Crohn's Disease

Inflammation | Crohn's Disease

United States, Spain, Bulgaria, Czech Republic, Poland, Slovakia
University of Copenhagen
Rigshospitalet, Denmark

Completed

Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome

Fatigue | Keratoconjunctivitis Sicca | Primary Sjögren's Syndrome | Xerostomia | Hyposalivation

Denmark
Birmingham Community Healthcare NHS
NSA, LLC

Completed

Effect of Dietary Intake of Dried Whole Food Concentrates (Juice Plus) on Clinical Outcomes Following Periodontal Therapy: A Pilot Study (BHAM-NSA-05-01)

Periodontitis

United Kingdom
Novo Nordisk A/S

Completed

A Randomised, Double-blind, Placebo-controlled, Parallel-group Trial to Assess Clinical Efficacy of NNC0114-0006 in Subjects With Active Rheumatoid Arthritis

Inflammation | Rheumatoid Arthritis

Spain, Hungary, Serbia, Bulgaria, Poland, Russian Federation, Latvia
Danone Research

Completed

A Single-centre, Randomised, Double-blind, Controlled, Parallel-group Study to Evaluate the Effect of a Fermented Dairy Product on Abdominal Distension, Digestive Symptoms and Rectal Sensitivity in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Women With IBS-C

United Kingdom
Merck KGaA, Darmstadt, Germany

Completed

A Multicentre, Randomised, Double-blind, Placebo-controlled Proof of Concept Study to Compare the Efficacy and Safety of r-hLIF (Emfilermin) for Improving Embryo Implantation Following in Vitro Fertilization (IVF) and Embryo Transfer (ET) in Women With Recurrent Implantation Failure

Infertility Implantation Failure
Novo Nordisk A/S

Completed

A Randomised, Double-blind, Placebo-controlled Trial to Assess Safety, Tolerability and Pharmacokinetics of Liraglutide in Obese Adolescent Subjects Aged 12 to 17 Years

Obesity | Metabolism and Nutrition Disorder

Germany
ASLAN Pharmaceuticals

Completed

Phase 1, Randomised Double Blinded Placebo Controlled Study of ASLAN003

Healthy Volunteers

Singapore
Bial - Portela C S.A.

Completed

A Single Centre, Phase I, Double-blind, Randomised, Placebo-controlled Study to Investigate the Safety, Tolerability, Pharmacokinetic Profile and Effects on EEG of Single Rising Oral Doses of BIA 2-093

Epilepsy

United Kingdom
Bayside Health

Completed

The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients

Post Operative Pain

Australia
Assistance Publique - Hôpitaux de Paris

Completed

Monocentric STUDY, Randomised Double Blinded (Healthy Subjects, or Transversal (Patients With Gitelman Syndrome) (DEPROGE)

Gitelman Syndrome | Potassium Depletion

France
Norgine

Completed

A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period

Faecal Incontinence

Spain, Poland, United Kingdom, Czech Republic, France, Germany, Hungary, Italy, Sweden
Imperial College London
MasterFoods

Completed

The Effect of Cocoa Flavonoids on Blood Pressure

Hypertension

United Kingdom
Hvidovre University Hospital

Completed

Fibrin Sealant in Bilateral Simultaneous Total Knee Arthroplasty With Focus on Blood Loss, Pain, Swelling and Strength

Blood Loss

Denmark
Queen Mary University of London
GlaxoSmithKline

Unknown

A Double Blind Randomised Study of Lapatinib and Placebo in Metastatic TCC of the Urothelium (LaMB)

Bladder Cancer

United Kingdom
LEO Pharma
Quintiles, Inc.

Completed

LEO 90105 Ointment in Japanese Subjects With Psoriasis

Psoriasis

Japan
Genzyme, a Sanofi Company

Terminated

A Randomised, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Sevelamer Carbonate Tablets Dosed Three Times a Day in Hyperphosphataemic Chronic Kidney Disease Patients Not on Dialysis (ASPIRE)

Chronic Kidney Disease | Hyperphosphatemia

Germany, Greece, Portugal, Austria, France, Hungary, Italy, Spain, Sweden
Bial - Portela C S.A.

Completed

A Double-blind, Randomised, Placebo-controlled, Rising Multiple Dose Study to Investigate the Safety, Tolerability, Steady State Pharmacokinetic Profile and CNS Effects of BIA 2-093

Epilepsy

United Kingdom
Herz-Zentrums Bad Krozingen

Completed

YUKON-drug-eluting Stent Below The Knee - Randomised Double-blind Study (YUKON-BTK)

Arterial Occlusive Diseases

Germany
Adocia

Completed

A Double-blinded, Randomised, Four-period Crossover Euglycemic Clamp Trial Investigating the Dose-response and Dose-exposure Relationship of BioChaperone Insulin Lispro in Three Different Doses in Subjects With Type 1 Diabetes

Diabetes Mellitus Type 1

Germany
Akron Molecules AG

Completed

A Placebo Controlled, Double Blind, Randomised, 8-week Phase IIa Proof of Concept Study to Assess the Efficacy and Safety of AKR 202 in Patients With Osteoarthritis Pain

Osteoarthritis

Austria
Boehringer Ingelheim

Completed

A Randomised, Parallel-group, Double-blind, Double-dummy Study to Compare the Effects of Lacidipine Versus Bendrofluazide on Markers of Platelet Activation and Haemorheological Factors in Hypertensive Patients

Hypertension
Boehringer Ingelheim

Completed

A Randomised, db, Placebo-controlled Study of BI 1356 for 18 Weeks Followed by a 34 Week Double-blind Extension Period (Placebo Patients Switched to Glimepiride) in Type 2 Diabetic Patients for Whom Treatment With Metformin is Inappropriate

Diabetes Mellitus, Type 2

United States, Canada, Mexico, Philippines, Romania, Russian Federation, Ukraine
AstraZeneca

Terminated

Randomised Double-Blind, Placebo-Controlled, Parallel Group Study in Patients With Active Rheumatoid Arthritis:Magnetic Resonance Imaging Sub-Study (OSKIRA 4 SS)

Rheumatoid Arthritis

United States, Bulgaria, Russian Federation, South Africa, United Kingdom, Germany, Hungary, Netherlands, Canada, Czech Republic, Poland
Novo Nordisk A/S

Completed

A Randomised, Single Centre, Double-blind, Two-period, Cross-over Trial in Healthy Subjects Investigating the Bioequivalence Between Subcutaneous Injections of Semaglutide Produced by Two Manufacturing Processes

Healthy | Diabetes

Germany
Boehringer Ingelheim

Completed

Double-blind, Randomised, Placebo-controlled Trial Investigating BIRT 2584 XX in Patients With Moderate/Severe Psoriasis

Psoriasis

Germany, Denmark, Belgium, Canada, France, Sweden, Netherlands, Finland, Spain, United Kingdom
The University of New South Wales

Completed

Prospective Double-blinded Randomised Comparison of Profix Mobile to Fixed Bearing Knee Replacements

Osteoarthritis

Australia
H. Lundbeck A/S

Terminated

Efficacy and Safety of Lu AA39959 in Patients With Bipolar Depression

Bipolar Disorder

United States
Boehringer Ingelheim
Pfizer

Completed

A Randomised, Double- Blind, Placebo Controlled, Cross-over Efficacy and Safety Comparison of Tiotropium 5 µg Once Daily and Tiotropium 2.5 µg Twice Daily for Four Weeks in Patients With Moderate Persistent Asthma

Asthma

Austria, Czech Republic, Estonia, Germany, Latvia
Centre for Addiction and Mental Health

Completed

The Effects of Repetitive Transcranial Magnetic Stimulation in Healthy Human Subjects

Healthy

Canada
Eisai Inc.
Eisai Co., Ltd.

Completed

Evaluation of Eperisone HCl in the Treatment of Acute Musculoskeletal Spasm Associated With Low Back Pain - A Double Blind, Randomised, Placebo Controlled Clinical Trial

Muscle Spasm; Back Pain

India
Norwegian University of Science and Technology
The Research Council of Norway; Nordic Myeloma Study Group, Germany

Completed

Thalidomide to Patients With Previously Untreated Multiple Myeloma

Multiple Myeloma

Norway

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