- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02235402
A Randomised, Parallel-group, Double-blind, Double-dummy Study to Compare the Effects of Lacidipine Versus Bendrofluazide on Markers of Platelet Activation and Haemorheological Factors in Hypertensive Patients
September 9, 2014 updated by: Boehringer Ingelheim
The aim of this study is to compare the effects of lacidipine on markers of platelet activation and other rheological factors in hypertensive patients with those of bendrofluazide
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
26
Phase
- Phase 4
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age 18 or over
- Hypertensive at screening: Diastolic blood pressure (DBP) 95 - 115 mm Hg and / or systolic blood pressure (SBP) >= 160 mm Hg on no therapy or on monotherapy. If currently on monotherapy, DBP could have been < 95 mm Hg and SBP < 160 mm Hg, but the patient must have been experiencing unacceptable side effects from their current treatment. Patient must then be able to stop treatment for the placebo run in phase of four weeks without endangering their health (at investigator's discretion)
- Hypertensive at randomisation: DBP 95-115 mm Hg and or SBP >=160
- Able to give written informed consent
Exclusion Criteria:
- Grad III or grad IV hypertensive retinopathy
- Renal impairment; serum creatinine > 150 µmol/L
- Heart failure. (New York Heart Association (NYHA) Class III or IV)
- Liver impairment (abnormal Liver function test (LFT) with aspartate-amino transferase (AST) / alanine-amino transferase (ALT) > 2x upper normal limit or bilirubin > 2x upper normal limit)
- Recent (< 2 months) history of unstable angina
- Recent (< 2 months) history of myocardial infarction
- Recent (< 2 months) history of stroke
- History of diabetes mellitus or impaired glucose tolerance or random blood glucose >= 9 mMol/L
- Any acute systemic illness or infection
- Any severe disease which could interfere with survival or well-being during the study (e.g. malignancy)
- Patients of child bearing potential
- Current or previous drug and / or alcohol abuse
- Severely limited venous access
- Haemoglobin < 10g/dL (male patients), haemoglobin < 9g/dL (female patients)
- Requirement for anticoagulant therapy
- Severe valvular heart disease (investigator's discretion)
- Atrial fibrillation or other serious cardiac dysrhythmia
- History of thyroid disease or abnormal thyroid function test (thyroid stimulating hormone (TSH) < 0.4 mU/L or > 5.4 mU/L)
- History of connective tissue disorder
- Concurrent participation in any other clinical trial or participation within two months enrolment
- Requirement for restricted drugs
- Patients currently on treatment with lacidipine or bendrofluazide (BNFZ)
- Patients unable to attend clinics
- Any clinical condition which in the opinion of the investigator, would preclude the safe fulfillment of the protocol and the safe administration of trial medication
- Seated blood pressure (BP) exceeding either 210 mm Hg (systolic) or 115 mm Hg (diastolic) at screening or randomization
- Standing BP < 140 mm Hg (systolic) and < 95 mm Hg (diastolic) at randomization
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo
|
|
Experimental: Lacidipine
|
|
Active Comparator: Bendrofluazide
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in ß-TG (thromboglobulin)
Time Frame: Up to week 12 after drug administration
|
Up to week 12 after drug administration
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in soluble p-selectin
Time Frame: Up to week 12 after drug administration
|
Up to week 12 after drug administration
|
Changes in rheological factors
Time Frame: Up to week 12 after drug administration
|
Up to week 12 after drug administration
|
Changes in lipid levels between randomisation and last visit
Time Frame: Up to week 12 after drug administration
|
Up to week 12 after drug administration
|
Number of patients with clinical significant findings in laboratory parameters
Time Frame: Up to week 12 after drug administration
|
Up to week 12 after drug administration
|
Number of patients with adverse events
Time Frame: Up to week 12 after drug administration
|
Up to week 12 after drug administration
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
December 1, 1997
Primary Completion (Actual)
March 1, 2000
Study Registration Dates
First Submitted
September 9, 2014
First Submitted That Met QC Criteria
September 9, 2014
First Posted (Estimate)
September 10, 2014
Study Record Updates
Last Update Posted (Estimate)
September 10, 2014
Last Update Submitted That Met QC Criteria
September 9, 2014
Last Verified
September 1, 2014
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Hypertension
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Antihypertensive Agents
- Natriuretic Agents
- Membrane Transport Modulators
- Diuretics
- Calcium-Regulating Hormones and Agents
- Calcium Channel Blockers
- Sodium Chloride Symporter Inhibitors
- Bendroflumethiazide
- Lacidipine
Other Study ID Numbers
- 231.336
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Hypertension
-
National Taiwan University Hospital Hsin-Chu BranchRecruitingHypertension,Essential | Hypertension, MaskedTaiwan
-
University of Alabama at BirminghamTroy UniversityCompletedHypertension | Hypertension, Resistant to Conventional Therapy | Uncontrolled Hypertension | Hypertension, White CoatUnited States
-
BayerCompletedPrimary HypertensionChina
-
Columbia UniversityAgency for Healthcare Research and Quality (AHRQ)Active, not recruitingWhite Coat Hypertension | Hypertension,EssentialUnited States
-
Addpharma Inc.Completed
-
Universidade Federal de Santa MariaCompletedHealthy Volunteers | Hypertension, EssentialBrazil
-
Sheffield Teaching Hospitals NHS Foundation TrustUniversity of SheffieldCompletedIdiopathic Pulmonary Arterial Hypertension | Chronic Thromboembolic Pulmonary HypertensionUnited Kingdom
-
China Academy of Chinese Medical SciencesGuang'anmen Hospital of China Academy of Chinese Medical SciencesCompletedHypertension, Resistant to Conventional Therapy | Primary HypertensionChina
-
Sulaiman AlRajhi CollegesUnknownHypertension, Essential | β-hydroxybutyrate
Clinical Trials on Placebo
-
SamA Pharmaceutical Co., LtdUnknownAcute Bronchitis | Acute Upper Respiratory Tract InfectionKorea, Republic of
-
National Institute on Drug Abuse (NIDA)CompletedCannabis UseUnited States
-
AstraZenecaParexel; Spandauer Damm 130; 14050; Berlin, GermanyCompletedMale Subjects With Type II Diabetes (T2DM)Germany
-
Heptares Therapeutics LimitedCompletedPharmacokinetics | Safety IssuesUnited Kingdom
-
GlaxoSmithKlineCompletedPulmonary Disease, Chronic ObstructiveUnited Kingdom, Netherlands
-
ItalfarmacoCompletedBecker Muscular DystrophyNetherlands, Italy
-
Shijiazhuang Yiling Pharmaceutical Co. LtdXuanwu Hospital, BeijingCompleted
-
GlaxoSmithKlineCompletedInfections, BacterialUnited States
-
West Penn Allegheny Health SystemCompletedAsthma | Allergic RhinitisUnited States