Search clinical trials for: Inadequate Response to Antidepressant Therapy

Total 476166 results

Merck Sharp & Dohme LLC

Terminated

Safety and Efficacy of MK-6096 as Adjunctive Therapy in Participants With Major Depressive Disorder And Partial Response to Antidepressant Monotherapy (MK-6096-022)

Major Depressive Disorder, Recurrent
Hoffmann-La Roche

Completed

A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy (TOSCA)

Rheumatoid Arthritis

France
H. Lundbeck A/S
Otsuka Pharmaceutical Co., Ltd.

Terminated

Efficacy and Safety of Brexpiprazole as Adjunctive Treatment in Elderly Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment

Major Depressive Disorder

United States
Emory University
National Institute of Mental Health (NIMH)

Completed

Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment

Depression

United States
Incyte Corporation

Completed

INCB028050 Compared to Background Therapy in Patients With Active Rheumatoid Arthritis (RA) With Inadequate Response to Disease Modifying Anti-Rheumatic Drugs

Rheumatoid Arthritis

United States, Czechia
Hoffmann-La Roche

Completed

A Study of Tocilizumab Added to DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to DMARDs.

Rheumatoid Arthritis

Russian Federation
Massachusetts General Hospital
National Alliance for Research on Schizophrenia and Depression

Completed

Quantitative Electroencephalogram (QEEG) Predictors of Response to Psychotherapy Versus Antidepressant Treatment in Depression

Major Depressive Disorder

United States
GlaxoSmithKline

Terminated

Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to MTX Therapy

Arthritis, Rheumatoid

Poland, Russian Federation, Argentina, Belgium, Peru, Spain, Australia, Czechia, South Africa, Chile, Hungary, United Kingdom, Romania
New York State Psychiatric Institute
National Institute of Mental Health (NIMH); University of Ottawa

Completed

Does Dual Therapy Hasten Antidepressant Response?

Major Depressive Disorder

United States, Canada
Hoffmann-La Roche

Completed

A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD Therapy

Rheumatoid Arthritis

Serbia
Hoffmann-La Roche

Completed

A Study of MabThera (Rituximab) in Participants With Rheumatoid Arthritis Who Have Had an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARD) and/or Anti-Tumor Necrosis Factor (Anti-TNF) Therapy.

Rheumatoid Arthritis

Israel
H. Lundbeck A/S

Completed

Evaluation of the Safety of Adjunct Brexpiprazole in Elderly Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Treatment

Major Depression Disorder

Germany, United States, Estonia, Finland, Poland
H. Lundbeck A/S
Otsuka Pharmaceutical Co., Ltd.

Completed

Brexpiprazole as Adjunctive Treatment in Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment

Major Depressive Disorder

Finland, Sweden, Estonia, Bulgaria, United States, Canada, Germany, Korea, Republic of, Latvia, Lithuania, Mexico, Poland, Romania, Russian Federation, Ukraine, United Kingdom
Hoffmann-La Roche

Completed

Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Participants With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Non-Biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) and/or Anti-tumor Necrosis Factor (Anti-TNF) Therapy

Rheumatoid Arthritis

India
Centre Hospitalier Universitaire de Besancon

Unknown

Oral Fluency and the Response to Antidepressant Therapy in the Elderly With a Unipolar Depressive Episode (PREDICTage)

Unipolar Depression

France
H. Lundbeck A/S

Completed

Efficacy of Vortioxetine Versus Escitalopram on Cognitive Function in Patients With Inadequate Response to Current Antidepressant Treatment of Major Depressive Disorder

Major Depressive Disorder

Finland, Germany, Serbia, Slovakia
Hoffmann-La Roche

Completed

ARTDeCo Study: A Study of RO4995819 in Patients With Major Depressive Disorder And Inadequate Response to Ongoing Antidepressant Treatment

Major Depressive Disorder

United States, Germany, Austria, Russian Federation, Ukraine, Canada, Slovakia, South Africa
Hoffmann-La Roche

Terminated

An Observational Study of MabThera/Rituxan (Rituximab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Anti-TNF Therapy (REPEAT)

Rheumatoid Arthritis

Romania
Emory University
National Institute of Mental Health (NIMH)

Completed

Identifying Factors That Predict Antidepressant Treatment Response

Depression

United States
Hoffmann-La Roche

Completed

An Observational Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis And Inadequate Response Or Intolerance to a First Anti-TNF Alpha Therapy

Rheumatoid Arthritis

Korea, Republic of
Naurex, Inc, an affiliate of Allergan plc

Completed

Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants

Major Depressive Disorder

United States
Johns Hopkins University
Bristol-Myers Squibb

Completed

Safety and Efficacy of Abatacept in Subjects With Chronic Urticaria Who Have Had an Inadequate Response to Anti-histamine Therapy (TAHOE)

Urticaria

United States
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Pharmaceutical Co., Ltd.

Completed

Brexpiprazole as Adjunctive Therapy With Major Depressive Disorder and an Inadequate Response to Previous Adjunctive Therapy

Major Depressive Disorder (MDD)

United States
Bristol-Myers Squibb

Completed

Methotrexate-Inadequate Response Study

Rheumatoid Arthritis (RA)

Italy, Korea, Republic of, Mexico, Taiwan, United States, Chile, France, Poland, United Kingdom, Argentina, Belgium, Ireland, Germany, Netherlands, Canada, India, Russian Federation, Turkey, Australia, South Africa, Brazil, Hungary, Per... and more
Hoffmann-La Roche

Completed

An Exploratory Study of Tocilizumab in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Current Non-Biologic DMARDs and/or Anti-TNF Therapy.

Rheumatoid Arthritis

Belgium, Czech Republic, France, Italy, Spain, Sweden, United Kingdom, Canada, Greece, Ireland, Portugal, Turkey, Netherlands, Denmark, Finland, Germany, Luxembourg, Austria, Switzerland, Poland, Australia, Hungary, Saudi Arabia, Romania and more
Mark Frye
University of California, Los Angeles

Withdrawn

Can Additional Drug Therapy Accelerate Response Time to Antidepressants

Depression

United States
Genentech, Inc.
Biogen

Completed

A Study of the Safety of Rituxan in Patients With Rheumatoid Arthritis After an Inadequate Response to Previous Anti-TNF Therapy (SUNSTONE) (SUNSTONE)

Rheumatoid Arthritis

United States, Puerto Rico
Hoffmann-La Roche

Completed

An Extension to Study MA21573, Evaluating Tocilizumab in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biological DMARDs and/or Anti-tumor Necrosis Factor (TNF) Therapy

Rheumatoid Arthritis

Czech Republic, France, Italy, Spain, United Kingdom, Canada, Portugal, Netherlands, Poland, Australia, Saudi Arabia, Romania, Hungary, Greece
Nanfang Hospital of Southern Medical University
Major Science and Technology Special Project of China Eleventh Five-year

Unknown

Efficacy Optimizing Extension Study of Chronic Hepatitis B Patients With Inadequate Response to NUC Therapy (Dragon-Ex)

Chronic Hepatitis B | Inadequate Response | Nucleos(t)Ide Analogues Treatment

China
GlaxoSmithKline

Terminated

Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to TNF-α Antagonist Therapy

Arthritis, Rheumatoid

Italy, Argentina, Germany, Peru, Korea, Republic of, Denmark, Spain, Sweden, France, Netherlands, Norway, United Kingdom
H. Lundbeck A/S

Completed

A Study of Vortioxetine (Lu AA21004) in Comparison to Agomelatine in Adults Suffering From Major Depression With Inadequate Response to Previous Medication (REVIVE)

Major Depressive Disorder
Nanfang Hospital of Southern Medical University
JiangSu Chia-Tai Tianqin Pharmacy Co.Ltd

Unknown

Efficacy Optimizing Research of Chronic Hepatitis B Patients With Inadequate Response to NUC Therapy

Hepatitis B

China
Hoffmann-La Roche

Terminated

A Study of Tocilizumab (RoActemra/Actemra) in Patients With Ankylosing Spondylitis Who Have Had an Inadequate Response to Previous Tumor Necrosis Factor (TNF) Antagonist Therapy

Spondylitis, Ankylosing

Belgium, Czech Republic, France, Germany, Italy, Spain, United States, Canada, Poland, South Africa, United Kingdom, Australia, Denmark, Netherlands, Bulgaria, India, Lithuania, Brazil, Slovakia
Medtronic - MITG

Completed

EEG Biomarkers for Predicting Response to Antidepressant Therapy

Major Depressive Disorder

United States
Bristol-Myers Squibb

Completed

Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy

Rheumatoid Arthritis

Belgium, Spain, United States, Germany, Italy, Mexico, United Kingdom, France, Czech Republic, Ireland
Centre for Addiction and Mental Health
Ontario Mental Health Foundation

Completed

Stress Generation and Recurrent Depression: The Role of Differential Treatment Response

Depression | Major Depressive Disorder

Canada
Centre for Addiction and Mental Health
Ontario Mental Health Foundation

Completed

Patient Dimensions as Predictors of Varied Treatment Responses and Outcomes in Patients With Major Depression

Depression | Major Depressive Disorder

Canada
Abbott

Completed

Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severely Active Psoriatic Arthritis Subjects With Inadequate Response to Disease Modifying Anti-Rheumatic Drug Therapy

Arthritis | Psoriatic
University of Siena
Merck Sharp & Dohme LLC

Unknown

Infections Caused by ESbL-Producing Enterobacteriaceae in Italy

Skin Diseases | Pneumonia | Bacteremia | Urinary Tract Infections | Enterobacteriaceae Infections

Italy
Fondation Hôpital Saint-Joseph

Not yet recruiting

Impact of Performing a Rapid Antibiotic Susceptibility Test on Antibiotic Therapy Adaptation in Adult Patients With Enterobacterales Bacteremia (MHR-Blood)

Bacteremia
University of Udine

Recruiting

Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy (ENDOmiRNA)

Endometriosis

Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna

Recruiting

RISK FACTORS FOR NON-RESPONSE TO HORMONAL MEDICAL THERAPY IN PATIENTS WITH ENDOMETRIOSIS

Endometriosis

Italy
Johns Hopkins University

Recruiting

Using Personalized Assessments in the Treatment of Childhood OCD

Obsessive-Compulsive Disorder

United States
Celgene
Bristol-Myers Squibb

Recruiting

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation (KarMMa-9)

Multiple Myeloma

Austria, United States, Spain, Australia, Japan, France, Israel, Italy, Canada, Greece, Belgium, Norway, Romania, Czechia, Denmark, Germany, Korea, Republic of, United Kingdom, Poland
Ohio State University Comprehensive Cancer Center

Not yet recruiting

Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer

Metastatic Renal Cell Carcinoma | Metastatic Cutaneous Melanoma | Stage IV Renal Cell Cancer AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
Scipher Medicine

Recruiting

PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT) (PREDICT)

Rheumatoid Arthritis

United States
St. Jude Children's Research Hospital
AbbVie

Not yet recruiting

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

T-cell Lymphoma | T-cell Acute Lymphoblastic Leukemia | Mixed Phenotype Acute Leukemia

United States
Cairo University

Recruiting

Plasticity Biomarkers,Interleukin-6 and Motor Performance in Response to Vagus Nerve Stimulation After Stroke

Stroke | Motor Disorders

Egypt
AbbVie

Recruiting

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab (Switch-Up)

Atopic Dermatitis

United States
University of Bern
Swiss National Science Foundation; University of Zimbabwe

Not yet recruiting

The Friendship Bench Plus Trial (FB+)

Major Depressive Disorder | Severe Depressive Episode Without Psychotic Symptoms

Zimbabwe

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