Search clinical trials for: Randomized double-blind phase III study

Total 141926 results

Pfizer's Upjohn has merged with Mylan to form Viatris...
The Cleveland Clinic

Completed

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen (PRECISION)

Arthritis, Rheumatoid

United States, Taiwan, Philippines, Mexico, Canada, Australia, Colombia, Brazil, Ukraine, Costa Rica, Hong Kong, Panama, Peru
Istituto Scientifico Romagnolo per lo Studio e...

Unknown

Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumor Lysate or Homogenate Combined With Immunomodulating Radiotherapy and/or Preleukapheresis IFN-alfa in Patients With Metastatic Melanoma: a Randomized "Proof-of-principle" Phase II Study (ABSIDE)

Malignant Melanoma of Skin Stage III | Malignant Melanoma of Skin Stage IV

Italy
Lawson Health Research Institute

Completed

A Randomized Phase III Study of Palliative Radiation of Advanced Central Tumors With Intentional Avoidance of the Esophagus (PROACTIVE)

Non-Small Cell Lung Cancer

Canada
Novartis Pharmaceuticals

Completed

A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma

Melanoma

Canada, Spain, United Kingdom, Netherlands, United States, Argentina, Australia, France, Germany, Greece, Italy, Russian Federation, Sweden, Ukraine
Technical University of Munich

Completed

Randomized, Double-blind, Two Arms, Multicenter, Phase III Study of Berinert for Treatment of ACE Induced Angioedema

Acute ACE-induced Angioedema

Germany
Krankenhaus Nordwest

Completed

Randomized Multicenter Phase II/III Study With Adjuvant Gemcitabine Versus Neoadjuvant / Adjuvant FOLFIRINOX for Resectable Pancreas Carcinoma

Resectable Prancreas Carcinoma

Germany
Pfizer

Completed

Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Subjects With Alopecia Areata

Alopecia Areata

United States, Canada, Australia
Second Affiliated Hospital, School of Medicine,...

Unknown

A Multicenter, Prospective, Phase III Randomized Controlled Clinical Study for the Treatment of N2-3 Nasopharyngeal Carcinoma Patients

Nasopharyngeal Carcinoma | Neoadjuvant Chemotherapy

China
Shandong Luoxin Pharmaceutical Group Stock Co.,...

Completed

A Multi-center, Randomized, Double-blind, Parallel-group, Placebo Controlled Phase III Study to Evaluate the Efficacy and Safety of LXI-15028 in Non-erosive Reflux Disease in Chinese Patients for 4 Weeks

Non-erosive Reflux Disease

China
Hoffmann-La Roche

Completed

A Randomized Phase 2 Study of Atezolizumab (an Engineered Anti-PDL1 Antibody) Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum Therapy - "POPLAR"

Non-Small Cell Lung Cancer

United States, Spain, Korea, Republic of, Belgium, Turkey, United Kingdom, Germany, Poland, Canada, France, Thailand, Italy, Sweden
AGC Biologics S.p.A.

Completed

NGR015: Study in Second Line for Patient With Advanced Malignant Pleural Mesothelioma Pretreated With Pemetrexed

Malignant Pleural Mesothelioma

United States, Spain, United Kingdom, Ireland, Italy, Belgium, Egypt, Canada, France, Netherlands, Poland, Sweden
Taejoon Pharmaceutical Co., Ltd.

Completed

A Multi-center, Randomized, Blinded Evaluator, Active Control, Parallel, Phase III Study to Evaluate the Efficacy and Safety of TJO-002 in POAG or Ocular Hypertension Patients

Ocular Hypertension | Primary Open-angle Glaucoma

Korea, Republic of
National Cancer Institute (NCI)

Completed

Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer

Lung Adenocarcinoma | Minimally Invasive Lung Adenocarcinoma | Malignant Pleural Effusion | Stage IIIB Lung Non-Small Cell Cancer AJCC v7 | Stage IV Lung Non-Small Cell Cancer AJCC v7 | Malignant Pericardial Effusion | Lung Adenosquamous Carcinoma

United States
Pfizer

Completed

Study To Evaluate Pf-04965842 In Subjects With Moderate To Severe Atopic Dermatitis

Atopic Dermatitis

United States, Canada, Australia, Germany, Hungary
Yonsei University

Unknown

A Phase III, Randomized, Multi-center Study to Determine the Efficacy of the Intercalating Combination Treatment of Chemotherapy and Gefitinib or Chemotherapy as Adjuvant Treatment in NSCLC With Common EGFR Mutations.

Completely Resected NSCLC With Common EGFR Mutations

Korea, Republic of
Pfizer

Completed

Study of CP-690,550 Versus Placebo In Rheumatoid Arthritis Patients On Background Methotrexate With Inadequate Response To Tumor Necrosis Factor (TNF) Inhibitors

Arthritis, Rheumatoid

Australia, United States, Austria, Germany, Ireland, Brazil, Spain, Taiwan, Belgium, Canada, France, Italy, Korea, Republic of, Puerto Rico
Medical University of Vienna

Unknown

AUSTrian Randomized Interventional Study on Dialysis Accesses (AUSTRIA)

End Stage Renal Disease | Catheter Infection | Shunt Malfunction

Austria
Biocad

Completed

An Open-label Randomized Multicenter Phase III Clinical Study Comparing Safety and Efficacy of Algeron (Cepeginterferon Alfa-2b) and and PegIntron (Peginterferon Alfa-2b) in Combination With Ribavirin as Combined Treatment of Chronic Hepatitis C in Human Immunodeficiency Virus-1 Infected Patients

Hepatitis | Hepatitis C | Hepatitis C/ Human Immunodeficiency Virus Coinfection

Russian Federation
GlaxoSmithKline

Completed

A Study to Evaluate the Immune Response and Safety of GSK Biologicals' HPV-16/18 L1 VLP AS04 Vaccine/Cervarix TM Vaccine in Healthy Females Aged 15-25 Years

Infections, Papillomavirus

Korea, Republic of
Norgine

Completed

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults (NOCT)

Colon Cancer | Colorectal Carcinoma | Colon Cleansing

United States
Norgine

Completed

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults.

Colorectal Cancer | Colorectal Carcinoma | Colon Cleansing

Netherlands, United Kingdom, Spain, Germany, Italy, Poland
Norgine

Completed

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults. (MORA)

Colorectal Cancer | Colorectal Carcinoma | Colon Cleansing

United Kingdom, Spain, Belgium, France, Germany, Italy, Poland
Association for Innovation and Biomedical Research...
European Vision Institute Clinical Research Network

Completed

Prospective, Randomized, Multicentre, Open-label, Phase II / III Study to Assess Efficacy and Safety of Ranibizumab 0.5 mg Intravitreal Injections Plus Panretinal Photocoagulation (PRP) Versus PRP in Monotherapy in the Treatment of Subjects With High Risk Proliferative Diabetic Retinopathy. (PROTEUS)

High Risk Proliferative Diabetic Retinopathy

Portugal, Italy, United Kingdom, France
Singapore General Hospital
National Cancer Centre, Singapore; National Medical Research Council (NMRC)... and other collaborators

Unknown

Study to Compare Selective Internal Radiation Therapy (SIRT) Versus Sorafenib in Locally Advanced Hepatocellular Carcinoma (HCC) (SIRveNIB)

Hepatocellular Carcinoma

Taiwan, Korea, Republic of, Malaysia, New Zealand, Philippines, Singapore, China, Thailand, Brunei Darussalam, Indonesia, Mongolia, Myanmar
Mycenax Biotech Inc.

Unknown

A Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of ENIA11 in Combination With DMARDs Versus DMARDs Alone in Patients With Rheumatoid Arthritis

Combination With DMARDs

Taiwan
Roswell Park Cancer Institute

Completed

Phase III Randomized Study of Cyclophosphamide With or Without Antithymocyte Globulin Before Bone Marrow Transplantation in Patients With Aplastic Anemia

Aplastic Anemia

United States
Bayer

Terminated

Colorectal Cancer Treated With Adjuvant Regorafenib Versus Placebo After Curative Treatment of Liver Metastases in a Randomized, Double-blind, Placebo-Controlled Phase-III STudy (COAST)

Colorectal Neoplasms

Belgium, France, Spain, China, United States, Canada, Germany, Portugal, Japan, Israel, United Kingdom, Italy, Australia, Brazil
GlaxoSmithKline

Terminated

A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder (orvepitant MDD)

Depressive Disorder, Major

United States, Canada
Centre Francois Baclesse
Hoffmann-La Roche; Groupe Français de Pneumo-Cancérologie

Terminated

A Multicenter Randomized Phase III Study Comparing Second-line Treatment With Chemotherapy Associated or Not to Erlotinib in NSCLC Patients With Secondary Resistance to TKI-EGFR (FLARE)

NSCLC Patients With EGFR Activating Mutation

France
National Institute of Diabetes and Digestive and...
Long Island Jewish Medical Center

Terminated

Phase III Randomized Study of SYNSORB Pk in Children With E. Coli-Associated Hemolytic Uremic Syndrome

Hemolytic Uremic Syndrome

United States, Canada
ProCore Ltd.

Completed

A Phase I, Prospective, Randomized, Open-label, Active-Controlled Clinical Trial for Safety Evaluation of Intra-articular Injection of RegenoGel-SP for the Treatment of Moderate to Severe Osteoarthritis

Osteoarthritis

Israel
Boryung Pharmaceutical Co., Ltd

Completed

A Randomized, Double-blind, Multicenter, Phase III Study to Evaluate the Efficacy and Safety of Combination of Fimasartan/Rosuvastatin in Comparison to Each Component Administered Alone in Patients With Essential Hypertension and Dyslipidemia

Essential Hypertension, Dyslipidemia

Korea, Republic of
Pfizer

Terminated

Study to Evaluate PF-04965842 in Patients With Moderate to Severe Psoriasis

Plaque Psoriasis

United States, Canada
Novartis Pharmaceuticals

Completed

A Phase III Randomized, Double Blind, Placebo Controlled Multi-center Study of Panobinostat for Maintenance of Response in Patients With Hodgkin's Lymphoma (HL) (PATH)

Hodgkin's Lymphoma

United States, Belgium, Germany, Canada, Singapore, Netherlands, France, Australia, Russian Federation, Israel, Brazil, Italy, New Zealand, Poland
Pfizer

Completed

A 12 Day Study To Evaluate A Topical Drug To Treat Plaque Psoriasis

Psoriasis Vulgaris

Germany
Arbeitsgemeinschaft medikamentoese Tumortherapie
Hoffmann-La Roche

Completed

A Multicentre, Randomized Phase III Study of Rituximab as Maintenance Treatment Versus Observation in Patients With Aggressive B-cell Lymphoma: NHL-13

Diffuse Large B-Cell Lymphoma (DLBCL) | Follicular NHL Grade 3b

Hong Kong, Thailand, Sweden, Taiwan, Mexico, Austria, Serbia, China, Czech Republic, Australia, Malaysia, Croatia, Israel, South Africa, Bosnia and Herzegovina, Brazil, Bulgaria, Estonia, Latvia, Macedonia, The Former Yugoslav... and more
University of Oxford
AstraZeneca

Unknown

A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia (AspECT)

Esophageal Cancer | Precancerous Condition
New Mexico Cancer Care Alliance

Completed

A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients

Cancer

United States
Cancer Institute and Hospital, Chinese Academy...

Unknown

A Randomized Phase III Study of Adjuvant Chemotherapy With or Without Chemo-radiotherapy in Patients With Local Advanced Gastric Cancer After D2 Resection.

Gastric Cancer

China
King Faisal Specialist Hospital & Research Center

Completed

Multi-national, Randomized, Phase III, GCIG Intergroup Study Comparing Pegylated Liposomal Doxorubicin (CAELYX) and Carboplatin vs. Paclitaxel and Carboplatin in Patients With Epithelial Ovarian Cancer in Late Relapse. (CALYPSO)

Epithelial Ovarian Cancer
Pfizer

Completed

Randomized Phase III Study Of Exemestane (Aromasin) For 5 Years Versus Tamoxifen for 2.5 to 3 Years Followed By Exemestane (TEAM)

Breast Neoplasms

United States
CSL Behring

Completed

An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure (BE1116_3003)

Reversal of Coagulopathy

United States, Belarus, Bulgaria, Lebanon, Romania, Russian Federation
FDA Office of Orphan Products Development
Medical University of South Carolina

Completed

Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital Osteopetrosis

Osteopetrosis
State University of New York

Completed

Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease

Dupuytren's Contracture
FDA Office of Orphan Products Development
Centocor, Inc.

Completed

Phase III Randomized Study of Anti-Tumor Necrosis Factor Chimeric Monoclonal Antibody (cA2) for Patients With Enterocutaneous Fistulae as a Complication of Crohn's Disease

Crohn's Disease
FDA Office of Orphan Products Development

Completed

Phase III Randomized Study of the Inhalation of Tobramycin in Patients With Cystic Fibrosis

Cystic Fibrosis | Bacterial Infection
University of Florida

Completed

Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis

Lactic Acidosis
United Therapeutics

Completed

Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension

Pulmonary Hypertension

United States
European Lung Cancer Working Party

Completed

Randomized Study of Cisplatin-Etoposide Versus an Etoposide Regimen Without Cisplatin in Extensive Small-Cell Lung Cancer

Small Cell Lung Carcinoma, Extensive Disease

Belgium, France, Greece, Spain
Pfizer

Completed

Pharmacokinetics/Pharmacodynamics Biomarker Study in Active Ulcerative Colitis Patients

Colitis, Ulcerative

Canada, United States, France, Netherlands, Germany, Spain, Austria, Hungary, Bulgaria, Poland, Romania

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