Search clinical trials for: Small molecule LCDM

Total 11915 results

Yuzuncu Yıl University

Completed

The Effect of Intrathecal Magnesium Sulfate on Shivering

Cesarean Section Complications | Postoperative Shivering | Magnesium Sulfate Causing Adverse Effects in Therapeutic Use

Turkey
Tampere University Hospital

Completed

Prognosis in UC After First Biological (biological)

Ulcerative Colitis
AstraZeneca
Parexel

Completed

A Study in Healthy Male Subjects to Understand How Savolitinib When Taken With Midazolam Behaves Inside the Body

Solid Tumors

United States
Oncoethix GmbH

Completed

A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)

Triple Negative Breast Cancer | Pancreatic Ductal Adenocarcinoma | Castrate-resistant Prostate Cancer | CRPC | NUT Midline Carcinoma | Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation
Nourhan M.Aly
Alexandria University

Completed

Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus

Erosive Lichen Planus

Egypt
Effector Therapeutics

Terminated

A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies

Lymphoma

United States
Famewave Ltd.

Terminated

Study of CM-24 (MK-6018) Alone and In Combination With Pembrolizumab (MK-3475) in Participants With Selected Advanced or Recurrent Malignancies (MK-6018-001)

Melanoma | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Bladder Cancer | Non-small Cell Lung Carcinoma (NSCLC)

United States, Israel
AstraZeneca
Parexel

Completed

A Study in Healthy Male Subjects to Understand How Savolitinib Behaves Inside the Body (Pharmacokinetics) When Administered Alone and in Combination With Famotidine

Solid Tumours

United States
Istituto Scientifico Romagnolo per lo Studio e...
European Institute of Oncology

Unknown

Italian Observational Study of Patients With Acute Myeloid Leukemia Treated With Small Molecule Inhibiting BCL-2 (AVALON)

Acute Myeloid Leukemia

Italy
AstraZeneca

Completed

A Study in Healthy Subjects to Assess the Pharmacokinetics of Savolitinib When Administered Alone and in Combination With Rifampicin

Solid Tumors

United States
National Cancer Institute (NCI)

Completed

Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors

GIST

United States
AstraZeneca
Parexel

Completed

A Study to Investigate the Effect of Single Dose of AZD6094 (600 mg) on Cardiac Repolarization in Healthy Volunteers

Solid Tumors

United States
Cardiff University
Cancer Research UK

Unknown

Trial to Test the Effects of Adding 1 of 2 New Treatment Agents to Commonly Used Chemotherapy Combinations (AML18)

Myelodysplastic Syndrome | Acute Myeloid Leukaemia

Denmark, United Kingdom
AstraZeneca
Parexel

Completed

A Study to Evaluate the Amount of Drug That Becomes Available in the Blood Circulation When Savolitinib is Administered Alone and in Combination With Itraconazole

Solid Tumour

United States
National Cancer Institute (NCI)

Completed

Cabozantinib Plus Docetaxel and Prednisone for Advanced Prostate Cancer

Prostatic Neoplasms

United States
AstraZeneca
Quintiles, Inc.

Completed

Immune-Modulated Study of Selected Small Molecules (Gefitinib, AZD9291, or Selumetinib + Docetaxel) or a 1st Immune-Mediated Therapy (IMT; Tremelimumab) With a Sequential Switch to a 2nd IMT (MEDI4736) in Patients With Locally Advanced or Metastatic Non-Small-Cell Lung Cancer

Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (Stage IIIB-IV)

United States
Centro Nacional de Investigaciones Oncologicas...
Fundacion CRIS de Investigación para Vencer el Cáncer

Completed

ME-344 in Early HER2-negative Breast Cancer With Antiangiogenic-induced Mitochondrial Metabolism

Breast Cancer | Early-Stage Breast Carcinoma | Human Epidermal Growth Factor 2 Negative Carcinoma of Breast

Spain
Bayer

Completed

BAY73-4506 Probe Substrate Study

Neoplasms

Canada
National Cancer Institute (NCI)

Completed

AMG 386 and Abiraterone for Advanced Prostate Cancer

Prostatic Neoplasms | Prostate Cancer | Neoplasm, Prostate | Neoplasm,Prostatic

United States
Endocyte

Completed

An Exploratory Study of the Folic Acid-tubulysin Conjugate EC1456 in Ovarian Cancer Subjects Undergoing Surgery

Ovary Cancer

Canada, United States
Lysosomal and Rare Disorders Research and Treatment...

Unknown

Cellular Pharmacodynamics of Small Molecules in Lysosomal Storage Disorders

Lysosomal Storage Diseases

United States
Astellas Pharma Inc
Astellas Pharma Global Development, Inc.

Completed

An Open-label Phase I Study of Orally Available Novel Small-molecule Fibroblast Growth Factor Receptors (FGFR) 1,2,3 and 4 Inhibitor, ASP5878 at Single and Multiple Doses in Patients With Solid Tumors

Solid Tumors

United States, Japan, Korea, Republic of, Taiwan
Duke University
Prostate Cancer Foundation; Janssen Diagnostics, LLC

Completed

Characterization of Circulating Tumor Cells Captured by c-MET (CTC-MET)

Renal Cell Carcinoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Prostate Cancer | Bladder Cancer | Non-small Cell Lung Cancer | Advanced MET Amplified Solid Tumor

United States
M.D. Anderson Cancer Center
OSI Pharmaceuticals

Terminated

Phase II Trial of Erlotinib, Prior to Surgery or Radiation in Patients With Squamous Cell Cancers (SCC) of the Skin

Skin Cancer

United States
Hospital Clinic of Barcelona

Suspended

Role of Hyoscine Bromide in Latent and Active Labor

Labor, First Stage

Spain
Memorial Sloan Kettering Cancer Center

Completed

Registry for Patients With Acquired Resistance to Small Molecule Kinase Inhibitors in Non-Small-Cell Lung Cancer

Unresectable or Metastatic Non-small Cell Lung Cancer (NSCLC)

United States
Beijing Chao Yang Hospital

Unknown

The Study on the Pulmonary Vessel Disease and Its Changes in Metabolism of Small Molecules

Pulmonary Vessel Disease

China
BioLineRx, Ltd.

Terminated

Phase IIb-III Study of BL-1020 Small Molecule for Schizophrenia (CLARITY)

Schizophrenia | Cognitive Effect on Schizophrenic Patients

India, Moldova, Republic of, Romania
Pfizer

Completed

Phase 1 Study To Evaluate Antiviral Activity Of Small Molecule Direct Antiviral Agent At Multiple Doses In Subjects With Chronically Infected Hepatitis C Virus.

Hepatitis, Chronic | Hepatitis C Virus

United States
Axelar AB

Completed

Study of AXL1717 Compared to Docetaxel to Treat Squamous Cell Carcinoma or Adenocarcinoma of the Lung

Non-small-cell Lung Cancer | Squamous Cell Carcinoma | Adenocarcinoma of the Lung

Russian Federation, Ukraine, Belarus, Hungary, Poland
Bayer

Completed

Clinical Study to Evaluate Safety and Maximum Tolerated Dose of BAY1000394 Given in a 4 Week on / 2 Week Off Schedule in Subjects With Advanced Malignancies

Neoplasms

United States
Welichem Biotech Inc.

Completed

Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream

Dermatitis, Atopic

Canada
Tracon Pharmaceuticals Inc.

Completed

Study of TRC102 in Combination With Pemetrexed in Cancer Patients

Neoplasm

United States
Taipei Medical University WanFang Hospital

Unknown

Development and Exploration of the Feasibility of Using Locally Synthesized Small Molecule Inhibitors to Treat Human Acute Leukemia Cells

Acute Myeloid Leukemia
Welichem Biotech Inc.

Completed

Phase IIa Study of WBI-1001 Cream for Atopic Dermatitis (WBI-1001-201)

Dermatitis, Atopic

Canada
OPKO Health, Inc.

Completed

Safety and Efficacy Study of Small Interfering Ribonucleic Acid (RNA) Molecule (Cand5) to Treat Wet Age-Related Macular Degeneration

Macular Degeneration

United States
OPKO Health, Inc.

Completed

Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema

Diabetic Macular Edema

United States
SGX Pharmaceuticals, Inc.

Terminated

Safety Study of SGX523, a Small Molecule Met Inhibitor, to Treat Solid Tumors

Advanced Cancer

United States
SGX Pharmaceuticals, Inc.

Terminated

Safety Study of SGX523, a Small Molecule Met Inhibitor, to Treat Solid Tumors

Advanced Cancer

United States
National Institute of Dental and Craniofacial Research...

Completed

Chemical and Genetic Effects of the Experimental Anti-Cancer Drugs in Cheek Cells in Cancer Patients

Cancer

United States
Dartmouth-Hitchcock Medical Center
Dartmouth College

Completed

The Effect of Cinnamon on HbA1c Among Adolescents With Type I Diabetes

Type 1 Diabetes Mellitus

United States
Shanghai East Hospital

Recruiting

Chemokine and Co-stimulatory Molecule-modified Mesenchymal Stem Cells for the Treatment of Advanced Colorectal Cancer

Advanced Colorectal Cancer

China
First Affiliated Hospital of Zhejiang University

Recruiting

Efficacy and Safety of Modified Si Jun Zi Tang in Perioperative NSCLC Treatment (MSJZT-NSCLC)

Non Small Cell Lung Cancer | Perioperative Complication

China
KaliVir Immunotherapeutics

Not yet recruiting

A Study of VET3-TGI in Patients With Solid Tumors (STEALTH-001)

Kidney Cancer | Renal Cell Carcinoma | Cervical Cancer | Mesothelioma | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Solid Tumor, Adult | Microsatellite Stable Colorectal Cancer | Melanoma Stage IV | Merkel Cell Carcinoma of Skin
Shanghai Chest Hospital

Recruiting

A Study of Molecular Residual, Dynamic Monitoring and Recurrence of Stage III Driver Mutated NSCLC

Non Small Cell Lung Cancer

China
Taizhou Hospital

Not yet recruiting

Toripalimab Plus Anlotinib for the Maintenance of Extensive Stage Small Cell (SCLC)

SCLC | Maintenance Treatment
University Hospital, Brest

Not yet recruiting

Impact of Respiratory Rehabilitation on Quality of Life in Patients With Metastatic Non-small Cell Lung Cancer Treated With Immunotherapy and Chemotherapy in the Maintenance Phase (REHABIM)

Cancer
Shanghai Municipal Hospital of Traditional Chinese...

Not yet recruiting

LCMD for Type 2 Diabetes Remission: Evaluation of Effectiveness and Exploration of Individual Differences (LCMD)

Type 2 Diabetes | Type 2 Diabetes Mellitus in Obese

China
Hunan Province Tumor Hospital
Hunan Cancer Hospital

Recruiting

Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases (EPIC)

Non-Small Cell Lung Cancer

China
University of Palermo

Not yet recruiting

SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF (DAPA-TONIC)

Heart Failure With Reduced Ejection Fraction | Heart Failure With Preserved Ejection Fraction | Diabetes Type 2 | Heart Failure Acute

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