Search clinical trials for: Tumor Mutation Burden High
Total 53710 results
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National Cancer Institute (NCI)RecruitingGlioma | Glioblastoma | Malignant Glioma | Low Grade Glioma | High Grage GliomaUnited States
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University Health Network, TorontoRecruitingMelanoma | Lymphoma | Kidney Cancer | Leukemia | Cancer | Breast Cancer | Head and Neck Cancer | Ovarian Cancer | Lynch Syndrome | Lung Cancer | Colon Cancer | Meningioma | BRCA1 Mutation | BRCA2 Mutation | Myeloma | Mutation | Uterine Cancer | Cowden SyndromeCanada
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CelgeneRecruitingLymphoma, Mantle-CellSpain, Italy, Germany, Austria, France, Greece, Netherlands
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Ascentage Pharma Group Inc.Merck Sharp & Dohme LLCRecruitingMelanoma | P53 Mutation | Uveal Melanoma | Cutaneous Melanoma | Mucosal Melanoma | Malignant Peripheral Nerve Sheath Tumors | MPNST | Unresectable or Metastatic Melanoma or Advanced Solid Tumors | MDM2 Gene MutationUnited States, Australia
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Sichuan UniversityGeneplus-Beijing Co. Ltd.RecruitingNon-small Cell Lung CancerChina
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Novartis PharmaceuticalsRecruitingMelanoma | Solid Tumor | High Grade Glioma | Non Small Cell Lung Cancer | Rare CancersSpain, Germany, United States, Argentina, Austria, Denmark, France, Hungary, Netherlands, China, Japan, Thailand
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Abramson Cancer Center at Penn MedicineRecruitingPancreatic CancerUnited States
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McGill UniversityMcGill University Health Centre/Research Institute of the McGill University... and other collaboratorsRecruitingOvarian Neoplasms | Ovarian Cancer | Endometrial Neoplasms | Endometrial Cancer | Safety | Early Diagnosis | Screening | Reduced Mortality | Reduced MorbidityCanada
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ECOG-ACRIN Cancer Research GroupNational Cancer Institute (NCI)RecruitingStage IB Non-Small Cell Lung Carcinoma AJCC v7 | Stage II Non-Small Cell Lung Cancer AJCC v7 | Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 | Stage IIB Non-Small Cell Lung Carcinoma AJCC v7 | Stage IIIA Non-Small Cell Lung Cancer AJCC v7 | ALK Gene Rearrangement | ALK Gene Translocation | ALK...United States, Guam, Puerto Rico
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National Cancer Institute (NCI)Active, not recruitingRecurrent Breast Carcinoma | Metastatic Triple-Negative Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Stage IV Breast Cancer AJCC v6 and v7 | Metastatic Breast Carcinoma | Metastatic BRCA Hereditary Breast CarcinomaUnited States, Puerto Rico
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Hoffmann-La RocheActive, not recruitingMelanomaUnited States, Korea, Republic of, United Kingdom, Australia, France, Belgium, Italy, Portugal, Spain, Brazil, Canada, Russian Federation, Germany, New Zealand, Israel, Poland, Greece, Austria, Hungary, Netherlands
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Eli Lilly and CompanyNSABP Foundation IncActive, not recruitingBreast CancerUnited States, Spain, China, Germany, Canada, Taiwan, United Kingdom, Singapore, Italy, Australia, Japan, Hungary, Russian Federation, India, Belgium, New Zealand, Austria, Saudi Arabia, France, Czechia, Korea, Republic of, Finland, Argentin... and more
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ECOG-ACRIN Cancer Research GroupNational Cancer Institute (NCI)Active, not recruitingAnatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic... and other conditionsUnited States
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Mirati Therapeutics Inc.Active, not recruitingMetastatic Colorectal Cancer | Advanced Colorectal CancerUnited States, Spain, Belgium, Canada, France, Italy, United Kingdom, Korea, Republic of, Austria, Denmark, Taiwan, Germany, Malaysia, Czechia, Colombia, Singapore, Australia, Thailand, Netherlands, Romania, Greece, Brazil, Argentina, Polan... and more
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Revolution Medicines, Inc.Active, not recruitingAdvanced Solid Tumor | Pancreatic Ductal Adenocarcinoma | Non-Small Cell Lung Cancer (NSCLC) | Colorectal Cancer (CRC)United States, Spain, France, Korea, Republic of, Malaysia, Taiwan, Italy, Thailand, Australia, Czechia, Singapore, Poland, Serbia
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UroGen Pharma Ltd.TerminatedBladder Cancer | Urothelial Carcinoma Bladder | Urothelial CarcinomaUnited States, Israel, Russian Federation, Georgia, Bulgaria, Estonia, Latvia, Poland, Serbia, Ukraine
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SWOG Cancer Research NetworkNational Cancer Institute (NCI)Active, not recruitingStage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Advanced Lung Non-Squamous Non-Small Cell Carcinoma | Recurrent Lung Non-Squamous Non-Small Cell CarcinomaUnited States
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SWOG Cancer Research NetworkNational Cancer Institute (NCI)Active, not recruitingStage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Lung Non-Small Cell Squamous Carcinoma | Recurrent Lung Non-Small Cell Carcinoma | Deleterious BRCA1 Gene Mutation | Deleterious BRCA2 Gene Mutation | Recurrent Lung Adenocarcinoma | Loss of Heterozygosity | Recurrent... and other conditionsUnited States
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St. Jude Children's Research HospitalNovartis PharmaceuticalsCompletedGlioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditionsUnited States
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Memorial Sloan Kettering Cancer CenterBristol-Myers Squibb; UConn Health; Adaptive Biotechnologies; MedGenomeCompleted
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Hoffmann-La RocheTerminatedLocally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)United States, Korea, Republic of, Canada, Australia, Russian Federation, United Kingdom, Belgium, Brazil, China, France, Italy, Portugal, Spain, Japan, India, Thailand, Ukraine, Taiwan, Poland, Turkey, Hungary, South Africa, Germany
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Hoffmann-La RocheActive, not recruitingNon-Small Cell Lung CancerHungary, Korea, Republic of, Australia, Spain, China, Denmark, Italy, Germany, Mexico, Poland, United States, Brazil, Peru, Thailand, Serbia, Switzerland, Japan, Turkey, Netherlands, Austria, Taiwan, Russian Federation, Ukraine, Greece
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Hoffmann-La RocheCompletedNeoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Neoplasms, Glandular and Epithelial | Endocrine System Diseases | Gastrointestinal Neoplasms | Neoplasms, Germ Cell and Embryonal | Head and Neck Neoplasms | Carcinoma, Non-Small-Cell Lung | Respiratory Tract... and other conditionsFrance, Spain, United States, Korea, Republic of, United Kingdom, Taiwan, China, Belgium, Singapore, Netherlands, Germany, Italy, Hong Kong
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Assistance Publique - Hôpitaux de ParisBristol-Myers SquibbCompletedBrain Cancer | High Grade GliomaFrance
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Ludwig-Maximilians - University of MunichBayer; Roche Pharma AGActive, not recruiting
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Relay Therapeutics, Inc.Active, not recruitingCholangiocarcinoma | Intrahepatic Cholangiocarcinoma | FGFR2 Gene Mutation | FGFR2 Amplification | FGFR2 Gene Fusion/Rearrangement | FGFR2 Gene Translocation | FGFR2 Gene Activation | Other Solid Tumors, AdultUnited States, France, Italy, United Kingdom, Korea, Republic of, Spain, Taiwan, Sweden, Germany, Netherlands, Singapore, Australia, Hong Kong
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ECOG-ACRIN Cancer Research GroupNational Cancer Institute (NCI)Active, not recruitingFinancial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing TreatmentStage III Colon Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage IIIA Colon Cancer AJCC v8 | Stage IIIA Rectal Cancer AJCC v8 | Stage IIIB Colon Cancer AJCC v8 | Stage IIIB Rectal Cancer AJCC v8 | Stage IIIC Colon Cancer AJCC v8 | Stage IIIC Rectal Cancer AJCC v8 | Stage IIA Rectal Cancer AJCC... and other conditionsUnited States
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UNICANCERAstraZeneca; National Cancer Institute, France; Pierre Fabre LaboratoriesActive, not recruitingBreast Cancer | Head and Neck Cancer | Prostate Cancer | Cervix Cancer | Advanced Solid TumoursFrance
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PrECOG, LLC.Genentech, Inc.CompletedFollicular Lymphoma | Non-Hodgkin's Lymphoma Follicular | Non-Hodgkin's Lymphoma, Adult High GradeUnited States
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Centre Leon BerardCompletedGastrointestinal Stromal Tumors | Resected Gastrointestinal Stromal Tumors | Non-metastatic | High Risk of Recurrence | KIT Gene MutationFrance
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Tempus AIGlaxoSmithKlineActive, not recruitingMelanoma | Head and Neck Cancer | Pancreatic Cancer | Esophageal Cancer | Solid Tumor | Metastatic Cancer | Endometrial Cancer | Urologic Cancer | Breast Tumor | Locally Advanced Solid Tumor | Lung Tumor | Colon Tumor, MalignantUnited States
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PfizerMerck KGaA, Darmstadt, Germany; Ono Pharmaceutical Co. Ltd; Pierre Fabre MedicamentCompletedBRAF V600E-mutant Metastatic Colorectal CancerUnited States, Spain, Korea, Republic of, United Kingdom, Australia, Czechia, Taiwan, Belgium, France, Hungary, Canada, Japan, Russian Federation, Netherlands, Israel, Germany, Turkey, Austria, Brazil, Poland, Italy, Argentina, Chile, Denmar... and more
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Novartis PharmaceuticalsCompletedGlioblastoma | Astrocytoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Pleomorphic Xanthoastrocytoma | Ganglioglioma | Pleomorphic Xanthoastrocytoma | Diffuse Astrocytoma | Anaplastic Oligodendroglioma | Pilocytic Astrocytoma | Gangliocytoma | Central Neurocytoma | Oligodendroglioma, Childhood and other conditionsUnited States, Italy, Japan, Germany, Spain, France, Canada, Australia, Brazil, Israel, Russian Federation, Argentina, United Kingdom, Finland, Belgium, Denmark, Czechia, Sweden, Switzerland, Netherlands
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Pierre Fabre MedicamentEuropean Organisation for Research and Treatment of Cancer - EORTCActive, not recruitingMelanomaSpain, Canada, Hungary, Italy, Belgium, Netherlands, Australia, Czechia, Greece, Brazil, Portugal, Serbia, Sweden, Norway, Germany, Argentina, Romania, Poland, United Kingdom, Austria, Switzerland, France, South Africa
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John L. Villano, MD, PhDActive, not recruitingTumor, SolidUnited States
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University of NebraskaNational Cancer Institute (NCI)CompletedKidney Cancer | Melanoma (Skin)United States
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Novartis PharmaceuticalsCompletedMelanomaUnited States, Belgium, Canada, Spain, United Kingdom, Netherlands, Argentina, Australia, Austria, Brazil, Czechia, Denmark, France, Germany, Greece, Israel, Italy, Japan, New Zealand, Norway, Poland, Russian Federation, Sweden, Switz... and more
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Volastra Therapeutics, Inc.AmgenCompletedAdvanced Solid TumorsUnited States, Canada, Italy, Australia, Japan, Belgium, Spain
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Novartis PharmaceuticalsCompletedCancerFrance, Spain, Netherlands, Canada, Austria, United States, Germany, Italy, Japan, Norway, Korea, Republic of, Denmark, Sweden, Belgium
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Basilea PharmaceuticaArQule, Inc. (a wholly owned subsidiary of Merck Sharp and Dohme, a subsidiary...CompletedSolid TumorUnited States, Italy
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Charles KunosNational Center for Advancing Translational Sciences (NCATS)CompletedLarge-Cell Neuroendocrine CarcinomaUnited States
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AbbVieRadiation Therapy Oncology GroupCompletedGlioblastoma | GliosarcomaUnited States, Argentina, Australia, Austria, Belgium, Brazil, Canada, China, Colombia, Czechia, France, Germany, Hong Kong, Ireland, Israel, Italy, Korea, Republic of, Mexico, Netherlands, New Zealand, Portugal, Russian Federation, Singapor... and more
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Chonnam National University HospitalRoche Pharma AGCompletedLung Neoplasm MalignantKorea, Republic of
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Hoffmann-La RocheCompletedTriple Negative Breast CancerUnited States, Korea, Republic of, Belgium, Canada, Germany, United Kingdom, Argentina, Australia, Brazil, Finland, France, Greece, Hungary, Poland, Slovenia, Spain, Taiwan, Turkey, Japan, Singapore, Colombia, Bosnia and Herzegovina, Guatema... and more
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Peking University People's HospitalJiangsu HengRui Medicine Co., Ltd.; OrigiMedCompleted
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Incyte CorporationTerminatedMetastatic Urothelial Carcinoma | Unresectable Urothelial CarcinomaSpain, France, United States, Italy, Japan, Ireland, Slovakia, Austria, Belgium, Canada, Finland, Germany, Poland, Portugal, Romania, United Kingdom
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AbbVieNo longer availableHigh Grade Serous Ovarian Cancer | Solid Tumors With Documented BRCA, BARD, or PALB or Other Acceptable DNA Mutations or Anomalies That Are Scientifically Sound | Triple Negative Breast Cancer (TNBC) | Patients Requiring Veliparib Suspension Formulation
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Australia New Zealand Gynaecological Oncology GroupBeiGeneWithdrawn
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University of PennsylvaniaChildren's Hospital of PhiladelphiaCompletedLymphoblastic Leukemia, Acute, ChildhoodUnited States
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Assistance Publique - Hôpitaux de ParisBristol-Myers SquibbTerminatedNon Small Cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Non Small Cell Lung Cancer Stage III | Non-Small Cell Carcinoma of LungFrance