- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03933761
Pamiparib in Fusion Positive, Reversion Negative High Grade Serous Ovarian Cancer or Carcinosarcoma With BRCA1/2 Gene Mutations If Progression on Substrate Poly ADP Ribose Polymerase Inhibitbor (PARPI) or Chemotherapy (PRECISE)
A Phase II, Signal-Seeking Trial of the Clinical Benefit Rate Associated With Pamiparib in Subjects With Germline or Somatic BRCA1/2 High Grade Serous Ovarian Cancer or Carcinosarcoma Who Have Progressed on P-gp Substrate Chemotherapy or PARPi With the Presence of an ABCB1 Fusion and the Absence of a BRCA1/2 Reversion
This study is a phase II, multi-centre, open label study in patients with advanced ovarian cancer. The treatment being tested is Pamiparib, with daily dosing.
All patients enrolled to the study will receive treatment with pamiparib. Patients will be selected for entry into the study based on the molecular signature of their cancer.
Study Overview
Detailed Description
Ovarian cancer is the deadliest gynaecologic cancer in Western women. Although initially responsive to therapy, drug resistance commonly evolves.
Novel mechanisms of drug resistance in ovarian cancer have been identified and include genetic mutations that result in the activation of a drug efflux pump and secondary mutations in BRCA1/2 genes that restore the cancer cell's ability to repair treatment related DNA damage. It is hypothesized that patients with BRCA1/2 mutant high grade serous ovarian cancer or carcinosarcoma who have progressed on recent therapy and have an activated efflux pump without a secondary BRCA1/1 mutation will be selectively sensitive to a new PARPi, Pamiparib, which does not get effluxed out of cancer cells.
The primary objective of this trial is to assess the clinical benefit rate at > 4 months in 2 cohorts of patients (cohort 1: post substrate-PARP inhibitor and cohort 2: post chemotherapy) defined as response or absence of progression. Secondary objectives are to determine the median progression free and overall survival of patients treated with Pamiparib and the impact on symptom burden and benefit.
Study Type
Phase
- Phase 2
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria - Pre-Screening
- Patient has provided written informed consent for pre-screening
- Patient is able to comply with the study protocol and follow-up procedures, in the Investigator's judgement
- Patient is female aged ≥ 18 years at time of consent
- ECOG performance status 0-2 (refer to Appendix 1)
- Patient has the ability to take oral medications without medical history of malabsorption or other chronic gastrointestinal disease, or other conditions that may harm compliance and/or absorption of the study agent
Patients with a histopathological diagnosis of HGSC or carcinosarcoma of the ovary (including primary peritoneal cancers and fallopian tube cancers) as defined by histological diagnosis and immunohistochemistry (IHC) and with a germline or somatic BRCA1/2 mutation:
- Mixed histologies are allowed provided that >80% of the primary tumour is a HGSC based on diagnostic pathology review and IHC profile
Patients with progressive disease defined by GCIG CA-125 and/or RECIST v1.1 criteria after 3 or more lines of chemotherapy or after progression on a P-gp substrate PARPi (i.e.
olaparib, niraparib)
- Patients may continue on treatment as per standard of care by their usual clinician while awaiting the results of pre-screening with no impact on usual care
- Patients who have been treated with both substrate PARPi and substrate chemotherapy will be considered eligible for either cohort 1 or cohort 2 based on the therapy they have most recently progressed on (cohort 1 is progression on PARPi and cohort 2 is progression on chemotherapy)
Disease that is amenable to a biopsy and/or ascitic drainage
- Lesions intended to be biopsied should not be target lesions with the preference of the biopsy site having progressed on most recent imaging where clinically safe and feasible
- Patient has a life expectancy > 12 weeks
- Patient has consented to the collection and use of their fresh tumour biopsies and/or ascites samples
Exclusion Criteria - Pre-Screening
- Patients with a clear cell, mucinous, or other non-high grade serous histological subtype
Prior treatment with non-substrate P-gp PARPi (pamiparib or veliparib)
- Prior treatment with substrate PARPi is allowed (olaparib, niraparib, rucaparib, and talazoparib)
- Patients who are pregnant or nursing
- Patient has a diagnosis of myelodysplastic syndrome (MDS)
Patient has other diagnoses of malignancy
- Except for surgically excised non-melanoma skin cancer, adequately treated carcinoma in situ of the cervix, adequately treated non-invasive bladder cancer, ductal carcinoma in situ treated surgically with curative intent, or a malignancy diagnosed >2 years ago with no current evidence of disease and no therapy ≤2 years prior to pre-screening
- Prior radiation therapy to target lesions in the absence of documented progression at the treated target lesion
- Patient has uncontrolled pleural effusion, pericardial effusion, or ascites requiring weekly recurrent drainage procedures
- Known history of intolerance to the excipients of the pamiparib capsule
- Active bleeding disorder, including gastrointestinal bleeding, as evidenced by hematemesis, significant hemoptysis, or melena ≤6 months prior to registration to pre-screening
Previous complete gastric resection, chronic diarrhea, active inflammatory gastrointestinal disease, or any other disease-causing malabsorption syndrome
- Gastroesophageal reflux disease under treatment with proton-pump inhibitors is allowed
Inclusion Criteria - Main Study
- Patient has provided written informed consent for main PRECISE study
- Patient continues to meet all pre-screening inclusion criteria
- Patient has an ABCB1 fusion(s) and the absence of a BRCA1/2 reversion
Patient has platinum sensitive or platinum resistant HGSC
- Patients who are refractory (progress during or within 4 weeks) to second or subsequent lines of platinum-based chemotherapy are eligible
- Patients who are primary platinum refractory (progress during or within 4 weeks of first line chemotherapy) are considered ineligible
- Recurrent disease that is measurable according to RECIST v1.1 or evaluable disease using CA-125 according to GCIG criteria
Adequate haematologic and end-organ function, as defined by the following laboratory results (obtained within 7 days prior to registration to the main study):
- Absolute neutrophil count (ANC) ≥1.5 x 109/L
- Platelet count ≥ 100 x 109/L
- Haemoglobin (Hb) ≥ 90 g/L (≥ 28 days after transfusion)
- Estimated glomerular filtration rate ≥ 30 mL/min/1.73 m2 by the Modification of Diet in Renal Disease study equation (MDRD STUDY EQ; www.mdrd.com or Appendix 5)
- Total serum bilirubin ≤ 1.5 x upper limit of normal (ULN)
- ≤ 4 x ULN, if Gilbert's syndrome or if indirect bilirubin concentrations suggestive of extrahepatic source of elevation
- Aspartate and alanine aminotransferase (AST and ALT) ≤ 3 x upper limit of normal (ULN) or ≤ 5 x ULN for patients with liver metastases
Females who are of childbearing potential
- Females of childbearing potential require a negative serum pregnancy test within 7 days prior to registration into the main study
- Females of childbearing potential must practice highly effective methods of birth control (refer to Appendix 2) for the duration of the study and for at least 6 months after last study drug
- Patients must have recovered to ≤ grade 1 from their treatment-related adverse event (AE) with the exception of alopecia and peripheral neuropathy
Able to provide a formalin-fixed paraffin embedded (FFPE) tumour block, representative of the patient's primary disease
- In cases where there is insufficient FFPE tumour, a discussion with the Coordinating Principal Investigator (CPI) must be had before registration to the main study
Exclusion Criteria - Main Study
Patients who have received chemotherapy, biologic therapy, immunotherapy, investigational agent, anticancer Chinese medicine, or herbal remedies ≤ 5 half-lives if the half-life is known, ≤ 14 days if not known, prior to registration to the main study
- Bisphosphonate and denosumab use are allowed on study, if administered at a stable dose > 28 days prior to registration to the main study
- The use or anticipated need for food or drugs known to be strong CYP3A inducers (Appendix 7) ≤ 5 half-lives if the half-life is known or ≤ 14 days if not known prior to registration to the main study
Major surgical procedure, open biopsy, or significant traumatic injury ≤ 14 days prior to registration to the main study, or anticipation of need for major surgical procedure during the course of the study
- Placement of vascular access device is not considered major surgery
- Prior radiation therapy ≤ 14 days prior to registration to the main study to non-target lesions. Patients who have received palliative radiotherapy of non-target lesions for local symptom control > 14 days prior to registration to the main study must have stabilisation of any AEs or a return to baseline prior to registration to the main study
- Leptomeningeal disease or uncontrolled, untreated brain metastases
Patients with a history of treated and asymptomatic brain metastases are eligible, provided they meet all of the following:
- Only supratentorial metastases
- Brain imaging at screening without evidence of interim progression
- No ongoing requirement for corticosteroids as therapy for brain metastases
- Anticonvulsants at a stable dose allowed (except for contraindicated medications carbamazepine and phenytoin)
- No stereotactic radiation or whole-brain radiation ≤ 14 days prior to registration to the main study
Any of the following cardiovascular criteria:
- Cardiac chest pain, defined as moderate pain that limits instrumental activities of daily living, ≤ 28 days prior to registration to the main study
- Symptomatic pulmonary embolism ≤ 28 days prior to registration to the main study
- Any history of acute myocardial infarction ≤ 6 months prior to registration to the main study
- Any history of heart failure meeting New York Heart Association (NYHA) Classification III or IV (refer to Appendix 8) ≤ 6 months prior to registration to the main study
- Any event of ventricular arrhythmia ≥ Grade 2 in severity ≤ 6 months prior to registration to the main study
- Any history of cerebrovascular accident (CVA) ≤ 6 months prior to registration to the main study
Active infection requiring systemic treatment, acute/viral hepatitis or active chronic hepatitis B or C or active tuberculosis
- Patients with untreated chronic hepatitis B or chronic hepatitis B virus (HBV) carriers whose HBV DNA is > 500 IU/mL or patients with active hepatitis C should be excluded. Note: Inactive hepatitis B surface antigen carriers, treated and stable hepatitis B (HBV DNA < 500 IU/mL), and cured hepatitis C patients can be enrolled
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Pamiparib (BGB-290)
Drug: Pamiparib Oral capsules 60mg twice daily continuously Although treatment is continuous, a cycle is defined as 4 weeks or 28 days.
|
60 mg of pamiparib (3 capsules of 20mg) will be administered orally twice a day, once in the morning and once in the evening continuously in 28 day cycles.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Clinical benefit rate
Time Frame: Assessed at 16 weeks after commencing treatment.
|
as assessed by RECIST v1.1 or by Gynaecological Cancer Intergroup (GCIG) Cancer antigen (CA)-125 criteria
|
Assessed at 16 weeks after commencing treatment.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Frequency of ABCB1 fusions and BRCA1/2 reversions
Time Frame: At Baseline
|
in patients with germline or somatic BRCA1/2 high grade serous cancer or carcinosarcoma
|
At Baseline
|
Median progression free survival
Time Frame: Through study completion, on average 6 months.
|
in BRCA1/2 high grade serous cancer or carcinosarcoma patients with ABCB1 fusions in the absence of BRCA1/2 reversions treated with pamiparib.
|
Through study completion, on average 6 months.
|
Median overall survival
Time Frame: Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
in BRCA1/2 high grade serous cancer or carcinosarcoma patients with ABCB1 fusions in the absence of BRCA1/2 reversions treated with pamiparib.
|
Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Duration of response
Time Frame: Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Duration of response according to RECIST v1.1 in the subset of patients who achieved partial response or complete response.
|
Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Best overall response according to RECIST v1.1
Time Frame: Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Best overall response is the best response from commencement of treatment according to RECIST v1.1
|
Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Best overall response according to CA-125
Time Frame: Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
defined as best response from commencement of treatment determined by GCIG CA-125 criteria
|
Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Patient reported symptom burden
Time Frame: At the time of consent to screening, at every cycle to 16 weeks, then every 4 cycles, and again at the time of progression. Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Using the Measure of Ovarian Cancer Symptoms and Treatment Concerns (MOST) v2 patient reported outcome measure (PROM)
|
At the time of consent to screening, at every cycle to 16 weeks, then every 4 cycles, and again at the time of progression. Assessed for up to 3 years after the last patient enrolled has commenced treatment.
|
Patient reported results of the 40 item State-trait anxiety inventory for adults (STAI-ADTM)
Time Frame: This will be assessed 3 times - at the time of pre-screening consent, immediately prior to clinician consult with notification of pre-screening results, and immediately following notification of pre-screening results.
|
|
This will be assessed 3 times - at the time of pre-screening consent, immediately prior to clinician consult with notification of pre-screening results, and immediately following notification of pre-screening results.
|
The type, grade and relationship to treatment of adverse events
Time Frame: During the treatment period, on average 3 years
|
The type, grade and relationship to treatment of adverse events, assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v5.0
|
During the treatment period, on average 3 years
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Alison Freimund, Peter MacCallum Cancer Centre, Australia
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Neoplasms, Connective and Soft Tissue
- Neoplasms by Histologic Type
- Neoplasms
- Urogenital Neoplasms
- Neoplasms by Site
- Carcinoma
- Neoplasms, Glandular and Epithelial
- Genital Neoplasms, Female
- Endocrine System Diseases
- Ovarian Diseases
- Adnexal Diseases
- Gonadal Disorders
- Endocrine Gland Neoplasms
- Neoplasms, Complex and Mixed
- Sarcoma
- Ovarian Neoplasms
- Carcinosarcoma
- Mixed Tumor, Mullerian
- Carcinoma, Ovarian Epithelial
Other Study ID Numbers
- ANZGOG 1721/2018
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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