Search clinical trials for: novel P2Y12 inhibitors

Total 67102 results

University of Roma La Sapienza

Unknown

Potential Impact of Cigarette Smoking on Platelet Reactivity in Patients on Dual Antiplatelet Therapy With P2Y12 Inhibitors (COPTER)

Coronary Artery Disease

Italy
Portola Pharmaceuticals

Completed

A Phase 2 Safety and Efficacy Study of PRT060128, a Novel Intravenous and Oral P2Y12 Inhibitor, in Non-Urgent PCI (INNOVATE-PCI)

Percutaneous Coronary Intervention

United States, Austria, Canada, Germany, Poland
IGLESIAS Juan Fernando
Clinical Trials Unit University of Bern

Not yet recruiting

STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT (STARS DAPT)

ST Elevation Myocardial Infarction

Switzerland
Pusan National University Yangsan Hospital
AstraZeneca

Unknown

Comparison of Antiplatelet Effect of Ticagrelor vs Tirofiban in Patients With Non-ST Elevation Acute Coronary Syndrome (TE-CLOT)

Non-ST Segment Elevation Acute Coronary Syndrome

Korea, Republic of
AstraZeneca

Withdrawn

A Clinical Study of Safety and P2Y12 Receptor Inhibition Effects of Ticagrelor and Clopidogrel in Vietnamese Patient

Coronary Heart Disease
Hull University Teaching Hospitals NHS Trust

Completed

Is Efficacy of PLAtelet Aggregation Inhibition by Ticagrelor Mediated P2Y12 Blockade Dependent Upon Endogenous Endothelial Nitric OXide? (PLATE NOX)

Acute Coronary Syndome

United Kingdom
Samsung Medical Center
Seoul St. Mary's Hospital; Chonnam National University Hospital; Gachon University... and other collaborators

Recruiting

Aspirin and a PoTent P2Y12 Inhibitor Versus Aspirin and Clopidogrel in Patients Undergoing PCI for Complex Lesion (ATTEMPT)

Coronary Artery Disease

Korea, Republic of
IGLESIAS Juan Fernando
University of Bern

Not yet recruiting

P2Y12 Inhibitor-based Single Antiplatelet Therapy After a Short DAPT vs. Conventional DAPT Following PCI With a Polymer-free Drug-coated Stent for Unprotected Left Main Coronary Artery Disease (ULTRA-LM) (ULTRA-LM)

Left Main Coronary Artery Stenosis

Switzerland
Shiraz University of Medical Sciences

Completed

Ticagrelor vs. Clopidogrel in Post PCI Patients

Stable Chronic Angina

Iran, Islamic Republic of
Ottawa Heart Institute Research Corporation
Canadian Institutes of Health Research (CIHR)

Completed

A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk (RAPID MANAGE)

Acute Coronary Syndrome | Percutaneous Coronary Intervention

Canada
Assistance Publique - Hôpitaux de Paris
AstraZeneca; Action Research Group

Completed

Assessment of Loading With the P2Y12 Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting (ALPHEUS)

Myocardial Infarction | Myocardial Ischemia | Cardiovascular Diseases | Coronary Artery Disease | Stent Thrombosis

France
Erasmus Medical Center
Covance

Completed

Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans (HI-TECH) (HI-TECH)

Cardiovascular Diseases

Spain, Netherlands, Italy, Switzerland
Gyeongsang National University Hospital

Unknown

Comparison of Platelet Inhibition With Adjunctive Cilostazol Versus High Maintenance-Dose Clopidogrel According to Hepatic Cytochrome 2C19 Allele (CYP2C19) Polymorphism (ACCEL2C19)

Coronary Artery Stenosis | Maximal Platelet Aggregation | Late Platelet Aggregation | High Post-Treatment Platelet Reactivity

Korea, Republic of
Marco Valgimigli

Completed

Synergy Between Stent and Drugs to Avoid Ischemic Recurrences After Percutaneous Coronary Intervention (PRODIGY)

Coronary Artery Disease

Italy
University Hospital, Geneva

Completed

Antithrombotics' Therapeutic Optimization in Hospitalized Patients Using Physiologically- and Population-based Pharmacokinetic Modeling (OptimAT)

Cardiovascular Diseases

Switzerland
University of Oklahoma

Completed

Influence of the Proton Pump Inhibitor Omeprazole on the Anti-Platelet of P2Y12 Antagonists in Subjects With Coronary and Peripheral Artery Disease

Coronary Artery Disease | Peripheral Artery Disease

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy (OPTICA)

Non ST Segment Elevation Acute Coronary Syndrome

Netherlands
The First Affiliated Hospital with Nanjing Medical...
National Natural Science Foundation of China

Unknown

Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients (DPABIAP)

Coronary Artery Disease

China
University of Zagreb
Clinical Hospital Centre Zagreb; Croatian Science Foundation

Completed

Efficacy and Safety of Individualized P2Y12 Receptor Antagonists Treatment Based on Agregometry Versus Fixed Dose Regimen in Patients After Acute Myocardial Infarction (SPARELIFE)

Acute Coronary Syndrome | STEMI | NSTEMI - Non-ST Segment Elevation MI | PLATELET AGGREGATION | INDIVIDUALIZED THERAPY

Croatia
Beijing Anzhen Hospital

Unknown

Twelve vs 24 Months of Dual Antiplatelet Therapy in Patients With Coronary Revascularization for In-stent Restenosis

Percutaneous Coronary Intervention

China
Faculty Hospital Kralovske Vinohrady

Completed

The Laboratory AntiPlatelet Efficacy and Clinical Outcome Registry (LAPCOR)

Platelet Aggregation Onhibitors

Czechia
A.H. Tavenier
Isala

Completed

The Effect of Opioids on P2Y12 Receptor Inhibition in Patients With ST-Elevation Myocardial Infarction Who Are Pre-treated With Crushed Ticagrelor (ON-TIME 3)

STEMI | STEMI - ST Elevation Myocardial Infarction

Netherlands
Diagram B.V.

Completed

Short-term Dual Anti Platelet Therapy in Patients With ACS Treated With the COMBO Dual-therapy Stent (REDUCE)

Acute Coronary Syndrome
AstraZeneca
Parexel

Completed

A Study to Compare if the Uptake of Ticagrelor in the Body Differs When Different Tablets Are Administered

Sickle Cell Disease

Germany
Samsung Medical Center

Unknown

Safety of 6-month Duration of Dual Antiplatelet Therapy After Acute Coronary Syndromes (SMART-DATE) (SMART-DATE)

Acute Coronary Syndrome

Korea, Republic of
University of Roma La Sapienza

Unknown

Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa) (gRANADa)

Coronary Artery Disease

Italy
University of Roma La Sapienza

Unknown

"Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER- (dOPPLER)

Coronary Artery Disease

Italy
Humanitas Hospital, Italy

Unknown

Bioresorbable Polymer-Coated EES in Patients at High Bleeding Risk Undergoing PCI Followed by 1-Month DAPT (POEM)

Coronary Artery Disease | Acute Coronary Syndrome

Italy
St. Antonius Hospital

Recruiting

Pharmacodynamic Outcomes in CCS Patients Treated With an Individualized Treatment Strategy

Coronary Artery Disease | Platelet Reactivity

Netherlands
Seoul National University Hospital
B. Braun Korea Co., Ltd.

Completed

Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy (HOST-IDEA) Trial (HOST-IDEA)

Stable Angina | Unstable Angina | Non-ST Segment Elevation Myocardial Infarction

Korea, Republic of
Chang Gung Memorial Hospital

Unknown

Post-operative Treatment of Diabetic Peripheral Arterial Disease Guided by Platelet Reactivity Unit

Peripheral Artery Disease
Aggredyne, Inc.

Completed

Study of AggreGuide A-100 (ADP) Assay

Risk Factor, Cardiovascular | Platelet Dysfunction Due to Drugs
MicroPort CRM
European Cardiovascular Research Center

Active, not recruiting

Evaluation of a Modified Anti-Platelet Therapy Associated With Low-dose DES Firehawk in Acute Myocardial Infarction Patients Treated With Complete Revascularization Strategy (TARGET-FIRST)

Coronary Artery Disease | Myocardial Infarction, Acute

Netherlands, France, Spain, Italy, Portugal, Austria
ECRI bv
University of Bern; European Cardiovascular Research Center; Terumo Medical Corporation and other collaborators

Completed

Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen (MASTER DAPT)

Coronary Artery Disease | PCI | High Bleeding Risk

Netherlands, France, United Kingdom, Australia, Singapore, Japan, Italy, Poland, Spain, Switzerland, Israel, Argentina, Austria, Bahrain, Bangladesh, Belgium, Bulgaria, Czechia, Denmark, Estonia, Germany, Hungary, India, Korea, Republic... and more
Collegium Medicum w Bydgoszczy

Completed

Which Platelet Function Test Best Reflects the In Vivo Plasma Concentrations of Ticagrelor and Its Active Metabolite? (HARMONIC)

Myocardial Infarction | Infarction | Ischemia | Pathologic Processes | Necrosis | Myocardial Ischemia | Heart Diseases | Cardiovascular Diseases | Vascular Diseases

Poland
The Medicines Company

Completed

A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX) (CHAMPION)

Atherosclerosis | Acute Coronary Syndrome | Percutaneous Coronary Intervention

United States
Abbott Medical Devices

Completed

XIENCE 28 USA Study

Coronary Artery Disease | Renal Insufficiency | Ischemic Stroke | Anemia | Thrombocytopenia | Coagulation Disorder | Hemorrhagic Stroke | Bleeding Disorder | Hematological Diseases

United States, Hong Kong, Canada, China, Spain, Belgium, Germany, Portugal, Switzerland, Taiwan, United Kingdom, Austria, Italy, Netherlands, Singapore
National University of Ireland, Galway, Ireland

Recruiting

The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent (PIONEER-IV)

Coronary Artery Disease

Belgium, Netherlands, Ireland, United Kingdom, Spain
Medical University of Warsaw
University of Pecs; Polish Cardiac Society

Unknown

Bedside Genetic or Pharmacodynamic Testing to Prevent Periprocedural Myonecrosis During PCI (ONSIDE TEST) (ONSIDE TEST)

Stable Angina

Poland, Hungary
R&D Cardiologie
St. Antonius Hospital

Unknown

What is the Optimal antiplatElet and Anticoagulant Therapy in Patients With Oral Anticoagulation Undergoing revasculariSaTion 2. (WOEST 2)

Myocardial Infarction | Stroke | Bleeding | Acute Coronary Syndromes | Coronary Artery Diseases | Atrial Fibrillations | Heart Valve Prostheses

Belgium, Netherlands
Second Affiliated Hospital, School of Medicine,...

Unknown

DUAL Antithrombotic Therapy in Patients With AF and ACS

Atrial Fibrillation | Acute Coronary Syndromes
University Hospital of Ferrara

Completed

ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts (NATHAN-NEVER)

Coronary Artery Disease | Chronic Obstructive Pulmonary Disease

Italy
RSD dr. Soebandi
University of Brawijaya; Universitas Jember

Recruiting

Effect of Colchicine on MMP-9, NOX2, and TGF-β1 in Myocardial Infarct

ST Elevation Myocardial Infarction | Colchicine | Cardiac Remodeling, Ventricular

Indonesia
Clinical Hospital Centre Zagreb
Croatian Science Foundation; University of Zagreb School of Medicine

Recruiting

Pharmacogenomics in Prediction of Cardiovascular Drugs Adverse Reaction

Drug-Related Side Effects and Adverse Reactions | Pharmacogenetics | Cardiovascular Drugs

Croatia
Dong-A University

Unknown

3 Months Versus 12 Months Dual Antiplatelet Therapy After Drug-eluting Stent Implantation in STEMI (BULK-STEMI)

ST Elevation Myocardial Infarction

Korea, Republic of
University of Messina
Natasha Irrera; Gianluca Di Bella; Antonio Micari; Roberto Licordari

Recruiting

Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction (BETA-MI)

Myocardial Infarction | Myocardial Fibrosis | Myocardial Remodeling, Ventricular

Italy
Fu Wai Hospital, Beijing, China

Not yet recruiting

Anti-inflammatory Therapy for Recurrent In-stent Restenosis

In-stent Restenosis

China
Boston Scientific Corporation

Completed

PROMUS Element Plus US Post-Approval Study

Coronary Artery Disease

United States
James J. Peters Veterans Affairs Medical Center

Recruiting

Transdermal Administration by a Novel Wireless Iontophoresis Device

Constipation | Spinal Cord Injuries | Neurogenic Bowel | Fecal Incontinence

United States
The Netherlands Cancer Institute
Hoffmann-La Roche

Not yet recruiting

NOvel Immunotherapy Strategies for Advanced Triple Negative Breast Cancer (TNBC) Patients: TONIC-3 Trial (TONIC-3)

Metastatic Breast Cancer

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