Search clinical trials for: Monotherapy

Total 1623 results

University of British Columbia

Unknown

Androgen Suppression Combined With Elective Nodal and Dose Escalated Radiation Therapy

Prostate Cancer

Canada
GlaxoSmithKline
NSABP Foundation Inc

Completed

Treatment With Pazopanib for Neoadjuvant Breast Cancer

Neoplasms, Breast

United States, Canada
Aegerion Pharmaceuticals, Inc.

Completed

The Safety & Efficacy of Combination BMS-201038 (AEGR-733) & Ezetimibe vs. Monotherapy in Moderate Hypercholesterolemia

Hypercholesterolemia

United States
Heidelberg Pharma AG
U.S. Army Medical Research and Development Command

Completed

Combination of Oral WX-671 Plus Capecitabine vs. Capecitabine Monotherapy in First-line Her2-negative Metastatic Breast Cancer

Metastatic Breast Cancer

United States, Belgium, Brazil, Germany, Israel
Daiichi Sankyo, Inc.

Completed

Welchol as Monotherapy for Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
Mitsubishi Tanabe Pharma Corporation

Completed

Monotherapy Study of MP-513 in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

Japan
Germans Trias i Pujol Hospital

Completed

Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens

HIV Infections

Spain
Gilead Sciences

Terminated

Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension

United States, Israel, Australia, Canada, Mexico, Spain, Belgium, Austria, Germany, United Kingdom
Ardea Biosciences, Inc.

Completed

Naïve HIV POC Monotherapy Trial

HIV Infections

Germany, United Kingdom
Eisai Inc.

Completed

A Study to Evaluate the Safety and Efficacy of Zonisamide an Antiepileptic Drug as Monotherapy or Adjunctive Therapy in Treatment of Adult Patients With Partial, Generalized or Combined Seizures.

Partial, Generalized and Combined Seizures

India
RenJi Hospital

Completed

Comparison of Metformin and Repaglinide Monotherapy in the Treatment of New Onset Type 2 Diabetes Mellitus in China

Diabetes Mellitus, Type 2

China
National Taiwan University Hospital

Unknown

Erlotinib Monotherapy Versus Docetaxel and Cisplatin as Neoadjuvant Therapy in Patients of stageIIIA Lung ca (Oncology)

Non-small Cell Lung Cancer(NSCLC)

Taiwan
Amgen

Completed

Evaluating Panitumumab (ABX-EGF) Monotherapy in Patients With Metastatic Colorectal Cancer Following Treatment With Fluoropyrimidine, Irinotecan, and Oxaliplatin Chemotherapy

Colorectal Cancer | Metastatic Cancer
Shanghai Zhongshan Hospital

Unknown

Antidepressant Monotherapy on Depressive and Anxiety Symptom in Chinese Patients

Anxiety Disorders and Symptoms | Adverse Drug Reaction

China
Herzog Hospital
Israel Science Foundation

Completed

D-serine Monotherapy for Schizophrenia

Schizophrenia

Israel
UCB Pharma

Completed

Monotherapy With Levetiracetam in Newly Diagnosed Patients Suffering From Epilepsy

Generalized Epilepsy
UCB Pharma

Completed

Monotherapy With Levetiracetam or Carbamazepine in Patients Suffering From Epilepsy.

Epilepsy, Tonic-clonic
Bristol-Myers Squibb

Completed

Entecavir Plus Adefovir Combination Therapy Versus Entecavir Monotherapy vs Therapy With Adefovir Plus Lamivudine for Chronic Hepatitis B Infected Subjects With Lamivudine-resistant Virus (DEFINE)

Hepatitis B, Chronic

Australia, Korea, Republic of, Taiwan, Thailand, Hong Kong, United States, Poland, Greece, Canada, Singapore, Philippines, Brazil, India, Indonesia, Italy, Malaysia, Russian Federation, Turkey
Ajou University School of Medicine
Korea University Guro Hospital; MCM Vaccines B.V.; Hallym University Medical... and other collaborators

Completed

Asthma Control in Elderly Patients With Montelukast (ACEM)

Persistent Asthma | Elderly

Korea, Republic of
AbbVie (prior sponsor, Abbott)

Completed

ABT-348 as Monotherapy or Combination With Carboplatin or Docetaxel to Treat Advanced Solid Tumors

Advanced Solid Tumors

United States
Boehringer Ingelheim

Completed

Combination of Telmisartan 40 mg Plus Hydrochlorothiazide (HCTZ) 12.5 mg vs. Telmisartan 40 mg Alone in Patients With Essential Hypertension Who Fail to Respond Adequately to Telmisartan Monotherapy

Hypertension

Japan
Sang Hak Lee

Unknown

Comparison of the Efficacy and Safety of AtorVastatin mOnotherapy vs. Combination Atorvastatin/Fenofibric Acid (AVOCADO)

Mixed Hyperlipidemia

Korea, Republic of
Johnson & Johnson Taiwan Ltd

Completed

First Add-on vs. Mono-therapy Study of Topiramate in Neuro-Surgical Patients (TEAMS)

Epilepsy
Intergroupe Francophone de Cancerologie Thoracique

Completed

Chemotherapy of Elderly Patients With Non-Small-Cell Lung Cancer (NSCLC)

NSCLC

France
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Efficacy and Safety of SP2086 as Monotherapy in Patients With Type 2 Diabetes

Type 2 Diabetes

China
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Study of the Effectiveness and Safety of SP2086 to Treat Type 2 Diabetes

Type 2 Diabetes

China
Massachusetts General Hospital

Withdrawn

Memantine Monotherapy for Executive Dysfunction and ADHD

ADHD | Executive Function Deficits (EFD's)
Targacept Inc.

Completed

Glycemic Control, Safety and Tolerability of TC-6987 Monotherapy in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
Fundacion SEIMC-GESIDA
Abbott

Completed

Prevention of Lipoatrophy in Patients Treated With Lopinavir/Ritonavir in Monotherapy Versus ZDV + 3TC + ABC (KALIPO)

HIV Infections | HIV Infection

Spain
Fred Hutchinson Cancer Center

Completed

TCAD vs. Monotherapy for Influenza A in Immunocompromised Patients

Influenza

United States
Novartis Pharmaceuticals

Withdrawn

A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa

Malignant PEComa (Perivascular Epithelioid Cell Tumors)

Spain
AbbVie (prior sponsor, Abbott)

Completed

Efficacy and Safety of Adalimumab and Methotrexate (MTX) Versus MTX Monotherapy in Subjects With Early Rheumatoid Arthritis (PREMIER)

Early Rheumatoid Arthritis

United States, Australia, Austria, Belgium, Canada, Czech Republic, Denmark, Finland, France, Germany, Ireland, Italy, Netherlands, Norway, Slovakia, Spain, Sweden, Switzerland, United Kingdom
Hospitales Universitarios Virgen del Rocío

Completed

Darunavir Levels, Virological Efficacy, Proviral ADN and Resistances in Patients on Darunavir/Ritonavir Monotherapy (MonDar)

HIV-infection

Spain
Universitair Ziekenhuis Brussel

Completed

Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate

Infertility
Oslo University Hospital

Unknown

Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty

Staphylococcal Infections | Prosthesis-related Infections

Norway
Janssen Korea, Ltd., Korea

Completed

A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy

Epilepsy | Seizures | Osteoporosis | Osteopenia | Convulsions
Hoffmann-La Roche

Terminated

A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on Progression-Free Survival in Patients With Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC) Having Received Tarceva Monotherapy.

Non-Small Cell Lung Cancer

United States, Canada, France, Poland
Yonsei University

Completed

Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Study

Myofascial Pain Syndrome of the Upper Trapezius

Korea, Republic of
University of Cambridge
British Heart Foundation

Unknown

Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension (Pathway 1)

Essential Hypertension | Hypertension, Resistant to Conventional Therapy

United Kingdom
Shi-Ming Lin

Unknown

Combine TACE and RFA Versus RFA Monotherapy in Unilobar HCC of 3.1 to 7 cm Patient

Hepatocellular Carcinoma

Taiwan
Bamrasnaradura Infectious Diseases Institute
Department of Disease Control, Thailand

Completed

Maintenance Boosted Lopinavir Monotherapy Following Salvage Protease-inhibitor (PI) Based Regimen in HIV With Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI) Based Regimen Failure (BIDI-MONO)

HIV | AIDS | Treatment Failure | Lopinavir

Thailand
Johnson & Johnson Pte Ltd

Completed

A Study to Assess Tolerability and Efficacy of Topiramate Monotherapy in Recently Diagnosed Patients With Epilepsy

Epilepsy
Swiss National Fund for Scientific Research
University Hospital, Geneva

Completed

Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia (BICAP)

Community-acquired Pneumonia

Switzerland
Hanmi Pharmaceutical Company Limited

Completed

The Efficacy and Safety Study of Anti-hypertension Combination Drug in Patients Uncontrolled With Monotherapy.

Hypertension
Andrea Harzstark
Novartis

Withdrawn

Everolimus/Sorafenib or Sunitinib in Patients With Metastatic Renal Cell Carcinoma (RCC)

Locally Metastatic Malignant Neoplasm
Ines Perez

Terminated

Analysis of Changes in Adipose Tissue of Patients With Lipoatrophy HIV Infection Treated With Nucleoside Thymidine, After Switching to Monotherapy With Lopinavir / Ritonavir (BIOKAL)

HIV Infections

Spain
Celgene Corporation

Completed

Efficacy and Safety Study of CC-5013 Monotherapy in Subjects With Myelodysplastic Syndromes

Myelodysplastic Syndromes

United States, Denmark, Australia, Belgium, Czech Republic, France, Germany, Greece, Italy, Netherlands, Russian Federation, Spain, Sweden, Switzerland, United Kingdom
Pfizer

Completed

Comparison Of 5 CP-690,550 Doses Vs. Placebo, For The Treatment Of Rheumatoid Arthritis In Japan

Arthritis, Rheumatoid

Japan
Fundacion SEIMC-GESIDA
Abbott

Completed

Lopinavir/r Monotherapy Versus Abacavir/Lamivudine and Lopinavir/r for Limb Fat Recovery in Persons With Lipoatrophy (KRETA)

HIV Infections | HIV Infection | Lipodystrophy

Spain
Fundacion SEIMC-GESIDA
Abbott

Completed

Treatment of HIV/HCV Coinfection With Peg-IFN and Ribavirin in Patients Receiving ART Monotherapy With Lopinavir/r (PEKARI)

HIV Infections | HIV/HCV Co-infection

Spain

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