Clinical Trials Sponsored by Bill and Melinda Gates Foundation

Total 476 results

University of Witwatersrand, South Africa
Bill and Melinda Gates Foundation

Recruiting

A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa (CoTeT)

COVID-19

South Africa
Otsuka Pharmaceutical Development & Commercialization...
Bill and Melinda Gates Foundation

Completed

A Phase 1/2 Trial of Multiple Oral Doses of OPC-167832 for Uncomplicated Pulmonary Tuberculosis

Pulmonary TB

South Africa
Drugs for Neglected Diseases
Bayer; Bill and Melinda Gates Foundation

Completed

Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside

Filariasis

United Kingdom
Boston University
Bill and Melinda Gates Foundation; Thrasher Research Fund

Completed

Omphalitis Community Based Algorithm Validation Study (OCAVS)

Omphalitis

Zambia
PATH
Bill and Melinda Gates Foundation; SK Bioscience Co., Ltd.

Recruiting

A Trial to Assess the Safety, Immunogenicity and Efficacy of a Trivalent Rotavirus P2-VP8 Subunit Vaccine in Prevention of Severe Rotavirus Gastroenteritis in Healthy Infants in Africa and India

Rotavirus Infection of Children

Zambia
University of Oxford
Yale University; Bill and Melinda Gates Foundation

Unknown

Investigating Typhoid Fever Pathogenesis (TYGER)

Salmonella Typhi Infection

United Kingdom
Drugs for Neglected Diseases
Bayer; Bill and Melinda Gates Foundation

Completed

First in Man Clinical Trial of Emodepside (BAY 44-4400)

Healthy Volunteers

United Kingdom
Drugs for Neglected Diseases
Bayer; Bill and Melinda Gates Foundation

Completed

Relative Bioavailability Study of Emodepside IR-tablets and Solution

Filariasis

United Kingdom
University of California, San Diego
Bill and Melinda Gates Foundation

Completed

Bihar Family Health Initiative (Ananya)

Maternal and Child Health
FHI 360
Bill and Melinda Gates Foundation; Marie Stopes International

Completed

A Prospective Observational Study of the Clinical Performance of Zarin in Madagascar

Long-term and Permanent Contraceptive Methods

Madagascar
Aga Khan University
Tufts University; Bill and Melinda Gates Foundation

Completed

Evaluation of Zinc and / or Micronutrient Supplementation on Intestinal Flora, Diarrheal Disease Burden, Intestinal Mucosal Integrity and Growth Among Children of Pakistan

Pneumonia | Diarrhea | Malnutrition | Growth

Pakistan
D'Or Institute for Research and Education
Bill and Melinda Gates Foundation

Active, not recruiting

Assessment of Immunogenicity, Safety and Reactogenicity of a Booster Dose of Various COVID-19 Vaccine Platforms in Individuals Primed With Several Regimes.

COVID-19

Brazil
Bill & Melinda Gates Medical Research Institute

Completed

Early Bactericidal Activity of TBA-7371 in Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
Bill & Melinda Gates Medical Research Institute

Terminated

A Trial to Evaluate Safety and Efficacy of Rivaroxaban (COVID-19)

COVID-19

United States, United Kingdom
Bill & Melinda Gates Medical Research Institute

Not yet recruiting

Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population

Healthy Volunteers

Kenya, Uganda
Bill & Melinda Gates Medical Research Institute

Recruiting

Safety, Tolerability, Pharmacokinetics and Protective Efficacy of MAM01 in Healthy Adults

Malaria

United States
Bill & Melinda Gates Medical Research Institute

Active, not recruiting

Impact of Bi-26 Supplementation on Weight Gain in Underweight Infants

Underweight | Paediatrics

Pakistan
Bill & Melinda Gates Medical Research Institute

Active, not recruiting

Epidemiologic Study to Assess the IGRA Positivity in Populations With a High TB Burden

Tuberculosis, Pulmonary

South Africa, Bangladesh, Brazil, India, Indonesia, Mozambique, Zambia, Congo, The Democratic Republic of the, Gambia, Kenya, Peru, Philippines, Uganda, Vietnam
Bill & Melinda Gates Medical Research Institute

Active, not recruiting

Bacille Calmette Guerin (BCG) Revaccination of Healthy Adolescents for the Prevention of Mycobacterium Tuberculosis Sustained Infection

Tuberculosis

South Africa
University of Pennsylvania
Bill and Melinda Gates Foundation; Desmond Tutu HIV Foundation

Completed

Effect of U=U Messaging on HIV in South Africa (U=U)

HIV/AIDS

South Africa
University of North Carolina, Chapel Hill
Bill and Melinda Gates Foundation; University of Zambia

Recruiting

Antenatal and Postnatal Care Research Collective - Household Survey (ARCH) (ARCH)

Maternal Health | Pregnancy Outcomes

Zambia
Hospital de Clinicas de Porto Alegre
Bill and Melinda Gates Foundation

Active, not recruiting

Assessment of Body Composition in Premature Children Submitted to an Early Stimulation Program

Preterm Birth | Parent-Child Relations | Nutrition, Healthy | Very Low Birth Weight Infant | Early Intervention

Brazil
FHI 360
Bill and Melinda Gates Foundation; Ministry of Health, Zambia

Completed

Safety and Effectiveness of Different ShangRing Device Sizes for Adult Male Circumcision in Lusaka, Zambia

Male Circumcision

Zambia
UnitedHealth Group
Bill and Melinda Gates Foundation; Quest Diagnostics-Nichols Insitute

Completed

Impact of Swab Site and Sample Collector on Testing Sensitivity for COVID-19 Virus in Symptomatic Individuals

Cough | Fever | Infections, Respiratory

United States
University of Virginia
Bill and Melinda Gates Foundation; Haydom Lutheran Hospital

Active, not recruiting

ELICIT 2.0: Pilot Study of the Effect of Maternal Protein Supplementation During Lactation on Childhood Growth

Malnutrition | Growth Failure | Stunting | Protein Malnutrition

Tanzania
Gynuity Health Projects
Bill and Melinda Gates Foundation; University of Liverpool

Completed

Fever After Misoprostol Administration for the Treatment of Primary Postpartum Hemorrhage

Postpartum Hemorrhage

Ecuador
London School of Hygiene and Tropical Medicine
Bill and Melinda Gates Foundation

Withdrawn

A Case-control Study of the Efficacy of a New Serogroup A Meningococcal Conjugate Vaccine (MenAfriVac) in Mali and Niger (VES)

Meningococcal Disease

Mali, Niger
Serum Institute of India Pvt. Ltd.
Bill and Melinda Gates Foundation

Not yet recruiting

Clinical Study to Evaluate SIIPL qHPV Vaccine (CERVAVAC®) in Women Living With HIV Aged 15-25 Years

Human Papillomavirus Infection

Kenya, Mozambique, South Africa
Haydom Lutheran Hospital
Bill and Melinda Gates Foundation; University of Virginia

Completed

Early Life Interventions for Childhood Growth and Development In Tanzania (ELICIT)

Malnutrition | Stunting | Cognitive Development | Enteric Pathogens

Tanzania
Weill Medical College of Cornell University
Bill and Melinda Gates Foundation

Completed

From Obstacles to Opportunities for Male Circumcision in Tanzania

Male Circumcision

Tanzania
Jeffrey Jensen
Bill and Melinda Gates Foundation

Completed

HSG and Tubal Patency Study

Tubal Patency

United States
RAND
University of California, Los Angeles; Bill and Melinda Gates Foundation; Pathfinder...

Completed

Beyond Bias - Reducing Provider Bias Towards Adolescents to Increase Contraception Take-Up in Tanzania, Burkina Faso, and Pakistan

Family Planning Services

United States
Boston University
Bill and Melinda Gates Foundation; University of Witwatersrand, South Africa

Recruiting

Gathering Records to Evaluate Antiretroviral Treatment-South Africa (GREAT)

HIV

South Africa
Jhpiego
Bill and Melinda Gates Foundation; Addis Continental Institute of Public Health

Completed

Family Led Postnatal Care in Ethiopia (FPNC)

Postnatal Complication

Ethiopia
Massachusetts General Hospital
Bill and Melinda Gates Foundation; Kenya Medical Research Institute

Active, not recruiting

The KEN SHE Study on HPV-vaccine Efficacy

Papillomavirus Infections

Kenya
International Vaccine Institute
Bill and Melinda Gates Foundation; SK Bioscience Co., Ltd.

Completed

Immune Equivalence Between Multi-dose and Single Dose Formulation of Vi-DT and Their Overall Safety (Phase III)

Typhoid

Philippines
International Vaccine Institute
Bill and Melinda Gates Foundation; SK Bioscience Co., Ltd.

Completed

Safety, Reactogenicity and Immunogenicity of Vi-DT;Typhoid Conjugate Vaccine

Typhoid

Philippines
Boston University
Bill and Melinda Gates Foundation; University of Witwatersrand, South Africa

Completed

Revised Simplified Algorithm for Treatment Eligibility for HIV (SLATEII) (SLATEII)

HIV/AIDS | Antiretroviral Therapy

South Africa
St George's, University of London
Bill and Melinda Gates Foundation; York Hospitals

Terminated

Reactogenicity and Immunogenicity of Vaginal CNgp140 (SG06RS02)

HIV Infections | Acquired Immune Deficiency Syndrome

United Kingdom
Fidec Corporation
Bill and Melinda Gates Foundation; Centers for Disease Control and Prevention

Completed

Safety and Immunogenicity of 1 or 2 Doses of IPV in Latin American Infants Primed With Bivalent OPV Vaccine

Poliomyelitis

Colombia, Dominican Republic, Guatemala, Panama
International Centre for Diarrhoeal Disease Research...
Bill and Melinda Gates Foundation

Recruiting

Maternal Probiotic Intervention to Improve Gut Health (MPIGH)

Environmental Enteric Dysfunction | Gut Microbiota Dysbiosis

Bangladesh
Johns Hopkins Bloomberg School of Public Health
Bill and Melinda Gates Foundation

Recruiting

Evaluation of Prototype Solutions for Optimizing Maternal Health Behaviors

Maternal Behavior

Ethiopia
Aga Khan University
Yale University; Bill and Melinda Gates Foundation; RTI International

Recruiting

Community-based RSV Surveillance in Infant Mortality: Minimally Invasive Tissue Sampling Study in Karachi, Pakistan (RSV-MITS)

Infant Death | Respiratory Syncytial Virus (RSV) | Community-Acquired Infections

Pakistan
Jhpiego
Bill and Melinda Gates Foundation; Addis Continental Institute of Public Health

Terminated

Ethiopia Group Antenatal Care Study at the Health Post Level (ARC004)

Antenatal Care

Ethiopia
Boston University
Bill and Melinda Gates Foundation; University of Witwatersrand, South Africa

Withdrawn

Evaluation of Six-month HIV Treatment Dispensing in South Africa

HIV

South Africa
Murdoch Childrens Research Institute
Bill and Melinda Gates Foundation; Royal Children's Hospital

Completed

BCG Vaccination to Protect Healthcare Workers Against COVID-19 (BRACE)

COVID-19 | Corona Virus Infection | Coronavirus Disease 2019 (COVID-19) | Respiratory Illness

Australia, Brazil, Netherlands, Spain, United Kingdom
International Centre for Diarrhoeal Disease Research...
Bill and Melinda Gates Foundation

Active, not recruiting

Saving Lives With Better Gestational Age Estimation

Premature Birth

Bangladesh
University of Pittsburgh
Bill and Melinda Gates Foundation; MIMR-PHI Institute, Australia

Completed

Expression of IFN-epsilon in the Female Reproductive Tract (Epsilon)

Interferon Expression in the Female Reproductive Tract

United States
Karnataka Health Promotion Trust
University of Manitoba; Bill and Melinda Gates Foundation

Completed

Evaluation of an MNCH Mentoring Intervention in Karnataka

Maternal-child Health Services

India
Columbia University
Bill and Melinda Gates Foundation; University of Cape Town; EngenderHealth

Terminated

Screen and Treat for Cervical Cancer Prevention (SAT)

Cervical Cancer

South Africa

Clinical Trials Sponsored by Bill and Melinda Gates Foundation

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Jordan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations