Search clinical trials for: Africa

Total 5225 results

National Institute of Allergy and Infectious Diseases...
Johns Hopkins University

Recruiting

Investigation of Immune Amnesia Following Measles Infection in Select African Regions

Measles Infection

Guinea, Mali
ModernaTX, Inc.

Recruiting

A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated Mothers

Respiratory Syncytial Virus

Canada, United Kingdom, Japan, United States, Chile, Denmark, Panama, South Africa
Peking University Cancer Hospital & Institute

Recruiting

Niraparib Maintenance in HRD-Positive Advanced Ovarian Cancer Following Front-Line Chemotherapy + Bevacizumab (BRAND)

Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma

China
Merck Sharp & Dohme LLC

Recruiting

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States, Israel, Taiwan, United Kingdom, Chile, Canada, Japan, Brazil, China, Colombia, Norway, South Africa
ViiV Healthcare
GlaxoSmithKline; PPD

Not yet recruiting

Long-term Follow-up of Long-acting Cabotegravir (CAB LA) for PrEP (Pre-exposure Prophylaxis) in Participants at Risk of Acquiring HIV (Human Immunodeficiency Virus) (PALISADE)

HIV Infections

Brazil, Argentina, Peru, Botswana, Kenya, Malawi, South Africa, Thailand, Uganda, Vietnam, Zimbabwe
Massachusetts General Hospital
Bill and Melinda Gates Foundation; Centre for the AIDS Programme of Research... and other collaborators

Recruiting

Vaginal lIve Biotherapeutic RANdomized Trial (VIBRANT)

Bacterial Vaginosis

United States, South Africa
University of Cape Town
University of Cape Town Lung Institute; Leiden University Medical Center; European... and other collaborators

Recruiting

Same Day Diagnosis of Extrapulmonary TB (TB Serositis and TB Meningitis). (Epi-TB)

Tuberculosis, Extrapulmonary

South Africa, Zambia, Zimbabwe
MRC/UVRI and LSHTM Uganda Research Unit
London School of Hygiene and Tropical Medicine; Assistance Publique - Hôpitaux... and other collaborators

Not yet recruiting

Implementing Oral (Event-driven and Daily) and Long-acting Pre-Exposure Prophylaxis in Mobile Men in Sub-Saharan Africa (MOBILEMEN)

HIV
Neopenda, PBC
Amref Health Africa

Not yet recruiting

A Pilot Study for Adaptation of Neospot Device for Health Care at Primary Health Facilities in Kenya

Morbidity

Kenya
Tulane University
National Institute on Minority Health and Health Disparities (NIMHD); National...

Recruiting

Blood Pressure Lowering Strategies to Eliminate Hypertension Disparities (BLESSED) (BLESSED)

Hypertension

United States
University of Chicago

Recruiting

Sleep Extension or Regularity to Reduce Diabetes Risk in African American and Black Adults

Overweight or Obesity

United States
University College, London
London School of Hygiene and Tropical Medicine; Radboud University Medical... and other collaborators

Recruiting

Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB (PARADIGM4TB)

Pulmonary Tuberculosis

South Africa
Washington D.C. Veterans Affairs Medical Center
Boehringer Ingelheim

Recruiting

Effect of Empagliflozin on Podocyte Specific Proteins in African American Veterans With NDKD (NDKD)

Chronic Kidney Diseases

United States
AstraZeneca
Daiichi Sankyo

Recruiting

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

Breast Cancer

United States, Spain, China, Italy, Australia, United Kingdom, Korea, Republic of, Vietnam, Japan, Turkey, Brazil, Taiwan, Thailand, Canada, Argentina, India, France, Singapore, Mexico, Germany, Philippines, Poland, South Africa
Pfizer

Recruiting

A Study to Learn About the Amount of the Study Medicine (Sisunatovir) in Blood and Its Safety in Infants and Children With Pneumonia Caused by RSV

Respiratory Syncytial Virus Infections

United States, Israel, Japan, Korea, Republic of, South Africa, Argentina, Canada
University of California, San Diego
LEGO Foundation; Impact and Innovations Development Centre (IIDC), Uganda; NaNa...

Recruiting

Responsible Engaged and Loving (REAL) Fathers Intervention Evaluation

Child Abuse | Parent-Child Relations | Child Development | Contraception Behavior | Violence, Domestic | Violence, Sexual | Violence, Physical | Violence, Gender-Based | Conflict Resolution | Communication, Partner

Uganda
Merck Sharp & Dohme LLC

Recruiting

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)

Melanoma | Renal Cell Carcinoma | Non-Small Cell Lung Cancer

Poland, United States, Argentina, Chile, Japan, Australia, France, New Zealand, South Africa, Turkey
BioCryst Pharmaceuticals

Recruiting

Dose Escalation of BCX10013 in Subjects With Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria

South Africa, Malaysia
Assiut University
AsyutUniversity

Not yet recruiting

Prevalence of Irritable Bowel Syndrome in Medical Students Africa (Irritablebowel)

Faculty of Medicine
AstraZeneca

Recruiting

MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma (eVOLVE-Meso)

Unresectable Pleural Mesothelioma

Denmark, Italy, Australia, Korea, Republic of, Belgium, Poland, United States, Canada, Japan, United Kingdom, Spain, China, France, Taiwan, Norway, Brazil, Germany, Switzerland, South Africa, Turkey, Netherlands
World Health Organization
London School of Hygiene and Tropical Medicine; University of Ghana; Biomedical... and other collaborators

Recruiting

An Adolescent Health and Wellbeing Check-up Programme in Three African Cities (Y-Check) (Y-Check)

Health-Related Behavior | Adolescent Behavior | Adolescent Development | Health Care Seeking Behavior

Ghana, Tanzania, Zimbabwe
AstraZeneca

Recruiting

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

Chronic Kidney Disease With High Proteinuria

Italy, United States, Poland, Germany, Argentina, Denmark, Japan, Norway, Spain, Sweden, Bulgaria, France, China, Malaysia, Taiwan, Thailand, Vietnam, Brazil, Mexico, Philippines, Israel, United Kingdom, South Africa, Austria, Korea, Republic... and more
Eastern Virginia Medical School
University of Pittsburgh; United States Agency for International Development... and other collaborators

Recruiting

Safety and PK Multi-dose Study of TAF/EVG Vaginal Insert

Safety Issues

United States, Kenya, South Africa
Seqirus

Recruiting

A Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an Adjuvanted Influenza Vaccine Compared to a Non-adjuvanted Influenza Vaccine in Adults ≥65 Years of Age

Influenza, Human

Belgium, Bulgaria, Czechia, Finland, Georgia, Italy, Korea, Republic of, Lithuania, Netherlands, Philippines, Poland, Romania, South Africa, Spain, Taiwan, Turkey
Shionogi

Recruiting

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants

Gram-Negative Bacterial Infections

United States, South Africa, Taiwan
University of South Carolina
Centers for Disease Control and Prevention

Recruiting

Mindful Walking Program for Older African Americans

Cognitive Function | Behavior, Health | Aging Well

United States
Karex Industries Sdn. Bhd.
Essential Access Health; Match Research; Sigma3 Services SARL

Recruiting

Evaluation of Synthetic Nitrile Male Condom Compared to Standard Latex Male Condom

Sexually Transmitted Diseases

United States, South Africa
George Washington University
Columbia University; Harvard School of Public Health (HSPH); Ifakara Health Institute and other collaborators

Not yet recruiting

Multiple Micronutrient Supplementation for Maternal Anemia Prevention in Tanzania (MMS-MAP)

Pregnancy Related
University of Chicago

Recruiting

A Mobile Health (mHealth) Strategy for Improving Blood Pressure Control Among Adult Hypertensive African Americans

Hypertension | Blood Pressure

United States
Pfizer

Recruiting

A Study to Learn About the Study Medicine Sisunatovir in Adults With Respiratory Syncytial Virus (RSV) Infection

Respiratory Syncytial Virus Infection

United States, South Africa, China, Taiwan, Japan, Canada, India, Australia, Argentina
Sanofi

Recruiting

A Study to Evaluate SAR441566 Efficacy and Safety in Adults With Rheumatoid Arthritis (SPECIFI-RA)

Rheumatoid Arthritis

Chile, Mauritius, United States, Canada, China, Argentina, Georgia, Japan, South Africa, Spain, Czechia, Poland, Germany, Brazil, Slovakia, Mexico
George Washington University
Columbia University; Harvard School of Public Health (HSPH); Ifakara Health Institute and other collaborators

Not yet recruiting

Multiple Micronutrient Supplementation (MMS) Iron Dose Acceptability Crossover Trial

Pregnancy Related
George Washington University
Columbia University; Harvard School of Public Health (HSPH); Ifakara Health Institute and other collaborators

Not yet recruiting

Multiple Micronutrient Supplementation (MMS) IFA- Iron Dose Acceptability Crossover Trial

Pregnancy Related
Novo Nordisk A/S

Recruiting

A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor (REIMAGINE 2)

Type 2 Diabetes Mellitus

Korea, Republic of, United States, Hungary, Serbia, Spain, China, Australia, Finland, United Kingdom, Italy, Denmark, Canada, Taiwan, Poland, Germany, Sweden, South Africa, Argentina, Brazil, Bulgaria, Japan, Mexico, Turkey, Greece, Col... and more
Bill & Melinda Gates Medical Research Institute
Bill and Melinda Gates Foundation; Wellcome Trust

Recruiting

Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults

Tuberculosis

Indonesia, Kenya, South Africa, Vietnam, Malawi, Mozambique, Zambia
Spero Therapeutics
GlaxoSmithKline

Recruiting

A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (PIVOT-PO)

Urinary Tract Infection | Acute Pyelonephritis

Moldova, Republic of, Georgia, United States, Serbia, Bulgaria, Romania, South Africa, Bosnia and Herzegovina, Croatia, Hungary, Poland, Slovakia, Estonia
Global Alliance for TB Drug Development

Recruiting

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis

Drug Sensitive Tuberculosis | Pulmonary Tuberculosis | Pulmonary TB

Philippines, South Africa, Tanzania, Georgia, Uganda
ISA Associates, Inc.

Recruiting

A Smartphone-Based Intervention to Improve Colorectal Cancer Screening in African American Men

Colorectal Cancer

United States
Statens Serum Institut
Bill and Melinda Gates Foundation; Aurum Institute; Leiden University Medical... and other collaborators

Recruiting

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107e/CAF®10b (nTB-01)

Healthy

South Africa
Rohan, Lisa, PhD
United States Agency for International Development (USAID)

Recruiting

MATRIX-002: Trial to Assess Acceptability and Safety of Two Placebo Vaginal Films

Safety | Usability | Acceptability

Kenya, Zimbabwe, South Africa, United States
Thirty Respiratory Limited

Recruiting

Evaluating the Early Bactericidal Activity, Safety and Tolerability of Nebulised RESP301 in Adults With Tuberculosis

Rifampicin Susceptible Pulmonary Tuberculosis

South Africa
North-West University, South Africa
King's College London; Swiss Federal Institute of Technology

Recruiting

Effects of Exercise and Galactooligosaccharide Supplementation on Inflammation and Iron Absorption (FexerGOS) (FexerGOS)

Resistance Exercise

South Africa
University of Michigan

Not yet recruiting

Program AACTIVE: African American's Coming Together to Increase Vital Exercise

Depression | Type 2 Diabetes
Emory University
National Institute of Mental Health (NIMH); University of KwaZulu

Recruiting

Support for Adolescents Living With HIV in South Africa (InTSHA VIP)

HIV | Human Immunodeficiency Virus

South Africa
AbbVie

Recruiting

A Study to Assess Change in Disease Activity, Adverse Events, and How the Drug Moves Through the Body in Adult Participants Living With Human Immunodeficiency Virus (HIV) Receiving Intravenous (IV) Infusion of Budigalimab and/or ABBV-382

Human Immuno-deficiency Virus (HIV) Disease

United States, Puerto Rico, Japan, Spain, Germany, Canada, Belgium, France, Poland, South Africa, Italy
AstraZeneca

Recruiting

A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension (BaxHTN)

Resistant Hypertension | Uncontrolled Hypertension

Canada, United States, South Africa, Korea, Republic of, Australia, Poland, Belgium, Japan, Spain, Vietnam, Argentina, Bulgaria, Turkey, Malaysia, Taiwan, Thailand, Italy, Germany, France, Israel, India, Netherlands, Sweden, United Kingdom and more
Sanofi

Recruiting

Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study (RIVER-ASTHMA)

Asthma

Korea, Republic of, Argentina, Chile, South Africa, United States, Hungary, Japan, Poland, Turkey, United Kingdom, Canada
University of California, San Francisco
National Institute on Alcohol Abuse and Alcoholism (NIAAA); University of California... and other collaborators

Recruiting

The Outreach and Prevention at ALcohol Venues in East Africa Study (OPAL-East Africa- Aim 2) (OPAL-Aim 2) (OPAL-Aim 2)

HIV/AIDS

Kenya, Uganda
Wits RHI Research Centre Clinical Research Site
University of Alabama at Birmingham; University of California, San Francisco

Recruiting

PrEP Restart for Adolescent Girls and Young Women Using STI Self Testing and Assessment of Risk (PALESA)

HIV Prevention

South Africa
Advancing Clinical Therapeutics Globally for HIV...
National Institute of Allergy and Infectious Diseases (NIAID)

Recruiting

Pausing Antiretroviral Treatment Under Structured Evaluation (PAUSE)

HIV-1-infection

Malawi, Botswana, South Africa

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