Search clinical trials for: Disease Modifying Antirheumatic Drugs (DMARDs)

Total 436472 results

AbbVie

Completed

A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs (SELECT-BEYOND)

Rheumatoid Arthritis

United States, Australia, Austria, Belgium, Canada, Czechia, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Korea, Republic of, Latvia, New Zealand, Poland, Portugal, Puerto Rico, Russian Federation, Slovakia, ... and more
Sohag University

Not yet recruiting

Outcomes of Biological Therapy on Rheumatoid Arthritis

Rheumatoid Arthritis

Egypt
Bristol-Myers Squibb

Completed

An Exploratory Study of Changes in Synovial Immune Responses Following BMS-188667 Therapy in Subjects With Active Rheumatoid Arthritis on Background DMARDs Who Have Failed Anti-TNF Therapy

Rheumatoid Arthritis

United Kingdom
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDs

Rheumatoid Arthritis

Indonesia
Wyeth is now a wholly owned subsidiary of Pfizer

Withdrawn

A Multicenter Study to Compare the Efficacy and Safety of the Combination of Etanercept and Methotrexate in Treatment of Rheumatoid Arthritis (DOTAR)

Rheumatoid Arthritis
Hoffmann-La Roche

Completed

A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid Arthritis (OSCAR)

Rheumatoid Arthritis

Netherlands
Sanofi
Regeneron Pharmaceuticals

Completed

A Study Assessing the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis (SARIL-RA-HARUKA)

Rheumatoid Arthritis

Japan
Sabine Dieperink
University of Copenhagen; University of Aarhus; Statens Serum Institut

Completed

Bloodstream Infections in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis | Staphylococcus Aureus Bacteremia
Hoffmann-La Roche

Completed

A Study of Tocilizumab in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic DMARDs

Rheumatoid Arthritis

Finland
Hoffmann-La Roche

Completed

An Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs

Rheumatoid Arthritis

Slovakia
Merck Sharp & Dohme LLC
AESCA Pharma GmbH

Terminated

Induction of Remission in RA Patients at Low Disease Activity by Additional Infliximab Therapy (Study P04644AM1) (TERMINATED)

Rheumatoid Arthritis
Hoffmann-La Roche

Completed

ARMONIA: An Observational Study of Biologic Drugs in Monotherapy or Combination With DMARDs in Italian Clinical Practice and the Efficacy and Safety of RoActemra/Actemra (Tocilizumab) Monotherapy in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Italy
GlaxoSmithKline
Iqvia Pty Ltd

Completed

Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and/or Janus Kinase (JAK) Inhibitors (contRAst 3)

Arthritis, Rheumatoid

United States, Germany, Canada, Czechia, Poland, South Africa, Korea, Republic of, Spain, Japan, Argentina, Belgium, Hungary, United Kingdom, Italy, Lithuania
Hoffmann-La Roche

Completed

Study to Evaluate the Safety, Tolerability and Efficacy of Tocilizumab in Participants With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Non-Biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) and/or Anti-tumor Necrosis Factor (Anti-TNF) Therapy

Rheumatoid Arthritis

India
Noha Mansour

Completed

Montelukast Use in Rheumatoid Arthritis

Rheumatoid Arthritis

Egypt
Hoffmann-La Roche

Completed

A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent (ACT-MOVE)

Rheumatoid Arthritis

United Kingdom
Hoffmann-La Roche

Completed

A Study of Tocilizumab as Monotherapy or in Combination With DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis

Rheumatoid Arthritis

United Arab Emirates, Kuwait, Bahrain, Iran, Islamic Republic of, Qatar
Daiichi Sankyo, Inc.

Completed

A Study of DU-176b in Preventing Blood Clots After Hip Replacement Surgery

Thrombosis | Hip Replacement

Ukraine, United States, Canada, Russian Federation, Hungary, Latvia, Denmark
Osservatorio Epidemiologico GISEA

Unknown

Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent.

Rheumatoid Arthritis (RA)

Italy
Hoffmann-La Roche

Withdrawn

A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs

Rheumatoid Arthritis
Hôpital Cochin

Unknown

Effect of Pharmaceutical Consultations Just Before Rheumatology Consultations on Improving Knowledge and Skills for Patients With Inflammatory Arthritis With Subcutaneous Biologic DMARDs

Arthritis, Rheumatoid | Spondyloarthritis | Biological Therapy

France
Shanghai Henlius Biotech

Completed

A Randomised, Double-blind, Phase I/II Study to Evaluate the PK, PD, Safety, and Efficacy Between HLX01 and Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis and Inadequate Response to Treatment With DMARDs

Rheumatoid Arthritis
AO GENERIUM

Completed

Comparison of Complarate® (Tocilizumab Biosimilar) and Actemra® in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Russian Federation
Hoffmann-La Roche

Completed

An Observational Study to Describe in Routine Clinical Practice the Treatment Patterns of Usage of Biological DMARDs in RA Patients.

Rheumatoid Arthritis

China
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs (REMISSION)

Rheumatoid Arthritis

Morocco
University of Tennessee
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Completed

Oral Collagen for Rheumatoid Arthritis

Rheumatoid Arthritis

United States
Hoffmann-La Roche

Completed

A Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs or Anti-TNF

Rheumatoid Arthritis

Saudi Arabia
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy

Heart Failure | Mitral Regurgitation

China
Garlapati Komali

Unknown

Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus

Oral Lichen Planus

India
Hoffmann-La Roche
Clalit Health Services

Completed

A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic and/or Biologic DMARDS

Rheumatoid Arthritis

Israel
Flinders University
medac GmbH; University of South Australia

Recruiting

Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis

Rheumatoid Arthritis | Endothelial Dysfunction | Cardiovascular Risk Factor | Stiffness, Aortic

Australia
Hoffmann-La Roche

Completed

An Exploratory Study of Tocilizumab in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Current Non-Biologic DMARDs and/or Anti-TNF Therapy.

Rheumatoid Arthritis

Belgium, Czech Republic, France, Italy, Spain, Sweden, United Kingdom, Canada, Greece, Ireland, Portugal, Turkey, Netherlands, Denmark, Finland, Germany, Luxembourg, Austria, Switzerland, Poland, Australia, Hungary, Saudi Arabia, Romania and more
Hoffmann-La Roche

Completed

An Extension to Study MA21573, Evaluating Tocilizumab in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biological DMARDs and/or Anti-tumor Necrosis Factor (TNF) Therapy

Rheumatoid Arthritis

Czech Republic, France, Italy, Spain, United Kingdom, Canada, Portugal, Netherlands, Poland, Australia, Saudi Arabia, Romania, Hungary, Greece
Hoffmann-La Roche

Completed

A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs.

Rheumatoid Arthritis

United Kingdom
Helsinki University Central Hospital
Foundation for Paediatric Research, Finland; Päivikki and Sakari Sohlberg Foundation... and other collaborators

Completed

Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (ACUTE-JIA)

Juvenile Idiopathic Arthritis

Finland
Children's Hospital of Fudan University

Recruiting

Preventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy

Cholangitis | Anti-Bacterial Agents | Biliary Atresia

China
Novartis Pharmaceuticals

Not yet recruiting

Modifying PEST for Psoriatic Arthritis Screening (ScreenX)

Plaque Psoriasis | Psoriatic Arthritis
ImmuneMed, Inc.

Not yet recruiting

A Study to Assess the Efficacy and Safety of Burfiralimab (hzVSF-v13) and DMRD (Disease-modifying Antirheumatic Drug)

Moderate to Severe Rheumatoid Arthritis

Netherlands
University of Aarhus
Aarhus University Hospital; Regionshospitalet Viborg, Skive; Gødstrup Hospital; Sorbonne University

Recruiting

Comparative Study of High-Efficacy Disease Modifying Treatment of Relapsing Multiple Sclerosis (CoSHEDRMS)

Relapsing Remitting Multiple Sclerosis

Denmark
VA Office of Research and Development

Recruiting

Dynamic Treatment Regiments for Glucocorticoid Tapering (SMART-RA)

Rheumatoid Arthritis

United States
University of Sao Paulo General Hospital
GlaxoSmithKline

Recruiting

Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases (RZVRheum)

Rheumatoid Arthritis | Systemic Lupus Erythematosus | Systemic Sclerosis | Juvenile Idiopathic Arthritis | Sjogren's Syndrome | Spondylitis, Ankylosing | Spondyloarthritis | Behçet Disease | Idiopathic Inflammatory Myopathies | Vasculitis, Systemic | Dermatomyositis, Juvenile

Brazil
Biogen

Not yet recruiting

A Study to Evaluate Long-Term Safety of Vumerity and Tecfidera in Participants With Multiple Sclerosis (MS)

Multiple Sclerosis
Medical University of Vienna
Medical University of Graz; Medical University Innsbruck; Hospital Hietzing; Krankenhaus...

Not yet recruiting

Screening for Flare After b/tsDMARD Discontinuation in Rheumatoid Arthritis

Rheumatoid Arthritis
University Hospital Ostrava
University of Ostrava

Not yet recruiting

Therapeutic Monitoring of Drugs Used in the Treatment of Multiple Sclerosis

Multiple Sclerosis

Czechia
Universidade Nova de Lisboa
Centro Hospitalar de Vila Nova de Gaia/Espinho; Centro Hospitalar Lisboa Ocidental... and other collaborators

Recruiting

The Role of Microbiome on Biological Therapy Efficacy in axSpA and RA (MicroSpA & RA)

Arthritis, Rheumatoid | Axial Spondyloarthritis

Portugal
Amsterdam UMC, location VUmc

Recruiting

Discontinuing Disease-modifying Therapies in Stable Relapsing - Onset Multiple Sclerosis (DOT-MS). (DOT-MS)

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting | Multiple Sclerosis, Secondary Progressive

Netherlands
National Institute of Allergy and Infectious Diseases...
PPD; Rho Federal Systems Division, Inc.; Immune Tolerance Network (ITN); Blood...

Recruiting

Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS) (BEAT-MS)

Relapsing Multiple Sclerosis | Relapsing Remitting Multiple Sclerosis | Secondary Progressive Multiple Sclerosis

United States
AbbVie

Active, not recruiting

A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug (bDMARD) (SELECT - PsA 2)

Psoriatic Arthritis

United States, Belgium, Brazil, Canada, Chile, Czechia, France, Greece, Hungary, Italy, Japan, Netherlands, New Zealand, Portugal, Puerto Rico, Spain, United Kingdom
AbbVie

Active, not recruiting

A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy (KEEPsAKE 1)

Psoriatic Arthritis

United States, Argentina, Australia, Belgium, Bosnia and Herzegovina, Brazil, Bulgaria, Canada, Chile, Croatia, Czechia, Denmark, Estonia, Finland, Germany, Greece, Israel, Italy, Korea, Republic of, Latvia, Lithuania, Malaysia, Mexico and more
Kiniksa Pharmaceuticals, Ltd.

Completed

Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor

Arthritis, Rheumatoid

United States, Poland, Hungary, Georgia, Czechia, South Africa, Bulgaria

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