Search clinical trials for: Dose response

Total 32943 results

Peptinov SAS

Recruiting

Dose Escalation Study Assessing the Safety and Immune Response of PPV-06 Vaccine

Knee Osteoarthritis

France
Stanford University

Recruiting

Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation

Treatment Resistant Depression

United States
Hospital de Clinicas de Porto Alegre
Federal University of Rio Grande do Sul

Recruiting

Resistance Plus Aerobic Training Using Different Weekly Frequencies And Hypertension (RADAH)

Cardiovascular Diseases | Hypertension | Cardiovascular Risk Factor

Brazil
Massimo Girardis

Recruiting

Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock. (IgM-FAT)

Sepsis | Shock, Septic | Hypoglobulinemia

Italy
The Netherlands Cancer Institute
Bristol-Myers Squibb

Recruiting

Immune Induction Strategies to Improve Response to Immune Checkpoint Blockade in Triple Negative Breast Cancer (TNBC) Patients (TONIC-2)

Metastatic Breast Cancer

Netherlands
Erasmus Medical Center

Recruiting

Pentoxifylline Dose Optimization in Neonatal Sepsis

Neonatal Late Onset Sepsis

Netherlands, Poland
University of Alabama at Birmingham

Recruiting

B Cell and Antibody Response to Seasonal Influenza Vaccines in Younger and Older Adults

Influenza

United States
University of Roehampton

Recruiting

The Effect of a Botanical Plant Extract on Gut Health, Immunity and Metabolic Disorders in Healthy Adults (GHIMD)

Healthy

United Kingdom
Centre Hospitalier Universitaire de Saint Etienne

Recruiting

A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty (PRADO)

Arthropathy of Hip

France
University of Athens

Recruiting

Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock (CORVICTES-ΥΜ)

Septic Shock

Greece
University of Athens
Naval Hospital, Athens; General Hospital of Nikaia "Saint Panteleimon"

Recruiting

Vitamin C, Hydrocortisone and Thiamine for Septic Shock (CORVICTES)

Shock, Septic

Greece
University Hospital, Lille

Recruiting

Utility of Sodium Lactate Infusion During Septic Shock (ULIS1)

Septic Shock

France
Queen Saovabha Memorial Institute

Recruiting

Effect of ERIG Injection on Day 7 After First Dose of Rabies Vaccination to Rabies Immune Response

Rabies

Thailand
Hospital JP Garrahan
Hospital Pereyra Rosell, Montevideo, Uruguay

Recruiting

Pediatric Hodgkin Lymphoma Treatment Trial With Low Cumulative Doses of Chemotherapy Agents and Reduced Radiation. (LHGALOP2017)

Pediatric Hodgkin's Disease

Argentina
National Institutes of Health Clinical Center (CC)

Recruiting

A Single Dose of Pembrolizumab in HIV-Infected People

Human Immunodeficiency Virus

United States
Dr. Diane Lougheed

Recruiting

Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol

Cough | Asthma | Cough Variant Asthma

Canada
National Institute of Mental Health (NIMH)

Recruiting

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Depression | Major Depressive Disorder | Healthy Volunteer

United States
Samsung Medical Center

Recruiting

Response-based Treatment of High-risk Neuroblastoma

Newly Diagnosed High Risk Neuroblastoma

Korea, Republic of
Lisette Nixon
Cancer Research UK

Recruiting

Study of Chemoradiotherapy in Oesophageal Cancer Including PET Response and Dose Escalation (SCOPE2)

Oesophageal Cancer

United Kingdom
University of Maryland, Baltimore
Vanderbilt University

Recruiting

Dose Response of Epinephrine (Epineprhine)

Diabetes Complications

United States
Peking University

Completed

A Dose-response Study to Validate the Biomarkers for Whole Grain Dietary Intake

Chronic Disease Prevention

China
AstraZeneca

Active, not recruiting

Dose Exploration Intramuscular/Intravenous Prophylaxis Pharmacokinetic Exposure Response Study

COVID-19

United States
University of Pittsburgh
National Institutes of Health (NIH); National Institute on Aging (NIA)

Completed

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Healthy | Cognitive Function 1, Social

United States
National Cancer Institute (NCI)

Active, not recruiting

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

Neurofibromatosis 1 | Neurofibroma, Plexiform | Neurofibromatosis Type 1 | NF1

United States
University of Birmingham

Active, not recruiting

A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC) (ALL-RIC)

Acute Lymphoblastic Leukemia

United Kingdom
AstraZeneca

Active, not recruiting

Olaparib Tablets Maintenance Monotherapy Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy (L-MOCA)

Relapsed Ovarian Cancer | Following Complete or Partial Response to Platinum Based Chemotherapy | Platinum Sensitive

China, Malaysia
Hernando Gomez
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Enrolling by invitation

Safety and Feasibility of Metformin for Sepsis Induced AKI

Sepsis | Septic Shock | Acute Kidney Injury | Metformin

United States
Vejle Hospital
Hvidovre University Hospital

Active, not recruiting

Repeat Dose Steroid to Prevent Pain Relapse After Total Knee Arthroplasty in Patients With High Pain Response

Post Operative Pain, Acute

Denmark
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Dose-Response of Aerobic Training in Women at High-Risk for Development of Breast Cancer

High Risk for Developing Breast Cancer

United States
AstraZeneca

Active, not recruiting

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

Cervical Cancer | Ovarian Cancer | Pharmacokinetics | Endometrial Cancer | Pharmacodynamics | Safety and Tolerability | Advanced Solid Malignancy | Tumour Response | Advanced or Metastatic Breast Cancer | PIK3CA | AKT1 | PTEN | ER Positive | HER2 Positive

United States, Italy, Canada, France, Japan, United Kingdom, Spain, Netherlands, Denmark, Singapore
Soterios Ltd

Completed

A Phase 2 Placebo Controlled, Clinical Trial Designed to Assess the Efficacy, Safety and Dose Response Characterisation of STS01 for the Treatment of Mild-moderate Alopecia Areata (AA) (SOT01)

Alopecia Areata

United Kingdom
M.D. Anderson Cancer Center

Active, not recruiting

Temsirolimus in Combination With Metformin in Patients With Advanced Cancers

Advanced Cancers

United States
University of Arizona
National Institute on Aging (NIA)

Completed

Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment (TMS-fMRI)

Mild Cognitive Impairment

United States
Spanish Breast Cancer Research Group
AstraZeneca

Completed

Analysis of Olaparib Response in Patients With BRCA1 and/or 2 Promoter Methylation Diagnosed of Advanced Breast Cancer (COMETABreast)

Advanced Breast Cancer

Spain
University of Nebraska
National Institute of Mental Health (NIMH)

Terminated

Dose Response Relationship of Oxytocin on Irritability in Youths

Irritable Mood

United States
Kyowa Kirin, Inc.

Completed

A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy

Parkinson's Disease

United States
Gary Van Guilder
Western Colorado University; Auckland University of Technology

Completed

The Dose-response Effects of High Intensity Functional Training on Metabolic Syndrome Risk Factors

Metabolic Syndrome | Insulin Resistance | Endothelial Dysfunction | Atherogenic Dyslipidemia

United States
Assiut University

Completed

Clinical Impact of an Antibiotic Stewardship Program in a Neonatal Intensive Care Unit

Neonatal Sepsis

Egypt
GlaxoSmithKline
CureVac

Completed

A Study on the Safety, Reactogenicity and Immune Response of a Vaccine Against Influenza in Healthy Younger and Older Adults

Influenza, Human

Belgium, Spain, Canada
University of California, San Francisco
amfAR, The Foundation for AIDS Research; University of Utah

Terminated

Immunologic Response to Kansui in Treated HIV+ Individuals: a Dose Escalation Study

HIV | Human Immunodeficiency Virus

United States
Aerospace Center Hospital

Completed

Different Dose of Esketamine Inhibiting Response to Laryngeal Mask Airway Insertion

Anesthesia

China
Iuliu Hatieganu University of Medicine and Pharmacy

Completed

Interventions Meant to Improve the Outcome of Critical Care Patients in the ED

Sepsis Syndrome | Emergency Department | Biomarker

Romania
Renibus Therapeutics, Inc.

Completed

Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing CABG and/or Cardiac Valve Surgery (START)

AKI

United States, Australia, Canada
Novartis Pharmaceuticals

Active, not recruiting

Extension Study to Assess Effects of Non-interrupted Versus Interrupted and Long Term Treatment of Two Dose Regimes of Secukinumab in Subjects With Hidradenitis Suppurativa

Hidradenitis Suppurativa

Belgium, Italy, United Kingdom, Hungary, Malaysia, Russian Federation, Taiwan, Germany, Netherlands, France, Israel, Korea, Republic of, Japan, Lebanon, United States, Australia, Singapore, Spain, Switzerland, Austria, Lithuania, ... and more
University Hospital, Basel, Switzerland
Swiss National Science Foundation

Active, not recruiting

MechSens - Dose-response Relationship of in Vivo Ambulatory Load and Mechanosensitive Cartilage Biomarkers (MechSens)

Articular Cartilage Degeneration

Switzerland
Hartford Hospital
Yale University

Active, not recruiting

Hippocampal Response to Acute Oral Doses of CBD During an fMRI Memory Task

CBD

United States
Prothya Biosolutions
PRA Health Sciences

Completed

Dose-Response in PD and Safety of Cofact Under VKA Anticoagulation

Healthy Volunteers

Netherlands
GlaxoSmithKline

Completed

A Study on the Immune Response and Safety Elicited by a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a Vaccine Against Influenza in Adults Aged 65 Years and Above

Respiratory Syncytial Virus Infections

United States
Casa di Cura San Raffaele Cassino
University of Rome Tor Vergata; IRCCS San Raffaele Roma; University of Urbino... and other collaborators

Enrolling by invitation

To Evaluate the Dose-response Effects of a Defined Volume of Physical Exercise on the Change of Peripheral Biomarkers, Clinical Response and Brain Connectivity in Parkinson's Disease: a Prospective, Observational, Cohort Pilot Study (METEX-PD)

Parkinson Disease

Italy
GlaxoSmithKline

Active, not recruiting

A Safety and Immune Response Study to Evaluate Varying Doses of an mRNA Vaccine Against Coronavirus Disease 2019 (COVID-19) in Healthy Adults

COVID-19

United States

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