Search clinical trials for: Enzyme Replacement

Total 52227 results

Rothman Institute Orthopaedics

Enrolling by invitation

Pain Relief After PrimaryTKA

Pain, Postoperative

United States
Gaia Herbs Inc.
Nutrasource Pharmaceutical and Nutraceutical Services, Inc.

Completed

A Study to Evaluate the Effect of Turmeric in Healthy Participants

Healthy

Canada
Regeneron Pharmaceuticals
Teva Pharmaceutical Industries, Ltd.

Completed

Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip (FACT OA2)

Osteoarthritis, Knee | Osteoarthritis, Hip

United States
Damascus University
Unipharma, HamaPharma, Almujtahed hospital

Completed

Rivaroxaban vs. Warfarin in CVT Treatment (RWCVT)

Cerebral Vein Thrombosis

Syrian Arab Republic
Shaare Zedek Medical Center

Completed

Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy

Gaucher Disease, Type 1

Israel
Ross Leighton
Nova Scotia Health Authority

Withdrawn

A Cohort Study With 100 Subjects Having a Primary Total Knee Replacement, Taking Pradax Post Discharge for Ten Days

Thromboembolism

Canada
Rush University Medical Center

Withdrawn

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

Osteoarthritis | Degenerative Joint Disease

United States
Galenicum Health

Completed

Comparative Bioavailability Study of Metformin/Sitagliptin 850 mg/50 mg Tablets in Healthy Male and Female Volunteers

Diabetes Mellitus, Type 2 | Bioequivalence

Canada
Sanofi

Approved for marketing

Compassionate Use Program for Olipudase Alfa Enzyme Replacement Therapy for Patients With Chronic Acid Sphingomyelinase Deficiency (ASMD)

Sphingomyelin Lipidosis
National Taiwan University Hospital
Sanofi

Completed

Eliglustat on Gaucher Disease Type IIIB

Gaucher Disease, Type III

Taiwan
M.D. Anderson Cancer Center

Completed

Apalutamide and Gonadotropin-Releasing Hormone Analog With or Without Abiraterone Acetate in Treating Participants With Prostate Cancer

Prostate Adenocarcinoma | Stage IIIA Prostate Cancer AJCC v8 | Stage IIC Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IIB Prostate Cancer AJCC v8

United States
Nottingham University Hospitals NHS Trust
University of Washington; Seattle Children's Hospital; The Leeds Teaching Hospitals... and other collaborators

Active, not recruiting

CFTR Modulators and Gastrointestinal Complications (CFTR-MAGIC)

Lung Diseases | Cystic Fibrosis | Digestive System Disease | Pancreatic Disease | Distal Intestinal Obstruction Syndrome | Pancreatic Enzyme Abnormality | Gastrointestinal System Disease

United Kingdom
First Wave Bio, Inc.

Completed

OPTION: A Trial to Assess the Safety & Efficacy of MS1819 in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis (OPTION)

Cystic Fibrosis (CF) | Exocrine Pancreatic Insufficiency (EPI)

United States, Poland
University of Puerto Rico

Completed

Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement

Pain | Total Knee Arthroplasty | Opioid Use | Multimodal Analgesia | Hispanics

Puerto Rico
University Health Network, Toronto

Completed

IPACK Study in Total Knee Arthroplasty Patients

Knee Replacement Arthroplasty

Canada
Incyte Corporation

Terminated

Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies

Solid Tumors

United States, Belgium, France
University of Pharmacy, Yangon

Completed

Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal Meningitis

Cryptococcal Meningitis

Myanmar
Menzies School of Health Research
University of Malaya; Nanyang Technological University; Griffith University; The... and other collaborators

Active, not recruiting

Hospitalised Pneumonia With Extended Treatment (HOPE) Study (HOPE)

Pneumonia

Australia, Malaysia, New Zealand
Daiichi Sankyo, Inc.
Chiltern International Inc.

Completed

Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)

Atrial Fibrillation

Canada, United States, Spain, Italy, Germany, Switzerland, France, Netherlands, United Kingdom, Belgium, Japan, Austria, Korea, Republic of, Poland
Instituto Nacional de Cirugia Cardiaca, Uruguay
Universidad de la Republica

Completed

Anticoagulation for Aortic Bioprosthesis (ANTIPRO)

Aortic Valve Stenosis | Aortic Valve Disease | Aortic Valve Insufficiency | Aortic Valve Regurgitation

Uruguay
Organon and Co

Completed

Evaluation of Potential for Drug Interaction Between SCH 58235 (Ezetimibe) and Pitavastatin (Study P03962)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)

Pain, Postoperative
Unidad de Investigacion Medica en Enfermedades...

Completed

The Effect of Enalapril, Losartan or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients

Oxidative Stress

Mexico
Medstar Health Research Institute

Active, not recruiting

Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement

Aortic Stenosis

United States
University of Florida
Patient-Centered Outcomes Research Institute; Merck Sharp & Dohme LLC; AbbVie

Completed

Study of Oral Treatments for Hepatitis C (PRIORITIZE)

Chronic Hepatitis C

United States
Federal Research and Clinical Center of Physical-Chemical...
Moscow State University of Medicine and Dentistry

Completed

Intestinal Microbiota Composition in Patients With Chronic Pancreatitis and Pancreatic Exocrine Insufficiency

Chronic Pancreatitis | Pancreatic Exocrine Insufficiency

Russian Federation
Zimmer Biomet

Completed

Total Temporomandibular Joint Replacement System Post Approval Study

Arthroplasty

United States
HK inno.N Corporation

Completed

A Phase 3 Study to Evaluate the Efficacy and Safety of Triple Therapy With CJ-12420 in H. Pylori Positive Patients

Helicobacter Pylori Infection

Korea, Republic of
The University of Tennessee, Knoxville
Zimmer Biomet, Inc.

Completed

Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty (PCR PS TKA)

Osteoarthritis, Knee | Arthroplasty, Replacement, Knee

United States, France
Chinese University of Hong Kong

Completed

The Interaction of Herbs and Statins

Drug Interaction

Hong Kong
University of Maryland, Baltimore

Completed

Pharmacokinetics of Antiepileptics in Patients on CRRT (PADRE)

Renal Insufficiency | Renal Failure | Acute Kidney Injury | Pharmacokinetics

United States
University Hospital, Ghent
Kom Op Tegen Kanker; Anticancer Fund, Belgium

Completed

Study of Pembrolizumab, Radiation and Immune Modulatory Cocktail in Cervical/Uterine Cancer (PRIMMO)

Cervical Cancer | Endometrial Cancer | Uterine Cancer

Belgium
Hasan Kalyoncu University

Completed

The Effect of Enzyme Replacement Therapy in Mucopolysaccharidosis

Mucopolysaccharidosis

Turkey
Shire

Completed

Replagal Enzyme Replacement Therapy for Children With Fabry Disease

Fabry Disease

Canada, United States
BioMarin Pharmaceutical

Completed

Long-Term Efficacy and Safety Extension Study of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome)

Morquio A Syndrome | MPS IVA | Mucopolysaccharidosis IV A

United States, Canada, France, Taiwan, Argentina, Colombia, Spain, Turkey, Japan, Saudi Arabia, Netherlands, Denmark, Korea, Republic of, Brazil, United Kingdom, Germany, Norway, Portugal, Italy, Qatar
Gachon University Gil Oriental Medical Hospital
Catholic Kwandong University

Completed

Efficacy and Safety of Chuna Manual Treatment as an Adjunctive Therapy After Total Knee Arthroplasty: A Study Protocol for a Single-Center, Randomized, Assessor Blind, Parallel-Group Clinical Trial

Total Knee Replacement | Manipulation

Korea, Republic of
Shire

Completed

A Study of Gene-Activated® Human Glucocerebrosidase (GA-GCB) Enzyme Replacement Therapy in Gaucher Disease

Gaucher Disease, Type 1

Israel, Paraguay, Argentina, Russian Federation, Tunisia
Shire

Completed

A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase®

Hunter Syndrome

United States, United Kingdom
Shire

Completed

Study of Velaglucerase Alfa Enzyme Replacement Therapy in Japanese Patients With Gaucher Disease

Gaucher Disease

Japan
Shire

Completed

Open-Label Extension Study Evaluating Long Term Safety in Patients With Type 1 Gaucher Disease Receiving DRX008A (ERT)

Gaucher Disease

Israel, Romania, Serbia
Shire

Completed

FST-201 in the Treatment of Acute Otitis Externa

Acute Otitis Externa

American Samoa
Shire

Completed

Efficacy and Safety Study of Velaglucerase Alfa in Children and Adolescents With Type 3 Gaucher Disease

Gaucher Disease, Type 3

Egypt, India, Tunisia
Shire

Completed

Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment (AIM-IT)

Hunter Syndrome

Spain, United States, Canada, United Kingdom, France, Australia, Mexico
Shire

Completed

Extension of Study TKT024 Evaluating Long-Term Safety and Clinical Outcomes in MPS II Patients Receiving Idursulfase

Hunter Syndrome | Mucopolysaccharidosis II (MPS II)

United States, France, United Kingdom, Germany, Sweden, Spain, Brazil, Canada, Italy, Romania
Shire

Completed

An Open-Label Extension Study of GA-GCB ERT in Patients With Type 1 Gaucher Disease

Gaucher Disease, Type 1

United States, Israel, Argentina, India, Korea, Republic of, Paraguay, Poland, Russian Federation, Spain, Tunisia, United Kingdom
Shire

Completed

Iduronate-2-sulfatase Enzyme Replacement Therapy in Mucopolysaccharidosis II (MPS II)

Mucopolysaccharidosis II

United States, United Kingdom, Brazil, Germany
Shire

Completed

Study of GA-GCB Enzyme Replacement Therapy in Type 1 Gaucher Disease Patients Previously Treated With Imiglucerase

Gaucher Disease

United States, Israel, United Kingdom, Poland, Spain
Shire

Completed

Safety Study of Replagal® Therapy in Children With Fabry Disease

Fabry Disease

United States
Shire

Completed

A Multicenter Open-Label Treatment Protocol to Observe the Safety of Replagal (Agalsidase Alfa) Enzyme Replacement Therapy in Canadian Patients With Fabry Disease

Fabry Disease

Canada
Shire

Completed

Study of Gene-Activated® Human Glucocerebrosidase (GA-GCB) ERT Compared With Imiglucerase in Type I Gaucher Disease

Gaucher Disease, Type 1

Spain, Israel, United States, India, Paraguay, United Kingdom, Russian Federation, Tunisia, Argentina

Search clinical trials for: Enzyme Replacement

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Malaysia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations