Search clinical trials for: Open randomized multi-centre clinical trial in Africa

Total 466148 results

Pfizer

Terminated

A Phase 2B Multicenter, Randomized, Comparative Trial Of UK-453,061 Versus Etravirine In Combination With Darunavir/Ritonavir And A Nucleos(t)Ide Reverse Transcriptase Inhibitor For The Treatment Of Antiretroviral Experienced HIV-1 Infected Subjects With Evidence Of NNRTI Resistant HIV-1

HIV-1

Spain, United Kingdom, Malaysia, United States, Portugal, Brazil, Germany, Italy, Poland, Puerto Rico, South Africa, Taiwan, Ukraine
Pfizer

Completed

A Multi-Center Trial To Evaluate The Safety And Efficacy Of Pegaptanib Sodium(Macugen) Injected Into The Eye Every 6 Weeks For Up To 2 Years For Macular Swelling Associated With Diabetes, With An Open-Label Macugen Year Extension.

Macular Edema Associated With Diabetes Mellitus

United States, Colombia, Australia, Germany, Italy, South Africa, Greece, France, Austria, United Kingdom, Denmark, India, Portugal, Brazil, Canada, Czechia, Netherlands, Switzerland
GlaxoSmithKline

Terminated

Open-Label Extension Study of the Phase 3 VRX-RET-E22-302 Double-Blind Trial. 115097

Epilepsy

Spain, Australia, Russian Federation, Israel, Belgium, Hungary, France, Germany, Poland, South Africa, Ukraine, United Kingdom
Simunye Primary Health Care

Completed

A Randomized Controlled Trial of Open Surgical vs. Rapid, Minimally-invasive Voluntary Adult Male Circumcision

Circumcision

South Africa
Pfizer

Terminated

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects (SPIRE-1)

Cardiovascular Disease

Finland, United States, Netherlands, Spain, Korea, Republic of, China, Israel, Belgium, Germany, Australia, Czechia, Taiwan, Denmark, United Kingdom, Hungary, Poland, France, Mexico, Turkey, Canada, New Zealand, Colombia, Switzerland, Irelan... and more
Organogenesis

Completed

Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers (DEVO)

Venous Leg Ulcer

United States, United Kingdom, Poland, South Africa, Austria, Estonia, Germany, Sweden
Association for Innovation and Biomedical Research...
European Vision Institute Clinical Research Network

Completed

Prospective, Randomized, Multicentre, Open-label, Phase II / III Study to Assess Efficacy and Safety of Ranibizumab 0.5 mg Intravitreal Injections Plus Panretinal Photocoagulation (PRP) Versus PRP in Monotherapy in the Treatment of Subjects With High Risk Proliferative Diabetic Retinopathy. (PROTEUS)

High Risk Proliferative Diabetic Retinopathy

Portugal, Italy, United Kingdom, France
Universidade Federal de Goias

Unknown

TAmoxifen Versus LIdocaine Cream. A Randomized Clinical Trial for Reducing Pain and Discomfort During Mammography (TALI)

Pain | Discomfort

Brazil
University of Cape Town
Imperial College London; Institute of Tropical Medicine, Belgium; European and... and other collaborators

Completed

Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone (Pred-ART)

HIV | Tuberculosis | Immune Reconstitution Inflammatory Syndrome

South Africa
Bing Wang

Unknown

Effects of Combined Surgery on Obstructive Sleep Apnea in Obese Patients: an Open-label Randomized Controlled Clinical Trial

To Compare the Difference of AHI Variation Between LSG and Combined Surgery
Daewon Pharmaceutical Co., Ltd.

Completed

A Multicenter, Randomized, Open-labeled, Cross-over, Active-controlled, Phase IV Clinical Trial to Evaluate the Preference of Formulation and the Efficacy and Safety of Renamezin and Kremezin in Pre-dialysis Patients With Chronic Renal Failure

Chronic Renal Failure

Korea, Republic of
National Institute of Allergy and Infectious Diseases...

Completed

An Open Label Non-Randomized Dose Escalating Trial to Assess Safety and Tolerability of Alb-Interferon Alfa 2b Every Two Weeks With Ribavirin Among HIV/HCV Coinfected Individuals

HIV Infections | HCV

United States
Medical University of South Carolina
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Tablet-Aided BehavioraL Intervention EffecT on Self-management Skills (TABLETS)

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type II | Diabetes Mellitus, Adult-Onset | Diabetes Mellitus, Non-Insulin-Dependent | Diabetes Mellitus, Noninsulin Dependent

United States
ProCore Ltd.

Completed

A Phase I, Prospective, Randomized, Open-label, Active-Controlled Clinical Trial for Safety Evaluation of Intra-articular Injection of RegenoGel-SP for the Treatment of Moderate to Severe Osteoarthritis

Osteoarthritis

Israel
Biogen
Elan Pharmaceuticals

Completed

A Prospective, Open-label, Non-randomized, Clinical Trial to Determine if Natalizumab (Tysabri®) Improves Ambulatory Measures in Relapsing-remitting Multiple Sclerosis (RRMS) Patients (TIMER)

Relapsing Remitting Multiple Sclerosis (RRMS)

Belgium, Mexico, Poland, Romania, Saudi Arabia, Ukraine
University of the Western Cape

Completed

Interventions for Patients With a Shortened Dental Arch (SDA-RCT)

Anomaly of Dental Arch

South Africa
Centre For International Health
Makerere University

Completed

Randomized Clinical Trial Assessing Laryngeal Mask Airway Versus Face-mask Ventilation in Neonatal Resuscitation (LMAvsFMV)

Asphyxia Neonatorum

Uganda
Alcon Research

Completed

Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Glaucoma

Glaucoma

Argentina
Haruhiko Fukuda
Ministry of Health, Labour and Welfare, Japan

Completed

A Trial to Evaluate Laparoscopic Versus Open Surgery for Colorectal Cancer

Colorectal Cancer

Japan
Pfizer

Completed

A Study Evaluating The Efficacy And Safety Of CP-690,550 In Patients With Moderate To Severe Ulcerative Colitis (OCTAVE)

Ulcerative Colitis

United States, Spain, Canada, Israel, Australia, Germany, Serbia, Japan, Denmark, France, Hungary, Poland, United Kingdom, Belgium, New Zealand, Netherlands, Austria, Colombia, Croatia, Czech Republic, Estonia, Italy, Latvia, Romania, Russian... and more
Ajou University School of Medicine
B. Braun Korea Co., Ltd.

Unknown

ISAR-DAPT (A Comparative Evaluation of Efficacy and Safety in the 3-Months DAPT Group vs. the 6-Months DAPT Group of Patients Treated With the Coroflex ISAR Stent; A Prospective, Multicenter, Randomized, Open-Label Clinical Trial)

Stable Angina, Unstable Angina, Silent Coronary Ischemia, Coronary Artery Disease

Korea, Republic of
AcelRx Pharmaceuticals, Inc.

Completed

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™) for the Treatment of Post-Operative Pain in Patients After Open Abdominal Surgery

Post-Operative Pain

United States
José Cunha-Vaz

Completed

Prospective, Randomized, Multicenter, Open Label, Phase II Study to Access Efficacy and Safety of Lucentis® Monotherapy Compared With Lucentis® Plus Panretinal Photocoagulation (PRP) and PRP in the Treatment of Patients With High Risk Proliferative Diabetic Retinopathy

High Risk Proliferative Diabetic Retinopathy

Portugal
Nationwide Children's Hospital
Ohio State University

Unknown

Vitamin D in Pediatric Asthma: a Randomized Controlled Open-label Pilot Trial (D-Asthma)

Vitamin D Deficiency | Asthma

United States
AcelRx Pharmaceuticals, Inc.

Completed

A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain

Post-Operative Pain

United States
Eurofarma Laboratorios S.A.

Completed

Non-inferiority, Open-label, Multicenter and Randomized Clinical Trial About the Treatment of Mild to Moderate Persistent Allergic Rhinitis (NOEX)

Allergic Rhinitis

Brazil
Korea United Pharm. Inc.

Completed

A Randomized, Open-label, Single Dose, Two-way Crossover Clinical Trial to Compare the Safety, Pharmacokinetic Profiles of UI15AML055MT and Amosartan® Tablet 5/50 mg After a Single Oral Administration in Healthy Male Volunteers (UI15AML055MT)

Healthy

Korea, Republic of
Yonsei University

Completed

Randomized, Open Labeled Clinical Trial to Compare the Effectiveness of Amlodipine/Valsartan vs Hydrochlorothiazide/Telmisartan on Glucose Tolerance in Patients With Hypertension With Metabolic Syndrome

Hypertension

Korea, Republic of
Pfizer

Terminated

Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in Patients With Advanced NSCLC

Carcinoma, Non-Small-Cell Lung

United States, Canada, Belgium, Italy, Spain, United Kingdom, Korea, Republic of, Netherlands, Poland, Portugal, Turkey, Taiwan, Germany, Hungary, Brazil, Hong Kong, Singapore, South Africa, China, Austria, Czech Republic, India, Is... and more
Association for Innovation and Biomedical Research...

Completed

Prospective, Randomized, Open Label, Phase II Study to Assess Efficacy and Safety of Macugen® (Pegaptanib 0.3 mg Intravitreal Injections) Plus Panretinal Photocoagulation and PRP (Monotherapy) in the Treatment With High Risk PDR.

Diabetes Mellitus Type II | Diabetes Mellitus Type I | High Risk Proliferative Diabetic Retinopathy

Portugal
BioCryst Pharmaceuticals

Completed

A Phase II, Multicenter, Randomized, Placebo -Controlled, Study To Evaluate The Efficacy and Safety Of Intramuscular Peramivir 600 mg In Subjects With Uncomplicated Acute Influenza

Acute, Uncomplicated Human Influenza

United States, Australia, New Zealand, South Africa
Celladon Corporation

Completed

Efficacy and Safety Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure (CUPID)

Dilated Cardiomyopathy | Heart Failure, Congestive

United States
Second Affiliated Hospital of Xi'an Jiaotong University

Unknown

Laparoscopic Versus Open Devascularization for Portal Hypertension, a Randomized Controlled Trial

Liver Cirrhosis | Portal Hypertension

China
Justine Boles
European and Developing Countries Clinical Trials Partnership (EDCTP)

Completed

Europe-Africa Research Network for Evaluation of Second-line Therapy (EARNEST)

HIV | Human Immunodeficiency Virus

Kenya, Malawi, Uganda, Zambia, Zimbabwe
Northern Orthopaedic Division, Denmark
Company CCBR A/S

Completed

Proximal Tibial Open Wedge Osteotomy. A Clinical Prospective, Randomized RSA-trial.

Osteoarthritis, Knee

Denmark
Pfizer

Completed

A 12 Week Study to Confirm the Effectiveness of 8mg of Fesoterodine Compared to 4mg of Fesoterodine

Overactive Bladder

Korea, Republic of, United States, Denmark, Germany, Canada, Hungary, Poland, France, United Kingdom, Slovakia, Sweden, Mexico, Czech Republic, Finland, Italy, Lithuania, Argentina, Chile, Colombia, Egypt, Greece, Norway, Philippines, Russian Federation and more
University of Western Ontario, Canada
Schering-Plough

Completed

COMMIT (Combination Of Maintenance Methotrexate-Infliximab Trial)

Crohn's Disease

Canada
Proacta, Incorporated

Terminated

Randomized Phase 1/2 Open-Label Trial of PR104 and Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)

Hepatocellular Carcinoma

United States, Taiwan, Singapore, Hong Kong
Jaap Bonjer

Unknown

COLOR II: Laparoscopic Versus Open Rectal Cancer Removal (COLORII)

Rectal Cancer

Netherlands, Sweden, Spain, Korea, Republic of, Belgium, Canada, Denmark, Germany, Poland
Wyeth is now a wholly owned subsidiary of Pfizer

Terminated

Study Comparing Sirolimus With Cyclosporine in a Calcineurin Inhibitor (CNI)-Free Regimen in Kidney Transplant Recipients

Kidney Transplant

Spain, Italy, Argentina, Greece, Taiwan, Singapore, United States, Canada, United Kingdom, Chile, South Africa, Hungary, Turkey, Austria, Germany, France, Norway, Australia, Sweden, Portugal, Cyprus
Dong-A Pharmaceutical Co., Ltd.

Completed

A Randomized, Open Label, Single Dose, 2-Way Cross-over Clinical Trial to Compare the Safety and Pharmacokinetic Characteristics of Exforge® and G-0081 in Healthy Male Volunteers

Healthy Male Volunteer
National Taiwan University Hospital
National Science Council, Taiwan

Unknown

A Randomized Controlled Clinical Trial Comparing Oncological Results and Functional Recovery Between Laparoscopic and Open Method for the Treatment of Advanced Rectal Cancer After Concurrent Chemoradiation Therapy (CCRT)

Rectal Cancer

Taiwan
Merz Pharmaceuticals GmbH

Terminated

Open-Label, Long-Term Treatment Study, to Assess the Long-Term Safety and Tolerability and Efficacy of Neramexane in Patients With Subjective Tinnitus (OLLTT)

Subjective Tinnitus

United States, United Kingdom, Poland, Austria, Belgium, Brazil, Czech Republic, France, Germany, Mexico, Netherlands, Portugal, South Africa, Spain
Academisch Medisch Centrum - Universiteit van Amsterdam...
ZonMw: The Netherlands Organisation for Health Research and Development; Dutch...

Unknown

Diverticulitis: Antibiotics or Close Observation? (DIABOLO)

Diverticulitis

Netherlands
Chong Kun Dang Pharmaceutical

Completed

A Randomized, Open-label, Single-dose, Crossover Clinical Trial to Evaluate the Food Effect on the Pharmacokinetics of Dilatrend SR 64mg Capsule After Oral Administration in Healthy Male Volunteers

Chronic Stable Angina

Korea, Republic of
Pfizer

Completed

A Randomized, Open Label, Clinical Trial of the Pharmacokinetics of Azithromycin Following a Single Dose of Azithromycin Sustained Release (2 Gram) or Commercial Azithromycin Tablet (500 mg) to Cancer Patients That Require Lung Surgery

Pharmacokinetics

Italy
Novartis
Genentech, Inc.; Tanox

Completed

Open Label Study to Assess Safety and Immunogenicity of Omalizumab Liquid Formulation.

Asthma

United States, Argentina, Germany
University of Konstanz
German Research Foundation

Completed

Treatment of Formerly Abducted Children (FAC) in Uganda

Stress Disorders, Post-Traumatic

Uganda
University Hospital Dubrava
Ministry of Science, Education and Sport, Republic of Croatia

Unknown

Double Blinded Randomized Clinical Trial of the Effect of Open Versus Laparoscopic Colectomy on Neutrophils in Patients With Colon Cancer

Colonic Neoplasms

Croatia
Kenya Medical Research Institute
Dafra Pharma

Completed

A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni

Schistosoma Mansoni

Kenya

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