Search clinical trials for: Open to Options (O2O)

Total 477806 results

Chisquares Incorporated

Not yet recruiting

Collaborative Open Research Initiative Study (CORIS-1) (CORIS-1)

COVID-19 | Burnout, Professional | Patient Engagement | Artificial Intelligence | Substance Use Disorders | Mental Health Issue | Climate Change | Preventable Disease, Vaccine | Emerging Infectious Disease | Online Education
AstraZeneca
Daiichi Sankyo

Recruiting

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations (TROPION-Lung10)

Non-Small Cell Lung Cancer

Spain, Italy, Korea, Republic of, United States, Japan, Brazil, Taiwan, Australia, Austria, Canada, Poland, Belgium, United Kingdom, Turkey, Hungary, Germany, India
VistaGen Therapeutics, Inc.

Recruiting

Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-3) (PALISADE-3)

Social Anxiety Disorder

United States
Institute of Mental Health, Singapore

Recruiting

An Open-Label, Single Arm Study of the Efficacy of Accelerated Intermittent Theta Burst Stimulation in Schizophrenia Patients With Persistent Negative Symptoms (NOBLE-TMS)

Schizophrenia; Negative Type

Singapore
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (ALBUCHIP)

Postoperative Complications | Peritoneal Neoplasms | Fluid Therapy | Hyperthermic Intraperitoneal Chemotherapy | Intraoperative Care
Riphah International University

Recruiting

Evaluation of Performance-based Functional Outcome Measures After Open Abdominal Surgery

Laparotomy

Pakistan
Alvernia University

Recruiting

The Effects of Open Chain Versus Closed Chain Strengthening on Dynamic Valgus During a Step Down Test

Dynamic Knee Valgus

United States
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Short-term and Long-term Outcomes of Colorectal Cancer Treated With Natural Orifice Specimen Extraction Surgery : a National Registry-based Study

Colorectal Cancer

China
Cosima Locher
Brown University; University of Basel

Not yet recruiting

Conditioned Open-label Placebos to Facilitate Opioid Reduction in Patients With Chronic Non-cancer Pain (ROM)

Chronic Non-cancer Pain
Aya Ayman Ahmed

Not yet recruiting

Assessment of Serum Concentration of Interleukin-17 and Osteoprotegerin in Response to Surgical Trauma Induced by Management of Mandibular Fractures Via Intraoral Versus Extraoral Approaches: Prospective Cohort Study

Mandibular Fractures
AstraZeneca
Daiichi Sankyo

Recruiting

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer (TROPION-Lung14)

Non-small Cell Lung Cancer

Australia, China, Korea, Republic of, Taiwan
Dow University of Health Sciences

Recruiting

Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening (Antiviral)

Acute Apical Abscess

Pakistan
Dosentrx Ltd.

Not yet recruiting

Open Label, Controlled, Post Marketing, Registry Study of Ribociclib (Ribo) Treatment Adherence and Patient Reported Outcomes in Participants Using ReX Technology Platform

Any Solid Oral Medication

United States
Fondation Ophtalmologique Adolphe de Rothschild

Not yet recruiting

Immediate Corticosteroid Therapy and Rituximab to Prevent Generalization in Ocular Myasthenia: a PROBE Multicenter Open-label Randomized Controlled Trial. (IMCOMG)

Ocular Myasthenia Gravis
Shanghai Ninth People's Hospital Affiliated to...

Not yet recruiting

Accuracy of Two Methods of Making Impressions for Complete-arch Implant Supported Fixed Prosthesis

Edentulous Jaw
Nanjing First Hospital, Nanjing Medical University

Not yet recruiting

Efficacy and Safety of Tegoprazan Dual Therapy and Furazolidone-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication: A Prospective, Multicenter, Open-label, Randomized Controlled Clinical Study

Helicobacter Pylori Infection | Tegoprazan | Furazolidone
Major Extremity Trauma Research Consortium

Not yet recruiting

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures: A Multicenter Randomized Controlled Trial (iVAC)

Wound Heal | Wound Complication | Wound Dehiscence | Fracture of Tibia | Infected Wound
ASST Santi Paolo e Carlo

Not yet recruiting

Effect of Kron (Citicoline and Nicotinamide Oral Solution) on Patients With Open-angle Glaucoma

Glaucoma
Assiut University

Not yet recruiting

Approaches for Open Reduction and Internal Fixation of Mandibular Condylar Fracture

Mandibular Fractures
NaviFUS Corporation
NaviFUS US LLC

Not yet recruiting

Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)

Glioma | Neoplasms | Glioblastoma | Neoplasms, Nerve Tissue | Brain Tumor | Glioblastoma Multiforme

United States
Massachusetts General Hospital
Harvard Medical School (HMS and HSDM)

Recruiting

Open Pilot Trial of a Mind-Body Sexual Well-Being Intervention for Female GI Cancer Survivors

Colorectal Cancer | Sexual Dysfunction | Anal Cancer

United States
Novartis Pharmaceuticals

Recruiting

Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR) (REPLENISH-EXT)

Polymyalgia Rheumatica

Australia
Irish Research Radiation Oncology Group

Recruiting

Optimising Patient Experience in Head and Neck Radiotherapy (OPEN)

Head and Neck Cancer

Ireland
The Royal College of Surgeons of Edinburgh

Recruiting

Minimally Invasive Ridge Splitting Versus the Conventional Open Flap Technique

Alveolar Bone Loss

Egypt, Germany
Sir Ganga Ram Hospital

Recruiting

Vegetarian Versus Non Vegetarian Based Diet in the Recurrence of Hepatic Encephalopathy in Patients With Cirrhosis: An Open Label Pilot Study

Hepatic Encephalopathy

India
Cabaletta Bio

Recruiting

RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis

Systemic Sclerosis | Scleroderma

United States
M.D. Anderson Cancer Center
Active Biotech AB

Not yet recruiting

Open Label Phase 2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF)

Primary Myelofibrosis | Post-polycythemia Vera Myelofibrosis | Post-Essential Thrombocytosis Myelofibrosis

United States
Istituto Clinico Humanitas

Recruiting

Natural Orifice Specimen Extraction in Low Rectal Cancer Surgery (NOSES)

Rectal Cancer | Surgery

Italy
Johns Hopkins University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Not yet recruiting

CAPABLE Transplant

Depression | Quality of Life | End Stage Renal Disease | Disability Physical

United States
Lindsey Russell, MD
Napo Pharmaceuticals, Inc.

Not yet recruiting

Open-Label Pilot Study With Crofelemer in Patients With Short Bowel Syndrome

Short Bowel Syndrome

United States
Kasr El Aini Hospital

Recruiting

Fascia Transversalis Versus Transversus Abdominis Plane Block for Children Undergoing Inguinal Hernia Surgery

Fascia Transversalis Plane Block

Egypt
Taichung Veterans General Hospital

Not yet recruiting

ESP Versus PIFB for Analgesia in Open Cardiac Surgery: a Randomized Control Trial

Analgesia

Taiwan
Cairo University

Not yet recruiting

Effect of Rotator Cuff Training on Hand Grip in Adults

Hand Grasp
EyeD Pharma

Recruiting

Safety and Tolerability of a Timolol Releasing Intraocular Implant in Subjects With Primary Open-angle Glaucoma

Primary Open-angle Glaucoma

Germany, Belgium
Universitaire Ziekenhuizen KU Leuven

Not yet recruiting

Outcomes of Different Treatment Options in Chronic Venous Disease (VOS)

Chronic Venous Disease
Teva Branded Pharmaceutical Products R&D, Inc.

Recruiting

Open-label Trial Characterizing the PK of 3 SC Olanzapine Extended-release Formulations in Participants With Schizophrenia/Schizoaffective Disorder

Schizophrenia, Schizoaffective Disorder

United States
M.D. Anderson Cancer Center

Recruiting

Open-label, Single Center, Single-arm, Phase 2 Study of Neoadjuvant Pembrolizumab in Combination With Carboplatin and Paclitaxel in Patients With Stage 1 cT1b-T1cN0M0 Triple Negative Breast Cancer

Triple Negative Breast Cancer | Stage 1 cT1b-T1cN0M0

United States
Haukeland University Hospital

Recruiting

Dialectical Behavior Therapy for Adolescents With Self-harm and Suicidal Behavior- an Open Trial

Suicidal Ideation | Self-harm | Suicide and Self-harm

Norway
Teva Branded Pharmaceutical Products R&D, Inc.

Recruiting

An Open-Label Trial to Assess the Comparative Bioavailability of TV-44749 to Oral Olanzapine in Participants With Schizophrenia

Schizophrenia

United States
Ondokuz Mayıs University

Recruiting

Bilateral Erector Spinae Plane Block for Postoperative Chronic Pain After Open Heart Surgery

Chronic Pain | Cardiac Surgery | Post Operative Pain

Turkey
Sanoculis Ltd

Not yet recruiting

Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy

Primary Open Angle Glaucoma | Open Angle Glaucoma
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Recruiting

Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial

Cesarean Section Complications | Cesarean Section; Dehiscence | Uterine Bleeding | Uterus; Scar | Uterus Abnormal

Italy
Lantu Biopharma

Not yet recruiting

An Open-label Study of a Gene Therapy Product in Beta-Thalassemia

Beta-Thalassemia
Al-Razi Hospital

Not yet recruiting

Vastus Intermedius Dry Needling for Knee Stiffness Resulted From Surgically Managed Femoral Fractures With Open Reduction & Internal Fixation.

Femur Fracture
Studio Osteopatico Busto Arsizio

Recruiting

Open-label Placebo in Manual Therapy

Low Back Pain, Recurrent

Italy
Rigshospitalet, Denmark

Recruiting

Open Versus Laparoscopic Ablation of Liver Malignancies (OPTIMAL)

Hepatocellular Carcinoma | Cholangiocarcinoma | Liver Metastases

Denmark
Chinese University of Hong Kong

Not yet recruiting

Open and Closed Platform Robotic-assisted Versus Conventional Total Knee Arthroplasty

Knee Osteoarthritis | Total Knee Arthroplasty

Hong Kong
University of Southern Denmark

Not yet recruiting

Tissue Therapy of Transsphincteric Anal Fistula (REP-PAF)

Anal Fistula

Denmark
Central Arkansas Veterans Healthcare System
United States Department of Defense; University of Arkansas

Recruiting

DNA Methylation Markers in Veterans Exposed to Open Burn Pits

Open Burn Pit Exposure

United States
University of Minnesota

Recruiting

Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections

Open GI Surgery

United States

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