Search clinical trials for: Open-label trial

Total 42171 results

Universidade Federal de Goias

Unknown

TAmoxifen Versus LIdocaine Cream. A Randomized Clinical Trial for Reducing Pain and Discomfort During Mammography (TALI)

Pain | Discomfort

Brazil
University of Pittsburgh
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis

Cystic Fibrosis | Allergic Bronchopulmonary Aspergillosis

United States
Brigham and Women's Hospital

Completed

Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica) (LMR)

Sciatica | Radiculopathy

United States
Baxter Healthcare Corporation

Withdrawn

Open-label, Randomized Trial to Determine the Effect of Icodextrin Versus Dextrose (Dianeal 2.5%) in HOMA IR (ECOS)

End Stage Renal Disease | Continuous Ambulatory Peritoneal Dialysis

Colombia
Sunovion

Completed

Open-label Safety Study in Adults With ADHD

Adult Attention Deficit Hyperactivity Disorder

United States
KAI Pharmaceuticals

Terminated

Open-label Study to Assess the Long-term Safety and Efficacy of Etelcalcetide (Also Known as AMG 416 or KAI-4169) in Patients With Secondary Hyperparathyroidism

Secondary Hyperparathyroidism
The Medicines Company

Completed

Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH (BRAVO 2/3)

Transcatheter Aortic Valve Replacement | Aortic Valve Replacement | Severe Aortic Stenosis

Netherlands, Germany, United Kingdom, Canada, France, Italy, Switzerland
Novartis

Terminated

Open-label Trial of Imatinib Mesylate in Patients With Unresectable Recurrent Glioblastoma Multiforme Expressing PDGFR (Platelet Derived Growth Factor Receptors)

Glioblastoma

Brazil
Novartis Pharmaceuticals

Completed

Open-label Phase IV Clinical Trial to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastases

Prostate Cancer
Eyegate Pharmaceuticals, Inc.

Terminated

Open-label, Multli-center, Phase 1b/2a Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients With Macular Edema

Macular Edema

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery

Pain | Unspecified Adult Solid Tumor, Protocol Specific

United States
Amgen

Completed

AMG 172 First in Human Study in Patients With Kidney Cancer

Renal Cell Carcinoma | Clear Cell Renal Cell Carcinoma | Clear Cell Renal Carcinoma | Renal Cell Adenocarcinoma

France, United States, Germany
Huons Co., Ltd.

Completed

Trial to Evaluate the Efficacy on Local Anesthesia and Safety of 2% Lidocaine HCl With Different Epinephrine Concentration in Patients Undergoing Surgical Extraction of Impacted Lower Third Molars

Third Molar

Korea, Republic of
Otsuka Pharmaceutical Co., Ltd.

Completed

Open-label Dose-finding Trial of OPC-41061 in Patients With Chronic Renal Failure Undergoing Peritoneal Dialysis

Chronic Renal Failure

Japan
Central European Cooperative Oncology Group

Completed

Open-label Trial of GlivecWith Unresectable or Metastatic Malignant Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Tumors

Croatia, Bosnia and Herzegovina, Romania, Slovakia, Bulgaria, Czech Republic, Austria, Lithuania, Serbia, Slovenia
Northwell Health

Terminated

An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease

Parkinson's Disease

United States
Tong Lee

Completed

Open-label, Normal Healthy Volunteer Clinical Trial of a Novel Ondansetron Formulation

Healthy

United States
Midwest Vein Center

Unknown

Efficacy of Variable Lidocaine Concentrations in Tumescent Anesthesia for Pain Control During and After Endovenous Laser Procedure; Non-inferiority Trial

Pain During and After Endovenous Laser Obliteration of Large Saphenous Vein Based on Lidocaine Tumescent Concentration

United States
University of Erlangen-Nürnberg Medical School
German Research Foundation; University Hospital, Essen; Wuerzburg University... and other collaborators

Unknown

Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination (B-cell therapy)

Acute Myeloid Leukemia | Multiple Myeloma | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Aplastic Anemia | Non Hodgkin's Lymphoma | Hodgkin's Disease

Germany
Genzyme, a Sanofi Company

Terminated

Open-label Trial of Leukine in Active Crohn's Disease

Crohn Disease

Switzerland, United States, New Zealand, Canada, Australia, Brazil, United Kingdom, Ukraine, Russian Federation, Argentina
Boehringer Ingelheim

Completed

Open-label Follow-up Trial of Fixed Dose Combination of Telmisartan + Hydrochlorothiazide in Hypertensive Patients

Hypertension

France, Switzerland, Italy, Germany, Hong Kong, Netherlands, South Africa, Spain, Denmark, Sweden, Finland, Ireland, Korea, Republic of, Malaysia, Norway, Taiwan
Ingalls Memorial Hospital

Unknown

Regenecare® Wound Gel in Treating Rash in Patients Receiving Cetuximab or Other Epidermal Growth Factor Receptor Inhibitor Therapy for Cancer

Unspecified Adult Solid Tumor, Protocol Specific | Dermatologic Complications

United States
Fiechtner, Justus J., M.D., P.C.

Completed

Open-label Trial of Acthar Gel in Subjects With Moderate to Severe Active Systemic Lupus Erythematosus (ACTH)

Lupus Erythematosus Systemic Exacerbation

United States
Lumara Health, Inc.

Completed

Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort

Vulvodynia

United States, Canada
AstraZeneca

Completed

A Clinical Trial to Compare Efficacy and Tolerability of Fulvestrant 250mg, 250mg (Plus 250mg Loading Regimen) and 500mg (FINDER I)

Advanced Breast Cancer | Metastatic Breast Cancer

Japan
Novartis Pharmaceuticals

Completed

Open-label Trial on the Effect of I.V. Zoledronic Acid 4 mg on Bone Density in Hormone Sensitive Prostate Cancer Patients With Bone Metastasis

Prostate Cancer

United States
Fudan University

Not yet recruiting

Enhanced vs. Routine Follow-Up After Total Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial

Quality of Life | Gastric Cancer | Postoperative Care | Follow-up | Total Gastrectomy
Ohio State University
Patient-Centered Outcomes Research Institute; Northwestern University; Preeclampsia...

Not yet recruiting

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL (ASPIRIN)

Preeclampsia | Gestational Hypertension | Hypertensive Disorders of Pregnancy

United States
Assiut University

Recruiting

Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis

Acute Radiation Enteritis | Acute Radiation Proctitis

Egypt
University of East Anglia
Clinical Research and Trials Unit (Norfolk & Norwich University Hospital,...

Recruiting

The Role of SGLT2i in Management of Moderate AS

Moderate Aortic Valve Stenosis

United Kingdom
BioNTech SE

Not yet recruiting

A First-in-human Safety Trial of BNT331 Administered as Single Ascending Doses in Healthy Women and as Multiple Ascending Doses in Women Diagnosed With Bacterial Vaginosis

Bacterial Vaginosis

United States
Mikko Niemi
University of Helsinki

Recruiting

KF2023#1-Trial: Influence of Statin Intake on Cellular Readouts

Pharmacodynamics

Finland
Timothy Poterucha
Pfizer; American Heart Association; Eidos Therapeutics, a BridgeBio company

Recruiting

Cardiac Amyloidosis Discovery Trial

Cardiac Amyloidosis

United States
Kors van der Ent
European Union

Recruiting

Clinical Trial to Evaluate the Efficacy and Safety of Dirocaftor/Posenacaftor/Nesolicaftor in Adults With CF (CHOICES)

Cystic Fibrosis

Netherlands, Spain, France, Germany, Italy, United Kingdom, Portugal, Belgium, Sweden
Fundacion Miguel Servet

Recruiting

Effect of a Multicomponent Exercise Program With Virtual Reality (MEP-VR) vs Standard Approaches on Functional and Cognitive Domains in Hospitalized Geriatric Patients: Study Protocol for a Randomized Controlled Trial. (MEP-VR)

Frailty | Hospital Acquired Condition

Spain
First Affiliated Hospital of Xinjiang Medical University

Not yet recruiting

Efficacy of Local Antibiotic Injection Via a Catheter for Treating Acute Periprosthetic Infections After Knee DAIR Surgery (YES)

Local Antibiotic Injection Catheter Acute Periprosthetic Infections Knee DAIR Randomized Controlled Trial
Casa di Cura Dott. Pederzoli
University of Padova

Recruiting

First-day Versus Early Drain Removal Following PD: a Randomized Controlled Trial (FIDEL)

Pancreas Fistula Abdominal Drains

Italy
Assuta Ashdod Hospital

Not yet recruiting

Oxytocin Effectiveness in First Trimester Dilatation and Curettage - a Double Blind Placebo Controlled Randomized Trial

Missed Abortion
Regeneron Pharmaceuticals

Not yet recruiting

A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

Fallopian Tube Cancer | Epithelial Ovarian Cancer | Primary Peritoneal Carcinoma

United States
Luye Pharma Group Ltd.

Recruiting

Phase II Clinical Trial to Evaluate the Efficacy and Safety of LPM3480392 Injection for Moderate to Severe Pain After Orthopedic Surgery

Pain, Postoperative

China
Ruijin Hospital

Recruiting

A Trial on the Recurrence Free Survival Rate of Type I AIP With High-risk of Recurrence

Type 1 AIP

China
Shanghai Simnova Biotechnology Co.,Ltd.

Not yet recruiting

F01 in the Treatment of Moderate-to-severe Refractory Systemic Lupus Erythematosus

Lupus Erythematosis

China
University of Birmingham
Université d'Abomey-Calavi; Kigali University Teaching Hospital

Not yet recruiting

A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI (MARLIN)

Surgical Site Infection

South Africa, Ghana, Benin, India, Mexico, Nigeria, Rwanda
Luca Brazzi
A.O.U. Città della Salute e della Scienza - Molinette Hospital

Not yet recruiting

Videolaryngoscopy vs Direct Laryngoscopy for Double Lumen Tube Lumen Tube Placement - A Multicentre Randomized-controlled Trial (VOLCANO Study) (VOLCANO)

Intubation Complication | One Lung Ventilation
4C Medical Technologies, Inc.

Not yet recruiting

AltaValve Pivotal Trial

Mitral Regurgitation | Mitral Valve Regurgitation | Mitral Valve Incompetence | Mitral Insufficiency | Mitral Incompetence
Quiropraxia y Equilibrio

Not yet recruiting

High-intensity Laser Therapy and Stretching Exercises for Chronic Non-specific Neck Pain

Chronic Non-specific Neck Pain

Chile
Longevity Biotech Australia Pty Ltd (subsidiary)

Not yet recruiting

A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Participants and in Participants With Parkinson's Disease.

Parkinson Disease

Australia
The University of Hong Kong

Not yet recruiting

Supportive Clinic for Patients Living With Advanced and Metastatic Cancers

Cancer | Physical Symptom Distress

Hong Kong
Juan M. Ramos Acevedo

Not yet recruiting

Puerto Rico Embolization of the Middle Meningeal Artery for the Treatment of Chronic Subdural Hematoma Trial (PREMMA) (PREMMA)

Chronic Subdural Hematoma
KalVista Pharmaceuticals, Ltd.

Not yet recruiting

Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II (KONFIDENT-KID)

Hereditary Angioedema

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