Search clinical trials for: Resistance mechanism

Total 102554 results

University of Nottingham
University of Oxford

Recruiting

Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune) (Rapamune)

Muscle Atrophy | Age-Related Sarcopenia

United Kingdom
Universitas Sebelas Maret

Not yet recruiting

KurCoSmart Effects on People With Type 2 DM

Inflammation | Diabetes Mellitus, Type 2 | Body Weight | Insulin Resistance

Indonesia
Alice Mims
National Cancer Institute (NCI)

Recruiting

IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)

Acute Myeloid Leukemia

United States
Jonsson Comprehensive Cancer Center

Recruiting

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

Castration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IVA Prostate Cancer AJCC v8 | Stage IVB Prostate Cancer AJCC v8 | Stage IV Prostate Cancer American Joint Committee on Cancer (AJCC) v8

United States
Laekna Limited

Recruiting

Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1

Cervical Cancer | Esophageal Cancer | NSCLC | Solid Tumor | Endometrial Cancer | Gastric and Gastroesophageal Junction Adenocarcinoma

China
M.D. Anderson Cancer Center

Recruiting

A Phase II Study of the Combination of Azacitidine and Pembrolizumab for Patients Relapsed/Refractory Hodgkin's Lymphoma

Hodgkin's Lymphoma

United States
Beijing Anzhen Hospital

Recruiting

The Efficacy of SGLT-2 Inhibitor in Patients With CAD and DM Undergoing PCI.

Coronary Artery Disease | Diabete Mellitus

China
Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Mechanisms of Diuretic Resistance in Heart Failure, Aim 1 (MsDR)

Heart Failure

United States
Xiaojun Chen

Recruiting

GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients

Atypical Endometrial Hyperplasia | Endometrial Neoplasms | Progesterone Resistance

China
Roswell Park Cancer Institute

Recruiting

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

Plasma Cell Myeloma | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Smoldering Plasma Cell Myeloma

United States
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

Metastatic Colon Adenocarcinoma | Metastatic Rectal Adenocarcinoma | Stage III Colon Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage IV Colon Cancer AJCC v8 | Stage IV Rectal Cancer AJCC v8 | Unresectable Colon Adenocarcinoma | Unresectable Rectal Adenocarcinoma

United States, Puerto Rico
University of Copenhagen
Rigshospitalet, Denmark

Recruiting

Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms (PANACEA)

Neoplasms | Quality of Life | Insulin Resistance | Exercise | Body Composition | Sarcopenia | Cachexia | Physical Functional Performance | Muscle, Skeletal | Patient Reported Outcome Measures | Gastrointestinal Microbiome | Metabolism | Caregivers | Adipose Tissue | Proteomics | Mitochondria | Lipidomics | Epigenomics

Denmark
Dr. Ronnie Shapira

Not yet recruiting

Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma (MK3475-C01)

Metastatic Melanoma | Malignant Melanoma | Immunotherapy | Malignant Melanoma Stage IV | BRAF V600E
McGill University Health Centre/Research Institute...

Recruiting

Empagliflozin in Acute Heart Failure (DRIP-AHF-1)

Chronic Kidney Diseases | Acute Heart Failure

Canada
University of Washington

Recruiting

SpeeDx Ciprofloxacin gyrA Assay for N. Gonorrhoeae Gonococcal Infection

Neisseria Gonorrhoeae Infection

United States
Genelux Corporation
GOG Foundation

Recruiting

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Fallopian Tube Cancer | Platinum-resistant Ovarian Cancer | Platinum-refractory Ovarian Cancer | Primary Peritoneal Cancer | High-grade Serous Ovarian Cancer | Endometrioid Ovarian Cancer | Ovarian Clear Cell Carcinoma

United States
Fudan University
Merck Sharp & Dohme LLC

Recruiting

Pembrolizumab Plus Chemo in Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma (Eastern Cooperative Thoracic Oncology Projects 2004, ECTOP-2004) (HYPERION)

Esophageal Squamous Cell Carcinoma

China
Second Affiliated Hospital, School of Medicine,...

Recruiting

Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis

Keratitis, Ulcerative | Antibiotic Resistance, Microbial | Photothermal Therapy

China
Black Diamond Therapeutics, Inc.

Recruiting

Phase 1/2 Study of BDTX-1535 in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations

Non-Small Cell Lung Cancer | NSCLC | Metastatic Lung Cancer | Metastatic Lung Non-Small Cell Carcinoma | EGF-R Positive Non-Small Cell Lung Cancer | Advanced Lung Carcinoma | EGFR-TKI Resistant Mutation | Advanced Non-Small Cell Squamous Lung Cancer | Epidermal Growth Factor Receptor C797S | Epidermal...

United States
University Hospital, Clermont-Ferrand

Recruiting

Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia (RAVEN)

Chronic Lymphocytic Leukemia | Refractory Chronic Lymphocytic Leukemia | CLL | Relapsed Chronic Lymphocytic Leukemia | Progressive Chronic Lymphocytic Leukemia

France
University of Alberta

Recruiting

Extended-Release Tacrolimus Following Liver Transplantation

Cardiovascular Diseases | Renal Insufficiency | Metabolic Syndrome | Liver Transplant; Complications | Immunosuppressant Adverse Reaction

Canada
Pfizer
Eli Lilly and Company; Merck Sharp & Dohme LLC; Merck KGaA, Darmstadt, Germany

Recruiting

A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (SEAMARK)

Metastatic Colorectal Cancer

United States, Denmark, Spain, Australia, France, Italy, Belgium, Slovakia, Canada, Czechia, Germany, Netherlands, Norway, Poland, Sweden, United Kingdom
University of Oregon

Recruiting

Histamine as a Molecular Transducer of Adaptation to Exercise

Postexercise Hypotension

United States
Ruijin Hospital

Recruiting

Mechanism of Resistance to GNC-038 in Relapsed and Refractory Diffuse Large B-cell Lymphoma

Diffuse Large B Cell Lymphoma

China
Li Zhang, MD

Recruiting

Ensatinib Treat Second-generation ALK-TKI Resistance After Second-generation ALK-TKI Resistance (ERSGATR)

The Diagnosis Was ALK Positive NSCLC | Second Generation ALK-TKI is Resistant | Efficacy of Ensatinib in This Subset of Patients

China
Yonsei University

Not yet recruiting

Dual Antiplatelet Therapy in Patients With Clopidogrel Resistance Following Off-Pump Coronary Artery Bypass

Multi Vessel Coronary Artery Disease

Korea, Republic of
Stanford University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

Obesity | Diabetes Mellitus, Type 2 | Insulin Resistance | PreDiabetes | Diet Modification | Nonalcoholic Steatohepatitis | Nonalcoholic Fatty Liver

United States
Lithuanian Sports University
Kappa Bioscience AS; LSMU Kauno ligonine

Not yet recruiting

Vitamin K2 Supplements for Muscle Recovery (Recovery)

Cachexia | Muscle Atrophy

Lithuania
Assiut University

Not yet recruiting

Prevalence of Aspirin Resistance in Ischemic Stroke Patients at Assiut University Hospital

Ischemic Stroke

Egypt
University of Medicine and Pharmacy Craiova
Institutul Clinic Fundeni

Recruiting

"Mechanisms and Biomarkers of Response and Resistance to Current Targeted Therapies in Gastric Cancer" (THERRES) (THERRES)

Gastric Cancer

Romania
Eunice Kennedy Shriver National Institute of Child...

Recruiting

Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity

Inflammation | Obesity | Insulin Resistance

United States
Sheba Medical Center
Race Oncology Ltd

Recruiting

Bisantrene Combination for Resistant AML

Myelogenous Leukemia, Acute

Israel
Rennes University Hospital

Recruiting

Mechanisms fo Clopidogrel Resistance in Older Adults (CEPAGE) (CEPAGE)

Drug Resistance

France
Shanghai Pulmonary Hospital, Shanghai, China
Chinese Academy of Sciences

Not yet recruiting

Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy

Small Cell Lung Cancer

China
Peking University Third Hospital

Recruiting

The Interaction and Regulation Mechanism of Different Exercise Patterns With Metabolic Syndrome and Related Metabolic Diseases

Obesity | Metabolic Syndrome

China
Shanghai Chest Hospital

Recruiting

Analysis of Drug Resistance in Immune Checkpoint Inhibitors of Non-small Cell Lung Cancer

Non-Small Cell Lung Cancer

China
AstraZeneca

Recruiting

Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6) (SERENA-6)

ER-Positive HER2-Negative Breast Cancer

United States, Israel, Spain, Korea, Republic of, Italy, Poland, Belgium, Norway, Bulgaria, France, Germany, United Kingdom, Japan, Taiwan, Canada, Hungary, Australia, Austria, Portugal, Turkey, Russian Federation, Slovakia, Switzer...
Chelsea and Westminster NHS Foundation Trust

Recruiting

The Effect of Biktarvy (B/F/TAF) on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers

HIV-1-infection

United Kingdom
University of Luebeck
University Hospital Tuebingen; University of Giessen; University Hospital Freiburg and other collaborators

Recruiting

Monitoring of MDRO Dynamics and Resistance Mechanisms in a University Hospital Network (R-Net)

MDRO

Germany
University of Kansas Medical Center

Recruiting

Mitigating the Pro-inflammatory Phenotype of Obesity (MAPLE)

Obesity | Diabetes | Insulin Resistance | Blood Pressure | Diuretics Drug Reactions | Sympathetic Nerve Activity

United States
University of Aarhus
Aarhus University Hospital; Aalborg University Hospital; The University of Queensland

Recruiting

Mechanisms Behind Severe Insulin Resistance During Pregnancy in Women With Glucose Metabolic Disorders (SIR-MET)

Diabetes Mellitus, Type 2 | Insulin Resistance | Pregnancy, High Risk | Overweight and Obesity | Insulin Sensitivity | Gestational Diabetes | Pregnancy in Diabetic

Denmark
MEDSI Clinical Hospital 1, ICU

Recruiting

Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria

Respiratory Tract Infections | Pneumonia | Sepsis | Critical Illness | Respiratory Distress Syndrome | Pneumonia, Ventilator-Associated | Bloodstream Infection

Russian Federation
Massachusetts General Hospital
AbbVie

Recruiting

Venetoclax + Azacitidine vs. Induction Chemotherapy in AML

Acute Myeloid Leukemia

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With Relapsed Refractory Multiple Myeloma, The SCOPE Trial

Refractory Multiple Myeloma | Recurrent Multiple Myeloma

United States
University of California, San Francisco

Recruiting

Antibiotic Resistance In Eye Surgeries (ARIES)

Antibiotic Resistance | Ocular Surface Microbiome | Gut Resistome

United States
Henan Cancer Hospital

Recruiting

Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma

Primary Central Nervous System Lymphoma

China
Aretaieion University Hospital

Recruiting

Treatment of Pulmonary Hypertension in High-risk Cardiac Surgery Patients Using Inhalational and Intravenous Agents (levos-milr)

Hypertension, Pulmonary | Pulmonary Vascular Resistance Abnormality | Cardiac Failure

Greece
University of Kansas Medical Center

Recruiting

Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)

Cardiovascular Diseases | Hypertension

United States
Associazione Italiana Pazienti Leucemia Mieloide...

Not yet recruiting

Cardiovascular Assessment of Ponatinib as Third Line Treatment in Chronic Phase Chronic Myeloid Leukemia (CarPAs)

Chronic Myeloid Leukemia (CML)

Italy
Shanghai Pulmonary Hospital, Shanghai, China
Chinese Academy of Sciences

Recruiting

Combined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy

Small Cell Lung Cancer

China

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