Search clinical trials for: digitoxin

Total 203 results

Boehringer Ingelheim

Completed

The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

Healthy

Germany
Zagazig University

Completed

Lidocaine Versus Esmolol for Optimizing Surgical Field Visibility

Lumbar Disc Herniation

Egypt
Astellas Pharma Europe B.V.

Completed

Study to Evaluate the Effect of Solifenacin and Mirabegron on the Digoxin Concentrations in Blood in Healthy Subjects

Healthy Subjects | Pharmacokinetics | Drug-Drug Interaction (DDI)

Germany
Boehringer Ingelheim

Completed

Transporter Cocktail Mutual Interaction

Healthy

Germany
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Drug-Drug Interaction Study of Evobrutinib and Transporter Substrates

Healthy

Germany
Turning Point Therapeutics, Inc.

Recruiting

A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors

Advanced Solid Tumor | Metastatic Solid Tumor

United States
AstraZeneca
Parexel

Completed

A Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Digoxin, Rosuvastatin, Metformin, and Furosemide in Healthy Male Subjects

Healthy Male Subjects

Germany
Nantes University Hospital

Recruiting

Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation (EDearly AF)

Atrial Fibrillation

France
Karolinska Institutet

Completed

Kinetics of Fluvoxamine and Digoxin in Subjects With Different MDR1 Genotypes

Depression

Sweden
Reata, a wholly owned subsidiary of Biogen
Covance

Completed

A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone

Healthy Adult Subjects

United States
Boehringer Ingelheim

Recruiting

A Study to Compare How Different Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Handled by the Body of Healthy People and People With Liver Cirrhosis

Liver Cirrhosis

Germany
Boehringer Ingelheim

Withdrawn

Effect of BI 1181181 on Midazolam, Warfarin, Omeprazole and Digoxin

Healthy

Germany
Eli Lilly and Company
Loxo Oncology, Inc.

Not yet recruiting

A Drug-Drug Interaction Study of LY3537982 on Midazolam, Digoxin, and Rosuvastatin in Healthy Participants

Healthy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)

Heart Diseases | Cardiovascular Diseases | Atrial Fibrillation | Arrhythmia
AstraZeneca
Parexel

Completed

A Study to Assess the Effect of AZD5462 on the Pharmacokinetics of Midazolam, Rosuvastatin and Digoxin

Healthy Participants

United States
Nanjing First Hospital, Nanjing Medical University

Completed

Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure (PADN-5)

Pulmonary Hypertension

China
Wuhan University
West China Hospital; Guangdong Provincial People's Hospital; Shanghai Chest Hospital and other collaborators

Unknown

Catheter Ablation Versus Antiarrythmic Drugs for Atrial Fibrillation in China

Atrial Fibrillation

China
Eccogene

Recruiting

ECC5004 DDI Study With Atorvastatin, Rosuvastatin, Digoxin and Midazolam in Healthy Participants

Type 2 Diabetes Mellitus

United States
Seagen Inc.

Completed

A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib

Drug-drug Interaction

United States
DICE Therapeutics, Inc., a wholly owned subsidiary...

Completed

A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants

Healthy Participants

United States
Boehringer Ingelheim

Completed

A Study in Healthy People to Test Whether BI 730357 Affects How 4 Other Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Taken up in the Body

Healthy

Germany
Ironwood Pharmaceuticals, Inc.

Completed

Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers

Healthy Volunteers

United States
Boehringer Ingelheim

Completed

Interaction of BI 425809 With Midazolam, Warfarin, Omeprazole and Digoxin

Healthy

Germany
Altimmune, Inc.

Completed

ALT-801 DDI Study in Healthy Volunteers

NASH - Nonalcoholic Steatohepatitis

Australia
Alios Biopharma Inc.

Completed

A Drug-Drug Interaction Study to Evaluate the Effect of AL-794 on the Pharmacokinetics of Oseltamivir and JNJ-63623872

Influenza in Humans

United Kingdom
Radboud University Medical Center

Completed

Phenotyping of High Dose Rifampicin (PHENORIF)

Tuberculosis

South Africa
Tesaro, Inc.

Completed

An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects

Chemotherapy-induced Nausea and Vomiting

United States
Jiangxi Qingfeng Pharmaceutical Co. Ltd.

Completed

A Study to Evaluate the Drug-drug Interactions (DDIs) of GP681 With Rosuvastatin, Digoxin, Itraconazole, Oseltamivir in Chinese Healthy Volunteers

Healthy Volunteers

China
Bristol-Myers Squibb

Completed

A Phase 1 Drug-drug Interaction Study in Healthy Volunteers (DDI)

Drug-drug Interaction Study

United States
Jacobio Pharmaceuticals Co., Ltd.

Recruiting

A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects

Healthy Subjects

China
Bristol-Myers Squibb

Completed

Study to Investigate the Effect of BMS-986142 on the Pharmacokinetics (PK) of Methotrexate and Probe Substrate Cocktail in Healthy Patients

Rheumatoid Arthritis
Guangdong Raynovent Biotech Co., Ltd

Completed

Drug-durg Interaction of ZSP1273 With Digoxin, Rosuvastatin,Itraconazole and Probenecid

Drug Drug Interaction

China
Alexion Pharmaceuticals
Celerion; Achillion, a wholly owned subsidiary of Alexion

Completed

A Drug Interaction Study of ACH-0145228

Healthy

United States
Takeda

Completed

Drug-Drug Interaction Study Between TAK-272 and Itraconazole, Digoxin or Midazolam

Japanese Healthy Adult Males

Japan
Eli Lilly and Company

Recruiting

A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants

Healthy | Overweight | Obese

United States
University of Nebraska
National Cancer Institute (NCI)

Recruiting

FOLFIRINOX With Digoxin in Patients With Resectable Pancreatic Cancer

Pancreas Cancer | Adenocarcinoma of the Pancreas

United States
Juan A. Arnaiz

Unknown

Cost-effectiveness of Different Antiretroviral Treatment in Patients HIV Naive

Patient Compliance | Antiretroviral Therapy Intolerance

Spain
Icahn School of Medicine at Mount Sinai
National Heart, Lung, and Blood Institute (NHLBI); Canadian Institutes of Health... and other collaborators

Completed

Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation

Postoperative Atrial Fibrillation

United States, Canada
Intarcia Therapeutics

Completed

Study of the Effects of ITCA 650 on Gastric Emptying and Interaction of ITCA 650 on 4 Commonly Studied Drugs

Healthy

United States
Jemincare

Not yet recruiting

Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects

Solid Tumor, Adult
ViiV Healthcare

Completed

Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults

HIV Infections

United States
Global Alliance for TB Drug Development

Completed

A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults

Tuberculosis | Tuberculosis, Pulmonary | Pulmonary Disease | Multi Drug Resistant Tuberculosis | Drug Sensitive Tuberculosis | Drug-resistant Tuberculosis | Mycobacterium Tuberculosis Infection

United States
Celgene

Completed

A Study to Evaluate the Effect of Multiple Doses of CC-90001 on the Pharmacokinetics of Omeprazole, Midazolam, Warfarin, Rosuvastatin, Metformin, Digoxin, and Nintedanib in Healthy Adult Subjects

Heathy Volunteer

United States
Maastricht University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Acute Cardioversion Versus Wait And See-approach for Symptomatic Atrial Fibrillation in the Emergency Department (RACE 7 ACWAS)

Atrial Fibrillation

Netherlands
Bristol-Myers Squibb

Completed

A Study to Assess the Drug Levels of CC-92480 After Coadministration With Rifampin and Itraconazole, and the Drug Levels of Digoxin and Rosuvastatin After Coadministration With CC-92480 in Healthy Participants

Healthy Volunteers

United States
Mirati Therapeutics Inc.

Completed

PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates

Advanced Solid Tumor

United States
GlaxoSmithKline

Completed

Drug-drug Interaction Study of Gepotidacin

Infections, Bacterial

United States
Eli Lilly and Company

Completed

A Study of Imlunestrant (LY3484356) in Female Healthy Participants

Healthy

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Drug-drug Interaction Potential of BMS-986196 in Healthy Participants

Healthy Volunteers

United States
Boehringer Ingelheim

Completed

Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers

Healthy

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