Clinical Trials Sponsored by ADC Therapeutics

Total 7421 results

Kamau Therapeutics

Recruiting

Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease (RESTORE)

Sickle Cell Disease

United States
Cartesian Therapeutics

Recruiting

Descartes-08 Consolidation Treatment in Patients With High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy

Myeloma Multiple

United States
Amicus Therapeutics

Recruiting

A Study to Evaluate the Safety, Efficacy, PK, PD and Immunogenicity of Cipaglucosidase Alfa/Miglustat in IOPD Subjects Aged 0 to <18 (ROSSELLA)

Glycogen Storage Disease Type II Infantile Onset

United States, Taiwan, France, Germany, Italy, United Kingdom
AKARI Therapeutics

Recruiting

Nomacopan (rVA576) in Transplant Associated Thrombotic Microangiopathy

Thrombotic Microangiopathies

United States, United Kingdom, Poland
Catapult Therapeutics

Recruiting

CAP-100 for Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia

Lymphocytic Leukemia, Chronic | SLL

United States, Spain
MitoImmune Therapeutics

Recruiting

MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients (MIT-001)

Head and Neck Squamous Cell Carcinoma | Oral Mucositis

Korea, Republic of, United States
Aligos Therapeutics

Recruiting

A Study of ALG-000184 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects

Chronic Hepatitis B

Hong Kong, China, United Kingdom, Moldova, Republic of, New Zealand, Australia, Mauritius
Lykos Therapeutics

Not yet recruiting

A Multi-Site Study of MDMA-Assisted Psychotherapy for Eating Disorders (MED1)

Binge-Eating Disorder | Anorexia Nervosa Restricting Type
ImCheck Therapeutics

Recruiting

First-in-Human Study of ICT01 in Patients With Advanced Cancer (EVICTION)

Hematopoietic/Lymphoid Cancer | Solid Tumor, Adult

France, Belgium, United States, Germany, Spain, United Kingdom
Cartesian Therapeutics

Recruiting

Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)

Myasthenia Gravis, Generalized

United States, Canada
Dragonfly Therapeutics

Recruiting

Study of DF1001 in Patients With Advanced Solid Tumors

Solid Tumor, Adult

United States, Denmark, Netherlands, Belgium, France
Tarveda Therapeutics

Recruiting

PEN-866 in Patients With Advanced Solid Malignancies

Neoplasms | Carcinoma | Small Cell Lung Carcinoma | Gastric Cancer | Pancreatic Adenocarcinoma | Solid Tumor | Gastric Adenocarcinoma | Small-cell Lung Cancer | Advanced Cancer | Pancreatic Ductal Adenocarcinoma | Adenocarcinoma of the Pancreas | Endometrial Adenocarcinoma | Squamous Cell Carcinoma of the Penis | Gastroesophageal... and other conditions

United States
United Therapeutics

Enrolling by invitation

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Cardiovascular Diseases | Vascular Diseases | Lung Diseases | Hypertension | Connective Tissue Diseases | Pulmonary Arterial Hypertension | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary | Pulmonary Hypertension | PAH | Respiratory Tract Disease

United States, Spain, Australia, Taiwan, Canada, Singapore, United Kingdom, Italy, Germany, China, Mexico, Argentina, Korea, Republic of, Austria, Greece, Sweden, Portugal, Belgium, Brazil, Bulgaria, Chile, Croatia, Czechia, Denmark, Fr... and more
United Therapeutics

Enrolling by invitation

Extension Study of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis (TETON-OLE)

Idiopathic Pulmonary Fibrosis | Interstitial Lung Disease

United States, Spain, Australia, Taiwan, Israel, Korea, Republic of, Italy, Belgium, France, Argentina, Chile, Denmark, Mexico
Beacon Therapeutics

Active, not recruiting

Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (HORIZON)

X-Linked Retinitis Pigmentosa

United States
Monopar Therapeutics

Terminated

Camsirubicin + Pegfilgrastim to Determine MTD in ASTS

Advanced Soft-tissue Sarcoma

United States
PTC Therapeutics

Active, not recruiting

Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS (CARDINALS)

Amyotrophic Lateral Sclerosis

United States, Belgium, Spain, Australia, Germany, Italy, Czechia, France, Netherlands, Japan, Poland, Argentina, Sweden
Nektar Therapeutics

Completed

Study of NKTR 255 in Combination With Cetuximab in Solid Tumors

Cervical Cancer | Colorectal Cancer | Head and Neck Squamous Cell Carcinoma | Anal Squamous Cell Carcinoma | Cutaneous Squamous Cell Carcinoma

United States
Karuna Therapeutics

Enrolling by invitation

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Psychosis Associated With Alzheimer's Disease

United States
PTC Therapeutics

Enrolling by invitation

A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease

Inherited Mitochondrial Disease

United States, France, Spain, United Kingdom, Italy, Poland, Japan
Mahana Therapeutics

Completed

Mahana Tinnitus Pilot

Tinnitus

United States
Lykos Therapeutics

Completed

A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD (MAPPUSX)

PTSD

United States, Canada, Israel
Tempest Therapeutics

Active, not recruiting

Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors

Colorectal Cancer | Solid Tumor | Gastric Adenocarcinoma | Non Small Cell Lung Cancer | Squamous Cell Carcinoma of Head and Neck | Endometrial Cancer | Urothelial Carcinoma | Gastroesophageal Junction Adenocarcinoma | Solid Tumors With PIK3Ca Mutation

United States
Sangamo Therapeutics

Enrolling by invitation

Long-Term Follow-up of Subjects Who Were Treated With ST-920

Fabry Disease | Fabry Disease, Cardiac Variant

United States, Australia, United Kingdom
Therapeutics, Inc.

Completed

Safety, Tolerability, and Pharmacokinetics of UHE-103 Cream in Subjects With Tinea Cruris and/or Tinea Pedis

Tinea Pedis | Tinea Cruris

United States
Sangamo Therapeutics

Enrolling by invitation

Long-Term Follow-Up of TX200-TR101 (STEADFAST Long Term)

End Stage Renal Disease | Kidney Transplant Rejection

Belgium, Netherlands, United Kingdom
Amicus Therapeutics

Active, not recruiting

First-In-Human Study to Evaluate Safety, Tolerability, and PK of Intravenous ATB200 Alone and When Co-Administered With Oral AT2221

Pompe Disease

United States, Netherlands, United Kingdom, Australia, Germany, New Zealand
PTC Therapeutics

Completed

A Study to Evaluate the Safety and Pharmacokinetics of Ataluren in Participants From ≥6 Months to <2 Years of Age With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD)

Nonsene Mutation Duchenne Muscular Dystrophy

United States
Beacon Therapeutics

Active, not recruiting

A Study Comparing Two Doses of AGTC-501 in Male Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (SKYLINE)

X-Linked Retinitis Pigmentosa

United States
Celldex Therapeutics

Active, not recruiting

A Study of CDX-0159 in Patients With Chronic Inducible Urticaria

Chronic Inducible Urticaria

United States, Latvia, Spain, Poland, Georgia, South Africa, Germany, Lithuania, Estonia, Hungary, Bulgaria
Celldex Therapeutics

Active, not recruiting

A Phase 2 Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria

Spain, United States, Poland, Georgia, South Africa, Bulgaria, Hungary, Estonia, Germany
Karuna Therapeutics

Enrolling by invitation

An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

Schizophrenia

United States, Bulgaria, Serbia
Beacon Therapeutics

Enrolling by invitation

A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)

X-Linked Retinitis Pigmentosa

United States
Band Therapeutics

Completed

A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers

Intracranial Arteriosclerosis | Cerebrovascular Stroke | Large-Artery Atherosclerosis (Embolus/Thrombosis)

Austria
Intrinsic Therapeutics

Active, not recruiting

A Post Marketing Surveillance Study (6MM)

Lumbar Disc Herniation | Annular Disc Tear | Annular Tear of Lumbar Disc

Belgium, Germany
PTC Therapeutics

Completed

A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy (MIT-E)

Mitochondrial Diseases | Drug Resistant Epilepsy | Leigh Disease | Leigh Syndrome | Mitochondrial Encephalopathy (MELAS) | Pontocerebellar Hypoplasia Type 6 (PCH6) | Alpers Disease | Alpers Syndrome

United States, Spain, United Kingdom, Canada, France, Italy, Poland, Sweden, Japan
TCR2 Therapeutics

Active, not recruiting

A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer

Colorectal Neoplasms | Colorectal Cancer | Pancreatic Neoplasms | Pancreatic Cancer | Pancreatic Adenocarcinoma | Ovarian Neoplasms | Ovarian Cancer | Non Small Cell Lung Cancer | Mesothelioma | Mesothelioma, Malignant | Cholangiocarcinoma | Triple Negative Breast Cancer | Ovarian Adenocarcinoma | Mesotheliomas Pleural and other conditions

United States
Spero Therapeutics

Completed

A Study to Evaluate the Effect of Co-administration on the Pharmacokinetics of SPR720, Azithromycin, and Ethambutol in Healthy Participants

Healthy Volunteers

United States
3DBio Therapeutics

Terminated

AuriNovo for Auricular Reconstruction

Microtia

United States
Aprea Therapeutics

Completed

APR-246 & Azacitidine for the Treatment of TP53 Mutant Myelodysplastic Syndromes (MDS)

MDS

United States, France
Lykos Therapeutics

Completed

MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder

Posttraumatic Stress Disorder

United States
Spark Therapeutics

Active, not recruiting

Long-term Follow-up Study in Subjects Who Received Voretigene Neparvovec-rzyl (AAV2-hRPE65v2)

Inherited Retinal Dystrophy Due to RPE65 Mutations
Spark Therapeutics

Completed

Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors

Hematologic Diseases | Blood Coagulation Disorders, Inherited | Coagulation Protein Disorders | Hemorrhagic Disorders | Genetic Diseases, Inborn | Genetic Diseases, X-Linked | Gene Therapy | Blood Coagulation Disorder | Gene Transfer | Adeno-Associated Virus (AAV) | Factor VIII (FVIII) | Factor VIII (FVIII)... and other conditions

United States
Corcept Therapeutics

Completed

Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)

Adrenocortical Carcinoma

United States
AKARI Therapeutics

Withdrawn

Nomacopan Therapy in Adult Patients With Bullous Pemphigoid Receiving Adjunct Oral Corticosteroid Therapy (ARREST-BP) (ARREST-BP)

Bullous Pemphigoid

United States, Germany, Netherlands, Poland
Adiso Therapeutics

Completed

An Investigation of Oral BT051 in Subjects With Moderately to Severely Active Ulcerative Colitis (UC) (SCOUT)

Ulcerative Colitis

United States, Georgia, Moldova, Republic of, Poland
SCAI Therapeutics

Completed

Clinical Trial to Evaluate the Safety and Efficacy of SCAI-001 Compared to Restasis

Dry Eye Syndromes

Korea, Republic of
Prelude Therapeutics

Terminated

PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies

Follicular Lymphoma | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Myeloproliferative Neoplasm | Small Lymphocytic Lymphoma | B-cell Non-Hodgkin Lymphoma

United States
Allergy Therapeutics

Completed

Efficacy and Safety of PQ Grass in Subjects With Seasonal Allergic Rhinitis and/or Rhinoconjunctivitis Induced by Grass Pollen

Seasonal Allergic Rhinitis | Rhinoconjunctivitis

United States, Germany, Austria, Hungary, Czechia, Poland
Lykos Therapeutics

Completed

Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder

Posttraumatic Stress Disorder

United States

Clinical Trials Sponsored by ADC Therapeutics

Sponsors and Collaborators

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