Clinical Trials Sponsored by Pacylex Pharmaceuticals

Total 19701 results

Regeneron Pharmaceuticals

Not yet recruiting

An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting (SPECTRUM-US)

Visual Impairment | Diabetic Macular Edema (DME) | Neovascular Age-related Macular Degeneration (nAMD) | Wet Age-related Macular Degeneration (AMD)
Alnylam Pharmaceuticals

Recruiting

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy (cAPPricorn-1)

Cerebral Amyloid Angiopathy

Canada
Ferring Pharmaceuticals

Not yet recruiting

A Phase 4, Multi-center, Open Label Trial to Evaluate Efficacy of Retreatment With Nadofaragene Firadenovec in Subjects With CIS ± High-grade Ta/T1 and no Complete Response to First Nadofaragene Firadenovec Dose (ABLE-42)

Bladder Cancer | CIS | Ta/T1
Regeneron Pharmaceuticals

Not yet recruiting

First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)

Amyotrophic Lateral Sclerosis (ALS) | Mutation in the Superoxide Dismutase-1 (SOD1) Gene
Regeneron Pharmaceuticals

Not yet recruiting

A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC) (ROXI-CATH)

Venous Thromboembolism
Vanda Pharmaceuticals

Recruiting

A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

Dry Eye

United States
Regeneron Pharmaceuticals

Not yet recruiting

A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis) (LINKER-AL2)

Relapsed/Refractory Systemic Light Chain Amyloidosis
Regeneron Pharmaceuticals

Not yet recruiting

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma

Melanoma
Regeneron Pharmaceuticals

Recruiting

A Trial to Learn How REGN5381 Works and How Safe it is in Adults With Heart Failure With Reduced Ejection Fraction (HFrEF)

Heart Failure

Moldova, Republic of
Arrowhead Pharmaceuticals

Recruiting

Study of ARO-CFB in Adult Healthy Volunteers and Patients With Complement-Mediated Kidney Disease

IgA Nephropathy

New Zealand
Lexicon Pharmaceuticals

Recruiting

A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP) (PROGRESS)

Diabetic Peripheral Neuropathic Pain

United States
Regeneron Pharmaceuticals

Not yet recruiting

A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma

Melanoma
Kariya Pharmaceuticals

Not yet recruiting

Phase I Study to Evaluate KP405 in Healthy and Parkinson's Disease Patients

Tolerance | Safety Issues
Regeneron Pharmaceuticals

Recruiting

A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery

Resectable Non-small Cell Lung Cancer

United States
Regeneron Pharmaceuticals

Not yet recruiting

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma (LINKER-MGUS1)

Monoclonal Gammopathy of Undetermined Significance (MGUS) | Smoldering Multiple Myeloma (SMM)
Intercept Pharmaceuticals

Not yet recruiting

Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Obeticholic Acid (OCA) Compared to Placebo in Pediatric Participants With Biliary Atresia, Post-hepatoportoenterostomy

Biliary Atresia
Jazz Pharmaceuticals

Recruiting

Pregnancy Surveillance Program of Patients Exposed to Epidiolex/Epidyolex During Pregnancy

Pregnancy | Pregnancy Complication | Maternal Complications | Birth Outcomes, Adverse

United States
X4 Pharmaceuticals

Not yet recruiting

A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections

Neutropenia
Anebulo Pharmaceuticals

Recruiting

Observational Study of THC Concentrations in Acute Cannabinoid Intoxication

Acute Cannabinoid Intoxication

United States
Iacta Pharmaceuticals

Recruiting

A Study to Assess the Safety and Efficacy of IC265 Ophthalmic Solution for Dry Eye in Adult Participants

Dry Eye Syndromes

United States
Dizal Pharmaceuticals

Recruiting

Assessing the Effect of DZD9008 on the Pharmacokinetics of the Cocktail Probes Representative for CYP3A4, P-gp, BCRP and OATP1B1 in Patients With EGFR or HER2 Mutant Advanced Non-small Cell Lung Cancer (WU-KONG19)

Non-small Cell Lung Cancer

China
Jazz Pharmaceuticals

Recruiting

Ph4 PSG Combined JZP258-407

Narcolepsy | Idiopathic Hypersomnia

United States, Canada
Jazz Pharmaceuticals

Recruiting

A Switch Study From High-Sodium Oxybate to XYWAV to Evaluate Changes in Blood Pressure in Participants With Narcolepsy

Narcolepsy

United States, Belgium, Spain, France, Italy, Czechia
Dizal Pharmaceuticals

Recruiting

A Study of DZD8586 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

China
Jazz Pharmaceuticals

Recruiting

Long-Term Follow-Up of a Cohort of Participants Prescribed Epidyolex in France in a Real-life Setting (OPERA)

Seizures

France
Regeneron Pharmaceuticals

Recruiting

A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works. (ACCESS-EXT)

Paroxysmal Nocturnal Hemoglobinuria

Taiwan, Korea, Republic of, Turkey, Spain, Thailand, Singapore, Japan, Canada, Malaysia, Poland, Italy
Jazz Pharmaceuticals

Recruiting

Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma (EMERGE 101)

Ewing Sarcoma | Refractory Ewing Sarcoma | Relapsed Ewing Sarcoma

United States, Canada
Dizal Pharmaceuticals

Recruiting

A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)

Non-small Cell Lung Cancer

China, United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, Czechia, France, Germany, Italy, Netherlands, Poland, Spain, Turkey
Alnylam Pharmaceuticals

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects

Transthyretin-Mediated Amyloidosis

United Kingdom
Regeneron Pharmaceuticals

Recruiting

A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Non-Alcoholic Fatty Liver Disease (NAFLD)

Healthy Volunteers | Non-alcoholic Fatty Liver Disease (NAFLD)

United States
Intercept Pharmaceuticals

Recruiting

FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study (FRESH)

Alcohol Associated Hepatitis

United States, France, United Kingdom
Cantex Pharmaceuticals

Recruiting

Azeliragon and Chemoradiotherapy in Newly Diagnosed Glioblastoma

Glioblastoma

Spain
Cumberland Pharmaceuticals

Recruiting

Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis

United States
Regeneron Pharmaceuticals

Recruiting

A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy (Honey-B)

Hemophilia B

United States, Germany, United Kingdom, Canada
SymBio Pharmaceuticals

Recruiting

Study to Confirm of the Safety and Tolerability of Brincidofovir in Subjects With BK Virus Infection (Viremia) After Kidney Transplantation

BK Virus Infection | Kidney Transplantation | Nephropathy

Australia, Japan
Syndax Pharmaceuticals

Recruiting

Study of Radiolabeled Revumenib in Adults With Acute Leukemia

Acute Leukemia

United States
InDex Pharmaceuticals

Recruiting

Pharmacokinetics of Cobitolimod Enemas in Participants With Active Ulcerative Colitis

Ulcerative Colitis

Sweden
Ferring Pharmaceuticals

Recruiting

A Trial to Compare Efficacy and Safety of Follitropin Delta Versus Placebo (Inactive Treatment) in the Treatment of Men With Idiopathic Infertility (Unexplained Reduction of Semen Quality) (ADAM)

Male Idiopathic Infertility

Denmark, United States, Sweden, Belgium, Spain, Italy, Germany
SciClone Pharmaceuticals

Recruiting

PT-112 (Phosplatin's Platinum) Combine With Gemcitabine Injection for Advanced Solid Tumors

Biliary Tract Cancer

China
Rigel Pharmaceuticals

Recruiting

Study of R289 in Participants With Lower-risk Myelodysplastic Syndromes (LR MDS)

Low Risk Myelodysplastic Syndromes

United States
Regeneron Pharmaceuticals

Recruiting

A Study of ImmunoPet Imaging Using 89Zr-DFO-REGN5054 in Adult Participants With Solid Cancers Treated With Cemiplimab

Advanced Solid Tumor | Metastatic Solid Tumor

Netherlands
Veloxis Pharmaceuticals

Recruiting

Assess Safety and Tolerability of ART-123 + FOLFOX + Bevacizumab in Metastatic Colorectal Cancer Patients

Chemotherapy-induced Peripheral Neuropathy

United States, Japan
Marinus Pharmaceuticals

Not yet recruiting

Double-blind, Randomized, Placebo-controlled Trial of Ganaxolone in CDKL5 Deficiency Patients 6 Months to Less Than 2 Years Old

CDKL5 Deficiency Disorder
Reviva Pharmaceuticals

Recruiting

Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia (RECOVER)

Schizophrenia

United States
Regeneron Pharmaceuticals

Recruiting

A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer

Metastatic Castration-resistant Prostate Cancer

United States
Regeneron Pharmaceuticals

Recruiting

Study for Desensitization of Chronic Kidney Disease in Adult Patients in Need of a Kidney Transplant Who Are Highly Sensitized to Human Leukocyte Antigen

Chronic Kidney Disease (CKD)

United States
Arrowhead Pharmaceuticals

Recruiting

Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease

IgA Nephropathy | C3 Glomerulopathy

New Zealand, Australia, Korea, Republic of, Thailand, Germany, United Kingdom, Georgia
Regeneron Pharmaceuticals

Recruiting

A Study to Examine the Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Adult Patients With Symptomatic Generalized Myasthenia Gravis (NIMBLE)

Generalized Myasthenia Gravis

United States, Japan, Spain, Taiwan, Germany, Italy, Canada, Turkey, Georgia, Belgium, India, Poland, Australia, Denmark, France, United Kingdom, Korea, Republic of, Serbia, Czechia
Jazz Pharmaceuticals

Recruiting

To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (SCLC)

Extensive-stage Small-cell Lung Cancer

United States, Canada
Syros Pharmaceuticals

Recruiting

Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome

Myelodysplastic Syndromes

United States, Spain, Belgium, Israel, France, United Kingdom, Austria, Czechia, Italy, Poland, Canada, Hungary, Germany

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