Search clinical trials for: Amplification

Total 282 results

Children's Hospital of Fudan University

Withdrawn

Pathogenic Bordetella Rapid Detection

Pertussis

China
Ambrx, Inc.

Withdrawn

ARX788 in Selected HER2-mutated or HER2-amplified/Overexpressed Solid Tumors (ACE-Pan Tumor-02)

HER2 Mutation-Related Tumors | HER2 Amplified Solid Tumors

United States
Calithera Biosciences, Inc

Completed

Study of the Glutaminase Inhibitor CB-839 in Solid Tumors

Renal Cell Carcinoma | Non Small Cell Lung Cancer | Mesothelioma | Solid Tumors | Triple-Negative Breast Cancer | Fumarate Hydratase (FH)-Deficient Tumors | Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST) | Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal... and other conditions

United States
Symphogen A/S

Completed

Sym015 (Anti-MET) in Patients With Advanced Solid Tumor Malignancies

NSCLC | Non Small Cell Lung Cancer | Oncology | MET Gene Mutation | MET Gene Amplification

United States, Korea, Republic of, Denmark, Hong Kong, Taiwan, Spain
Samsung Medical Center

Active, not recruiting

Patients With Refractory, Metastatic Cancer Harboring KIT Mutation or Amplification to Investigate the Clinical Efficacy and Safety of Imatinib Therapy

Advanced, Refractory Cancer

Korea, Republic of
Samsung Medical Center

Completed

Single-arm Study to Evaluate the Safety and Efficacy of Pazopanib, in Subjects With FGFR2 Amplification, FGFR2 Mutation Refractory Solid Tumors

Refractory Solid Tumors

Korea, Republic of
Samsung Medical Center

Completed

Single-arm Study to Evaluate the Safety and Efficacy of Sunitinib, in Subjects With RET Fusion Positive or FGFR2 Amplification, Refractory Solid Tumors

Refractory Solid Tumors

Korea, Republic of
Samsung Medical Center

Completed

Phase Ib, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel, in Any Solid Cancer and Sequential Phase II, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel in Advanced Gastric Adenocarcinoma Patients With MET Amplification as a Second Line Treatment

Advanced Gastric Adenocarcinoma

Korea, Republic of
Samsung Medical Center

Completed

Study to Evaluate the Safety and Efficacy of Gefitinib, in Subjects With EFGR Amplification Refractory Solid Tumors

Solid Tumor

Korea, Republic of
Samsung Medical Center

Completed

Study of AZD6094 (Volitinib) in Advanced Gastric Adenocarcinoma Patients With MET Amplification as a Third-line Treatment

Advanced Gastric Adenocarcinoma

Korea, Republic of
University of Maryland, College Park

Withdrawn

Objective Measurement of Hearing Aid Benefit

Auditory Perceptual Disorders | Age-related Hearing Loss
Taipei Medical University WanFang Hospital
Buddhist Tzu Chi General Hospital; Taichung Veterans General Hospital; Chang-Hua... and other collaborators

Active, not recruiting

Xpert MTB/RIF Test in the Diagnosis of Pulmonary Tuberculosis

Pulmonary Tuberculosis Confirmation by Culture

Taiwan
H. Lee Moffitt Cancer Center and Research Institute

Terminated

Immune Response and Potential Booster for Patients Who Have Received HER2-pulsed DC1

Breast Cancer | Breast Cancer, Male | HER2-positive Breast Cancer | HER-2 Gene Amplification | Breast Cancer Female | HER2 Positive Breast Carcinoma | HER-2 Protein Overexpression

United States
Charles Taylor
Laureate Institute for Brain Research, Inc.

Suspended

Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression

Substance-Related Disorders | Depression | Alcohol Drinking | Drinking Behavior | Alcoholism | Alcohol-Related Disorders | Anxiety | Mental Disorder

United States
Sameek Roychowdhury
National Cancer Institute (NCI)

Withdrawn

Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | ALK Gene Mutation | Metastatic Malignant Neoplasm in the Brain | Advanced Malignant Neoplasm | ALK Fusion Protein Expression | Metastatic Malignant Neoplasm in the Central Nervous System | ROS1 Gene Mutation | ALK Gene... and other conditions

United States
Medical College of Wisconsin
University of Wisconsin, Milwaukee

Completed

Personal Sound Amplification Device (PSAD)

Hearing Loss

United States
Massachusetts Eye and Ear Infirmary

Completed

Use of Amplification in Children With Unilateral Hearing Loss (UHL)

Unilateral Hearing Loss

United States
Washington University School of Medicine

Completed

TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment

Diarrhea | Clostridium Difficile Infection

United States
Grupo Español de Investigación en Neurooncología
Pfizer

Completed

Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent Glioblastoma With EGFR Amplification or Presence of EGFRvIII Mutation. A Phase II CT.

Glioblastoma | Brain Tumor, Recurrent

Spain
Spectrum Pharmaceuticals, Inc

Terminated

A Mass Balance and Pharmacokinetics Study of 14C-Labeled Poziotinib in Cancer Patients Suitable for Treatment With Poziotinib

Solid Tumor

United States
San Diego State University
University of California, San Diego

Withdrawn

A Comparison of User-adjusted and Audiologist-adjusted Hearing Amplification

Hearing Loss
Loma Linda University

Withdrawn

Analysis of Joint Sounds in the Diagnosis of Knee Disorders (Joint)

Knee Arthroscopy | Arthritis of Knee | Normal Knee
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

Lung-MAP: AZD4547 as Second-Line Therapy in Treating FGFR Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | FGFR1 Gene Amplification | FGFR2 Gene Amplification | FGFR2 Gene Mutation | FGFR3 Gene Mutation | FGFR1 Gene Mutation | FGFR3 Gene Amplification

United States, Canada
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

CCND1 Gene Amplification | CCND2 Gene Amplification | CCND3 Gene Amplification | CDK4 Gene Amplification | Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7

United States
University of California, Davis
BioFire Diagnostics, LLC

Completed

Rapid Diagnostics for Upper Respiratory Infections in the Emergency Department (URIDxED)

Respiratory Tract Infections | Influenza, Human | Common Cold

United States
Novartis Pharmaceuticals

Terminated

Ceritinib (LDK378) for Patients Whose Tumors Have Aberrations in ALK or ROS1 (SIGNATURE) (SIGNATURE)

Tumors With Aberrations in ALK or ROS1

United States
UNICANCER

Terminated

Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss (COPAN-ORL06)

Carcinoma, Squamous Cell of Head and Neck

France
Hunter College of City University of New York
Universidad Autonoma Juan Misael Saracho; Gobierno Autonomo Departamental De... and other collaborators

Completed

Validation of Laboratory Techniques, Strategies, and Types of Samples for Epidemiological Control in the Covid-19 Pandemic

Covid19

Bolivia
Changhoon Yoo

Completed

Trastuzumab in HER2-positive Biliary Tract Cancer (BILHER)

Cholangiocarcinoma | Biliary Tract Cancer | HER-2 Gene Amplification | HER-2 Protein Overexpression

Korea, Republic of
Novartis Pharmaceuticals

Completed

PI3K Inhibitor BYL719 in Combination With the HSP90 Inhibitor AUY922 in Patients With Advanced or Metastatic Gastric Cancer

Stomach Neoplasms Esophageal Neoplasms Metastatic Gastric Cancer Mutated PI3KCA Protein Overexpressed HER2 Protein

Taiwan, Switzerland, Korea, Republic of, Germany, United States, Japan
University Hospital, Bordeaux

Unknown

Contribution of New Generation Oxford Nanopore-type High-throughput Sequencing in the Diagnostic Strategy of Neurogenetic Diseases. (NEURONGS3)

Neuro-Degenerative Disease
ArQule, Inc. (a wholly owned subsidiary of Merck...

Terminated

Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole

Ovarian Cancer | Endometrial Cancer | Solid Tumors

United States
Novartis Pharmaceuticals

Completed

A Study of BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA Gene

Estrogen Receptor Positive Breast Cancer | Advanced Solid Tumors With an Alteration of the PIK3CA Gene

United States, Netherlands, Spain, Germany, United Kingdom
University Hospital Tuebingen
University Hospital of Cologne

Completed

Amplification and Selection of Antimicrobial Resistance in the Intestine II (ASARI II)

Antibiotic Selection Pressure

Germany
Arog Pharmaceuticals, Inc.

Completed

Study of Crenolanib in Recurrent/Refractory Glioblastoma With PDGFRA Gene Amplification

Recurrent/Refractory Glioblastoma

United States
University of Aarhus
Odense University Hospital; Rigshospitalet, Denmark; Herlev Hospital; Vejle Hospital and other collaborators

Completed

DAPROCA Pelvic Lymph Node Irradiation to Prostate for High Risk Prostate Cancer: Phase I/II Study (Propel)

Prostate Cancer

Denmark
NYU Langone Health

Withdrawn

Degree of Benefit From Low-Frequency Acoustic Amplification Using the Advanced Bionics Acoustic Earhook

Cochlear Hearing Loss | Cochlear Implant

United States
AbbVie
European Organisation for Research and Treatment of Cancer - EORTC

Completed

Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas (INTELLANCE-2)

Glioblastoma

United States, Australia, Austria, Belgium, Canada, Czechia, Finland, France, Germany, Hungary, Ireland, Italy, Korea, Republic of, Mexico, Netherlands, Poland, Singapore, Spain, Switzerland, Taiwan, United Kingdom
Arog Pharmaceuticals, Inc.

Available

Individual Patient Compassionate Use of Crenolanib

FLT3-ITD Mutation | FLT3/TKD Mutation | PDGFR-Alpha D842V | PDGFRA Gene Amplification

Italy
Beijing Ditan Hospital

Unknown

Development of a Simple, Fast and Portable Recombinase Aided Amplification Assay for 2019-nCoV

New Coronavirus

China
Haihe Biopharma Co., Ltd.

Unknown

Glumetinib Combined With Osimertinib in the Treatment of Relapsed and Metastatic Non-small Cell Lung Cancer Patients Who Failed to Receive EGFR Inhibitors

Negative T790M Mutation and Met Amplification

China
Novartis Pharmaceuticals

Terminated

A Safety and Efficacy Study of INC280 Alone, and in Combination With Erlotinib, Compared to Chemotherapy, in Advanced/Metastatic Non-small Cell Lung Cancer Patients With EGFR Mutation and cMET Amplification

Non-Small Cell Lung Cancer

Italy, Singapore, Spain, Germany, Korea, Republic of, United States, Belgium, France, Netherlands, Japan
Asan Medical Center
Novartis

Completed

Dovitinib for Gastric Cancer With FGFR2 Amplification: GASDOVI-1

Gastric Cancer

Korea, Republic of
Jin-Hee Ahn
Asan Medical Center

Unknown

Trastuzumab Biosimilar (Samfenet®) Plus Treatment of Physician's Choice (TPC) in Patients With HER2-positive Solid Tumor (BIOs-Her)

HER-2 Gene Amplification | HER-2 Protein Overexpression
Assiut University

Unknown

Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma

Multiple Myeloma
Samsung Medical Center

Completed

Study of AZD5363 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring PIK3CA Mutation and/or PIK3CA Amplification as a Second-line Chemotherapy

Advanced Gastric Cancer

Korea, Republic of
Belfast Health and Social Care Trust
Queen's University, Belfast; Royal College of Emergency Medicine; Pediatric Emergency... and other collaborators

Completed

Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA. (PIC)

Sepsis | Meningitis, Meningococcal | Meningitis | Meningococcal Infections | Meningococcal Disease | Meningococcal Sepsis

United Kingdom
Tianjin Medical University Second Hospital
Jiangsu HengRui Medicine Co., Ltd.

Unknown

The Basket Study of Pyrotinib Maleate for HER2-Postive Solid Tumor

Solid Tumor | HER-2 Gene Amplification | HER2 Gene Mutation | HER-2 Protein Overexpression

China
University of California, San Diego
National Institutes of Health (NIH); Centers for Disease Control and Prevention

Completed

Implementation of Nucleic Acid Amplification Testing Screening to Identify Acute and Early HIV Infection

Acute HIV Infection

United States
Novartis Pharmaceuticals

Completed

A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies

Advanced Solid Tumors With Alterations of FGFR1, 2 and or 3 | Squamous Lung Cancer With FGFR1 Amplification | Bladder Cancer With FGFR3 Mutation or Fusion | Advanced Solid Tumors With FGFR1 Amplication | Advanced Solid Tumors With FGFR2 Amplication | Advanced Solid Tumors With FGFR3 Mutation

France, Spain, Taiwan, Germany, Netherlands, Singapore, United States, Australia, Korea, Republic of, Thailand, Israel, Italy, Turkey, Austria

Search clinical trials for: Amplification

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Canada

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations