Search clinical trials for: DNA Damage Response

Total 23276 results

National Institute of Allergy and Infectious Diseases...

Active, not recruiting

Safety and Immunogenicity of an Epstein-Barr Virus (EBV) gp350-Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV Infection

EBV | Epstein-Barr Virus Infection | Infectious Mononucleosis

United States
GlaxoSmithKline

Completed

A Study on the Immune Response and Safety of a Vaccine Against Herpes Zoster in Adults Aged 50 Years and Older in India

Herpes Zoster

India
Foundation IRCCS San Matteo Hospital
Merck Sharp & Dohme LLC; Università degli Studi di Pavia; Fondazione Regionale...

Active, not recruiting

Non Primary HCMV Infection: Natural History and Immune Response

Cytomegalovirus Infections

Italy
Matti Sällberg

Completed

A Randomized, Phase I Study of DNA Vaccine OC-007 as a Booster Dose of COVID-19 Vaccine (OpenCorona1)

COVID-19 Respiratory Infection | COVID-19 Vaccine Adverse Reaction

Sweden
Mayo Clinic

Terminated

Measuring Cell Free DNA During the Course of Treatment for Esophageal Cancer as a Marker of Response and Recurrence

Esophageal Cancer | Cancer of the Esophagus | Esophageal Neoplasm | Esophagus Cancer | Cancer of Esophagus | Neoplasm, Esophageal | Esophageal Neoplasms Malignancy Unspecified | Esophageal Neoplasms Malignant

United States
Invitae Corporation

Active, not recruiting

MRD Assay Evaluates Recurrence and Response Via a Tumor Informed Assessment (MARIA)

Cancer | Colorectal Cancer | Solid Tumor | Non Small Cell Lung Cancer | Bladder Cancer

United States
Instituto de Seguridad y Servicios Sociales de...

Completed

Nutritional Intervention and DNA Damage of Patients With HBOC

DNA Damage | Nutrition Therapy | HBOC Syndrome

Mexico
University Medical Center Groningen
Radboud University Medical Center; Maastricht University Medical Center; UMC... and other collaborators

Completed

PREPARE-iVAC Trial (PREPARE-iVAC)

Vaccine Response | Immunosuppression | COVID-19 Vaccines | Varicella Zoster Vaccine

Netherlands
Edoardo Melilli

Withdrawn

Introduction of mTor Inhibitors and the Activation of the Cytomegalovirus (CMV) -Specific Cellular Immune Response (ACTIVA)

Kidney Transplantation | Cytomegalovirus Infections

Spain
GlaxoSmithKline

Active, not recruiting

A Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline's Herpes Zoster Subunit Vaccine (HZ/su) When Given on a Two-dose Schedule to Adults at Least 50 Years of Age (YOA) Who Had Prior Episode of Shingles

Herpes Zoster

Spain, Panama, Mexico, Russian Federation, Finland, Estonia, Hong Kong, United Kingdom
GlaxoSmithKline

Active, not recruiting

A Study of Safety and Immune Response to Different Doses of a Cytomegalovirus Vaccine in Healthy Adults

Cytomegalovirus Infections

United States
GlaxoSmithKline

Active, not recruiting

A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy

Hepatitis B, Chronic

Bulgaria, Belgium, Taiwan, Singapore, Spain, Germany, Thailand, Hong Kong, France, Italy, Poland, Philippines, Romania, United Kingdom, Turkey
GlaxoSmithKline
IQVIA, USA

Active, not recruiting

A Study on the Immune Response and Safety of Various Potencies of an Investigational Chickenpox Vaccine Compared With a Marketed Chickenpox Vaccine, Given to Healthy Children 12 to 15 Months of Age

Chickenpox

Taiwan, Poland, United States, Estonia, Puerto Rico, Mexico
Hospital do Rim e Hipertensão

Enrolling by invitation

Real-world CMV Outcomes Among Kidney Transplant Recipients in Brazil

CMV Infection | CMV Viremia

Brazil
Stanford University

Completed

Consumer Responses to Alcohol Warnings

Alcohol Drinking

United States
Cadex Genomics

Completed

Development of a Cell Free DNA Assay as a Biomarker for Predicting Early Non-response to Therapy in Metastatic Cancer

Metastatic Colorectal Cancer | Metastatic Breast Cancer | Metastatic Non-Small Cell Lung Carcinoma

United States, Canada
University Hospital Southampton NHS Foundation...

Completed

Immune Responses to COVID-19 Vaccination in Lymphoma Patients (PROSECO)

Follicular Lymphoma | Burkitt Lymphoma | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Peripheral T-cell Lymphoma | Diffuse Large B Cell Lymphoma | Classical Hodgkin Lymphoma | Small Lymphocytic Lymphoma | High-grade B-cell Lymphoma | Nodular Lymphocyte... and other conditions

United Kingdom
Assistance Publique - Hôpitaux de Paris
Brain & Spine Institute (ICM)

Completed

Evaluation of Biological Response to SARS-COV2 (COVID-19) in Patients With Pre-existing Neurological Disease or Newly Neurological Symptoms (BIO-COCO-NEUROSCIENCES)

Neurologic Manifestations | Covid19 | Psychiatric Manifestations

France
Regina Elena Cancer Institute
Fondazione Policlinico Universitario Agostino Gemelli IRCCS; University of... and other collaborators

Active, not recruiting

Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer

Gastric Cancer | DNA Damage

Italy
GlaxoSmithKline

Active, not recruiting

A Study on the Long-term Efficacy, Safety and Persistence of Immune Response of a Vaccine Against Herpes Zoster in Older Adults

Herpes Zoster

United States, Australia, Finland, Germany, Japan, Taiwan, Sweden, Spain, Korea, Republic of, Brazil, Mexico, Italy, Canada, Czechia, Estonia, France, Hong Kong, United Kingdom
UMC Utrecht
Institut National de la Santé Et de la Recherche Médicale, France; Philips... and other collaborators

Completed

Liquid Biopsies and Imaging in Breast Cancer (LIMA)

Breast Cancer

Netherlands
University of Surrey

Completed

The Effects of Restriction Pressure on Muscle Damage Responses to Blood Flow Restriction Exercise

Muscle Soreness | Muscle Strength | Muscle Damage

United Kingdom
GlaxoSmithKline

Active, not recruiting

A Study to Test GlaxoSmithKline's (GSK) Herpes Zoster (HZ) Subunit Vaccine's Long-term Immune Response in Previously Vaccinated Kidney Transplant Adults and Then to Test if 2 Additional Doses of the Vaccine Are Safe and Able to Generate an Immune Response

Herpes Zoster

Spain, Canada, Belgium, Finland, Korea, Republic of, Panama, Taiwan
Stanford University
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

T Cell Responses to Varicella Zoster Virus (VZV) Vaccine SLVP020

Herpes Zoster

United States
Fundación FLS de Lucha Contra el Sida, las Enfermedades...
IrsiCaixa; BCN Checkpoint

Active, not recruiting

Characterization of Vaccine-induced Responses Against Monkeypox (MoVIHvax) An Observational Prospective Cohort Study

Monkeypox

Spain
University of Arizona

Terminated

Correlate BRCA1 Protein Expression With Response to DNA Damaging Chemotherapy

Breast Cancer

United States
GlaxoSmithKline

Active, not recruiting

A Study on Safety and Immune Response of Investigational RSV OA Vaccine in Combination With Herpes Zoster Vaccine in Healthy Adults (RSV-OA=ADJ-020)

Respiratory Syncytial Virus Infections | Respiratory Syncytial Viruses

United States, Canada
University of California, Los Angeles
National Eye Institute (NEI); Neurolign; Jules Stein Eye Institute

Completed

Rapid, Non-invasive, Regional Functional Imaging of the Retina. (Diabetic Retinopathy Diagnosis Device)

Diabetes | Retinal Disorders

United States
University of Aarhus
Aarhus University Hospital

Completed

Early Detection of Epstein-Barr Virus Related Disease.

Epstein-Barr Virus Infections | Post-transplant Lymphoproliferative Disorder | Hemophagocytic Lymphohistiocytoses | Epstein-Barr Virus-Related Hodgkin Lymphoma | Epstein-Barr Virus-Related Non-Hodgkin Lymphoma | Mononucleosis | Epstein-Barr Virus Related Malignancy | Epstein-Barr Viraemia | Hemophag...

Denmark
New York Medical College
Merck Sharp & Dohme LLC

Completed

Cytomegalovirus (CMV) Viremia and Disease Occurrence in Pediatric Allogeneic Stem Cell Transplantation Recipients

Cytomegalovirus Infections

United States
National Cancer Institute (NCI)

Completed

Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas

Lymphoma | Solid Tumors

United States
Bispebjerg Hospital
Sygehus Lillebaelt

Active, not recruiting

Quantification of DNA Repair Products in the Urine After Ultraviolet Radiation of the Skin

DNA Damage | Ultraviolet Rays; Injury | DNA Adduct Formation | DNA Damage, Radiation Induced

Denmark
Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb; Vanderbilt University; Avon Breast Health Access Fund

Active, not recruiting

Patient Response to Immunotherapy Using Spliceosome Mutational Markers (PRISMM) (PRISMM)

Metastatic Solid Tumor | SF3B1 Gene Mutation | Spliceosome Mutation | U2AF1 Gene Mutation | SRSF2 Gene Mutation

United States
University of Alabama at Birmingham
Lakeshore Foundation; YMCA of Greater Birmingham

Active, not recruiting

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study (M2M LEADERS)

Stroke | Multiple Sclerosis | Cerebral Palsy | Parkinson Disease | Traumatic Brain Injury | Spinal Cord Injuries | Spina Bifida

United States
Huahui Health

Active, not recruiting

A Study to Evaluate the Antiviral Activity and Safety of HH-003 in Chronic Hepatitis B Subjects With Low-level Viremia

Chronic HBV Infection

China
St. Jude Children's Research Hospital

Active, not recruiting

T-cell Responses to Concurrent HIV and Herpesvirus Infections

HIV Infections | HIV

United States
University of Chicago
National Cancer Institute (NCI)

Active, not recruiting

Nab-paclitaxel and Carboplatin Followed by Response-Based Local Therapy in Treating Patients With Stage III or IV HPV-Related Oropharyngeal Cancer (OPTIMA)

Human Papilloma Virus Infection | Stage III Squamous Cell Carcinoma of the Oropharynx | Stage IVA Squamous Cell Carcinoma of the Oropharynx | Stage IVB Squamous Cell Carcinoma of the Oropharynx

United States
ppharmaand GmbH
Bristol-Myers Squibb; Gynecologic Oncology Group; European Network of Gynaecological... and other collaborators

Active, not recruiting

A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy (ATHENA)

Fallopian Tube Cancer | Epithelial Ovarian Cancer | Primary Peritoneal | Newly Diagnosed | FIGO Stage III-IV | Partial Response | Complete Response

United States, United Kingdom, Korea, Republic of, Russian Federation, Canada, Denmark, Taiwan, New Zealand, Ireland, Japan, Spain, Australia, Israel, Italy, Greece, Sweden, Czechia, Finland, Poland, Belgium, Germany, Romania, Singa... and more
Daniel Benjamin
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (PTN_POPS)

Heart Failure | Epilepsy | Pain | Pneumonia | Sepsis | Inflammation | Hypertension | Chronic Kidney Diseases | Hemophilia | Schizophrenia | Central Nervous System Infections | Nosocomial Pneumonia | Insomnia | Anxiety | Bipolar Disorder | Neutropenia | Staphylococcal Infections | Bradycardia | Seizures | Urinary Tract Infections | Pulmonary... and other conditions

United States, Canada, United Kingdom, Israel, Singapore
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I)

Chronic Lymphocytic Leukemia (CLL) | Small Lymphocytic Lymphoma (SLL) | Safety and Tolerability | Compare SHINGRIX Vaccine Response Rates

United States
Dana Bovbjerg
National Cancer Institute (NCI)

Terminated

Brief Stresses Experimental Study

DNA Damage | Psychological Stress

United States
Pierre Fabre Dermo Cosmetique

Completed

Photoprotective Effects of a SPF50+ Sunscreen on Skin Genotoxicity Induced by Repeated Chronic Outdoor Sun Exposure

Sun Damaged Skin

France
Radboud University Medical Center
GlaxoSmithKline

Completed

Age Differences in Influenza and Herpes Zoster Vaccine Responses (INFLUENZA-SHINGRIX)

Influenza | Herpes Zoster

Netherlands
Sun Yat-sen University
Wuzhou Red Cross Hospital; First People's Hospital of Foshan; National Cancer...

Active, not recruiting

EPstein-barr Virus DNA Response to Systemic Therapy for Treatment Adaptation in High Risk NPC (EP-STAR) (EP-STAR)

Nasopharyngeal Carcinoma

China
Atara Biotherapeutics

No longer available

Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies

Lymphoproliferative Disorders | Stem Cell Transplant Complications | Epstein-Barr Virus (EBV) Infections | EBV+ Associated Lymphoma | EBV+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD) | Epstein-Barr Viremia | Lymphoma, AIDS-related | Epstein-Barr Virus-associated Lymphoproliferative... and other conditions
Appalachian State University
LycoRed Ltd.

Completed

Astaxanthin, Exercise Inflammation, Skin Health

Inflammatory Response | Metabolic Disturbance | Immune Suppression

United States
Hospital Pedro Hispano
Diogo Melo Pinto, MD, Hospital Pedro Hispano; Telma Fonseca, MD, Centro Hospitalar... and other collaborators

Completed

Evaluation of cfDNA as a Marker of Response in Rectal Cancer

Cancer of Rectum

Portugal
GlaxoSmithKline

Completed

A Study of GSK3228836 in Participants With Chronic Hepatitis B (CHB) (B-Clear)

Hepatitis B

United States, Germany, Korea, Republic of, Spain, Taiwan, Bulgaria, Italy, Russian Federation, Thailand, Canada, Singapore, France, Malaysia, China, Romania, Hong Kong, Philippines, Japan, Poland, South Africa, United Kingdom, Ar...
Hjalmar Bouma

Enrolling by invitation

Researching the Effects of Sepsis on Quality Of Life, Vitality, Epigenome and Gene Expression During RecoverY From Sepsis (REQOVERY)

Sepsis | Infection

Netherlands
Walter and Eliza Hall Institute of Medical Research
Johns Hopkins University

Active, not recruiting

Circulating Tumour DNA as a Marker of Residual Disease & Response to Adjuvant Chemotherapy in Stage I-IV Ovarian Cancer

Ovarian Cancer

Australia, United States

Search clinical trials for: DNA Damage Response

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Suriname

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations