Search clinical trials for: Severe Congenital Neutropenia

Total 18023 results

Prolong Pharmaceuticals

Withdrawn

ANF-Rho in the Treatment of Chronic Neutropenia

Neutropenia, Severe Chronic
Kuopio University Hospital

Completed

Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients

Sepsis

Finland
University College Dublin
National Children's Research Centre; Our Lady's Children's Hospital, Crumlin

Completed

Intranasal Fentanyl Versus Intravenous Morphine in the Treatment of Severe Painful Sickle Cell Crises in Children

Pain | Sickle Cell Disease

Ireland
Beijing Children's Hospital
Hopital Universitaire Robert-Debre; Shandong University; Rennes University Hospital

Unknown

Population Pharmacokinetics of Meropenem and Linezolid in Children With Severe Infectious Diseases

Children；Infection

China
Hospices Civils de Lyon

Completed

Local Oestrogen Versus Placebo as Preoperative Treatment in Patients With Severe Hypospadias: Effects on Post-operative Complications (HYPOSPADES)

Hypospadias

France
Christian Kern

Unknown

Severe and Transient Hypoxemia During Selective Intra-arterial Chemotherapy for Retinoblastoma in Children: Evaluation of the Right-sided Heart Function.

Retinoblastoma

Switzerland
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Terminated

Antibody Conditioning Regimen For Allogeneic Donor Stem Cell Transplantation Of Patients With Fanconi Anemia (Mafia)

Fanconi Anemia | Severe Aplastic Anemia

United States
University Hospital, Lille
Ministry of Health, France; Ligue contre le cancer, France

Completed

Distinction Risk of Severe Infection in Febrile Neutropenia After Chemotherapy

Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy

France
Martin-Luther-Universität Halle-Wittenberg

Unknown

FETO With Long Tail Balloon for a Treatment of Severe CDH (LongTailFETO)

Severe Congenital Diaphragmatic Hernia

Germany
Assiut University

Completed

Conjoined Twins: a Report of Four Cases. (CT)

Conjoined Twin
Mario Negri Institute for Pharmacological Research

Completed

Somatostatin In Patients With Autosomal Dominant Polycystic Kidney Disease And Moderate To Severe Renal Insufficiency (ALADIN2)

Autosomal Dominant Polycystic Kidney Disease

Italy
Masonic Cancer Center, University of Minnesota

Completed

Stem Cell Transplant for Bone Marrow Failure Syndromes

Diamond-Blackfan Anemia | Shwachman-Diamond Syndrome | Kostmann's Neutropenia

United States
Novo Nordisk A/S

Completed

A Multi-centre, Comparative, Double Blind, Randomised Cross-over Trial Investigating Single Dose Pharmacokinetics and Safety of Turoctocog Alfa Pegol From the Pivotal Process and Turoctocog Alfa Pegol From the Commercial Process in Patients With Severe Haemophilia A (pathfinder™7)

Congenital Bleeding Disorder | Haemophilia A

United States, Netherlands, Spain, Germany, France, Denmark
Washington University School of Medicine
HealthCore-NERI; Pediatric Blood and Marrow Transplant Consortium

Completed

Reduced Intensity Transplant Conditioning Regimen for Severe Thalassemia (URTH)

Severe Thalassemia

United States
Masonic Cancer Center, University of Minnesota

Completed

Stem Cell Transplant (SCT) for Dyskeratosis Congenita or SAA

Aplastic Anemia | Dyskeratosis Congenita

United States
Emory University
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease (STRIDE)

Sickle Cell Disease

United States
Medical University of Silesia
Military Institute of Medicine, Poland; Clinical Hospital No. 2 Pomeranian... and other collaborators

Unknown

Ablation of Atrial Fibrillation in Heart Failure Patients (CONTRA-HF)

Atrial Fibrillation | Severe Heart Failure

Poland
Joanne Kurtzberg, MD
Aldagen

Completed

Unrelated Umbilical Cord Blood Transplantation Augmented With ALDHbr Umbilical Cord Blood Cells

Anemia, Aplastic | MDS | Inborn Errors of Metabolism | Congenital Marrow Failure | Congenital Immunodeficiency Syndrome

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia

Thrombocytopenia | Neutropenia | Pancytopenia | Immunosuppresion

United States
St. Jude Children's Research Hospital

Completed

Partially Matched Stem Cell Transplantation for Patients With Refractory Severe Aplastic Anemia or Refractory Cytopenias

Anemia, Aplastic | Diamond-Blackfan Anemia | Amegakaryocytic Thrombocytopenia | Kostmann Syndrome

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia

Neutropenia | Pancytopenia | Aplastic Anemia | Severe Aplastic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Decitabine for High-Risk Sickle Cell Disease

Neutropenia | Sickle Cell Disease

United States
Novartis Pharmaceuticals

Completed

A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe Toxicity

Transfusional Iron Overload

United States, Greece, Italy
CSL Behring

Completed

Pharmacokinetic, Efficacy, and Safety Study of Recombinant Factor VIII Single Chain (rVIII-SingleChain) in Children With Severe Hemophilia A

Congenital Hemophilia A

United States, Austria, Germany, Malaysia, Netherlands, Philippines, Ukraine, Romania, Spain, Australia, France, Georgia, Italy, Lebanon, Poland, Portugal, Switzerland, Thailand, Turkey
Mallinckrodt

Terminated

Hospital-Based Program for Treatment of Severe Cardiopulmonary Disease With Inhaled Nitric Oxide

Sickle Cell Disease | Pulmonary Hypertension | Lung Disease | Lung Transplant | Cardiac Transplant

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States, Canada, Brazil, Taiwan, Singapore, South Africa, United Kingdom
HaEmek Medical Center, Israel

Completed

Does Azithromycin Cause QT Prolongation in Hospitalized Patients With Severe Community Acquired Pneumonia?

Pneumonia

Israel
Nantes University Hospital

Completed

Genetic Study of Severe Zinc Deficiencies (GENEZINC)

Acrodermatitis Enteropathica
Centre Hospitalier Universitaire Dijon

Completed

Screening for Genes in Patients With Congenital Neutropenia (neutropenias)

Congenital Neutropenia

France
Children's Hospital Los Angeles

Completed

Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells

Granuloma | Anemia | Thrombocytopenia | Neutropenia | Sickle Cell Disease | Thalassemia | Niemann-Pick Disease | Wiskott-Aldrich Syndrome | Osteopetrosis | Fucosidosis | Chediak Higashi Syndrome | Hurler Disease

United States
National Guard Health Affairs

Unknown

HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen

Sickle Cell Disease

Saudi Arabia
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cord Blood Stem Cell Transplantation Study (COBLT)

Neoplasms | Myelodysplastic Syndromes | Hematologic Diseases | Leukemia | Severe Combined Immunodeficiency | Fanconi Anemia | Anemia, Aplastic | Hematopoietic Stem Cell Transplantation
Sandoz
Sandoz GmbH

Terminated

Immunogenicity, Safety, and Efficacy of Zarzio®/Filgrastim HEXAL® in Patients With Severe Chronic Neutropenia

Severe Chronic Neutropenia

Germany, Sweden
University of Oklahoma

Completed

Effects of Power Mobility on Young Children With Severe Motor Impairments

Cerebral Palsy | Spinal Muscular Atrophy | Arthrogryposis | Other Central Nervous System or Musculoskeletal Disorders

United States
FDA Office of Orphan Products Development
Medical University of South Carolina

Completed

Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital Osteopetrosis

Osteopetrosis
David Rizzieri, MD

Completed

Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes

Sickle Cell Anemia | Pure Red Cell Aplasia | Paroxysmal Nocturnal Hemoglobinuria (PNH) | Severe Aplastic Anemia

United States
Tianjin Medical University Cancer Institute and...
Zhejiang Hisun Pharmaceutical Co. Ltd.

Unknown

Effect Study of Tigecycline to Treat Severe Sepsis and Septic Shock (Tigecycline)

Abdominal Infection

China
Emory University

Completed

Curative Versus Disease-Modifying Therapies in Children With Severe Sickle Cell Disease (SCD_Cross)

Sickle Cell Disease

United States
Emory University

Completed

Analysis of T-Cell Immune Reconstitution Following Allogeneic Hematopoietic BMT for Severe SCD

Sickle Cell Disease

United States
Cephalon

Completed

Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain

Pain | Cancer | Sickle Cell Anemia | Severe Burns

United States, Canada, Puerto Rico
Cyathus Exquirere Pharmaforschungsgmbh

Terminated

Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis

Haemodialysis

Austria
University of Sao Paulo General Hospital
University of Sao Paulo

Unknown

Early FETO for Severe Congenital Diaphragmatic Hernia

Congenital Diaphragmatic Hernia

Brazil
Telik

Terminated

Study of Ezatiostat (Telintra Tablets) for Treatment of Severe Chronic Neutropenia

Severe Chronic Neutropenia

United States
Mashhad University of Medical Sciences

Completed

Effect of Supragingival Irrigators Containing Chlorhexidine on Oral Health in Blood Dyscrasia

Thrombocytopenia | Chemotherapy | Severe Neutropenia | Blood Dyscrasia Patients

Iran, Islamic Republic of
Hospices Civils de Lyon

Completed

Efficacy and Safety of Bevacizumab for the Treatment Hemorrhagic Hereditary Telangiectasia (HHT) Associated With Severe Hepatic Vascular Malformations. Phase II Study (METAFORE)

Hemorrhagic Hereditary Telangiectasia

France
National Research Center for Hematology, Russia

Unknown

Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia

Septic Shock | Nonchemotherapy Drug-induced Neutropenia | Neutropenia After Chemotherapy in Oncohematological Patients | Neutropenia in Patients With Aplastic Anemia

Russian Federation
Mario Negri Institute for Pharmacological Research

Terminated

Sirolimus In Autosomal Dominant Polycystic Kidney Disease And Severe Renal Insufficiency (SIRENA-II)

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Italy
Mayo Clinic
Novartis; National Center for Research Resources (NCRR)

Completed

Octreotide in Severe Polycystic Liver Disease

Liver Diseases | Abdominal Pain | Polycystic Kidney, Autosomal Dominant | Hepatomegaly | Polycystic Liver Disease | Kidney, Polycystic

United States
Assistance Publique - Hôpitaux de Paris
Hoffmann-La Roche

Completed

Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections (EVAMICA)

Febrile Neutropenia | Severe Sepsis | Endocarditis

France
Nantes University Hospital

Completed

Genetic Study of Patients Suffering From Congenital Amaurosis of Leber or From an Early Severe Retinal Dystrophy

Retinal Diseases | Amaurosis

France

Search clinical trials for: Severe Congenital Neutropenia

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