Search clinical trials for: acute graft versus host disease

Total 390970 results

Mesoblast, Inc.
Quintiles, Inc.

Completed

A Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Participants Who Have Failed to Respond to Steroid Treatment for Acute Graft-Versus-Host Disease (aGVHD)

Grade B aGVHD | Grade C aGVHD | Grade D aGVHD

United States
Mesoblast, Inc.
Quintiles, Inc.

Completed

Safety Follow-up of Treatment With Remestemcel-L in Pediatric Participants Who Have Failed to Respond to Steroid Treatment for Acute GVHD

Grade B Acute Graft Versus Host Disease | Grade C Acute Graft Versus Host Disease | Grade D Acute Graft Versus Host Disease

United States
Emory University

No longer available

Expanded Use of G-CSF Mobilized Donor CD34+ Selected Cells for Allogeneic Transplantation

Acute Myeloid Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome

United States
Mesoblast, Inc.

Completed

Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease (GVHD)

Graft Versus Host Disease

United States, Italy, Australia, Canada, Switzerland, United Kingdom
Mesoblast, Inc.

Completed

Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD)

Graft Vs Host Disease

United States
Mesoblast, Inc.

Completed

Safety and Efficacy of Prochymal® for the Salvage of Treatment-Refractory Acute GVHD Patients

Graft Versus Host Disease

United States
Mesoblast, Inc.

Completed

Efficacy and Safety of Prochymal® Infusion in Combination With Corticosteroids for the Treatment of Newly Diagnosed Acute Graft Versus Host Disease (GVHD)

Graft Versus Host Disease

United States, Australia, Canada
M.D. Anderson Cancer Center
Sanofi

Completed

Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Leukemia | Transplantation Infection | Disorder Related to Bone Marrow Transplantation

United States
Xenikos
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Terminated

T-Guard as Treatment for Steroid Refractory Acute GVHD (BMT CTN 1802) (1802)

Steroid-Refractory Acute Graft Versus Host Disease

United States
Incyte Corporation

Completed

A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1)

Graft-versus-host Disease (GVHD)

United States
National Heart, Lung, and Blood Institute (NHLBI)
National Cancer Institute (NCI); Blood and Marrow Transplant Clinical Trials...

Completed

Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)

Graft vs Host Disease | Immune System Disorders

United States
Emory University

Completed

Rifaximin for Infection Prophylaxis in Hematopoietic Stem Cell Transplantation

Microbial Colonization

United States
ElsaLys Biotech

Available

Early Access Program With Inolimomab in Steroid-refractory Acute Graft Versus Host Disease

Steroid Resistant Acute Graft Versus Host Disease

France
H. Lee Moffitt Cancer Center and Research Institute

Completed

Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT

Myelodysplastic Syndromes | Primary Myelofibrosis | Multiple Myeloma | Hodgkin Lymphoma | Non-Hodgkin's Lymphoma | Chronic Myelomonocytic Leukemia | Chronic Myeloid Leukemia | Acute Leukemia in Remission

United States
Kalytera Therapeutics Israel, Ltd.

Active, not recruiting

An Open Label Study of Multiple Doses of Cannabidiol in the Prevention of Acute Graft-Versus-Host Disease (GVHD)

Prevention aGVHD

Australia, Israel
Lee Dupuis
C17 Council

Completed

Pharmacological Predictors of Successful Cyclosporine Acute GVHD Prophylaxis in Children Undergoing HSCT

Acute-graft-versus-host Disease

Canada
Gilead Sciences
Ohio State University

Terminated

Phase I Study of Milatuzumab for Graft Versus Host Disease

Myelodysplastic Syndrome | Chronic Myelogenous Leukemia (CML) | Multiple Myeloma (MM) | GVHD (Acute or Chronic) | Acute Myeloid or Lymphoblastic Leukemia (AML or ALL) | Non-Hodgekin Lymphoma (NHL-both Follicular & Diffuse Large Cell) | Chronic Lymphocytic Leukemia or Small Lymphocytic Leukemia...

United States
Jazz Pharmaceuticals

Completed

An Open-Label Study of Defibrotide for the Prevention of Acute Graft-versus-Host-Disease (AGvHD)

Acute-graft-versus-host Disease | Graft-versus-host Disease

United States, Belgium, United Kingdom, Greece, Germany, Spain, France, Italy, Austria, Canada, Bulgaria, Croatia, Poland, Portugal
Incyte Corporation

Completed

GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease

Graft-versus-host Disease (GVHD)

United States, Spain, Belgium, France, Italy, Korea, Republic of, Finland, United Kingdom, Germany, Israel, Switzerland, Austria, Australia, Czechia, Greece, New Zealand, Poland, Portugal, Taiwan
Merz Pharmaceuticals GmbH

Completed

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability (SIPEXI)

Stroke | Cerebral Palsy | Intellectual Disability | Traumatic Brain Injury | Chronic Troublesome Sialorrhea

Georgia, Hungary, Poland, Russian Federation, Serbia, Ukraine
EVIVE Biotechnology
Memorial Sloan Kettering Cancer Center

Completed

Study of IL-22 IgG2-Fc (F-652) for Subjects With Grade II-IV Lower GI aGVHD

Acute Graft vs Host Disease

United States
H. Lee Moffitt Cancer Center and Research Institute
Novartis

Completed

Panobinostat (LBH589): Acute Graft Versus Host Disease (aGVHD) Prevention

Graft Versus Host Disease | GVHD

United States
John Levine
National Cancer Institute (NCI)

Completed

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

GVHD | Graft-versus-host-disease

United States
Kiadis Pharma

Completed

Safety and Efficacy of Two Doses of ATIR101, a T-lymphocyte Enriched Leukocyte Preparation Depleted of Host Alloreactive T-cells, in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome

Canada, Belgium, Germany, Croatia, United Kingdom, Portugal
Central Hospital, Nancy, France
University of Cambridge

Completed

KIR Sequencing and Typing for Allograft in Nancy (KIR-STAN)

Stem Cell Transplant Complications
Baxalta now part of Shire

Terminated

Prevention of Graft-Versus-Host Disease in Patients With Advanced Leukemia or Lymphoma Who Are Eligible for Peripheral Stem Cell Transplantation

Lymphoma | Leukemia | Graft Versus Host Disease

United States, Australia
Loyola University

Withdrawn

Randomized Study: Standard of Care With or Without Atorvastatin for Prevention of GVHD for Matched Unrelated Donor BMT

Acute Myeloid Leukemia | Myelodysplastic Syndrome | Acute Lymphocytic Leukemia

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Studying Changes in Physical Function Measures in Stem Cell Transplant Patients at Risk for Steroid Myopathy

Acute Graft Versus Host Disease

United States
Kiadis Pharma

Completed

Safety and Efficacy of Donor T-lymphocytes Depleted ex Vivo of Host Alloreactive T-cells (ATIR) in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome

Canada, Germany, Belgium, United Kingdom
Indiana University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Bridging Pediatric and Adult Biomarkers in Graft-Versus-Host Disease

Graft-Versus-Host Disease

United States
Lund University Hospital

Completed

Haploidentical Stem Cell Transplantation for Children With Therapy Resistant Leukemia

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia

Sweden
CSL Behring

Terminated

Exploratory Safety Study of ALD518 in Subjects With Steroid-refractory Acute Graft Versus Host Disease (GVHD) (ALD518-010)

Acute GvHD

United States
Fred Hutchinson Cancer Center

Completed

Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated... and other conditions

United States
Rabin Medical Center

Unknown

Sitagliptin for the Treatment of Grade 3-4 and Refractory Acute Graft-versus-host Disease (GVHD)

Graft Vs Host Disease

Israel
Sherif S. Farag

Completed

Sitagliptin for Prevention of Acute Graft Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation | Graft vs Host Disease

United States
Baxalta now part of Shire
Kamada, Ltd.

Terminated

A Phase 2/3 Study of GLASSIA for the Treatment of Acute GvHD

Graft Versus Host Disease

United States
Radboud University Medical Center

Completed

Pharmacokinetics of Micafungin Given Twice Weekly Intravenously Compared to Micafungin Given Daily to Patients at Risk for Developing an Invasive Fungal Disease (MATADOR)

Allogeneic Stem Cell Transplant | Acute Myeloid Leucaemia | Myelo Dysplastic Syndrome | Acute Graft Versus Host Disease Grade II-IV

Netherlands, Belgium
Nanfang Hospital of Southern Medical University

Unknown

Efficacy and Safety of FMT Capsule Treating Steroid-refractory GI-aGvHD

Steroid-refractory Gastrointestinal Acute Graft Versus Host Disease

China
Innovent Biologics (Suzhou) Co. Ltd.

Terminated

A Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease

GVHD,Acute

China
Astex Pharmaceuticals, Inc.

Terminated

Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD

Acute Graft Versus Host Disease

United States
M.D. Anderson Cancer Center
Genzyme, a Sanofi Company

Completed

Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) With Busulfan, Fludarabine and Thymoglobulin

Leukemia | Stem Cell Transplantation

United States
Impatients N.V. trading as myTomorrows
Kamada, Ltd.

No longer available

Early Access Program Using Alpha 1 Antitrypsin Infusion for Patients With Steroid Refractory Acute GvHD After Hematopoietic Stem Cell Transplantation (HSCT)

Alpha 1-Antitrypsin Deficiency | Graft Vs Host Disease | Graft-versus-host-disease | Acute-graft-versus-host Disease | Steroid Refractory Acute Graft Versus Host Disease | Alpha-1 Proteinase Inhibitor | Alpha-1 Protease Inhibitor Deficiency | Acute Graft-Versus-Host Reaction Following Bone Marrow...
Peking University People's Hospital
Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China

Unknown

Human Amniotic Epithelial Cells Prevent Acute Graft-versus-host Disease After Hematopoietic Stem Cell Transplantation (hAECs-GVHD)

Acute-graft-versus-host Disease

China
Peking University People's Hospital

Unknown

Prophylaxis Roles of IL-2 Treatment on GVHD After Transplantation

Acute Graft-versus-host Disease

China
M.D. Anderson Cancer Center
Genzyme, a Sanofi Company

Terminated

Thymoglobulin, Sirolimus and Mycophenolate Mofetil for Prevention of Acute Graft-Versus-Host Disease (GVHD)

Lymphoma | Leukemia | Myelodysplastic Syndrome | Hematological Malignancies

United States
Peking University People's Hospital

Completed

Efficacy Study of Low-dose Glucocorticoid Prophylaxis for Acute Graft-versus-host Disease(GVHD)

Leukemia

China
Therakos, Inc., a Mallinckrodt Company

Terminated

Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease

Steroid Refractory Acute Graft Versus Host Disease

United States, Spain, France, Austria, Germany, Hungary, Italy, United Kingdom
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD

Myelodysplastic Syndromes | Leukemia | Graft Versus Host Disease

United States
Cynata Therapeutics Limited

Completed

A Study of CYP-001 for the Treatment of Steroid-Resistant Acute Graft Versus Host Disease

Graft vs Host Disease

Australia, United Kingdom
Azienda Socio Sanitaria Territoriale degli Spedali...
University of Turin, Italy; Università degli Studi di Brescia

Completed

Origin of CEC in Patients After Allo-HSCT (DCEC-PIANO)

Endothelial Dysfunction | Graft Versus Host Disease, Acute | Immune Tolerance

Italy

Search clinical trials for: acute graft versus host disease

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