Search clinical trials for: beta cell dysfunction

Total 65587 results

GPCR Therapeutics, Inc.

Recruiting

Ph2, Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

Multiple Myeloma

United States
AstraZeneca
UKCLL Forum

Recruiting

Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United Kingdom (EPIC)

Chronic Lymphocytic Leukemia, CLL

United Kingdom
National Cancer Institute (NCI)

Not yet recruiting

Testing the Use of Combination Therapy in Patients With Persistent Low Level Acute Myeloid Leukemia Following Initial Treatment, The ERASE Study (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Secondary Acute Myeloid Leukemia | Acute Myeloid Leukemia Arising From Previous Myeloproliferative Neoplasm | Acute Myeloid Leukemia Post Cytotoxic Therapy
National Cancer Institute (NCI)

Recruiting

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia | Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm | Acute Myeloid Leukemia Post Cytotoxic Therapy | Acute Myeloid Leukemia, Myelodysplasia-Related

United States, Puerto Rico
National Cancer Institute (NCI)

Not yet recruiting

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia
Prof. Dr. Thomas Luft

Recruiting

The Endothelial Cell Dysfunction and Outcome Project for Hematological Neoplasms (EndoCDO-H)

Endothelial Dysfunction | Hematological Neoplasm

Germany
Aalborg University Hospital
Odense University Hospital; University of Southern Denmark

Recruiting

The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling

Mitochondrial Diseases | Bone Remodeling Disorder

Denmark
Vertex Pharmaceuticals Incorporated
CRISPR Therapeutics

Recruiting

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Hematologic Diseases | Genetic Diseases, Inborn | Sickle Cell Disease | Hemoglobinopathies | Sickle Cell Anemia | Thalassemia | Beta-Thalassemia

United States, Italy, Germany, Saudi Arabia
Chinese University of Hong Kong

Not yet recruiting

Dorzagliatin and 1st Phase Insulin and Beta-cell Glucose Sensitivity in IGT and NGT

Glucose Intolerance
National Institute of Allergy and Infectious Diseases...

Recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

Chronic Granulomatous Disease

United States
University of Nottingham

Recruiting

Asthma: Phenotyping Exacerbations 3 (APEX3)

Asthma Attack

United Kingdom
Editas Medicine, Inc.

Recruiting

EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT)

Hemoglobinopathies | Thalassemia Major | Thalassemia Intermedia | Transfusion Dependent Beta Thalassemia

United States, Canada
Sumithira Vasu
National Cancer Institute (NCI)

Recruiting

Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies

Recurrent B Acute Lymphoblastic Leukemia | Refractory B Acute Lymphoblastic Leukemia | Refractory Chronic Lymphocytic Leukemia | Recurrent Non-Hodgkin Lymphoma | Refractory Non-Hodgkin Lymphoma | Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia | Recurrent High Grade... and other conditions

United States
Jennifer Eva Selfridge

Recruiting

Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Colorectal Cancer | Hodgkin Lymphoma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Non Hodgkin Lymphoma | Chronic Myeloid Leukemia | Plasma Cell Myeloma | Hematologic Malignancy | Rectum Cancer | Myeloproliferative Syndrome

United States
The University of Hong Kong
Queen Mary Hospital, Hong Kong

Recruiting

Fast-track Blood Test for Suspected Fever by Deficiency of a Kind of White Blood Cells As Main Defense Against Infection (FRANCiS-NF)

Neutropenic Fever

Hong Kong
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Sickle Cell Anemia | Beta Thalassemia

United States
University Hospital, Basel, Switzerland
Swiss National Science Foundation; Paul Scherrer Institute (PSI)

Recruiting

Combined Beta- Plus Auger Electron Therapy Using a Novel Somatostatin Receptor Subtype 2 Antagonist Labelled With Terbium-161 (161Tb-DOTA-LM3) (Beta plus)

Neuroendocrine Neoplasia's (NENs) | Gastroenteropancreatic Neuroendocrine Tumour (GEP-NET)

Switzerland
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

The Montreal Cognitive Assessment.Test in Adults With Sickle Cell Disease (EvaCAD)

Sickle Cell Anemia

France
Vinmec Research Institute of Stem Cell and Gene...

Recruiting

Umbilical Cord-Derived Mesenchymal Stem Cell (VCELL 1) for Male Patients With Sexual Deficiency

Sexual Dysfunction Male

Vietnam
Vinmec Research Institute of Stem Cell and Gene...

Recruiting

Adipose Tissue-derived Mesenchymal Stem Cell (AD-MSC) Therapy for the Treatment of Sexual Function Impairment in Female

Sexual Dysfunction Female

Vietnam
ART Fertility Clinics LLC
Organon and Co

Recruiting

Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI in Granulosa Cells

Infertility | Fertility Issues | Infertility,Female | Ovarian Function Insufficiency

United Arab Emirates
Nordin Hanssen

Recruiting

Encapsulated Faecal Microbiota Transplantation to Preserve Residual Beta Cell Function in Type 1 Diabetes Mellitus (ENCAPSULATE)

Type 1 Diabetes

Netherlands
Roswell Park Cancer Institute

Recruiting

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

Plasma Cell Myeloma | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Smoldering Plasma Cell Myeloma

United States
TC Erciyes University

Recruiting

Stem Cells and Stromal Vascular Fraction for Temporomandibular Joint Disease

Temporomandibular Joint Disorders | Temporomandibular Disorder | Temporomandibular Joint Pain | Temporomandibular Joint Osteoarthritis | Temporomandibular Joint Effusion

Turkey
Institut Pasteur
Höpital La Pitié-Salpêtrière

Not yet recruiting

Cellular microRNA Signatures in Multiple Sclerosis (SEP-MIR)

Multiple Sclerosis, Relapsing-Remitting

France
Yale University
Abbott

Recruiting

The DISCOVER INOCA Prospective Multi-center Registry (DISCOVER INOCA)

Endothelial Dysfunction | Coronary Vasospasm | Microvascular Angina | Coronary Microvascular Dysfunction | Ischemia and No Obstructive Coronary Artery Disease | Chest Pain With Normal Coronary Angiography

United States
Jagiellonian University

Recruiting

Immunotherapy With Dinutuximab Beta in Combination With Chemotherapy for the Treatment of Patients With Primary Neuroblastoma Refractory to Standard Therapy and With Relapsed or Progressive Disease (ChIm-NB-PL)

High-Risk Neuroblastoma

Poland
Mahidol University

Recruiting

Heart Rate Controller in Computed Tomography Coronary Angiography

Heart Rate | Coronary Computed Tomography Angiography

Thailand
Mansoura University

Not yet recruiting

Beta 3 Agonists in Treatment of Non-neurogenic Voiding Dysfunction in Children

Overactive Bladder | Voiding Disorders
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Recruiting

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion (HAPLOTAB)

Myelodysplastic Syndromes | Primary Immunodeficiency Diseases | Hemoglobinopathies | Chronic Myeloid Leukemia | Cytopenia | Severe Aplastic Anemia | Bone Marrow Failure Syndrome | Acute Myeloid Leukemia in Remission | Hemophagocytic Lymphohistiocytoses | Acute Lymphoblastic Leukemia in Remission | Severe...

United States
Assiut University

Not yet recruiting

Comparison Between Levosimendan and Adrenaline in CABG Patients

Open Heart Surgery
National Institute of Allergy and Infectious Diseases...

Recruiting

NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)

Chronic Granulomatous Disease | Infection

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Venetoclax and a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed B Cell Acute Lymphoblastic Leukemia

B Acute Lymphoblastic Leukemia | Ph-Like Acute Lymphoblastic Leukemia

United States
Rigshospitalet, Denmark

Recruiting

Muscle Dysfunction in Patients With Haematological Diseases

Lymphoma | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Hematologic Diseases | Acute Lymphoid Leukemia

Denmark
National Cancer Institute (NCI)
Childrens Oncology Group (COG); LLS PedAL LLC

Recruiting

Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory and That Expresses E-selectin Ligand on the Cell Membrane

Down Syndrome | Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Recurrent Mixed Phenotype Acute Leukemia | Refractory Mixed Phenotype Acute Leukemia | Acute Myeloid Leukemia Post Cytotoxic Therapy | Myelodysplastic...

United States
The Foundation for Orthopaedics and Regenerative...

Recruiting

Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cells for Peyronie's Disease, ED, and Interstitial Cystitis

Erectile Dysfunction | Interstitial Cystitis | Peyronie's Disease

Antigua and Barbuda
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Reproducibility and Accuracy of a Portable System for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Institut National de la Santé Et de la Recherche...

Recruiting

BeAT1D: Benign Autoimmunity and Type 1 Diabetes (BeAT1D)

Type 1 Diabetes

France
Boston University
American Heart Association

Recruiting

Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes (SFRNDM2)

Diabetes Mellitus, Type 2 | Endothelial Dysfunction

United States
Fondazione Policlinico Universitario Agostino Gemelli...
IRCCS Policlinico S. Donato; Centro Cardiologico Monzino

Recruiting

Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial). (PROMISE)

Myocardial Infarction With Non-Obstructive Coronary Arteries

Italy
Gustave Roussy, Cancer Campus, Grand Paris

Recruiting

A Pilot Study Evaluating a Ketogenic Diet Concomitant to Nivolumab and Ipilimumab in Patients With Metastatic Renal Cell Carcinoma (KETOREIN)

Metastatic Renal Cell Carcinoma

France
University of Florida
National Institute of General Medical Sciences (NIGMS)

Recruiting

Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis

Sepsis | Trauma Injury

United States
University Hospital, Strasbourg, France

Recruiting

T-cell Dysfunction in Chronic HBV Infection (VHB-Roche)

Chronic Hepatitis B Virus

France
Children's National Research Institute

Recruiting

Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease (ACT)

Sickle Cell Disease | Cognitive Deficit in Attention | Attention Deficit

United States
Fondazione Policlinico Universitario Agostino Gemelli...
Fresenius Hemocare

Recruiting

umBilical Or Adult Donor Red Blood Cells in Extremely Low Gestational Age Neonates and Retinopathy of Prematurity (BORN) (BORN)

Retinopathy of Prematurity

Italy
Duke University

Recruiting

A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).

Hematopoietic Cell Transplantation

United States
Medicenna Therapeutics, Inc.
Merck Sharp & Dohme LLC

Recruiting

A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1)

Clear Cell Renal Cell Carcinoma | Cervical Cancer | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Solid Tumor | Squamous Cell Carcinoma of Head and Neck | Bladder Cancer | Skin Cancer | Triple Negative Breast Cancer | Advanced Solid Tumor | Primary Peritoneal Cancer | Endometrial Carcinoma and other conditions

United States, Australia, Korea, Republic of, Canada
Assistance Publique - Hôpitaux de Paris
National Research Agency, France

Recruiting

Characterization of the microVAScular Dysfunction in Covid-19 ARDS (VASCOV)

ARDS, Human | COVID-19 Acute Respiratory Distress Syndrome

France
Joseph C. Wu
California Institute for Regenerative Medicine (CIRM)

Recruiting

Human Embryonic Stem Cell-Derived Cardiomyocyte Therapy for Chronic Ischemic Left Ventricular Dysfunction (HECTOR)

Chronic Ischemic Left Ventricular Dysfunction

United States

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