Search clinical trials for: repeated dose

Total 21529 results

Jerini Ophthalmic

Completed

A Phase 1 Safety Study of Single and Repeated Doses of JSM6427 (Intravitreal Injection) to Treat AMD

Macular Degeneration

United States
Sanofi

Completed

Cohort Study in Senegal Comparing Artesunate + Amiodaquine in the Treatment of Repeated Uncomplicated Plasmodium Falciparum Malaria Attacks

Malaria

Senegal
Tibotec Pharmaceuticals, Ireland

Completed

PEPI-TiDP23-C103: First-in-Human Study to Examine the Safety, Tolerability, and Plasma Pharmacokinetics of Increasing Single and Repeated Oral Doses of TMC558445 and of a Combined Single Day Dosing of Oral TMC558445 and Oral TMC310911 and Also Oral Darunavir

HIV-1
Alza Corporation, DE, USA

Completed

A Repeated-Dose Evaluation of a Pain Relieving Drug Use and Safety of OROS Hydromorphone HCI in Patients With Chronic Non-Malignant Pain

Pain | Analgesics | Opioid
Alza Corporation, DE, USA

Completed

A Repeated-Dose Evaluation of Use of a Pain Relieving Drug and Safety of OROS Hydromorphone HCI in Patients With Chronic Cancer Pain

Pain | Analgesics, Opioid
Alza Corporation, DE, USA

Completed

Safety and Tolerability of Long-term Administration of OROS Hydromorphone HCI (Slow Release) in Cancer Pain

Pain | Analgesics, Opioid
AstraZeneca

Completed

Phase I Study in Healthy Volunteers to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD4017 After Repeated Ascending Oral Doses (MAD)

Diabetes Mellitus Type 2

Sweden
Renovo

Completed

Safety Study of Repeated, Escalating Doses of Intradermal Avotermin (Juvista)

Cicatrix | Wound Healing

United Kingdom
AstraZeneca

Completed

Investigate the Effect on the QT/QTc Interval of Repeated and Escalating Doses of AZD3480 During 6 Days (TQT)

Healthy
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study With Repeated Doses of Stalevo

Pharmacokinetics

Finland
University Hospital, Montpellier

Completed

Assessment of Bupropion on Cognitive Function and Behaviour in Healthy Volunteers

Healthy

France
Assistance Publique - Hôpitaux de Paris
Danone Institute International

Terminated

Effects of Peptides Derived From Fermented Milk on Blood Pressure Regulation System in Healthy Volunteers.

Healthy

France
Chang Gung Memorial Hospital

Completed

Long-Term Lead Chelation Therapy and Progressive Renal Insufficiency

Urologic Disease

China
Azienda Usl di Bologna

Recruiting

Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock (EVSS)

Septic Shock | Renal Function Replacement

Italy
AstraZeneca

Not yet recruiting

A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With Asthma (BAIYUN)

Asthma

China
DSM Nutritional Products, Inc.
Nutrasource Pharmaceutical and Nutraceutical Services, Inc.

Not yet recruiting

A Pharmacokinetic Study of Single Oral Doses of Six Different Vitamin C Product Forms

Healthy | Pharmacokinetic
SWOG Cancer Research Network
National Cancer Institute (NCI)

Not yet recruiting

Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

Castration-Resistant Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8
Ohio State University
Patient-Centered Outcomes Research Institute; Northwestern University; Preeclampsia...

Not yet recruiting

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL (ASPIRIN)

Preeclampsia | Gestational Hypertension | Hypertensive Disorders of Pregnancy

United States
Fujian Cancer Hospital

Not yet recruiting

Phase II Study of Different Doses of Radiotherapy Combined With Sintilimab in the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
BioNTech SE

Not yet recruiting

A First-in-human Safety Trial of BNT331 Administered as Single Ascending Doses in Healthy Women and as Multiple Ascending Doses in Women Diagnosed With Bacterial Vaginosis

Bacterial Vaginosis

United States
Copernicus Memorial Hospital
Medical Research Agency, Poland

Not yet recruiting

Application of MET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme

Glioblastoma Multiforme

Poland
Janne Hastrup Jensen
Copenhagen University Hospital, Hvidovre

Not yet recruiting

Automated Oxygen Titration During Walking in Patients With Lung Fibrosis (OXYWILD) (OXYWILD)

Respiratory Therapy | Fibrosis Lung
Longevity Biotech Australia Pty Ltd (subsidiary)

Not yet recruiting

A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Participants and in Participants With Parkinson's Disease.

Parkinson Disease

Australia
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...
EMD Serono Research & Development Institute, Inc.

Not yet recruiting

Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

Generalized Myasthenia Gravis

United States, Germany
Yunpeng Liu
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Irinotecan Hydrochloride Liposome Combined With Capecitabine and Lenvatinib in Patients With Biliary Tract Carcinoma

Biliary Tract Carcinoma

China
Genelux Corporation
Newsoara Biopharma Co., Ltd.

Not yet recruiting

Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's of Choice Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer (VIRO-25) ((VIRO-25))

Non-small Cell Lung Cancer Stage III | Non-small Cell Lung Cancer | Advanced Non-squamous Non-small-cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Metastatic Squamous Non-Small Cell Lung Carcinoma | Non-small Cell Lung Cancer Recurrent | Metastatic Non-squamous Non Small Cell Lung Cancer and other conditions
GeneQuantum Healthcare (Suzhou) Co., Ltd.

Recruiting

A Study of GQ1010 in Subjects With Advanced Solid Tumors

Advanced Malignant Solid Tumors

China
University of Melbourne
Monash University; University of Adelaide; University of Sydney; The University... and other collaborators

Not yet recruiting

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] (PLATIPUS)

Preterm Birth
Pfizer
AbbVie

Not yet recruiting

A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH) (CHERISH)

Gram-negative Bacterial Infection
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy With SPACEOAR TM for Patients With Low-to-intermediate Risk Localized Prostate Cancer (DESAR-L) (DESAR-L)

Low-to-intermediate-risk Prostate Carcinoma

Korea, Republic of
Institute of Medical Biology, Chinese Academy of...

Not yet recruiting

Phase IV Study of Concomitant Administration of the sIPV and HepA

Hepatitis A | Polio

China
ProDa BioTech, LLC
Emory University; Georgia State University

Not yet recruiting

ProAgio in Combination With Gemcitabine in Patients With Metastatic Triple Negative Breast Cancer

Triple Negative Breast Cancer

United States
Ruijin Hospital

Not yet recruiting

The Efficacy of Allo-HSCT in ND HR-CBF-AML

Acute Myeloid Leukemia

China
University Hospital of North Norway
SINTEF Health Research; Helse Nord; Helseapps; Norinnova

Not yet recruiting

Patient-centered Dosage of Levothyroxine

Hypothyroidism | Thyroid | Thyroid Cancer
University Hospital, Basel, Switzerland

Not yet recruiting

TIL Therapy in Non-small-cell Lung Cancer (NSCLC) Patients (BaseTIL-02)

Non-Small Cell Lung Cancer

Switzerland
Turku University Hospital

Recruiting

Sleep Quality and Sleep-disordered Breathing in Bypass Surgery Patients (UNI-CABG)

Coronary Artery Disease | Sleep Disorder

Finland
SNLD, Ltd.

Recruiting

A Phase I Study of TRN501 in Healthy Volunteers

Parkinson Disease

Japan
University Health Network, Toronto

Not yet recruiting

A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment (ABLATE)

Locally Advanced Pancreatic Adenocarcinoma
Regeneron Pharmaceuticals

Not yet recruiting

A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults

Healthy Volunteers
Technical University of Munich
Universitaire Ziekenhuizen KU Leuven; Helmholtz Zentrum München; Skane University... and other collaborators

Recruiting

Anti-viral Action Against Type 1 Diabetes Autoimmunity

Diabetes Mellitus, Type 1

Belgium, Germany, Sweden
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Safety and Efficacy Study of Pilocarpine HCl Ophthalmic Solution in Participants With Presbyopia

Presbyopia
Claris Biotherapeutics, Inc.

Recruiting

Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency

Limbal Stem Cell Deficiency

United States
Tonghua Dongbao Pharmaceutical Co.,Ltd

Recruiting

A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide in Healthy Chinese Subjects

Healthy

China
SURGE Therapeutics

Not yet recruiting

Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

Prostate Cancer
NEXBIOME THERAPEUTICS

Not yet recruiting

Efficacy, Safety, and Dose-response of a Live Biotherapeutic Product in Women With Acute Vaginal Infection (ELINA)

Bacterial Vaginosis | Vulvovaginal Candidiasis
University of North Carolina, Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Not yet recruiting

Dose Optimization of Caffeine for HIE

Hypoxic-Ischemic Encephalopathy

United States
BioNTech SE

Not yet recruiting

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Small-cell Lung Cancer | Extensive-stage Small-cell Lung Cancer
BioNTech SE

Not yet recruiting

Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy

Triple Negative Breast Cancer | Locally Advanced Breast Cancer
University Medical Center Groningen
M.D. Anderson Cancer Center

Not yet recruiting

PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer (PIRATES)

Head and Neck Cancer | Oropharyngeal Cancer

Netherlands

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