Search clinical trials for: Metabolite

Total 468 results

National Institute of Allergy and Infectious Diseases...

Completed

Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites

HIV Infections | Bacterial Infections | Mycoses

United States
University of Calgary
University of Lethbridge

Completed

Diagnosis of Sport-related Concussion Using Urine Metabolites

Concussion, Mild | Diagnoses, Syndromes, and Conditions

Canada
Assistance Publique - Hôpitaux de Paris
ICAN Nutrition Education and Research

Completed

The Interaction Between Protein Intake, Gut Microbiota and Type 2 Diabetes in Subjects With Different Ethnic Backgrounds (MICRODIET)

Type 2 Diabetes

France
Acerta Pharma BV
AstraZeneca

Completed

Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite

Hepatic Insufficiency | Healthy Subjects | Hepatic Impairment

United States
Xijing Hospital

Completed

Gut Microbiome and Serum Metabolome Alterations in ADHD Patients (ADHD)

Attention-deficit/Hyperactivity Disorder

China
University of California, Davis

Completed

Absorption and Digestion Kinetics of Human Metabolites

Postprandial Inflammation

United States
University of California, Davis
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Using Breath Metabolites to Determine Specific Virus Infection in Asthmatic Patients

Upper Respiratory Tract Infections, Asthma, Exhaled Breath

United States
The Christie NHS Foundation Trust
University of Oxford

Completed

Measurement of Gemcitabine Metabolites in Blood and Urine as Predictors of Response to GemX Bladder Radiotherapy (Gemtrans)

Bladder Cancer

United Kingdom
Odonate Therapeutics, Inc.

Terminated

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Emalex Biosciences Inc.
Syneos Health; Nuventra

Completed

Drug-Drug Interaction Study to Evaluate the Effect of Inhibition of UGTs on the PK of Ecopipam and Its Active Metabolite

Drug Interaction

United States
Osijek University Hospital
Josip Juraj Strossmayer University of Osijek

Completed

Metabolites of Tramadol in the Postoperative Surgical Patients (METRAS)

Respiratory Failure | Renal Failure | Abdominal Surgery | Liver Dysfunction | Multiorgan Failure

Croatia
Peking University Third Hospital

Completed

Correlation Between Intestinal Microflora Metabolites and Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

China
AstraZeneca

Completed

PK Study of Ticagrelor in Children Aged Less Than 24 Months, With Sickle Cell Disease (HESTIA4) (HESTIA4)

Sickle Cell Disease

Belgium, United Kingdom, Italy, Spain, Kenya, Lebanon
University of Parma
Azienda Ospedaliero-Universitaria di Parma

Suspended

Metabotypes in the Urinary Excretion of Flavan-3-ol Metabolites: "Metanols" (Metanols)

Diet Modification

Italy
Rockefeller University
National Institutes of Health (NIH); Weill Medical College of Cornell University

Completed

Effects of Dietary Fructose on Gut Microbiota and Fecal Metabolites in Obese Men and Postmenopausal Women: A Pilot Study

Obesity | Non-Alcoholic Fatty Liver Disease

United States
Kaohsiung Veterans General Hospital.

Completed

Plasticizers and in Vitro Fertilization Outcomes

Fertilization in Vitro

Taiwan
Poitiers University Hospital

Unknown

MRI Biomarkers in Diabetic Kidney Disease (MR3T - DKD)

Diabetic Nephropathies

France
InfanDx AG
Cukurova University; University Children's Hospital Tuebingen

Unknown

Asphyxia Associated Metabolite Biomarker Investigation 2 (AAMBI2)

Birth Asphyxia

Turkey
Janssen Pharmaceutica N.V., Belgium

Terminated

A Study to Evaluate the Effect of Renal Impairment on JNJ-64417184 and Its Two Minor Metabolites JNJ-68294291 and JNJ-65201526 in Adult Participants

Renal Impairment

Germany
National Taiwan Sport University

Unknown

To Explore the Effects of Different Training Periods and Dietary Pattern on the Gut Microbiota, Metabolites and Protein Expression Levels of Strength and Endurance Athletes and to Find Relevant Biological Indicators.

Athlete

Taiwan
Life Science Inkubator
Cukurova University; University Children's Hospital Tuebingen

Completed

Asphyxia Associated Metabolite Biomarker Investigation (AAMBI) (AAMBI)

Asphyxia Neonatorum

Turkey
University of Massachusetts, Amherst

Completed

Interindividual Variation in Excretion of Curcumin

Gut Microbiota | Metabolites

United States
Radboud University Medical Center

Completed

PharmacoKINEtics of TAMoxifen and Its Metabolites in Breast Cancer Patients: the Influence of a Dose Increase in Phenotypic Poor Metabolizers of CYP2D6 (KINETAM) (KINETAM)

Breast Cancer

Netherlands
MedDay Pharmaceuticals SA
Quotient Sciences

Completed

Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-MD1003 in Healthy Male Subjects

Healthy Volunteers

United Kingdom
China Agricultural University
General Hospital of Chinese Armed Police Forces; Peking University Shougang... and other collaborators

Completed

The Correlation Between Gut Microbiome/Metabolite and End Stage Renal Disease (ESRD)

Kidney Failure, Chronic

China
Wageningen University
University Medical Center Groningen

Completed

Fiber Fermentation Kinetics Inside the Gut, and Utilization of Bacterial Metabolites

Metabolism | Dietary Fiber | Intestine

Netherlands
The First Affiliated Hospital of Xiamen University

Unknown

Camrelizumab Combined With Apatinib Mesylate Tablets and Nab-paclitaxel in the Second-line Treatment of Advanced Gastric Cancer

Locally Advanced or Metastatic Gastric Adenocarcinoma

China
Centro De Investigación Y De Estudios Avanzados...
Centro de Estudios Cardiometabólicos S.C. (CESCAM); Inulina y Miel de Agave...

Completed

Gastrointestinal Tolerability to Agavins and Impact on Host-gut Microbiota-metabolism Interactions Modulation

Healthy | Obesity

Mexico
Klinikum Nürnberg

Unknown

Determination of Drugs and Their Metabolites in Hospitalized Patients

Neoplasms

Germany
AstraZeneca
Quotient Sciences

Completed

A Study to Assess the Mass Balance Recovery, Pharmacokinetics, Metabolite Profile and Metabolite Identification of [14C]AZD4831

Cardiovascular Disease

United Kingdom
Celgene

Completed

Drug Interaction Study of the Effect on Cyclosporine on Ozanimod and Major Active Metabolites

Healthy Volunteers

United States
Shenzhen People's Hospital

Unknown

Functional Study of Metabolites in Patients With Aortic Dissection

Aortic Dissection

China
Fraunhofer-Institute of Toxicology and Experimental...

Completed

Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites (18-03 EONOV)

Atopic Asthma

Germany
Hospital Universitario Dr. Jose E. Gonzalez
Instituto de Información e Investigación en Salud Mental A. C.

Unknown

Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients

Anxiety Disorders | Major Depressive Disorder

Mexico
Northumbria University
Quorn

Completed

The Effects of Replacing Red and Processed Meat With Quorn on Biomarkers of Gut Health (MYCOMEAT)

Colorectal Cancer

United Kingdom
Perosphere Pharmaceuticals Inc, a wholly owned...
World Wide Clinical Trials Early Phase Services, LLC

Completed

An Open-label, Single-dose, Non-randomized Study of IV 14C-labeled PER977 in Healthy Male Subjects

Healthy

United States
Hallym University Kangnam Sacred Heart Hospital

Unknown

Pediatric Obesity Related Metabolite Profile and Gut Microbiota

Obesity, Childhood

Korea, Republic of
Xiangya Hospital of Central South University

Unknown

Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage

Frontal Lobe Dysfunction
Universitaire Ziekenhuizen KU Leuven

Completed

AXOS and Microbial Metabolites in CKD

Chronic Kidney Disease

Belgium
Universitaire Ziekenhuizen KU Leuven

Withdrawn

The Colonic Transit Time: a Modifiable Determinant of Intestinal Production and Uptake of Microbial Metabolites?

Constipation

Belgium
Universitaire Ziekenhuizen KU Leuven

Unknown

Intestinal Transport of Microbial Metabolites in Chronic Kidney Disease

Chronic Kidney Disease

Belgium
Corcept Therapeutics

Completed

Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites

Healthy

United States
Eisai Inc.
Purdue Pharma LP

Completed

Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared to Healthy Subjects

Hepatic Impairment

United States
Eisai Inc.
Purdue Pharma LP

Completed

Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Normal Renal Function or With Severe Renal Impairment

Renal Impairment

United States
Glac Biotech Co., Ltd

Completed

Double-blind Clinical Trials of Probiotic Products in Oral Health.

Probiotics | Oral Health | Probiotic Metabolites

Taiwan
Laval University

Completed

Investigation of Microbiome-Derived Metabolite Production in Response to a Mediterranean Diet (META)

Food Habits

Canada
Astellas Pharma Europe B.V.
FibroGen

Completed

A Phase 1 Study of Roxadustat in Subjects With Different Degrees of Renal Function

Impaired Renal Function | Normal Renal Function

Germany, United Kingdom
Fytexia

Completed

Mangoselect®: Characterization, Pharmacokinetics and Bioavailability of Xanthone Metabolites

Dietary Modification

Spain
Imperial College London

Completed

Application of New Technologies and Tools to Nutrition Research (NutriTech)

Obesity | Diabetes

United Kingdom
Universiti Putra Malaysia

Unknown

Postprandial Metabolites of Meal Challenge Test in Diabetes State

Type2 Diabetes | Postprandial Hyperglycemia

Malaysia

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