Interindividual Variation in Excretion of Curcumin

University of Massachusetts Amherst

Sponsors

Lead Sponsor: University of Massachusetts, Amherst

Source University of Massachusetts, Amherst
Brief Summary

The objective of this project is to elucidate the interindividual variations in excretion of curcumin and its metabolites.

Overall Status Completed
Start Date 2018-09-01
Completion Date 2019-10-01
Primary Completion Date 2019-03-01
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Determine the concentration of curcumin and its metabolites in the human fecal samples. 3-4 weeks
Enrollment 8
Condition
Intervention

Intervention Type: Dietary Supplement

Intervention Name: curcumin

Description: subjects will be assigned to consume one capsule of curcumin (330 mg of curcumin per capsule) three times a day (one capsule with each meal).

Arm Group Label: Curcumin

Eligibility

Criteria:

Inclusion Criteria: - 18-30 year old healthy adults Exclusion Criteria: - Exclusion criteria included those who are <18 or >30 years old, have a BMI of <20 or >29 kg/m2, have a weight change >4.5 kg in the past 3 months, exceed exercise activities of a curcumin level over the past 3 months, have any diseases, especially intestinal disorders, had abnormal liver or kidney function tests. Those who smoke, consume more than two alcoholic drinks per day, use medication affecting gut microbiota profile (e.g., antibiotics and probiotics) in past three months will also be excluded. - Additionally, this study excludes menopausal women, those using hormone-based contraceptives, those with abnormal menstrual cycles, and those who are pregnant, lactating or planning to become pregnant.

Gender:

All

Minimum Age:

18 Years

Maximum Age:

30 Years

Healthy Volunteers:

Accepts Healthy Volunteers

Overall Contact Contact information is only displayed when the study is recruiting subjects.
Location
Facility: Institute for Applied Life Sciences
Location Countries

United States

Verification Date

2020-03-01

Responsible Party

Type: Sponsor

Has Expanded Access No
Number Of Arms 1
Arm Group

Label: Curcumin

Type: Experimental

Description: subjects will be assigned to consume one capsule of curcumin (330 mg of curcumin per capsule) three times a day (one capsule with each meal).

Study Design Info

Allocation: N/A

Intervention Model: Single Group Assignment

Primary Purpose: Treatment

Masking: None (Open Label)

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