Search clinical trials for: Resistance mechanism

Total 102554 results

Shanghai Chest Hospital
The Affiliated Hospital of Qingdao University; Zhejiang University; Anhui Provincial...

Active, not recruiting

Cadonilimab in Patients (Pts) With Advanced Non-small Cell Lung Cancer (NSCLC) (AK104IIT018)

NSCLC Stage IV | NSCLC Stage IIIB | NSCLC Stage IIIC

China
AbbVie
Genentech, Inc.

Active, not recruiting

A Study Evaluating Venetoclax in Combination With Azacitidine in Participants With Treatment-Naïve Higher-Risk Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndromes (MDS)

United States, Australia, Canada, France, Germany, Italy, United Kingdom
Monica Bhatia

Completed

Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease

Sickle Cell Disease | Graft Versus Host Disease

United States
Novartis Pharmaceuticals

Terminated

A Study of Sabatolimab in Combination With Azacitidine and Venetoclax in High or Very High Risk MDS Participants (STIMULUS-MDS3)

Myelodysplastic Syndrome (MDS)

France, Spain, Belgium, Italy, Greece, Hungary, Germany
National Cancer Institute (NCI)

Completed

Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-Mutated, Non-Small Cell Lung Cancer After Treatment With Osimertinib

Lung Neoplasms | Lung Adenocarcinoma

United States
Organon and Co

Completed

Ezetimibe (+) Simvastatin vs. Atorvastatin Comparative Study in DM or Metabolic Syndrome Patients (0653A-093)

Hypercholesterolemia
University of Missouri-Columbia

Active, not recruiting

ENAC Blockade and Arterial Stiffness

Insulin Resistance | Overweight and Obesity

United States
Memorial Sloan Kettering Cancer Center
Bristol-Myers Squibb

Completed

Evaluate the Mediators of Sensitivity and Resistance to Nivolumab Plus Ipilimumab in Patients With Advanced NSCLCs

Advanced Stage Non-small Cell Lung Cancer

United States
Organon and Co

Completed

A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Ezetimibe/Simvastatin in Patients With Metabolic Syndrome (0653A-107)(COMPLETED)

Metabolic Syndrome | Hypercholesterolemia
University Hospital Tuebingen

Terminated

Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin Secretion

Insulin Resistance | Hypercholesterolemia | Insulin Secretion

Germany
Organon and Co

Completed

A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331)

Hypertension | Metabolic Disorder
National Cancer Institute (NCI)

Completed

TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas

NSCLC | Solid Tumors | Lymphomas | Granulosa Cell Ovarian Cancer | Metastatic Colon Carcinoma

United States
Vanderbilt University Medical Center

Active, not recruiting

Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity

Healthy | Obesity | Insulin Resistance

United States
Assistance Publique Hopitaux De Marseille

Active, not recruiting

Precision Immuno-Oncology for Advanced Non-small Cell Lung Cancer Patients With PD-1 ICI Resistance (PIONeeR)

Non-small Cell Lung Cancer

France
Novartis Pharmaceuticals

Active, not recruiting

Study of Efficacy and Safety of MBG453 in Combination With Azacitidine in Subjects With Intermediate, High or Very High Risk Myelodysplastic Syndrome (MDS) as Per IPSS-R, or Chronic Myelomonocytic Leukemia-2 (CMML-2) (STIMULUS-MDS2)

Myelodysplastic Syndromes | Leukemia, Myelomonocytic, Chronic

China, Czechia, Japan, Saudi Arabia, Taiwan, Turkey, Germany, Spain, Netherlands, Italy, Singapore, Australia, Austria, France, United Kingdom, Korea, Republic of, Thailand, Israel, Belgium, Canada, Switzerland, Lithuania, Russian Federation and more
Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb; Celgene; Stand Up To Cancer; Syndax Pharmaceuticals; Rhone-Poulenc... and other collaborators

Completed

Phase II Anti-PD1 Epigenetic Therapy Study in NSCLC. (NA_00084192)

Non-Small Cell Lung Cancer | Epigenetic Therapy

United States
Novartis Pharmaceuticals

Active, not recruiting

A Study of MBG453 in Combination With Azacitidine and Venetoclax in AML Patients Unfit for Chemotherapy (STIMULUS-AML1)

Acute Myeloid Leukemia

Italy, Spain, Canada, Germany, Korea, Republic of, Japan, Australia, France, United States, Taiwan
Washington University School of Medicine
Celgene Corporation

Active, not recruiting

Nab-Paclitaxel and Cisplatin or Nab-paclitaxel as Induction Therapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC) (APA)

Head and Neck Cancer | Squamous Cell Carcinoma of the Head and Neck | Cancer of Head and Neck | Neoplasms, Head and Neck | Cancer of the Head and Neck | Carcinoma, Squamous Cell of the Head and Neck

United States
Washington University School of Medicine
Sunesis Pharmaceuticals

Completed

Vosaroxin and Azacitidine in Treating Patients With Myelodysplastic Syndromes

Myelodysplastic Syndromes

United States
Novartis Pharmaceuticals

Active, not recruiting

A Study of Siremadlin in Combination With Venetoclax Plus Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Chemotherapy.

Acute Myeloid Leukemia

Italy, Hong Kong, Israel, Hungary, Turkey, Malaysia, United States
University of California, San Diego
Takeda; Celgene; Janssen, LP

Active, not recruiting

Daratumumab, Ixazomib, Pomalidomide, and Dexamethasone as Salvage Therapy in Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

United States
Centre Hospitalier Universitaire Saint Pierre
AstraZeneca

Terminated

Effect of the Antidiabetic Drug Dapagliflozin on the Coronary Macrovascular and Microvascular Function in Type 2 Diabetic Patients (DAPAMICRO)

Diabetes Mellitus, Type 2

Belgium
Pfizer

Active, not recruiting

Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma (COLUMBUS)

Melanoma

Canada, United States, Spain, Germany, Korea, Republic of, Australia, Czechia, Netherlands, France, Hungary, United Kingdom, Switzerland, Singapore, Russian Federation, Italy, Japan, Israel, Brazil, Portugal, Mexico, Greece, Argen... and more
Fundacion SEIMC-GESIDA
ViiV Healthcare

Completed

Lamivudine/Dolutegravir in Virologically Suppressed Subjects With Expected or Confirmed Resistance to Lamivudine (VOLVER)

HIV Infections

Spain
Unity Health Toronto
Gilead Sciences; CIHR Canadian HIV Trials Network

Terminated

Virtual PrEP: Rendering PrEP Delivery More Efficient (VPrEP)

HIV Infections

Canada
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Prediabetes

United States
National Institute of Allergy and Infectious Diseases...

Completed

Using Biomarkers to Predict TB Treatment Duration

Pulmonary Tuberculosis

South Africa
M.D. Anderson Cancer Center
AstraZeneca

Active, not recruiting

Selumetinib and Olaparib in Solid Tumors

Malignant Neoplasms of Female Genital Organs | Malignant Neoplasm of Breast | Malignant Neoplasms of Thyroid and Other Endocrine Glands | Malignant Neoplasms of Digestive Organs | Malignant Neoplasms of Male Genital Organs

United States
SINA Health Education and Welfare Trust
Horizon Pharmaceutical Pvt Ltd

Completed

Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient

Glucose Metabolism Disorders | Diabetes Mellitus, Type 2 | Hypoglycemic Agents | Empagliflozin

Pakistan
Assistance Publique - Hôpitaux de Paris

Completed

Study of Colchicine Resistance in Familial Mediterranean Fever (COLCHI-RESIST)

Colchicine Resistance | Mediterranean Fever

France
Memorial Sloan Kettering Cancer Center
GlaxoSmithKline

Completed

A Phase 1/2 Trial of Trametinib and Erlotinib in Patients With EGFR-Mutant Lung Adenocarcinomas and Acquired Resistance to Erlotinib

Lung Cancer | Lung Cancer Metastatic | Lung Adenocarcinoma | Lung Cancer Stage IV | Recurrent Lung Adenocarcinoma | Recurrent Lung Cancer

United States
Memorial Sloan Kettering Cancer Center

Completed

Rituximab, Methotrexate, Procarbazine and Vincristine Followed by High-dose Chemotherapy With Autologous Stem-cell Rescue in Newly-diagnosed Primary CNS Lymphoma (PCNSL)

Non-Hodgkin's Lymphoma | CNS Lymphoma | CNS Brain Cancer

United States
Grant Dorsey, M.D, Ph.D.
National Institutes of Health (NIH); Infectious Diseases Research Collaboration...

Active, not recruiting

Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda

Malaria

Uganda
Zhejiang University

Completed

Double-blind and Placebo-controlled Study on Intervention Effect of Medium and Long Chain Fatty Acid Triglyceride on Glycolipid Homeostasis in Patients With Metabolic Syndrome and Mechanisms

Metabolic Syndrome

China
Theodoros Foukakis

Terminated

HR+/HER2- Advanced Breast Cancer and Endocrine Resistance (PASIPHAE)

Breast Cancer Metastatic

Sweden, United Kingdom
Chelsea and Westminster NHS Foundation Trust

Completed

The Effect of Dolutegravir on Whole-body Insulin Sensitivity, Lipid and Endocrine Profile in Healthy Volunteers (DTG Clamp)

HIV-1-infection on Healthy Volunteers

United Kingdom
Iowa State University

Completed

Feasibility of Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms

Major Depressive Disorder

United States
Takeda

Active, not recruiting

A Study of Pevonedistat and Venetoclax Combined With Azacitidine to Treat Acute Myeloid Leukemia (AML) in Adults Unable to Receive Intensive Chemotherapy (PEVENAZA)

Acute Myeloid Leukemia (AML)

United States, France, Italy, Poland, Canada
Xinhua Hospital, Shanghai Jiao Tong University...

Completed

Tislelizumab Combined Treatment in Refractory Extranodal NK/T-cell Lymphoma

Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type

China
Aprea Therapeutics

Completed

APR-246 & Azacitidine for the Treatment of TP53 Mutant Myelodysplastic Syndromes (MDS)

MDS

United States, France
Assistance Publique - Hôpitaux de Paris

Active, not recruiting

Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation (AGIR)

Recurrent IDH1/2 Mutated Glioma

France
Nantes University Hospital
AstraZeneca

Active, not recruiting

MEchanisms of Resistance in EGFR Mutated Nonpretreated Advanced Lung Cancer Receiving OSimErtib (MELROSE)

Non-small Cell Lung Cancer

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Quizartinib With Azacitidine or Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

FLT3 Gene Mutation Negative | FLT3 Internal Tandem Duplication Positive | Recurrent Acute Myeloid Leukemia | Recurrent Chronic Myelomonocytic Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Chronic Myelomonocytic Leukemia | Refractory Myelodysplastic...

United States
Pfizer

Completed

PF-06863135 As Single Agent And In Combination With Immunomodulatory Agents In Relapse/Refractory Multiple Myeloma

Multiple Myeloma

Canada, United States
Mayo Clinic

Active, not recruiting

Immunomodulatory Drugs (Lenalidomide With or Without Pomalidomide) in Combination With a Corticosteroid Drug (Dexamethasone) for the Treatment of Multiple Myeloma

Plasma Cell Myeloma | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Smoldering Plasma Cell Myeloma

United States
Cristina Gasparetto
Celgene

Active, not recruiting

Bendamustine + Pomalidomide + Dex in R/R Multiple Myeloma

Multiple Myeloma

United States
Institute of Tropical Medicine, Belgium
Damien Foundation

Active, not recruiting

Novel Triple-dose Tuberculosis Retreatment Regimen (Tri-Do-Re)

Tuberculosis | Pulmonary Tuberculosis | Multidrug-resistant Tuberculosis | Resistance to Tuberculostatic Drugs

Niger
University of Cologne

Completed

EGF816 and Trametinib in Patients With Non-small Cell Lung Cancer Harboring Activating EGFR Mutations (EATON)

Bronchial Neoplasms

Spain, Germany
Duke University

Completed

Understanding Immunotherapy Resistance Mechanisms in Advanced Melanoma

Melanoma

United States

Search clinical trials for: Resistance mechanism

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