Search clinical trials for: pharmacokinetic mechanism

Total 104881 results

Ahon Pharmaceutical Co., Ltd.
Affiliated Hospital of Hebei University; The First Hospital of Jilin University and other collaborators

Recruiting

Study of Efficacy, Safety, and Pharmacokinetics of FCN-437c in Combination With Fulvestrant or Letrozole+Goserelin

Breast Neoplasms

China
Zhou Chengzhi
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Recruiting

Chemotherapy Combined With Camrelizumab and Apatinib in First-line Treatment of ES-SCLC

Extensive Stage Small Cell Lung Cancer

China
Zhengzhou University

Recruiting

A Prospective Clinical Study of Ruxolitinib and Etoposide Combined With DDGP Regimen (RUE-DDGP) in Induction Therapy of T/NK Cell Lymphoma-associated Hemophagocytic Syndrome. (RUE-DDGP)

Hemophagocytic Syndrome | T/NK-Cell Lymphoma

China
The University of Queensland
Chinese University of Hong Kong; University of Malaya; The Alfred; Centre Hospitalier... and other collaborators

Recruiting

PNEUmonia DOSing in Critically Ill Patients (PNEUDOS) (PNEUDOS)

Pneumonia

Hong Kong, France, Belgium, Australia, Malaysia
IlDong Pharmaceutical Co Ltd

Recruiting

IDG-16177 for the Evaluation of Its Safety and Pharmacokinetics

Type 2 Diabetes

Germany
Bambino Gesù Hospital and Research Institute
Radboud University Medical Center; University of Exeter; Consorzio per Valutazioni...

Recruiting

A New Posaconazole Dosing Regimen for Paediatric Patients With Cystic Fibrosis and Aspergillus Infection (cASPerCF)

Cystic Fibrosis | Aspergillosis

Ireland, Spain, Netherlands, France, United Kingdom, Czechia, Germany, Greece, Italy, Portugal, Switzerland
Children's Hospital of Fudan University

Not yet recruiting

PK/PD of Caspofungin in Children Severe Infection

Pharmacokinetics | Infection, Fungal

China
Angion Biomedica Corp
Nucleus Network Ltd

Not yet recruiting

Study to Evaluate the Pharmacokinetics of ANG-3777 in Hemodialysis Subjects

Hemodialysis

United States
Astex Pharmaceuticals, Inc.

Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

Acute Myeloid Leukemia | Myelodysplastic Syndromes

Spain, Poland, Bulgaria, Lithuania, Slovakia, Romania
Astex Pharmaceuticals, Inc.

Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

Acute Myeloid Leukemia | Myelodysplastic Syndromes

Spain, Poland, Bulgaria, Lithuania, Slovakia, Romania
Xuanzhu Biopharmaceutical Co., Ltd.

Recruiting

Effect of Clarithromycin and Rifampicin on the Pharmacokinetics of XZP-3287 in Healthy Subjects

Healthy

China
Seoul National University Hospital
National Institute of Food and Drug Safety Evaluation (Republic of Korea)

Not yet recruiting

Pharmacokinetic Study of Post-transplant Cyclophosphamide in Pediatric Patients

Hematopoietic Stem Cell Transplantation
Seoul National University Hospital
National Institute of Food and Drug Safety Evaluation (Republic of Korea)

Recruiting

Pharmacokinetic Study of Melphalan in Pediatric Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation

Korea, Republic of
Jill M Kolesar
National Cancer Institute (NCI); Novartis

Recruiting

Nilotinib Plus Dabrafenib/Trametinib in Metastatic Melanoma

Metastatic Melanoma | BRAF Gene Mutation

United States
Rennes University Hospital

Recruiting

Monocentric, Prospective Study to Assess the Pharmacokinetic Profile of Continuous and Diurnal Subcutaneous Apomorphine Infusion in Patients With Parkinson's Disease (PHARM-APO)

Parkinson Disease

France
University Hospital Inselspital, Berne
Centre Hospitalier Universitaire Vaudois

Recruiting

Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in Patients With Liver Cirrhosis

Liver Cirrhosis

Switzerland
Seoul National University Hospital
National Institute of Food and Drug Safety Evaluation (Republic of Korea)

Recruiting

Pharmacokinetics and Pharmacodynamics of Mycophenolate Mofetil in Pediatric Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation

Korea, Republic of
Duke University
The Emmes Company, LLC

Recruiting

Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana (BMS02)

HIV Infections | Lactating Women on Select DOI | Breastmilk Fed Infants of Mothers on Select DOI

South Africa
Zhejiang Cancer Hospital

Not yet recruiting

A Prospective Study of PD-1 Inhibitor Combined With ICE in the Treatment of Relapsed/Refractory Gray Area Lymphoma

Chemotherapy Effect | Gray Zone Lymphoma | Relapse/Recurrence
Hospices Civils de Lyon

Recruiting

NIRAPK : Study of the Relationship(s) Between Clinical, Biological and Pharmacokinetic Metrics and Toxicities When Niraparib is Used as Maintenance Treatment for Ovarian Cancer Patients. (NIRAPK)

Adult Patients With Platinum-sensitive, Relapsed, High Grade Serous Epithelial Ovarian Cancer

France
Vaccinex Inc.
Merck Sharp & Dohme LLC

Recruiting

Pepinemab in Combination With Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (KEYNOTE-B84)

Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (HNSCC)

United States
Nanjing Sanhome Pharmaceutical, Co., Ltd.

Not yet recruiting

The Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SH-1028

Healthy Male Volunteers

China
Shandong University
The Second Hospital of Shandong University

Recruiting

Population Pharmacokinetics and Dosage Individualization of Antibiotics in Elderly Patients

Elderly Infection

China
Vita Green Health Products Co. Ltd

Not yet recruiting

Pharmacokinetic and Pharmacodynamic Study of a Novel Sublingual Aspirin Tablet

Cardiovascular Diseases
Pharmaceutical Project Solutions, Inc.

Not yet recruiting

Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution

ENT Disorder
Prakash Pandalai

Recruiting

Flat Dose Vs. Weight-based IP Chemotherapy for CRS/HIPEC

Peritoneal Carcinomatosis

United States
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

ALK Fusion-positive Solid or CNS Tumors

United States, Korea, Republic of, China, Spain, Canada, Australia, United Kingdom, Denmark, France, Italy, Germany, Brazil
Shandong University
Children's Hospital of Chongqing Medical University

Recruiting

Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance

Bacterial Meningitis | Augmented Renal Clearance

China
Seattle Gummy Company

Not yet recruiting

A Single Dose Randomized Five-Way Crossover Pharmacokinetics (PK) Study of Tadalafil Semi-Chewable (Gummy) Formulations in Healthy Volunteers

Erectile Dysfunction
University of KwaZulu
Centre for the AIDS Programme of Research in South Africa

Recruiting

Pharmacokinetics of Twice or Once Daily DTG (50mg) in Children With HIV and TB (ORCHID)

Tuberculosis | Hiv

South Africa
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

United States
Institut Curie
Fondation Rothschild Paris

Recruiting

Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome (RETINO2018)

Retinoblastoma

France
Henan Cancer Hospital

Recruiting

Alotinib Plus Durvalumab-Platinum-Etoposide in First-line Treatment Extensive Small-cell Lung Cancer

SCLC, Extensive Stage

China
PENTA Foundation
ViiV Healthcare; Hospital Universitario 12 de Octubre; Cromsource; PHPT Foundation

Recruiting

Safety and Pharmacokinetics Evaluation of Fostemsavir + (OBT) in HIV-1 Infected Children and Adolescents Who Are Failing Their cART and Have Dual- or Triple-class Antiretroviral Resistance

HIV Infections With Multi Drug Resistant Virus

United States, South Africa, Mexico, Spain
GE Healthcare
Covance

Recruiting

A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients (Rapiscan PIP)

Myocardial Ischemia | Coronary Artery Disease

France, Greece, Italy, United Kingdom
CARsgen Therapeutics Co., Ltd.
Fudan University; Peking University Cancer Hospital & Institute

Recruiting

Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection

Pancreatic Cancer | Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

China
UCB Biopharma SRL

Recruiting

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal Seizures (LENS)

Epilepsy | Electroencephalographic Neonatal Seizures

United States, Australia, Canada
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

HIV Infections | Tuberculosis

United States, Malawi, Puerto Rico, South Africa, Thailand, Zimbabwe, Brazil, Kenya, Uganda, India, Tanzania, Botswana
GlaxoSmithKline

Recruiting

An Intravenous (IV) Zanamivir Pharmacokinetics (PK) Study in Hospitalized Neonates and Infants With Influenza Infection

Arthralgia | Influenza, Human

Spain, United Kingdom, Poland, Netherlands
Suzhou Transcenta Therapeutics Co., Ltd.
Bristol-Myers Squibb

Recruiting

A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

Advanced Cancer

China
Natural Immune Systems Inc

Recruiting

Antioxidant Bioavailability

Pharmacokinetics

United States
Genentech, Inc.

Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Colorectal Cancer | Non-Small Cell Lung Cancer | Advanced Solid Tumors

United States, Korea, Republic of, Spain, United Kingdom, Brazil, Israel, New Zealand, Netherlands, Canada, Australia, Switzerland, Belgium, Italy, Norway, Poland, Hungary, Kenya, Russian Federation, Germany
Grand Life Science (Liaoning) Co., Ltd.
The First Hospital of Jilin University

Recruiting

To Evaluate the Patient Tolerance, Pharmacodynamics and Pharmacokinetics of Lanthanum Polystyrene Sulfonate Powder

Hyperphosphatemia

China
Beijing Tongren Hospital

Recruiting

GPED Regimen for Relapsed/Refractory or Advanced ENKTCL

Extranodal NK/T-cell Lymphoma, Nasal Type

China
Shandong University
West China Second University Hospital

Recruiting

Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA

Patent Ductus Arteriosus

China
Shandong University
West China Second University Hospital

Not yet recruiting

Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN

Persistent Pulmonary Hypertension of the Newborn

China
Lee's Pharmaceutical Limited

Recruiting

Study of ZKAB001 Combined With Carboplatin and Etoposide in the Extensive Small Cell Lung Cancer

Extensive Stage Small Cell Lung Cancer

China
Universitaire Ziekenhuizen KU Leuven

Recruiting

Pharmacokinetics of Apixaban in Patients With Short Bowel Syndrome Requiring Long Term Parenteral Nutrition (ABSORB)

Anticoagulation | Short Bowel Syndrome

Belgium
Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)

Heart Failure | Pain | Pneumonia | Hypertension | Edema | Hemophilia | Insomnia | Pulmonary Arterial Hypertension | Coagulation Disorder | Asthma in Children | Down Syndrome | Attention Deficit Hyperactivity Disorder | Bronchopulmonary Dysplasia | Hypokalemia | Hyperphosphatemia | Primary Hyperaldosteronism | Adrenal Insufficiency and other conditions

United States, Canada
Ottawa Hospital Research Institute

Recruiting

The Influence of Concurrent Oral Calcium Carbonate Supplementation on Steady State Pharmacokinetics of Oral Raltegravir. (RCPK)

Calcium Supplementation in HIV Patients Using Raltegravir

Canada

Search clinical trials for: pharmacokinetic mechanism

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