Study of Efficacy, Safety, and Pharmacokinetics of FCN-437c in Combination With Fulvestrant or Letrozole+Goserelin

Evaluation of the Antitumor Activity, Safety, and Pharmacokinetic Profile of FCN-437c in Combination With Fulvestrant or Letrozole + Goserelin in Female Patients With ER+, HER2- Advanced Breast Cancer

This is a multicenter, open-label clinical study to evaluate the safety and antitumor activity of FCN-437c in combination with Fulvestrant for the treatment of post-menopausal female patients with ER+ and HER2- advanced breast cancer, FCN-437c in combination with Letrozole + Goserelin for the treatment of pre-menopausal female patients with ER+ and HER2- advanced breast cancer, and to evaluate the PK characteristics of the FCN-437c combination therapies.

This study is consist of two cohorts, Cohort 1: FCN-437c in combination with Fulvestrant (1st or 2nd line treatment for postmenopausal ER+, HER2-advanced breast cancer); Cohort 2: FCN-437c in combination with Letrozole + Goserelin (1st line treatment for premenopausal ER+, HER2- advanced breast cancer). Thirty patients will be enrolled in each cohort, for a total of 60 patients.

Tumor Assessment:

Tumor evaluation will be performed every 8 weeks (±7 days) according to RECIST version 1.1 until disease progression, withdrawal of informed consent, or death; for patients who discontinue the drug due to toxicity, imaging evaluation is required until disease progression.

End of Treatment and End of Study:

End of Study (EOS) is defined as 2 years after the last patient's first dose or the end of treatment (whichever is earlier). At the end of the study, the investigator will decide whether the patients whose disease has not progressed shall continue taking FCN-437c and other combination agents or not based on clinical benefit.

Cohort 1: Post-menopausal patients diagnosed with ER+, HER2- advanced breast cancer, who have not received prior systemic therapy for advanced breast cancer, or who have disease progression determined by imaging assessment during their 1st line endocrine therapy; Cohort 2: Pre-menopausal patients diagnosed with ER+, HER2- advanced breast cancer, who have not received prior systemic therapy for advanced breast cancer;

Study Overview

• Status: Recruiting
• Conditions: Breast Neoplasms
• Intervention / Treatment: Drug: FCN-437c+Fulvestrant; Drug: FCN-437c+Letrozole+Goserelin

Detailed Description

Screening period (Day-28 to Day-1);

• Continuous dose treatment period: 28 days for each treatment cycle, with patients evaluated every 8 weeks until disease progression, withdrawal of informed consent or death; for patients discontinued due to toxicity, imaging evaluation is required until disease progression;
• Follow-up after the end of treatment (within 30 days from the last dose);
• Survival follow-up (once telephone follow-up every 3 months until the end of study);

Primary Objectives:

• To observe the efficacy and safety of continuous oral administration of FCN-437c in combination with Fulvestrant in post-menopausal female patients with ER+, HER2- advanced breast cancer;
• To observe the efficacy and safety of continuous oral administration of FCN-437c in combination with Letrozole + Goserelin in pre-menopausal female patients with ER+, HER2- advanced breast cancer;

Secondary Objectives:

• To characterize the PK profile of FCN-437c in combination with Letrozole + Goserelin;
• To characterize the PK profile of FCN-437c in combination with Fulvestrant; End of study: 2 years after the last patient's first dose or the end of treatment (whichever is earlier);

• Study Type: Interventional
• Enrollment (Anticipated): 70
• Phase: Phase 2

Contacts and Locations

• Study Contact: Name: Yunjiang Liu, doctor; Phone Number: 13703297890; Email: lyj818326@126.com
• Study Contact Backup: Name: Meiqi Wang, Master; Phone Number: 18633051639; Email: maggie92320@hotmail.com

Study Locations

• China
  • Hebei
    • Shijiazhuang, Hebei, China
      • Recruiting
      • Fourth Hospital of Hebei Medical University
      • Contact: Yunjiang Liu, doctor; Phone Number: 13703297890; Email: lyj818326@126.com
      • Contact: Meiqi Wang, Master; Phone Number: 18633051639; Email: maggie92320@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Subjects are eligible to be included in the study only if they meet all of the following criteria:

  1. Patients with advanced breast cancer diagnosed as ER+, HER2-; ER+ is defined as histologically or cytologically confirmed ER+ with positive nuclear staining of estrogen receptor tumor cells ≥ 1% by immunohistochemistry; HER2- is defined as histologically or cytologically confirmed HER2-, with a negative ISH test result or an IHC test result of 0, 1+, or 2+, and if the IHC test result is 2+, the ISH test result must be negative;

  2. Criteria of menopausal status and prior treatment, and see Appendix 3 for definition of menopause:

     Cohort 1 (FCN-437c in combination with Fulvestrant): post-menopausal patients with advanced breast cancer, who are not suitable for curative surgical resection or radiation therapy and have not previously received systemic therapy, or have disease progression supported by imaging evaluation during their first-line endocrine therapy (including anti-estrogen or aromatase inhibitors).

     Cohort 2 (FCN-437c in combination with Letrozole + Goserelin): pre-menopausal patients with advanced breast cancer, who are not suitable for curative surgical resection or radiation therapy and have not received systemic therapy; Note: If any relapse or metastases occur within 12 months from the treatment start during the (neo) adjuvant endocrine therapy or within 12 months after the (neo) adjuvant endocrine therapy, such (neo) adjuvant endocrine therapy will be taken as one line of systemic therapy.

  3. ECOG (Eastern Cooperative Oncology Group) performance status score at 0 or 1;

  4. According to RECIST 1.1, patients must have at least one measurable lesion ( for any lesion received radiotherapy or other local treatments, it may be considered as a measurable lesion if disease progression is proved by radiographic evidence after completion of treatment).

     Note: Patients with only bone metastases must have at least one bone lesion that is predominantly osteolytic if no measurable lesion is present (for patients with no measurable lesion and only one osteolytic lesion, if prior radiotherapy to that lesion was performed, it is eligible if radiographic evidence supports disease progression of this bone lesion after radiotherapy).

  5. Life expectancy for at least 12 weeks;

  6. The bone marrow and organ function of the patient should be adequate:

     1. Absolute neutrophil count ≥1.5×109/L;
     2. Hemoglobin ≥ 90 g/L (without erythrocyte transfusion in 14 days);
     3. Platelets ≥75×109/L;
     4. Serum total bilirubin ≤1.5×ULN (upper limit normal), and ≤3.0×ULN for patients with Gilbert's syndrome;
     5. AST (aspartate aminotransferase), ALT(alanine aminotransferase) ≤2.5×ULN; for patients with liver metastasis, both AST and ALT should be ≤5×ULN;
     6. Creatinine < 1.5×ULN and creatinine clearance ≥50mL/min (Ccr=((140-age) × body weight (kg))/(72×Scr (mg/dl)) or Ccr=((140-age) × body weight (kg))/(0.818×Scr (umol/L)) Note: For females, the results should be calculated by × 0.85).
  7. Willingness and ability to comply with planned visits, treatment plans, laboratory tests and other trial procedures;
  8. Subject should fully understand this study and agree to sign the ICF (informed consent form).

Exclusion Criteria:

• Patients that meet any of the following conditions shall not be included in this clinical study:

  1. Prior treatment criteria:

     1. Prior treatment with a CDK4/6 inhibitor;
     2. Prior systemic chemotherapy for advanced breast cancer;
     3. Prior radiotherapy, major surgery, immunotherapy, monoclonal antibody therapy and other systemic anti-tumor therapy within 4 weeks before initiation of study drug administration;
     4. Cohort 1:

     i. (a) Previously received two or more lines of endocrine therapy; If relapse or metastases occur within 12 months from the treatment start during the (neo) adjuvant endocrine therapy or within 12 months after the (neo) adjuvant endocrine therapy, such (neo) adjuvant endocrine therapy will be taken as one line of systemic therapy; ii. Previously received Fulvestrant as first-line endocrine therapy for advanced breast cancer; e) Cohort 2: i. Previously treated with systemic anti-tumor therapy including endocrine therapy for advanced breast cancer; Note: Patients with disease progression after more than 12 months from the initiation or completion of the (neo) adjuvant therapy are eligible; Patients received Tamoxifen or an aromatase inhibitor within 14 days or an LHRH analogue within 28 days are eligible.

  2. Patients unsuitable for endocrine therapy due to metastases to any important organ or with large tumor loads, e.g., patients judged by the investigator to be unsuitable for endocrine therapy:

     1. symptomatic visceral metastases;
     2. rapid disease progression or impaired visceral functions;
     3. Non-visceral metastases requiring chemotherapy based on the investigator's clinical judgment;
  3. Failure to recover from toxic effects of prior anti-tumor therapy (> grade 2 as defined by NCI-CTCAE version 5.0);
  4. Receipt strong CYP3A inhibitors (amprenavir, atazanavir, boceprevir, clarithromycin, conivaptan, delavirdine, diltiazem, erythromycin, fosamprenavir, indinavir, itraconazole, ketoconazole, lopinavir, mibefradil, miconazole, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, verapamil, voriconazole, etc.) or strong CYP3A inducers (carbamazepine, felbamate, nevirapine, phenobarbital, phenytoin, primidone, rifabutin, rifampin, rifapentine, etc.) within 14 days before the first dose;

  5. Cardiac function and diseases that meet one of the following conditions:

     1. 12-lead electrocardiogram (ECG) measurements at the study site during the screening period, with a QTcF > 470 ms based on the QTcF formula;
     2. Arrhythmia with clinical significance, including but not limited to complete left bundle branch block and second-degree atrioventricular block;
     3. Any risk factors prolonging the QTc interval, such as hypokalemia, inherited long QT syndrome, use of drugs that prolong the QTc interval (mainly including Class Ia, Class Ic and Class III antiarrhythmic drugs; for drugs potentially prolong the QTc interval, see https://crediblemeds.org/index.php/tools/pdfdownload? f=cql_en; e.g., haloperidol, droperidolum, chloroquine, quinidine, procainamide, disopyramide, sotalol, amiodarone, doxepin, mianserin, mexiletine, loratadine, etc.).
     4. Cardiac failure congestive with New York Heart Association (NYHA) classification ≥ Class 3;
  6. Difficulty in swallowing, or with an active digestive disorder, or with major GI surgery, or with malabsorption syndrome, or other conditions that may impair the absorption of FCN-437c (e.g., ulcerative lesions, uncontrollable nausea, vomiting, diarrhea, malabsorption syndrome, and small bowel resection).
  7. Known hypersensitivity to the study drugs Letrozole, Fulvestrant, Goserelin, or to FCN-437c or any excipients;

  8. Uncontrolled CNS metastases, unless all of the following requirements are met:

     1. More than 4 weeks after radiotherapy or surgery before the start of the study treatment;
     2. CNS metastases are clinically stable, asymptomatic and do not require hormonal or other dehydration therapy;
     3. No meningeal metastases;
  9. Active infection, including patients with positive hepatitis B surface antigen (HBsAg), and HBV DNA ≥1.00×103 IU/ml; patients with positive hepatitis C virus antibody (Anti-HCV); patients infected with human immunodeficiency virus (HIV);

  10. For Cohort 2 only:

      i. Pregnant or lactating women; ii. For female patients of childbearing potential, disagreeing to use an effective contraceptive method, such as double barrier methods, condoms and or IUDs, during treatment and for at least 30 days after the last dose of the study treatment;

  11. Any other diseases or conditions with clinical significance that investigators believe may affect the compliance with the protocol or patients' signature of ICF, such as uncontrollable diabetes, active or uncontrollable infections;

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: FCN-437c with Fulvestrant; FCN-437c 200mg, oral administration under fasting conditions, QD, for 21 days, with 7-day discontinuation, 28 days for 1 cycle; Fulvestrant, C1D1 and C1D15 and Day 1 of each cycle, 500mg/day, intramuscularly.	Drug: FCN-437c+Fulvestrant; FCN-437c 200mg, oral administration under fasting conditions, QD, for 21 days, with 7-day discontinuation, 28 days for 1 cycle; Fulvestrant, C1D1 and C1D15 and Day 1 of each cycle, 500mg/day, intramuscularly.
Experimental: FCN-437c in combination with Letrozole + Goserelin; FCN-437c 200mg, oral administration under fasting conditions, QD, for 21 days, with 7-day discontinuation, 28 days for 1 cycle; Letrozole 2.5 mg, QD, for continuous dosing; Goserelin 3.6 mg, subcutaneously, once every 28 days.	Drug: FCN-437c+Letrozole+Goserelin; FCN-437c 200mg, oral administration under fasting conditions, QD, for 21 days, with 7-day discontinuation, 28 days for 1 cycle; Letrozole 2.5 mg, QD, for continuous dosing; Goserelin 3.6 mg, subcutaneously, once every 28 days.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall response rate	Overall response rate (ORR) of FCN-437c in combination of fulvestrant in post-menopausal patients and letrozole + goserelin in pre-menopausal patients based on RECIST 1.1	through study completion, assessed up to 24 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Safety and tolerability of the combination therapy	Assessed by grade and frequency of adverse events, serious adverse events, AEs leading to permanent drug discontinuation and death and changes in lab values, vital signs, ECGs, physical examinations and ECOG status.	Up to 30 days after EOT
PFS	Progression free survival (PFS) during the treatment.	through study completion, assessed up to 24 months
OS	overall survival (OS) during the treatment.	through study completion, assessed up to 24 months
1-year overall survival rate	1-year OS rate during the treatment.	through study completion, assessed up to 24 months
DOR	duration of response (DOR) during the treatment.	through study completion, assessed up to 24 months
CBR	Clinical benefit response (CBR) during the treatment.	through study completion, assessed up to 24 months
PK parameters of FCN-437c combination therapy Cmax	Plasma concentration of FCN-437c and PK parameters	Plasma concentration of FCN-437c and PK parameters
PK parameters of FCN-437c combination therapy AUC	Plasma concentration of FCN-437c and PK parameters	Plasma concentration of FCN-437c and PK parameters
PK parameters of FCN-437c combination therapy Tmax	Plasma concentration of FCN-437c and PK parameters	Plasma concentration of FCN-437c and PK parameters

Collaborators and Investigators

• Sponsor: Ahon Pharmaceutical Co., Ltd.
• Collaborators: Affiliated Hospital of Hebei University; The First Hospital of Jilin University; Hebei Medical University Fourth Hospital
• Investigators: Principal Investigator: Yunjiang Liu, Doctor, Hebei Medical University Fourth Hospital

Publications and helpful links

General Publications

• Cristofanilli M, Turner NC, Bondarenko I, Ro J, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Zhang K, Theall KP, Jiang Y, Bartlett CH, Koehler M, Slamon D. Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol. 2016 Apr;17(4):425-439. doi: 10.1016/S1470-2045(15)00613-0. Epub 2016 Mar 3. Erratum In: Lancet Oncol. 2016 Apr;17 (4):e136. Lancet Oncol. 2016 Jul;17 (7):e270.
• Sledge GW Jr, Toi M, Neven P, Sohn J, Inoue K, Pivot X, Burdaeva O, Okera M, Masuda N, Kaufman PA, Koh H, Grischke EM, Frenzel M, Lin Y, Barriga S, Smith IC, Bourayou N, Llombart-Cussac A. MONARCH 2: Abemaciclib in Combination With Fulvestrant in Women With HR+/HER2- Advanced Breast Cancer Who Had Progressed While Receiving Endocrine Therapy. J Clin Oncol. 2017 Sep 1;35(25):2875-2884. doi: 10.1200/JCO.2017.73.7585. Epub 2017 Jun 3.
• Slamon DJ, Neven P, Chia S, Fasching PA, De Laurentiis M, Im SA, Petrakova K, Bianchi GV, Esteva FJ, Martin M, Nusch A, Sonke GS, De la Cruz-Merino L, Beck JT, Pivot X, Vidam G, Wang Y, Rodriguez Lorenc K, Miller M, Taran T, Jerusalem G. Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: MONALEESA-3. J Clin Oncol. 2018 Aug 20;36(24):2465-2472. doi: 10.1200/JCO.2018.78.9909. Epub 2018 Jun 3.
• Im SA, Lu YS, Bardia A, Harbeck N, Colleoni M, Franke F, Chow L, Sohn J, Lee KS, Campos-Gomez S, Villanueva-Vazquez R, Jung KH, Chakravartty A, Hughes G, Gounaris I, Rodriguez-Lorenc K, Taran T, Hurvitz S, Tripathy D. Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer. N Engl J Med. 2019 Jul 25;381(4):307-316. doi: 10.1056/NEJMoa1903765. Epub 2019 Jun 4.

Helpful Links

• Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: MONALEESA-3
• Overall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer
• Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial
• Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer S.-A. Im, Y.-S. Lu, A. Bardia, N. Harbeck, M. Colleoni, F. Franke, L. Chow, J. Sohn, K.-S. Lee, S. Campos-Gomez, R. Villanueva-Vazquez, K.-H. Jung, A. Chakravartty, G. Hughes, I.
• MONARCH 2: Abemaciclib in Combination With Fulvestrant in Women With HR+/HER2- Advanced Breast Cancer Who Had Progressed While Receiving Endocrine Therapy
• hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3)
• Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer
• The Effect of Abemaciclib Plus Fulvestrant on Overall Survival in Hormone Receptor-Positive, ERBB2-Negative Breast Cancer That Progressed on Endocrine Therapy-MONARCH 2: A Randomized Clinical Trial

Study record dates

Study Major Dates

• Study Start (Actual): June 30, 2020
• Primary Completion (Anticipated): December 30, 2021
• Study Completion (Anticipated): June 30, 2023

Study Registration Dates

• First Submitted: June 15, 2021
• First Submitted That Met QC Criteria: August 5, 2021
• First Posted (Actual): August 13, 2021

Study Record Updates

• Last Update Posted (Actual): August 13, 2021
• Last Update Submitted That Met QC Criteria: August 5, 2021
• Last Verified: June 1, 2021

More Information

Terms related to this study

• Keywords: Breast Neoplasms; HER2-Negative; ER-Positive
• Additional Relevant MeSH Terms: Skin Diseases; Neoplasms; Neoplasms by Site; Breast Diseases; Breast Neoplasms; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Hormones, Hormone Substitutes, and Hormone Antagonists; Antineoplastic Agents, Hormonal; Hormone Antagonists; Aromatase Inhibitors; Steroid Synthesis Inhibitors; Estrogen Antagonists; Estrogen Receptor Antagonists; Letrozole; Fulvestrant; Goserelin
• Other Study ID Numbers: AH150202-1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No