Clinical Trials Sponsored by Lexigen Pharmaceuticals

Total 20454 results

Portola Pharmaceuticals

Completed

The Effect o f Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Betrixiban, an Oral FXa Antagonist

Hepatic Impairment

United States
Portola Pharmaceuticals

Withdrawn

BRAVO - Betrixaban Registry Using Real Time Observations in Acute Medical Illness to Assess Venous Thrombosis and Bleeding Outcomes

Venous Thromboses

United States
Jazz Pharmaceuticals
GW Pharmaceuticals

Completed

An Open-label Extension Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6)

Seizures | Tuberous Sclerosis Complex

United States
Solvay Pharmaceuticals
Unimed Pharmaceuticals

Completed

Observation Study of T-Gel (1%) in Treatment of Adolescent Boys With Hypogonadism

Primary or Secondary Hypogonadism | Constitutional Delay in Growth and Puberty (CDGP)

United States
Solvay Pharmaceuticals
Unimed Pharmaceuticals

Completed

Pharmacokinetic Evaluation of Testosterone Gel (1%)

Primary or Secondary Hypogonadism | Constitutional Delay in Growth and Puberty (CDGP)

United States
Leiden University
Dutch Cancer Society

Completed

External-Beam Radiation Therapy Compared With Vaginal Brachytherapy After Surgery for Stage I Endometrial Cancer (PORTEC-2)

Endometrial Cancer

Netherlands
Xigen SA

Completed

Efficacy and Safety of XG-104 for the Treatment of Dry Eye

Dry Eye

United States
Xigen SA

Completed

Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers

Inflammation

Switzerland
Xigen SA

Completed

Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation and Pain

Pain | Inflammation | Cataract

United States
Xigen SA

Completed

Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation

Pain | Inflammation | Cataract

United States
Portola Pharmaceuticals

Completed

Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 3 of 4)

Healthy Volunteers

United States
Portola Pharmaceuticals

Withdrawn

CELTIC-1: A Phase 2B Study of Cerdulatinib in Patients With Relapsed/Refractory Peripheral T-Cell Lymphoma (PTCL)

AITL | Peripheral T-Cell Lymphoma (PTCL NOS) | Nodal Lymphomas of T Follicular Helper (TFH) | Follicular T-cell Lymphoma (FTCL) | ALCL | HSTCL | EATL I,II | MEITL, EATL Type II | Nasal Lymphoma
Portola Pharmaceuticals

Completed

A Study in Older Subject to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Rivaroxaban

Bleeding

United States
Regeneron Pharmaceuticals
Alnylam Pharmaceuticals

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pozelimab in Combination With Cemdisiran in Healthy Adult Volunteers

Healthy

Belgium
Ferring Pharmaceuticals
Xanodyne Pharmaceuticals

Completed

A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding

Menorrhagia

United States
Leiden University
Bristol-Myers Squibb

Active, not recruiting

TIL and Anti-PD1 in Metastatic Melanoma (ACTME)

Effects of Immunotherapy | Adverse Drug Event | Toxicity, Drug

Netherlands
Leiden University Medical Center
Crucell B.V., Leiden, the Netherlands

Completed

Mucosal Response in Immunocompromised Host (MICH)

Kidney Transplantation | Immunity

Netherlands
ISA Pharmaceuticals
Regeneron Pharmaceuticals

Active, not recruiting

A Phase II Study of Cemiplimab and ISA101b in Patients With Recurrent/Metastatic HPV16 Positive OPC

Squamous Cell Carcinoma of the Oropharynx

United States, Israel, Belgium, Germany, Spain, United Kingdom, Italy, France, Czechia
Portola Pharmaceuticals

Completed

A Healthy Volunteer Pharmacokinetics (PK)/Pharmacodynamics (PD), Safety and Tolerability Study of Andexanet in Healthy Japanese and Caucasian Subjects

Bleeding

United States
Jazz Pharmaceuticals
GW Pharmaceuticals

Terminated

A Long-term Safety Study of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome

Rett Syndrome | RTT

United States, Canada, Italy, Spain, United Kingdom, Australia
Alexion Pharmaceuticals
Portola Pharmaceuticals

Completed

Phase 1/2a Dose Escalation Study in Participants With CLL, SLL, or NHL

Follicular Lymphoma (FL/Indolent NHL) | Aggressive NHL (a NHL) | Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL) | T-cell Lymphoma (PTCL and CTCL) | B-cell Non Hodgkin Lymphoma (NHL)

United States
NovaBay Pharmaceuticals, Inc.
Novum Pharmaceutical Research Services; International Dermatology Research,...

Completed

Safety and Efficacy of Topical NVC-422 Gel in Impetigo

Impetigo

Dominican Republic
PETHEMA Foundation
Millennium Pharmaceuticals, Inc.; Johnson & Johnson Pharmaceutical Research...

Completed

Velcade-Melphalan-Prednisone in Older Untreated Multiple Myeloma Patients.

Multiple Myeloma

Spain
Douglas Pharmaceuticals America Ltd
Novum Pharmaceutical Research Services; ACM Global Laboratories

Completed

A Therapeutic Equivalence Study of Ketoconazole Cream 2%

Tinea Pedis

Belize, United States
Leiden University Medical Center
KU Leuven; Maastricht University; Universiteit Leiden

Completed

Pain-related Fear as a Facilitator of Nocebo Hyperalgesia (LFS)

Hyperalgesia | Chronic Pain Syndrome | Fear of Pain | Chronic Pain, Psychogenic

Netherlands
Leiden University Medical Center
VU University of Amsterdam; Universiteit Leiden

Completed

Electrophysiological Correlates of Nocebo Effects on Pain

Chronic Pain | Hyperalgesia | Chronic Pain Syndrome | Chronic Pain, Psychogenic

Netherlands
Leiden University Medical Center

Recruiting

Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU) (EXTUBATE)

Critical Illness | Oxygen Consumption | Intensive Care Unit | Weaning Failure | Mechanical Ventilation | Spontaneous Breathing Trial

Netherlands
Leiden University Medical Center

Not yet recruiting

Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge)

Malaria,Falciparum
Leiden University Medical Center

Recruiting

The Bipolar Lithium Imaging Scan Study. (BLISS)

Bipolar Disorder

Netherlands
Leiden University Medical Center

Recruiting

Fluorescence-guided Resection Of Colorectal Liver Metastases Using SGM-101 and Indocyanine GREEN (FOCUS GREEN)

Colorectal Cancer | Image | Liver Metastasis Colon Cancer

Netherlands
Universiteit Leiden
Heliomare Revalidatie

Not yet recruiting

e-COGRAT: A Blended eHealth Intervention for Fatigue Following Acquired Brain Injury

Fatigue | Acquired Brain Injury
Leiden University Medical Center

Recruiting

Standard Versus Prolonged Antibiotic Prophylaxis After Pancreatoduodenectomy (SPARROW) (SPARROW)

Pancreatic Cancer

Netherlands
Leiden University Medical Center

Not yet recruiting

DIAbetes Maximal ACCeleration (DIAMACC)

Diabetic Foot | Peripheral Arterial Disease | Diagnosis
Leiden University Medical Center

Recruiting

PSMA Expression and PSMA PET Imaging in Soft Tissue Sarcomas and Urothelial Cell Carcinomas

Urothelial Carcinoma | Sarcoma,Soft Tissue

Netherlands
Leiden University Medical Center

Recruiting

Indocyanine Green for Perfusion Assessment of DIEP Flaps (FAFI)

Fat Necrosis

Netherlands
Leiden University Medical Center

Recruiting

Coadministration of GA2 Sporozoites With Adjuvants (CoGA)

Malaria,Falciparum

Netherlands
Leiden University Medical Center

Recruiting

Patient Satisfaction and Long-term Safety of Intravesical Aminoglycoside Instillations in UTI Prevention (INSTILMENT)

Urinary Tract Infections | Recurrent Urinary Tract Infection

Netherlands
Leiden University Medical Center

Recruiting

Influence of Δ9-tetrahydrocannabinol (THC) on Oxycodone Induced Ventilatory Depression in Healthy Volunteers (COXY)

Cannabis Use | Opioid Use | Respiratory Depression

Netherlands
Leiden University Medical Center

Recruiting

Pituitary Gland Stimulation for Cancer Pain Relief (PGS)

Oncology Pain

Netherlands
Leiden University Medical Center

Not yet recruiting

What is the Optimal Follow-up for Patients With Systemic Sclerosis? (PRASSc)

Systemic Sclerosis
Leiden University Medical Center

Recruiting

Reinducing Radioiodine-sensitivity in Radioiodine-refractory DTC Using Lenvatinib (RESET) (RESET)

Differentiated Thyroid Cancer

Netherlands
Leiden University Medical Center

Recruiting

Prevention of Low Blood Pressure After Cardiac Surgery in Heart Failure Patients With a Filter Called CytoSorb. (CytoSorb-HF)

Heart Failure | Vasoplegia

Netherlands
Leiden University Medical Center

Recruiting

Adoptive T Cell Therapy in Patients With Recurrent Ovarian Cancer (OVACURE)

Ovarian Cancer Recurrent

Netherlands
Leiden University Medical Center

Enrolling by invitation

Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation (TOPPER)

Diabetes Mellitus | Islets of Langerhans Transplantation | Pancreatitis, Chronic

Netherlands
Leiden University Medical Center

Completed

Repeated Controlled Human Schistosoma Mansoni Infection

Schistosomiasis | Schistosoma Mansoni

Netherlands
Leiden University Medical Center

Completed

Safety and Preliminary Protective Efficacy of Genetically Attenuated GA2 Parasites.

Plasmodium Falciparum Malaria

Netherlands
Leiden University Medical Center

Completed

Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis (ASCARA)

Rheumatic Diseases | Rheumatoid Arthritis

Netherlands
Leiden University Medical Center

Completed

Are Perception of Pain and Psychological Distress Before Knee Arthroplasty Associated With Reason for Revision?

Osteo Arthritis Knee | Psychological Distress

Netherlands
Leiden University Medical Center

Completed

Improving Quality Based on the Joint Registry (IQ Joint)

Knee Arthropathy | Quality Improvement | Hip Arthropathy | Registries | Hospital Performance

Netherlands
Leiden University Medical Center

Unknown

NIR Fluorescence Imaging With ICG for the Intraoperative Identification of Gastrointestinal Stromal Cell Tumours

GIST

Netherlands

Clinical Trials Sponsored by Lexigen Pharmaceuticals

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