Search clinical trials for: Active Phase

Total 25896 results

Eisai Inc.

Completed

Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users

Healthy | Drug Abuse

Canada
Hoffmann-La Roche

Completed

Phase IIIb Study to Evaluate the Safety and Tolerability of Herceptin SC With Perjeta and Docetaxel in Patients With HER2-positive Advanced Breast Cancer

Breast Cancer

Hungary, Italy, Spain, France, United Kingdom, Belgium, Germany, Portugal, Poland, Canada, Bulgaria, Mexico
Taejoon Pharmaceutical Co., Ltd.

Completed

A Multi-center, Randomized, Blinded Evaluator, Active Control, Parallel, Phase III Study to Evaluate the Efficacy and Safety of TJO-002 in POAG or Ocular Hypertension Patients

Ocular Hypertension | Primary Open-angle Glaucoma

Korea, Republic of
Amgen

Completed

Phase 3 Study of Carfilzomib, Melphalan, Prednisone vs Bortezomib, Melphalan, Prednisone in Newly Diagnosed Multiple Myeloma (CLARION)

Multiple Myeloma

Korea, Republic of, China, Spain, Taiwan, United States, Netherlands, Australia, Singapore, New Zealand, United Kingdom, Israel, France, Japan, Italy, Czechia, Belgium, Argentina, Austria, Bulgaria, Canada, Germany, Greece, Hungary, M... and more
Landspitali University Hospital
Memorial Sloan Kettering Cancer Center; Celgene; Amgen; University of Iceland

Enrolling by invitation

A Nationwide Phase 2 Trial of Patients With Smoldering and Active Multiple Myeloma (MM) (iStopMM)

Multiple Myeloma | Smoldering Multiple Myeloma

Iceland
Bristol-Myers Squibb
Cardioxyl Pharmaceuticals, Inc

Completed

A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure

Heart Failure | Decompensated Heart Failure | Acute Heart Failure

United States, Germany, Jordan, Poland, Russian Federation
Angde Biotech Pharmaceutical Co., Ltd.
Beijing Tiantan Hospital

Unknown

A PhaseⅡ of Injection for Recombinant Human Tissue Plasminogen Kinase Derivative in Treatment of Acute Ischemic Stroke.

Acute Ischemic Stroke

China
University of Pennsylvania
Takeda; Corporal Michael J. Crescenz VA Medical Center

Withdrawn

An Open Label Single-arm Phase 4 Study of Vedolizumab in Subjects With Newly Diagnosed Active Ulcerative Colitis

Ulcerative Colitis

United States
Allina Health System

Completed

Care Guides in the Primary Care Office (Phase II)

Hypertension | Diabetes | Congestive Heart Failure

United States
Aponia Laboratories, Inc.

Completed

Phase II Study of AP0302 5% Versus a Vehicle Comparator

Pain | Delayed Onset Muscle Soreness

United States
Celgene

Completed

Extension Study to Further Evaluate the Safety, Pharmacodynamics and Pharmacokinetics of Ozanimod and Active Metabolites

Healthy Volunteers

United States
Pfizer

Completed

A Study Of PF-06410293 (Adalimumab-Pfizer) And Adalimumab (Humira®) In Combination With Methotrexate In Subjects With Active Rheumatoid Arthritis (REFLECTIONS B538-02).

Rheumatoid Arthritis

Spain, Korea, Republic of, United States, Poland, Japan, Taiwan, Hungary, Serbia, Germany, Australia, Czechia, Estonia, Bulgaria, New Zealand, Lithuania, Georgia, Russian Federation, Peru, South Africa, Ukraine, Colombia, Brazil, Me... and more
Merck Sharp & Dohme LLC

Completed

An Active-Controlled Early Phase Study of MK-8189 in Adults With Schizophrenia (MK-8189-005)

Schizophrenia, Acute Episode

United States
Taro Pharmaceuticals USA

Completed

Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Multi-Site Phase 2b Clinical Study

Onychomycosis

United States
Taro Pharmaceuticals USA

Completed

Phase III Clinical Study in Patients With Mild to Severe Scalp Psoriasis

Scalp Psoriasis

United States
North Bristol NHS Trust
Ferring Pharmaceuticals; University of Bristol; University Hospitals Bristol... and other collaborators

Completed

Intramuscular Oxytocics: A Randomised Control Trial (IMox)

Post Partum Haemorrhage

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Investigate How Effective and Safe Solifenacin Succinate Suspension is in Treating Children/Adolescents Aged 5 to Less Than 18 Years With Symptoms of Overactive Bladder (OAB) Compared to a Non-active Drug (LION)

Urinary Bladder, Overactive

Belgium, United States, Brazil, Canada, Denmark, Former Serbia and Montenegro, Korea, Republic of, Mexico, Norway, Philippines, Poland, South Africa, Sweden, Turkey, Ukraine, United Kingdom
University of Pittsburgh

Completed

Pediatric Facial Fracture Study

Craniofacial Fracture

United States
Hospital Israelita Albert Einstein

Completed

Safety of Transcranial Direct Current Stimulation in the Subacute Phase After Stroke (NEUROSTIM)

Stroke

Brazil
Gilead Sciences

Completed

Safety, Tolerability, and Efficacy of GS-9876 in Participants With Active Rheumatoid Arthritis on Background Therapy With Methotrexate

Rheumatoid Arthritis

United States, Czechia, Bulgaria, Poland, Georgia, Moldova, Republic of, Ukraine
Taipei Veterans General Hospital, Taiwan

Unknown

Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide

Major Depressive Disorder

Taiwan
Light Chain Bioscience - Novimmune SA

Completed

Study of an Anti-TLR4 mAb in Rheumatoid Arthritis

Rheumatoid Arthritis

Serbia, Bosnia and Herzegovina, Bulgaria, Georgia, Hungary, Moldova, Republic of, Poland
Immatics Biotechnologies GmbH
BioNTech SE; University Hospital Tuebingen; BCN Peptides; EU-funded GAPVAC Consortium

Completed

GAPVAC Phase I Trial in Newly Diagnosed Glioblastoma Patients

Glioblastoma

Spain, Switzerland, Denmark, Germany, Netherlands
Institut Claudius Regaud

Completed

Phase II Study of Feasibility of Focal Therapy for Prostate Cancer of Good Prognosis With Permanent I125 Localized Implant. (CURIEFOCALE)

Localized Prostate Cancer

France
MedImmune LLC

Completed

A Phase 2a to Evaluate the Safety of MEDI8852 in Adults With Uncomplicated Influenza (MEDI8852)

Influenza

United States, South Africa
Pfizer

Completed

A Study of PF-06438179 (Infliximab-Pfizer) and Infliximab in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (REFLECTIONS B537-02).

Rheumatoid Arthritis

Jordan, Korea, Republic of, United States, Poland, Japan, Hungary, South Africa, Ukraine, Germany, Israel, Philippines, Serbia, Australia, Georgia, Czechia, Bosnia and Herzegovina, Brazil, Bulgaria, Canada, Guatemala, Lithuania, M... and more
University Medical Centre Ljubljana
Slovenian Research Agency

Unknown

Effects of Exercise and Exercise Counselling in Hemodialysis Patients.

Kidney Diseases | Chronic Kidney Diseases | Physical Activity | End Stage Renal Disease | Kidney Failure

Slovenia
Peking University People's Hospital
Monash University; Beijing ShuangLu Pharmaceutical Co., Ltd.

Completed

A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sjögren's Syndrome

Primary Sjögren's Syndrome

China
Gilead Sciences

Completed

Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children

HIV Infections

United States, United Kingdom, Panama
Sterna Biologicals GmbH & Co. KG

Completed

Efficacy, Pharmacokinetics, Tolerability, Safety of SB012 Intrarectally Applied in Active Ulcerative Colitis Patients (SECURE)

Colitis, Ulcerative

Germany
Hapten Sciences, Inc.

Completed

A Phase I, Single-Center Study of PDC-APB in Healthy Volunteers

Contact Dermatitis

United States
Lina Xu

Completed

A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis

Osteoarthritis of the Knee

United States
Eisai Inc.

Terminated

A Phase 3, Multicenter, Randomized, Double-blind,Active-controlled, Parallel-group Trial With an Open-labelExtension Phase to Evaluate the Efficacy and Safety of OralE5501 Versus Eltrombopag, in Adults With Chronic ImmuneThrombocytopenia (Idiopathic Thrombocytopenic Purpura)

Idiopathic Thrombocytopenic Purpura

United States
Icahn School of Medicine at Mount Sinai
Bristol-Myers Squibb

Terminated

CTLA-4 Blockade and Low Dose Cyclophosphamide in Patients With Advanced Malignant Melanoma

Melanoma

United States
Versailles Hospital

Completed

A Prospective Randomized Phase II Study Evaluating the Monitoring of Imatinib Mesylate Plasmatic Through Level in Patients Newly Diagnosed With CP-CML (OPTIMIMATINIB)

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

France
Melissa Burgess, MD
Genentech, Inc.

Terminated

Phase II Study of Cobimetinib in Combination With Vemurafenib in Active Melanoma Brain Metastases (CoBRIM-B)

Active Melanoma Brain Metastases

United States
Ferring Pharmaceuticals

Completed

An Efficacy and Safety Study of PENTASA in Chinese Patients With Left-sided Active Ulcerative Colitis Followed by a 24-Week Open-Label Extension Phase

Ulcerative Colitis

China
Biotest
AbbVie

Terminated

Study to Investigate the Safety and Efficacy of Tregalizumab in Subjects (MTX-IR) With Active Rheumatoid Arthritis (986)

Rheumatoid Arthritis

United States, Bulgaria, Canada, Czechia, Estonia, Germany, Hungary, Lithuania, Mexico, Poland, Russian Federation, Serbia, Slovakia, Ukraine
ANRS, Emerging Infectious Diseases
ViiV Healthcare

Completed

A Trial Evaluating Maintenance Therapy With Lamivudine (Epivir®) and Dolutegravir (Tivicay®) in Human Immunodeficiency Virus 1 (HIV-1) Infected Patients Virologically Suppressed With Triple Highly Active Antiretroviral Therapy (HAART) (ANRS 167 Lamidol)

HIV-1 Infection

France
AbbVie

Completed

A Phase 2 Study to Investigate the Safety, Tolerability and Efficacy of ABT-122 in Subjects With Active Psoriatic Arthritis (PsA) Who Have an Inadequate Response to Methotrexate (MTX)

Psoriatic Arthritis
Daewon Pharmaceutical Co., Ltd.

Completed

A Multicenter, Randomized, Open-labeled, Cross-over, Active-controlled, Phase IV Clinical Trial to Evaluate the Preference of Formulation and the Efficacy and Safety of Renamezin and Kremezin in Pre-dialysis Patients With Chronic Renal Failure

Chronic Renal Failure

Korea, Republic of
rEVO Biologics
Laboratoire français de Fractionnement et de Biotechnologies

Completed

Phase III Study of Coagulation FVIIa (Recombinant) in Congenital Hemophilia A or B Patients With Inhibitors

Hemophilia A With Inhibitors | Hemophilia B With Inhibitors

United States, Bulgaria, Poland, Russian Federation, Belarus, Georgia, Israel, Romania, Ukraine, United Kingdom
Universitätsklinikum Hamburg-Eppendorf

Completed

Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers

Sleep Disorders, Circadian Rhythm

Germany, Italy
Pfizer

Completed

ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer (ARCHER 1009)

Non-Small Cell Lung Cancer

United States, Korea, Republic of, United Kingdom, Greece, Slovakia, France, Belgium, Ireland, Japan, Spain, China, Sweden, India, Hungary, Switzerland, Russian Federation, Germany, Mexico, Denmark, Austria, Finland, Poland, South Africa
ProCore Ltd.

Completed

A Phase I, Prospective, Randomized, Open-label, Active-Controlled Clinical Trial for Safety Evaluation of Intra-articular Injection of RegenoGel-SP for the Treatment of Moderate to Severe Osteoarthritis

Osteoarthritis

Israel
AstraZeneca

Completed

24-Week, Multicenter, Randomized, Parallel-group, Open-label, Active Controlled Phase IV Study to Assess the Efficacy, Safety and Tolerability of Saxagliptin Compared With Acarbose When in Combination With Metformin in Patients With T2D Inadequately Controlled With Metformin Monotherapy (SMART)

Type 2 Diabetes Mellitus

China
Alligator Bioscience AB

Completed

ADC-1013 First-in-Human Study

Neoplasms | Solid Tumors

United Kingdom, Denmark, Sweden
Sidney Kimmel Comprehensive Cancer Center at Johns...

Withdrawn

A Phase 2 Study of Bicalutamide Plus Finasteride in Men With MRI Detectable Prostate Nodules Undergoing Active Surveillance

Detectable Prostate Nodules

United States
AbGenomics B.V Taiwan Branch

Completed

A Phase II Study Evaluating the Efficacy and Safety of AbGn-168H in Patients With Active Psoriatic Arthritis

Psoriatic Arthritis

United States
Sterna Biologicals GmbH & Co. KG

Completed

Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of the Topical Formulation SB011 Applied to Lesional Skin in Patients With Atopic Eczema

Mild to Moderate Atopic Dermatitis

Germany

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