Search clinical trials for: Intellectual Disability

Total 2569 results

Shenzhen Second People's Hospital
Guangzhou Women and Children's Medical Center; Shenzhen University

Recruiting

Autologous Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy and Adrenoleukodystrophy

Adrenoleukodystrophy | Metachromatic Leukodystrophy

China
Boston Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome

Intellectual Disability | Autism Spectrum Disorder | Phelan-McDermid Syndrome

United States
Boston Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)

Intellectual Disability | Tuberous Sclerosis | Autism Disorder

United States
Joanne Kurtzberg, MD
The Marcus Foundation

Recruiting

UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells (DUOC-01)

Mucopolysaccharidosis II | Brain Diseases, Metabolic, Inborn | Adrenoleukodystrophy | Batten Disease | Leukodystrophy, Metachromatic | Leukodystrophy, Globoid Cell | Alpha-Mannosidosis | Tay-Sachs Disease | Pelizaeus-Merzbacher Disease | Sandhoff Disease | Neimann Pick Disease | Sanfilippo Mucopolysaccharidoses

United States
Masonic Cancer Center, University of Minnesota

Recruiting

MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

Hurler Syndrome | Sphingolipidoses | Peroxisomal Disorders | Metachromatic Leukodystrophy | Alpha-Mannosidosis | Hunter Syndrome | Mucopolysaccharidosis Disorders | Maroteaux Lamy Syndrome | Sly Syndrome | Fucosidosis | Aspartylglucosaminuria | Glycoprotein Metabolic Disorders | Recessive Leukodystrophies | Globoid... and other conditions

United States
National Human Genome Research Institute (NHGRI)

Recruiting

Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation

Congenital Disorders of Glycosylation

United States
Eunice Kennedy Shriver National Institute of Child...

Recruiting

DS-Connect {TM}: The Down Syndrome Registry

Down Syndrome

United States
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Sequenom, Inc.

Recruiting

Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy

Down Syndrome | Fetal Aneuploidy

United States, Canada
Cure CMD

Recruiting

Congenital Muscle Disease Study of Patient and Family Reported Medical Information (CMDPROS)

Emery-Dreifuss Muscular Dystrophy | Congenital Myasthenic Syndrome | Limb-Girdle Muscular Dystrophy | Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency | Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy) and other conditions

United States
Simons Searchlight
Boston Children's Hospital; Geisinger Clinic; Simons Foundation

Recruiting

Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight

SMARCA4 Gene Mutation | DDX3X | 16P11.2 Deletion Syndrome | 16p11.2 Duplications | 1Q21.1 Deletion | 1Q21.1 Microduplication Syndrome (Disorder) | ACTL6B | ADNP | AHDC1 | ANK2 | ANKRD11 | ARID1B | ASH1L | BCL11A | CHAMP1 | CHD2 | CHD8 | CSNK2A1 | CTBP1 | CTNNB1 Gene Mutation | CUL3 | DNMT3A | DSCAM | DYRK1A | FOXP1 | GRIN2A | GRIN2B | HIVEP2-Related Intellectual... and other conditions

United States
National Institute of Mental Health (NIMH)

Recruiting

Defining the Brain Phenotype of Children With Williams Syndrome

Williams Syndrome | Duplication

United States
National Human Genome Research Institute (NHGRI)

Recruiting

Whole Genome Medical Sequencing for Genome Discovery

Congenital Anomaly | Rare Disorders | Intellectual Disabilities

United States
The Chaim Sheba Medical Center

Recruiting

The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS)

Fragile X Syndrome | Williams Syndrome | Velocardiofacial Syndrome

Israel
Vanderbilt University Medical Center
National Institute on Deafness and Other Communication Disorders (NIDCD)

Completed

Predictors of Speech Ability in Down Syndrome

Speech Intelligibility Intervention in Down Syndrome

United States
Baylor University
National Institutes of Health (NIH); National Institute on Deafness and Other...

Active, not recruiting

Written Language Intervention for Adults With Intellectual and Developmental Disabilities

Intellectual Disability | Developmental Disability

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Hypertension | Cardiovascular Disease | Williams Syndrome | Multisystem Developmental Disorder | Elastin Gene Deletion

United States
National Institute of Mental Health (NIMH)

Completed

Protein Synthesis in the Brain of Patients With Fragile X Syndrome

Healthy Volunteers | Fragile X Syndrome

United States
National Human Genome Research Institute (NHGRI)

Active, not recruiting

Natural History Study of Smith-Magenis Syndrome

Smith-Magenis Syndrome (SMS)

United States
National Institute of Mental Health (NIMH)

Active, not recruiting

Cognitive Neuroscience of Autism Spectrum Disorders

Children | Mental Retardation | Autism Spectrum Disorders | Asperger's Disorder | Adult

United States
Riphah International University

Completed

Effects of Rhythmic Aerobic Exercises on Functional Balance in Children With Down Syndrome

Down Syndrome

Pakistan
Riphah International University

Completed

Effects of Dohsa Hou Exercises on Functional Mobility

Down Syndrome

Pakistan
Riphah International University

Completed

Effects of Maze Activities in Down's Syndrome

Down Syndrome

Pakistan
Riphah International University

Completed

Action Observation Therapy on Balance in Children With Down Syndrome

Down Syndrome

Pakistan
Denali Therapeutics Inc.

Completed

A Study of Potential Treatment-Responsive Biomarkers and Clinical Outcomes in Hunter Syndrome

Mucopolysaccharidosis II

United Kingdom, United States, Netherlands
Vanderbilt University Medical Center

Completed

Strategies for Teaching Verbs

Down Syndrome | Language Development Disorders | Child Language

United States
Pfizer

Completed

Study of the Efficacy and Safety of Somatropin in Japanese Participants With PWS

Prader-Willi Syndrome

Japan
Neuren Pharmaceuticals Limited

Suspended

An Open-Label Study of Oral NNZ-2591 in Prader-Willi Syndrome (PWS-001) (PWS-001)

Prader-Willi Syndrome

United States
ACADIA Pharmaceuticals Inc.

Enrolling by invitation

OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome

Hyperphagia in Prader-Willi Syndrome

United States
Gedeon Richter Plc.

Completed

Study to Evaluate Efficacy, Safety, and Tolerability of RGH-706 in Prader-Willi Syndrome

Prader-Willi Syndrome

United States, Spain, France, Italy, Czechia
Massachusetts General Hospital

Active, not recruiting

Transcranial Photobiomodulation With Near-Infrared Light for Language in Individuals With Down Syndrome (TransPhoM-DS)

Down Syndrome

United States
Tufts Medical Center
Tufts University

Completed

Development and Evaluation of "Period Kits" for Adolescents With Intellectual and Developmental Disabilities

Patient Empowerment | Autistic Spectrum Disorder | Menstrual Discomfort

United States
Rare Thyroid Therapeutics International AB
Egetis Therapeutics; AnovoRx

Available

Expanded Access Program for Tiratricol in Patients With Monocarboxylate Transporter 8 Deficiency

Monocarboxylate Transporter 8 Deficiency | Allan-Herndon-Dudley Syndrome

United States
University of California, Davis
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Enrolling by invitation

Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities

Intellectual Disability | Down Syndrome | Attention Deficit Hyperactivity Disorder | Fragile X Syndrome

United States
Rett Syndrome Research Trust
Vanderbilt University Medical Center

Completed

A Study to Evaluate Ketamine for the Treatment of Rett Syndrome

Rett Syndrome

United States
bluebird bio

Completed

A Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD)

Cerebral Adrenoleukodystrophy (CALD)

United States, France, Germany, Italy, Netherlands, United Kingdom
Denali Therapeutics Inc.

Enrolling by invitation

An Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alfa (DNL310) in Participants With Mucopolysaccharidosis Type II (MPS II) From Study DNLI-E-0002 or Study DNLI-E-0007

Mucopolysaccharidosis II

United States, Canada, Belgium, Czechia, Netherlands
Children's Hospital of Philadelphia
Illumina, Inc.

Active, not recruiting

LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies

Mucopolysaccharidoses | Leukodystrophy | Adrenoleukodystrophy | Adrenomyeloneuropathy | X-linked Adrenoleukodystrophy | Gangliosidoses | Metachromatic Leukodystrophy | Krabbe Disease | Refsum Disease | Cadasil | Sjogren-Larsson Syndrome | Allan-Herndon-Dudley Syndrome | White Matter Disease | GM2 Gangliosidosis | Zellweger... and other conditions

United States
University of California, Davis
University of Alberta; St. Justine's Hospital

Completed

A Trial of Metformin in Individuals With Fragile X Syndrome (Met)

Neurobehavioral Manifestations | Genetic Diseases, X-Linked | Intellectual Disability | Fragile X Syndrome | Sex Chromosome Disorders | Fragile X Mental Retardation Syndrome | Trinucleotide Repeat Expansion | Fra(X) Syndrome | FXS | Mental Retardation, X Linked

United States, Canada
University of Castilla-La Mancha

Completed

Effect of Rhythmic Gymnastics Training in Children With Down Syndrome

Physical Conditioning, Human

Spain
VU University of Amsterdam

Completed

Effectiveness of the Serious Game 'Broodles' for Siblings of Children With Visual Impairment and/or Intellectual Disability

Healthy

Netherlands
Koraal
University of Amsterdam; Zuyd University of Applied Sciences

Completed

Improving the Cognitive Accessibility of Self-reports for People With ID

Mild Intellectual Disability | Borderline Intellectual Functioning

Netherlands
University of Oslo

Completed

Dietary Intervention and Adults With Intellectual Disabilities

Intellectual Disability | Intellectual Disabilities Nutritional

Norway
Nova Mentis Life Science Corp
KGK Science Inc.

Suspended

An Investigation of Psilocybin on Behavioural and Cognitive Symptoms of Adults With Fragile X Syndrome

Cognitive Dysfunction | Fragile X Syndrome | Behavior

Canada
Shire

Completed

An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment

Hunter Syndrome

United States, United Kingdom, Canada
Shire

Completed

Study of Long Term Safety and Clinical Outcomes of Idursulfase IT and Elaprase Treatment in Pediatric Participants Who Have Completed Study HGT-HIT-094

Hunter Syndrome

United States, Spain, Canada, United Kingdom, Mexico, Australia, France
Zynerba Pharmaceuticals, Inc.

Enrolling by invitation

Open Label Extension to Assess the Long-Term Safety and Tolerability of ZYN002 in Children and Adolescents With FXS

Fragile X Syndrome

United States, United Kingdom, New Zealand, Australia
Sangamo Therapeutics

Active, not recruiting

Long Term Follow-up (LTFU) of Subjects Who Received SB-318, SB-913, or SB-FIX (LTFU)

Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II

United States
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical...

Completed

Prader-Willi Syndrome Body Composition

Body Weight Changes | Sarcopenia | Prader Labhart Willi Syndrome

Taiwan
Washington University School of Medicine
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic

Covid19 | Intellectual Disability | Developmental Disability | Child Development Disorder

United States

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