Search clinical trials for: Moderate to severe acute pain

Total 475688 results

Depomed

Completed

Safety and Tolerability of Zipsor® in Pediatric Subjects (Ages 12-17 Years) With Mild to Moderate Acute

Pain

United States
Washington University School of Medicine

Completed

Moderate Acute Malnutrition (MAM) and Severe Acute Malnutrition (SAM) in Sierra Leone

Malnutrition

Sierra Leone
Purdue Pharma LP

Completed

Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children With Moderate to Severe Malignant and/ or Nonmalignant Pain Requiring Opioids

Pain

United States, Israel, Spain, United Kingdom, Greece, Hungary, New Zealand, Romania
Taiwan Mundipharma Pharmaceuticals Ltd.

Completed

A Study to Compare the Titration Efficacy and Safety of Control-released Oxycodone and Immediate-released Oxycodone in Patients With Moderate to Severe Cancer Pain

Pain | Cancer

Taiwan
Taiwan Mundipharma Pharmaceuticals Ltd.

Completed

Study Evaluating Safety and Tolerability of Oxycodone in Patients With Moderate to Severe Cancer Pain (STOP Pain)

Pain | Cancer

Taiwan
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis

Pain | Osteoarthritis | Joint Pain | Arthralgia | Osteoarthritis, Knee

United States, Canada
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain

Pain | Osteoarthritis | Joint Pain | Arthralgia | Osteoarthritis, Knee | Osteoarthritis, Hip

United States, Poland, Canada, Korea, Republic of
Purdue Pharma LP

Completed

Long-term Safety of Once-daily Hydrocodone Bitartrate (HYD) Tablets For Moderate to Severe Chronic Nonmalignant and Nonneuropathic Pain. Includes a 24-week Extension Period.

Chronic Nonmalignant and Nonneuropathic Pain

United States
Purdue Pharma LP

Completed

Efficacy and Safety of Hydrocodone Bitartrate (HYD) in Subjects With Moderate to Severe Chronic Low Back Pain

Chronic Low Back Pain

United States
Institut de Recherche pour le Developpement
United Nations World Food Programme (WFP); UNICEF; Sidaction; Global Fund

Completed

Nutritional Rehabilitation in Senegalese HIV-infected Children and Adolescents (SNAC'S)

HIV/AIDS | Malnutrition
Anna Meuronen, MD

Unknown

Intranasal Esketamine and Fentanyl for Pain in Minor Trauma

Acute Pain Due to Trauma

Finland
AbbVie

Terminated

A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain

Endometriosis

United States
Centre Hospitalier Annecy Genevois

Terminated

Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting (BPOP)

Pain | Emergencies | Injuries

France
Institute of Liver and Biliary Sciences, India

Completed

High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure

Acute Liver Failure

India
Cubist Pharmaceuticals LLC

Completed

Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia

Pneumonia, Bacterial
Cubist Pharmaceuticals LLC

Completed

Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumoniae

Pneumonia, Bacterial
Grünenthal GmbH
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Completed

A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee

Pain | Knee Osteoarthritis

Austria, Croatia, Germany, Hungary, Italy, Latvia, Netherlands, Poland, Portugal, Romania, Slovakia, Spain, United Kingdom
Dongzhimen Hospital, Beijing
Guangdong Provincial Hospital of Traditional Chinese Medicine; Beijing Tiantan... and other collaborators

Unknown

Xingnaojing for Moderate-to-severe Acute Ischemic Stroke (XMAS) (XMAS)

Acute Ischemic Stroke

China
Merz North America, Inc.

Completed

Evaluation of Pain With Belotero® Balance With Integral Lidocaine for Correction of the Nasolabial Folds

Correction of Moderate to Severe Nasolabial Folds

United States
Massachusetts General Hospital

Completed

Reduced Side-Effects Of Photodynamic Therapy For The Treatment Of Moderate To Severe Acne (i-PDT) (i-PDT)

Acne Vulgaris

United States
Eli Lilly and Company

Completed

A Study Comparing Dulaglutide With Insulin Glargine on Glycemic Control in Participants With Type 2 Diabetes (T2D) and Moderate or Severe Chronic Kidney Disease (CKD) (AWARD-7)

Type 2 Diabetes | Chronic Kidney Disease

Mexico, United States, Hungary, Ukraine, Brazil, Spain, Romania, South Africa, Poland
University of California, San Diego

Completed

Effects of Catheter Location on Postoperative Analgesia for Continuous Adductor Canal and Popliteal-Sciatic Nerve Blocks

Total Knee Arthroplasty | Post-surgical Pain | Foot/Ankle Surgery | Catheterization for Postop Analgesia

United States
Mundipharma (China) Pharmaceutical Co. Ltd

Completed

OXN PR Tablet 5/2.5 mg and20/10 mg PK Study in Chinese Moderate to Severe Chronic Non-malignant Patients

Chronic Pain

China
Brigham and Women's Hospital
Northeastern University

Completed

Patient Safety Learning Laboratory: Making Acute Care More Patient-Centered (PSLL)

Venous Thromboembolism | Patient Fall | Adverse Drug Event | Severe Hypoglycemia | Hospital Acquired Pressure Ulcer | Central Line-Associated Bloodstream Infection (CLABSI) | Catheter-Associated Infection | Opioid-Related Severe Adverse Drug Event | Severe Hospital Acquired Delerium | Rapid Response Related...

United States
Assistance Publique - Hôpitaux de Paris

Completed

Correction by ECCO2-R of Hypercapnia in Patients With DVP in Moderate to Severe ARDS Under Protective Ventilation. (COVAP)

Acute Respiratory Distress Syndrome | Hypercapnia

France
University of California, San Diego
Planned Parenthood Federation of America

Terminated

Paracervical Block for Pain Control With Osmotic Dilator Placement

Pain | Abortion Late

United States
Mundipharma (China) Pharmaceutical Co. Ltd

Unknown

A Study to Evaluate Buprenorphine Transdermal Patch in Chinese Subjects With Moderate to Severe Chronic Cancer Pain

Cancer Pain

China
Peking University
Peking Union Medical College Hospital; Chinese PLA General Hospital; The First... and other collaborators

Completed

Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients

Acute Lymphoblastic Leukemia

China
Shanghai Dermatology Hospital

Unknown

Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Moderate or Severe Acne

Acne

China
Centre Hospitalier Régional Metz-Thionville

Completed

Intranasal Fentanyl for the Treatment of Acute Severe Pain on the Pediatric Emergency Department of Mercy Hospital. (FENTANYLIN)

Acute Pain

France
University Hospital, Geneva

Completed

Adalimumab in Severe and Acute Sciatica (ASAS)

Sciatica

Switzerland
Taichung Tzu Chi Hospital

Completed

Safety and Efficacy of Wendan Decoction in Acute Moderated to Severe Brain Injury

Acute Brain Injury
Jaseng Hospital of Korean Medicine

Completed

Motion Style Acupuncture Treatment for Low Back Pain With Severe Disability (MSAT)

Complete Immobility Due to Severe Physical Disability

Korea, Republic of
Mundipharma Research Limited

Terminated

A Study to Characterize the Pharmacokinetics and Tolerability of Buprenorphine Patches in Children With Moderate to Severe Mouth Pain (BUP1501)

Chemotherapy Induced Mucositis | Mouth Pain

Denmark, United Kingdom
Mundipharma Research GmbH & Co KG

Completed

Oxycodone-naloxone Prolonged Release Tablets in Relieving Opioid-related Constipation

Pain
Mundipharma Research GmbH & Co KG

Completed

A Randomised, Double Blind, Placebo and Active Controlled, Double Dummy,Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Subjects With Moderate to Severe, Chronic Nonmalignant Pain

Subjects With Moderate to Severe, Chronic Nonmalignant Pain
Mundipharma Research GmbH & Co KG

Completed

Oxycodone-naloxone in Relieving Opioid-related Constipation

Pain
Mundipharma Research GmbH & Co KG

Completed

A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer Pain

Pain | Cancer | Constipation

United Kingdom
Mundipharma Research GmbH & Co KG

Completed

OXN PR Compared to OxyPR to Demonstrate Non-inferiority in Pain & Locomotor Function & Improvement in Symptoms of Constipation in OA Subjects

Chronic Osteoarthritis

Spain, Belgium, Finland, Czechia, Germany, Hungary
Merck Sharp & Dohme LLC

Completed

Multiple Attacks Study to Compare the Efficacy and Safety of MK-0974 With Placebo for Acute Migraine (MK-0974-031)

Migraines
Merck Sharp & Dohme LLC

Completed

Study of Telcagepant (MK-0974) in Participants With Moderate to Severe Acute Migraine With or Without Aura (MK-0974-011)

Migraine
Pfizer

Completed

Healthy Volunteers Study to Estimate the Effects of Food on the Bioavailability of Oxycodone and Naltrexone/6- Β -Naltrexol From a Extended Release Formulation of Oxycodone With Sequestered Naltrexone

Healthy

United States
Pfizer

Terminated

Safety and Pharmacokinetic Study of ALO-02 in Children Ages 7-17 With Pain

Moderate-severe Pain

United States
Norwegian University of Science and Technology
St. Olavs Hospital; Norwegian Fund for Postgraduate Training in Physiotherapy; Kommunal Landspensjonskasse

Completed

Effects of Resistance Training on Pain, Function and Work Ability in Patients With Moderate to Severe Neck Pain

Neck Pain

Norway
AbbVie (prior sponsor, Abbott)

Completed

A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain (ELARIS EM-I)

Endometriosis
AbbVie

Completed

A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain (ELARIS EM-II)

Endometriosis
Montefiore Medical Center

Completed

Safety of Hydromorphone in Adult Patients Presenting to the Emergency Department With Acute Severe Pain

Acute Pain

United States
Montefiore Medical Center

Completed

Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain

Acute Pain

United States
Norwegian University of Science and Technology
St. Olavs Hospital; Norwegian Fund for Postgraduate Training in Physiotherapy; Kommunal Landspensjonskasse

Completed

Effects of Resistance Training on Pain, Function and Work Ability in Patients With Moderate to Severe Low Back Pain

Low Back Pain

Norway
First Affiliated Hospital of Wenzhou Medical University

Unknown

Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. (HAPinsulin)

Hypertriglyceridemia | Acute Pancreatitis

3

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