Search clinical trials for: Open randomized multi-centre clinical trial in Africa

Total 465020 results

National Institute of Allergy and Infectious Diseases...
Duke University; National Institutes of Health (NIH); Department of Health and... and other collaborators

Not yet recruiting

A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum

HIV

United States, South Africa
University Hospital, Tours
Hospices Civils de Lyon; Centre Hospitalier Universitaire Dijon; CHU de Reims; University... and other collaborators

Not yet recruiting

Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial (CARVECIR)

Clinically Significant Portal Hypertension | Asymptomatic Cirrhosis

France
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Randomized, Open, Controlled, Multicenter Phase III Clinical Study of Fluzoparib in Combination With Apatinib Versus Investigator-Selected Chemotherapy for HRD-Positive/HER2-negative Advanced Breast Cancer

Breast Cancer

China
Hacettepe University

Recruiting

Clinical Investigation of Effectiveness of a Calcium Silicate Cement

Deep Caries | Dentin Caries

Turkey
Jagiellonian University
University Hospital in Krakow

Not yet recruiting

Beta-blockade in Unruptured Intracranial Aneurysm (BBLURAN)

Intracranial Aneurysm

Poland
Samsung Medical Center

Recruiting

Emulation of Randomized Clinical Trial in Cardiovascular Disease (RCT-BigData)

Myocardial Infarction | Coronary Artery Disease

Korea, Republic of
Sun Yat-sen University

Recruiting

A Multi-center, Randomized, Double-blind, Phase II/III Clinical Trial of AK104 or Placebo in Combination With Chemotherapy as Second-line or More Lines for Recurrent or Metastatic Nasopharyngeal Carcinoma (NPC)

Recurrent or Metastatic Nasopharyngeal Carcinoma

China
Digital Health Navigation Solutions, Inc
National Cancer Institute (NCI); Wake Forest University Health Sciences

Not yet recruiting

Feasibility of a Colorectal Cancer Screening Web App in Primary Care Patients

Colorectal Cancer Screening

United States
Xiang Lu

Recruiting

Neoadjuvant Tislelizumab Plus Chemotherapy for Resectable Locally-advanced Head and Neck Squamous Cell Carcinoma

Head and Neck Squamous Cell Carcinomas | Resectable Head and Neck Squamous-cell Carcinoma

China
M.D. Anderson Cancer Center

Recruiting

5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial

Intra-abdominal Cancer

United States
Yonsei University

Not yet recruiting

Randomized Comparison of Efficacy and Safety of High-intensity Rosuvastatin/Ezetimibe Combination Versus Treat-to-target Rosuvastatin Monotherapy for Patients With Peripheral Artery or Polyvascular Disease (CARE-PVD Trial)

Peripheral Artery Disease | Polyvascular Disease

Korea, Republic of
Research Institute for Physical Chemical Problems...
The state institution N. N. Alexandrov National Cancer Centre of Belarus; Unitary...

Not yet recruiting

An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II (ИНТЕЛОН-02)

Gastric Cancer With Peritoneal Dissemination

Belarus
Luis Alberto Chauca Bajaña
Universidad de Guayaquil

Not yet recruiting

Root Coverage With Tunneling Technique With Connective Tissue Versus Coronal Advancement Flap Technique.

Gingival Recession | Gingival Recession, Localized
Novo Nordisk A/S

Recruiting

A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

Type 2 Diabetes

United States, Taiwan, Australia, Hungary, Germany, India, Canada, Spain, Czechia, Argentina, Poland, Colombia, South Africa, France, Greece, Romania
Cairo University

Not yet recruiting

Assessment of Healing Properties Using Hyaluronic Acid Topical Application in Parasymphyseal Fracture Fixation: A Randomized Clinical Trial

Maxillofacial Trauma
University of Brasilia
Sarah Network of Rehabilitation Hospitals

Recruiting

Continuous Radiofrequency in Hip Osteoarthritis Pain: A Randomized Clinical Trial.

Hip Pain Chronic | Hip Osteoarthritis

Brazil
University of Coimbra

Recruiting

Unfolding the Wisdom Within: CFT for Adolescents in Residential Care (CFT_RYC)

Adolescent Behavior | Adolescent - Emotional Problem

Portugal
University of Bucharest

Recruiting

Mental Health Literacy and Academic Performance (MHLAP)

Mental Health Wellness 1

Romania
Zhujiang Hospital

Recruiting

A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial

High Grade Glioma | Radiation Toxicity | Overall Survival | Progression-free Survival | MRI Simulated Positioning

China
GlaxoSmithKline
Kwame Nkrumah University of Science and Technology; European & Developing Countries... and other collaborators

Recruiting

A Study on the Safety, Reactogenicity, and Immune Response to the GVGH iNTS-GMMA Vaccine Against Invasive Nontyphoidal Salmonella in Adults, Children, and Infants

Salmonella Infections

Ghana
Sohag University

Not yet recruiting

Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section: A Prospective Double-blind Randomized Clinical Trial

Post Spinal Anesthesia Hypotension
Bristol-Myers Squibb

Recruiting

A Study to Assess the Relative Bioavailability of 5 mg Mavacamten Opened Capsule Administered Via Nasogastric Tube Compared to Intact Oral 5 mg Mavacamten in Healthy Participants

Healthy Volunteers

United States
Sanofi
Regeneron Pharmaceuticals

Recruiting

A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD (AERIFY-4)

Chronic Obstructive Pulmonary Disease

United States, Argentina, Bulgaria, Chile, China, Czechia, Hungary, Israel, Poland, Taiwan, Canada, Portugal, United Kingdom, Korea, Republic of, Japan, Slovakia, South Africa
University Hospital, Basel, Switzerland

Recruiting

Follow-up Assessment of a Trial of Open-label Placebos for Women With Premenstrual Syndrome

Premenstrual Syndrome

Switzerland
University of Alabama at Birmingham
Mead Johnson Nutrition

Recruiting

Early DHA/ARA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial

Premature | Infant Malnutrition | Nutrition Disorder, Infant | Light-For-Dates With Signs of Fetal Malnutrition

United States
Maria Sklodowska-Curie National Research Institute...

Not yet recruiting

The Evaluation of the Effectiveness, Safety and Tolerability of Treatment, Using a PSMA-Lu177, in Patients With ACC- an Open, Non-commercial Clinical Trial (LuRM_ACC/2023)

Adenoid Cystic Carcinoma

Poland
Xuanwu Hospital, Beijing

Recruiting

Nurse-led Clinics Training Program on Mild Cognitive Impairment Patients

Mild Cognitive Impairment

China
City Clinical Hospital No.1 named after N.I. Pirogov
Pirogov Russian National Research Medical University

Not yet recruiting

Open vs. Endoscopic Transversus Abdominis Release Trial

Incisional Hernia of Midline of Abdomen

Russian Federation
Instituto Nacional de Perinatologia Isidro Espinosa...

Recruiting

Randomized Clinical Trial: Effect of an Exercise Routine on Postoperative Shoulder Pain in Laparoscopic Hysterectomy (ERPOSP)

Postoperative Pain | Laparoscopic Hysterectomy for Benign Conditions

Mexico
Peking University Third Hospital

Not yet recruiting

Randomized Controlled Clinical Trial of Internal Fixation of Intertrochanteric Fractures of Femur Guided by Conventional Versus IF-AI Artificial Intelligence Program

Hip Fractures
Yang Jianjun, PhD

Recruiting

Adebrelimab Combined With SOX Regimen in Preoperative Neoadjuvant Transformation Therapy for Locally Advanced Gastric Adenocarcinoma

Locally Advanced Gastric Adenocarcinoma

China
National Institute of Allergy and Infectious Diseases...
TB Alliance

Not yet recruiting

Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB)

Pulmonary Tuberculosis

Botswana, Brazil, Haiti, India, Kenya, Malawi, Mexico, Peru, Philippines, South Africa, Thailand, Uganda, Zimbabwe
Hochschule Osnabruck
Medizinische Gesellschaft für Myofasziale Schmerzen e.V.; Therapiecentrum Voxtrup... and other collaborators

Recruiting

Manual Therapy and Movement Control Exercises for Chronic Neck Pain. A Pilot Randomized Controlled Trial

Neck Pain | Temporomandibular Disorder

Germany
Beijing Tiantan Hospital

Not yet recruiting

Safety and Preliminary Efficacy of Aleeto in Amyotrophic Lateral Sclerosis (SPECIALS)

Amyotrophic Lateral Sclerosis

China
Sanofi

Recruiting

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis (COAST 2)

Dermatitis Atopic

Argentina, Japan, China, Czechia, Spain, United States, South Africa, United Kingdom, Denmark, Sweden, Turkey
Viridian Therapeutics, Inc.

Recruiting

An Open-label Study for Participants Who Are Non-responders at the End of Treatment Assessment on the VRDN-001-101 and VRDN-001-301 Pivotal Studies

Thyroid Eye Disease

United States
Shandong Suncadia Medicine Co., Ltd.

Not yet recruiting

A Randomized, Double-Blind, Dose-Escalation, Placebo-Controlled Phase I Clinical Trial Investigating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Oral Doses of HRS-7085 Tablets in Healthy Subjects, With Assessment of Food Effects

Inflammatory Bowel Disease
Ottawa Heart Institute Research Corporation

Not yet recruiting

Dapagliflozin in STEMI Randomized Clinical Trial (DAPA STEMI)

Myocardial Infarction | ST Elevation Myocardial Infarction

Canada
Faculty of Dental Medicine for Girls

Recruiting

Assessment of Low Level Laser Therapy Effect on Treatment Outcomes of Bony Supported Distal Jet for Correction of Angle Class II Malocclusion (Randomized Clinical Trial) (LLLT)

This Study Focus on the Effect of Low-Level Light Therapy on the Amount of Upper Molar Distalization

Egypt
Chinese University of Hong Kong

Recruiting

High-frequency Transcranial Random Noise Stimulation (Hf-tRNS) for Sleep Disturbances in Neurocognitive Disorders Due to Vascular Disease

Cognitive Impairment | Vascular Dementia | Sleep Disorders, Circadian Rhythm

Hong Kong
Universidad Nacional Autonoma de Honduras

Recruiting

Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial (CINNALAB)

Labor Onset and Length Abnormalities | First Birth

Honduras
Eslam Mohamed AHmed

Not yet recruiting

Femoral Neck Locking Plate Vs Multiple Cannulated Cancellous Screws in Treatment of Femoral Neck Fractures in Young Adults: Randomized Controlled Clinical Trial Study

Femoral Neck Fractures

Egypt
Apellis Pharmaceuticals, Inc.

Recruiting

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Geographic Atrophy

United States
McMaster University
Canadian Chiropractic Research Foundation; Surgical Methods Centre, McMaster... and other collaborators

Not yet recruiting

The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study

Back Pain

Canada
University of Sao Paulo General Hospital

Recruiting

Randomized, Double-blind, Placebo-controlled Cannabis Extract x Placebo for Cocaine Addicts

Cocaine Dependence

Brazil
Cairo University

Recruiting

Clinical Evaluation of Giomer Based Varnish Versus CPP-ACP Varnish in the Management of Dentin Hypersensitivity: a Randomized Clinical Trial

Dentin Hypersensitivity

Egypt
Altesa Biosciences, Inc.
Virtus Respiratory Research

Recruiting

RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection

Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases | Lung Diseases | Pulmonary Disease, Chronic Obstructive | Enterovirus Infections | Copd | Pulmonary Disease | Respiratory Disease | Respiratory Complication | Upper Respiratory Tract Infections | Respiratory Viral Infection | ... and other conditions

United Kingdom
Centro de Excelencia en Enfermedades de Cabeza...
Hospital San Vicente Fundación; Hospital Alma Mater de Antioquia; Clinica Las...

Recruiting

Lateral Cervical Node Dissection in Differentiated Thyroid Cancer.

Thyroid Cancer

Colombia
ModernaTX, Inc.

Recruiting

A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated Mothers

Respiratory Syncytial Virus

Canada, United Kingdom, Japan, United States, Chile, Denmark, Panama, South Africa
Genomic Prediction Inc.
Boston IVF

Recruiting

GEnetic Testing in Elective Single Embryo Transfer (GETSET): A Randomized Clinical Trial (GETSET)

Infertility, Female

United States

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