Search clinical trials for: Severe refractory asthma

Total 25254 results

AstraZeneca

Active, not recruiting

Patient-Reported Outcomes of Benralizumab in Real-World Use in Severe Eosinophilic Asthma Patients in Taiwan (BEAT)

Asthma

Taiwan
Nantes University Hospital
L'institut du thorax - INSERM UMR 1087 / CNRS UMR6291 - IRS-Université de... and other collaborators

Completed

Assessing the Expression and the Activity of Rac1 Protein in the Airway Smooth Muscle of Asthmatic Patient (NaRacAS)

Asthma

France
AstraZeneca

Active, not recruiting

Study to Evaluate Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma (WAYFINDER)

Asthma

United States, Belgium, Spain, United Kingdom, France, Argentina, Bulgaria, Germany, Poland, Mexico, Latvia
Roswell Park Cancer Institute

Active, not recruiting

Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

Acute Myeloid Leukemia | Polycythemia Vera | Myelofibrosis | Chronic Myelomonocytic Leukemia | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Secondary Acute Myeloid Leukemia | Sickle Cell Disease | Myelodysplastic Syndrome | Plasma Cell Myeloma | Chronic Granulomatous... and other conditions

United States
Suzhou Connect Biopharmaceuticals, Ltd.

Completed

Efficacy and Safety of CBP-201 in Patients With Moderate to Severe Persistent Asthma With Type 2 Inflammation

Moderate to Severe Persistent Asthma

United States, China, Hungary, Korea, Republic of, Poland
Shionogi

Completed

Evaluation of S-600918 in Adults With Refractory Chronic Cough

Chronic Cough

United States, United Kingdom, Japan, Ukraine, Poland, Czechia
Sanofi
Regeneron Pharmaceuticals

Active, not recruiting

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation (NOTUS)

Chronic Obstructive Pulmonary Disease

Greece, Belgium, Spain, Argentina, Hungary, South Africa, United Kingdom, France, Latvia, Germany, Netherlands, Russian Federation, Ukraine, United States, Australia, Brazil, Bulgaria, Canada, Chile, Colombia, Czechia, Lithuania, Me... and more
AstraZeneca

Active, not recruiting

Patient Reported Outcomes in Adults With Severe Eosinophilic Asthma on Benralizumab. (POWER)

Severe Eosinophilic Asthma

Canada
Bambino Gesù Hospital and Research Institute

Completed

Omalizumab in Severe Asthmatics With Food Allergy (OSAFA)

Asthma in Children | Food; Allergy, Anaphylactic Shock

Italy
AbbVie

Completed

A Study to Compare Safety and Efficacy of Upadacitinib to Dupilumab in Adult Participants With Moderate to Severe Atopic Dermatitis (Heads Up)

Atopic Dermatitis

United States, Australia, Canada, Croatia, Czechia, Finland, France, Germany, Hungary, Ireland, Israel, Italy, Malaysia, Netherlands, New Zealand, Norway, Poland, Singapore, Spain, Sweden, Taiwan, Ukraine, United Kingdom
Amgen

Active, not recruiting

A Study Assessing Rocatinlimab on Vaccine Antibody Response in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET - VOYAGER) (ROCKET-VOYAGER)

Atopic Dermatitis | Moderate-to-severe Atopic Dermatitis

United States, Canada
Haukeland University Hospital

Active, not recruiting

Inducible Laryngeal Obstruction in Severe Asthma in Severe Asthma

Vocal Cord Dysfunction | Asthma Chronic

Norway
Primus Pharmaceuticals
Prosoft Clinical

Terminated

DFD01 Spray HPA Axis Suppression Study in Adolescent Patients With Moderate to Severe Plaque Psoriasis

Plaque Psoriasis

United States
Sanofi

Completed

Proof of Concept Study of Rilzabrutinib in Adult Participants With Moderate-to-severe Asthma

Asthma

Spain, Korea, Republic of, Chile, Mexico, United Kingdom, Argentina, Bulgaria, Canada, Hungary, Poland, Romania, Turkey, Germany
King's College Hospital NHS Trust

Active, not recruiting

Study for Children & Adolescent With Severe Asthma With an Eosinophilic Phenotype Treated With Mepolizumab (CASAM)

Asthma in Children

United Kingdom
AbbVie

Active, not recruiting

Evaluation of Upadacitinib in Adolescent and Adult Patients With Moderate to Severe Atopic Dermatitis (Eczema) (Measure Up 1)

Atopic Dermatitis

United States, Argentina, Australia, Bosnia and Herzegovina, Bulgaria, Canada, China, Colombia, Croatia, Denmark, Estonia, Finland, France, Germany, Italy, Japan, Malaysia, New Zealand, Puerto Rico, Romania, Russian Federation, Sw... and more
AbbVie

Active, not recruiting

A Study to Evaluate Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis (Measure Up 2)

Atopic Dermatitis

United States, Australia, Austria, Belgium, Bulgaria, Canada, Croatia, Czechia, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Korea, Republic of, Netherlands, New Zealand, Portugal, Singapore, Spain, Taiwan, United Kingdom
Ludocare SAS
Clinact

Active, not recruiting

Evaluation of Efficacy and Tolerance of JOE on 4 to 11 Years Old Asthmatic Patients of GINA 2,3,4 and 5 Grades (JoeCare)

Asthma in Children

France
AstraZeneca

Completed

Real World Study With Benralizumab in Severe Asthma in Switzerland (BEEPS)

Severe Eosinophilic Asthma

Switzerland
Sanofi
Regeneron Pharmaceuticals

Completed

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation (BOREAS)

Chronic Obstructive Pulmonary Disease

Spain, Argentina, China, Mexico, Canada, Ukraine, Israel, Italy, Czechia, Korea, Republic of, Bulgaria, Chile, Denmark, Finland, Germany, Hungary, Japan, Poland, Romania, Russian Federation, Slovakia, Sweden, Turkey, United States
Keymed Biosciences Co.Ltd

Completed

A Study of CM310 in Subjects With Moderate to Severe Asthma

Asthma

China
SetPoint Medical Corporation

Active, not recruiting

Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis (RESET-RA)

Rheumatoid Arthritis

United States
RAPT Therapeutics, Inc.

Suspended

Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma

Asthma

United States, Bulgaria, Czechia, Poland
Aristotle University Of Thessaloniki
NHS Pulmonary Clinic G. Papanikolaou Hospital, Thessaloniki, Greece; Pulmonary... and other collaborators

Active, not recruiting

Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO) (MESILICO)

Severe Asthma | Asthma; Eosinophilic | Late-Onset Asthma

Greece
Chiesi Farmaceutici S.p.A.

Completed

Study in Adult Patients With Moderate to Severe Asthma (FEEL)

Asthma

Italy
Novartis Pharmaceuticals

Available

Managed Access Programs for INC424, Ruxolitinib

Primary Myelofibrosis (PMF) | Polycythemia Vera (PV) | Post Polycythemia Myelofibrosis (PPV MF) | Thrombocythemia Myelofibrosis (PET-MF) | Severe/Very Severe COVID-19 Illness | Steroid Refractory Acute Graft Versus Host Disease (SR aGVHD) | Steroid Refractory Chronic Graft Versus Host Disease...
Novartis Pharmaceuticals

Active, not recruiting

A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia

Aplastic Anemia

Thailand, Russian Federation, Portugal, United Kingdom, Hong Kong, United States
Hopital du Sacre-Coeur de Montreal
GlaxoSmithKline

Completed

Effectiveness of Anti-IL-5/IL5R Inhibitors

Severe Asthma

Canada
Novartis Pharmaceuticals

Completed

Study of the Efficacy of Early Intervention With Secukinumab 300 mg s.c. Compared to Narrow-band UVB in Patients With New-onset Moderate to Severe Plaque Psoriasis (STEPin)

Plaque Psoriasis

Spain, United Kingdom, Estonia, Germany, Bulgaria, Finland, Hungary, Poland, Argentina, Canada, Denmark, Switzerland, Sweden
Sanofi

Active, not recruiting

An Observational, Retrospective Multicentre Medical Record Review to Describe the Post-authorisation Early Clinical Experience of Dupilumab in the Treatment of Adult Severe Asthma (DUPIAZA)

Asthma

France
AstraZeneca

Completed

Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma (FRONTIER-3)

Asthma

United States, Germany, United Kingdom, Argentina, Poland, South Africa, Hungary
Shire

Completed

A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA)

Crohn's Disease | Ulcerative Colitis

Spain, United States, Korea, Republic of, Lebanon, Australia, Russian Federation, Romania, Hungary, Portugal, Israel, Italy, Turkey, Croatia, Belgium, Bulgaria, Germany, Netherlands, Poland, New Zealand, Argentina, United Kingdom, Greec... and more
AstraZeneca

Completed

Change in Patient-Reported Outcomes in Severe Eosinophilic Asthma Patients Treated With Benralizumab Under Real-life Conditions (imPROve)

Asthma

Germany
McMaster University
Teva Canada

Completed

Efficacy of Reslizumab Dose Escalation in Patients With Severe Asthma

Asthma; Eosinophilic

Canada
University of Liege
European Union

Completed

Effect of a Synbiotic "Probiotical®/Bactecal® " in Asthma

Asthma

Belgium
University Hospital Southampton NHS Foundation...
Novartis; Boehringer Ingelheim; National Institutes of Health (NIH); National Institute... and other collaborators

Active, not recruiting

Wessex Asthma Cohort of Difficult Asthma (WATCH)

Asthma

United Kingdom
Fundació Institut de Recerca de l'Hospital de la...
Spanish Clinical Research Network - SCReN

Completed

Non-Eosinophilic Neutrophilic Asthma (ANNE)

Neutrophilic Asthma

Spain
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant

Follicular Lymphoma | Diffuse Large B-Cell Lymphoma | Hodgkin Lymphoma | Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Acute Leukemia | Myelodysplastic Syndrome | Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | Myeloproliferative... and other conditions

United States
AstraZeneca
Amgen

Completed

Study to Evaluate the Pharmacokinetics of Tezepelumab in Children With Asthma (TRAILHEAD)

Asthma

United Kingdom, South Africa, Hungary
University of Leicester
Genentech, Inc.; Medical Research Council; Queen's University, Belfast

Active, not recruiting

Refractory Asthma Stratification Programme (RASP) Bronchoscopy Study

Persistent Asthma

United Kingdom
University of Pittsburgh

Active, not recruiting

Immune Interactions in Severe Asthma

Asthma

United States
AltruBio Inc.

Terminated

Efficacy&Safety of ALTB-168 in Patients With Moderate to Severe Active,Anti-TNF Alpha and/or Anti-integrin Refractory UC (TNF)

Ulcerative Colitis

United States, Puerto Rico
Children's Hospital of Fudan University

Completed

Clinical Characteristics of Severe Childhood Asthma

Severe Asthma

China
AstraZeneca

Completed

Real World Evidence of Benralizumab in Eosinophilic Severe AsThma in Russia (BEST)

Severe Eosinophilic Asthma

Russian Federation
Sanofi

Completed

Proof of Concept Study of Rilzabrutinib in Adult Patients With Moderate-to-severe Atopic Dermatitis

Atopic Dermatitis

Netherlands, Chile, United States, Canada, Czechia, Germany, Poland
University of Karachi

Enrolling by invitation

Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

Asthma Acute

Pakistan
Assistance Publique - Hôpitaux de Paris

Completed

Validity of a French Version of the Severe Asthma Questionnaire (TRAQUE)

Asthma

France
AstraZeneca
Faculdade de Medicina da Universidade do Porto - CINTESIS; Universidade do...

Active, not recruiting

Prevalence and Characterisation of Asthma Patients According to Disease Severity in Portugal (Epi-Asthma)

Asthma

Portugal
Lipella Pharmaceuticals, Inc.

Completed

The Safety, Tolerability and Efficacy of LP-10 in Subjects With Refractory Moderate to Severe Hemorrhagic Cystitis

Hemorrhagic Cystitis

United States
AstraZeneca

Completed

A Study to Compare Severe Asthma Patients Who Start Biologics and Who do Not Start (PROSPECT)

Asthma

Japan

Search clinical trials for: Severe refractory asthma

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Algeria

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations