Search clinical trials for: germline variants

Total 399 results

Universitätsklinikum Hamburg-Eppendorf
Deutsche Kinderkrebsstiftung

Active, not recruiting

International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

Brain Tumors

Germany, Denmark, United Kingdom, Belgium, Poland, Ireland, Austria, Italy, Czechia, France, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland
National Cheng-Kung University Hospital

Terminated

Genetic Variants and Chemotherapy-induced Abnormal Thermal Sensation

Chemotherapy-induced Abnormal Thermal Sensation

Taiwan
Beijing Tiantan Hospital

Completed

RNF213 Variants and Collateral Vessels in Moyamoya Disease

Moyamoya Disease

China
Hospices Civils de Lyon

Completed

COVID-19 - SARS-CoV-2 Community Contamination in Children and Adults - Impact of Variants (Dyn3CEA - Nosocor Phase 2)

Infection Viral

France
Memorial Sloan Kettering Cancer Center
University of Washington; Sarah Lawrence College

Completed

Germline BRCA1 and BRCA2 Mutations in Jewish Women Affected by Breast Cancer

Breast Cancer

United States
Assistance Publique - Hôpitaux de Paris
French rare diseases Healthcare Network; The French Foundation for Rare Diseases

Active, not recruiting

Non-syndromic Inherited Anomalies of Mineralized Tooth Tissues: a Whole Exome Study to Identify New Pathogenic Variants (EXODENT)

Amelogenesis Imperfecta | Dentinogenesis Imperfecta | Dentin Anomalies

France
Pfizer

Terminated

Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer

Early Breast Cancer

United States
Centers for Disease Control and Prevention, China

Active, not recruiting

Correlation Study of Isotype Switching and Neutralizing Capacity to the COVID-19 Variants Strain

COVID-19

China
William Beaumont Hospitals

Completed

The Impact of Vaccination on Severity of Illness in COVID-19

Covid19

United States
Washington University School of Medicine
Pfizer; Rising Tide Foundation

Terminated

Neoadjuvant Study of Palbociclib in Combination With Letrozole and Trastuzumab in Stage II-III ER+ HER2+ Breast Cancer (PALTAN)

Breast Cancer | Breast Carcinoma | Cancer of Breast

United States
Second Affiliated Hospital, School of Medicine,...

Completed

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria

Lynch Syndrome

China
Hospital General Universitario Gregorio Marañon
Fundación para la Investigación Biomédica del Hospital Gregorio Maranon

Completed

The Microbiome as a Target for Precision Medicine in Atherosclerosis (MIGATER)

Atherosclerosis | Acute Coronary Syndrome

Spain
Radboud University Medical Center
Canisius-Wilhelmina Hospital

Unknown

Multisystem Features of Malignant Hyperthermia or Rhabdomyolysis Related to RYR1 Variants

Malignant Hyperthermia | Rhabdomyolysis | RYR1 Variant

Netherlands
St Mary's University College
Fulham Football Club

Completed

Candidate Gene Association Study With Injury in Elite Male Youth Football Players

Injuries | Genetic Change

United Kingdom
AGO Research GmbH

Completed

Prevalence of BRCA in Patients With Ovarian Cancer

Ovarian Cancer | BRCA Status

Germany
Centre Hospitalier Régional Metz-Thionville
Central Hospital, Nancy, France

Completed

Evaluation of the New Variant 501Y.V2 of COVID-19 (VARICOVID)

Covid19

France
Pfizer

Terminated

Treatment Resistance Following Anti-cancer Therapies

Disease Progression

United States, Belgium, France, Argentina, United Kingdom
Endocyte

Completed

Phase 2 Study of EC145 Alone Versus EC145+Docetaxel Versus Docetaxel Alone in Participants With FR(++) 2nd Line Non Small Cell Lung Cancer (TARGET)

Non Small Cell Lung Cancer
National Cancer Institute (NCI)

Terminated

Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study)

Genetics

Ukraine
Hellenic Cooperative Oncology Group

Completed

Germline Mutations in Pancreatic Adenocarcinoma (PaMPA)

Pancreatic Cancer | Hereditary Cancer | Predisposition, Genetic | Germline Mutation Abnormality

Greece
Yale University

Completed

Prostate Cancer Screening in Men With Germline BRCA2 Mutations

Prostate Cancer

United States
Hôpital le Vinatier

Completed

Molecular Variants Associated With Schizophrenia: Differential Analysis of Monozygotic Twins With Variable Phenotypic 22q11 (CSRK05)

Di George Syndrome

France
Brigham and Women's Hospital

Terminated

APOL1 Gene Variants in African American Kidney Transplant Recipients

Kidney Failure, Chronic | Kidney Disease | Transplant;Failure,Kidney

United States
Hellenic Cooperative Oncology Group

Completed

Pathogenic Variants in Homologous Recombination Repair Genes in Patients With Epithelial Ovarian Cancer (PaVaClO)

Epithelial Ovarian Cancer
National Cancer Institute (NCI)

Completed

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma

Pheochromocytoma | Paraganglioma

United States
Seoul National University Hospital

Completed

Genetic Variants Replication Study Associated With Dependence on Sulfonylurea in Participants With Type 2 Diabetes

Diabetes Mellitus

Korea, Republic of
National Cancer Institute (NCI)

Completed

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Li-Fraumeni Syndrome

United States
University of Campania "Luigi Vanvitelli"
Federico II University; University of Salerno

Completed

Effect of PNPLA3, TM6SF2 and MBOAT7 Genetic Variants on Non-alcoholic Fatty Liver Disease Therapeutic Outcome.

Insulin Resistance | Non-Alcoholic Fatty Liver Disease

Italy
University Children's Hospital, Zurich

Completed

Genetic Variants in Linear Localized Scleroderma

Morphea

Switzerland
Ambry Genetics
Beth Israel Deaconess Medical Center; HonorHealth Research Institute; University...

Completed

Utilizing a Multi-gene Testing Approach to Identify Hereditary Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma

United States
University of Minnesota

Completed

Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations

Urticaria Pigmentosa | Cutaneous Mastocytosis

United States
National Cancer Institute (NCI)

Terminated

BMN 673 (Talazoparib), an Oral PARP Inhibitor, in People With Deleterious BRCA1/2 Mutation-Associated Ovarian Cancer Who Have Had Prior PARP Inhibitor Treatment

Ovarian Cancer

United States
RWJ Barnabas Health at Jersey City Medical Center

Unknown

Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation

Lynch Syndrome | Endometrial Cancer | Somatic Mutation | Cancer Gene Mutation

United States
National Cheng-Kung University Hospital

Unknown

Exploring the Effects of Genetic Variants and Inflammation on Vitamins Supplementation Treatment Outcomes in Epilepsy

Epilepsy

Taiwan
Memorial Sloan Kettering Cancer Center
United States Department of Defense

Completed

Clinical and Histopathologic Characteristics of BAP1 Mutations

Renal Cell Carcinoma | Cholangiocarcinoma | Malignant Pleural Mesothelioma (MPM) | Choroidal Nevus | Primary Uveal Melanoma (UM) | Metastatic Uveal Melanoma (UM)

United States
University Hospital, Rouen

Completed

Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation (PANEL)

Breast Cancer | Colorectal Cancer | Ovarian Cancer | Pediatric Cancers | Multiple Primary Malignant Tumours

France
German Institute of Human Nutrition
Technical University of Munich

Completed

SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition (SEGATROM)

Disorder of Glucose Regulation

Germany
UCB Biopharma SRL

Withdrawn

A Study to Test the Blood Concentration of 4 Padsevonil Product Variants and the Effect of Food on Padsevonil

Epilepsy | Healthy Participants
AstraZeneca
Quintiles; University of Tubingen - Germany

Completed

International Breast Cancer Biomarker,Standard of Care and Real World Outcomes Study (BREAKOUT)

Breast Cancer

United States, Bulgaria, Italy, Korea, Republic of, Russian Federation, Spain, Turkey, Canada, Poland, Australia, Hungary, Taiwan, Japan, Germany, United Kingdom
Baylor College of Medicine

Terminated

Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLO (THALLO)

Thalassemia

United States
University Hospital Inselspital, Berne

Completed

Genetic Variants and Non-genetic Variables and Postoperative Nausea and Vomiting

Analgesia | Anesthesia | Surgical Procedure, Operative

Switzerland
German Breast Group
AstraZeneca

Completed

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency (GeparOla)

Breast Cancer | Triple Negative Breast Neoplasms | HRpos Breast Neoplasms | BRCA 1 /2 and / or HRD

Germany
Leiden University Medical Center
Erasmus Medical Center; The Netherlands Cancer Institute; Medical Center Haaglanden and other collaborators

Unknown

Identifying Novel Variants in the DPYD Gene in Patients of Non-Western Descent (DPYD-NOW)

Neoplasms
Maastricht University Medical Center
RWTH Aachen University

Unknown

Atrial Fibrillation Ablation Registry (AFAB)

Atrial Fibrillation (Paroxysmal) | Atrial Fibrillation Recurrent | Atrial Fibrillation Common Gene Variants

Netherlands
Haukeland University Hospital

Unknown

Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes (SUtoChildT1D)

Insulin-dependent Diabetes Mellitus | Maturity-Onset Diabetes of the Young, Type 3 | Maturity Onset Diabetes of the Young, Type 1 | Childhood Diabetes Mellitus

Norway
Janssen Research & Development, LLC

Completed

A Study to Characterize the Elimination of Guselkumab Glycoform Variants in Healthy Participants

Healthy

United States
Hacettepe University
The Scientific and Technological Research Council of Turkey; University of...

Completed

FTO Gene Variants and Diet in Obesity

Obesity | Diet Habit | Genetic Predisposition

Turkey
National Institute on Drug Abuse (NIDA)

Completed

Stem Cell Study of Genetics and Drug Addiction

Induced Pluripotent Stem Cells

United States
National Institute on Drug Abuse (NIDA)

Terminated

Methylphenidate Studies for Drug Abuse Vulnerability Molecular Genentics

Substance Abuse

United States
Istituto Ortopedico Galeazzi

Unknown

Genetic Polymorphisms Associated With Vertebral Osteochondrosis (OSTEOGEN)

Spinal Osteochondrosis

Italy

Search clinical trials for: germline variants

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Ecuador

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations