Search clinical trials for: mutation

Total 3274 results

Merck KGaA, Darmstadt, Germany
Merck Quimica Argentina S.A.I.C

Completed

Prevalence of the Mutational Status of V-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) in Metastatic Colorectal Cancer (mCRC) in Argentine Patients

Colorectal Neoplasms

Argentina
Vertex Pharmaceuticals Incorporated
Cystic Fibrosis Foundation

Completed

Study of the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects With Cystic Fibrosis and the G551D Mutation

Cystic Fibrosis

United States
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

Laboratory Study Using Samples From Patients With Non-Small Cell Lung Cancer Treated on Clinical Trial CASE-2507

Lung Cancer
Myat Htut Nyunt
Kangwon National University

Completed

Molecular Assessment of Artemisinin Resistance Markers in Eastern and Western Border Areas of Myanmar

Day-3 Positive of Parasitaemia | Prevalence of Drug Resistance Gene Mutation

Myanmar
Deciphera Pharmaceuticals LLC

Completed

Study Safety and Preliminary Efficacy of DCC-2036 in Patients With Leukemias (Ph+ CML With T315I Mutation)

Chronic Myeloid Leukemia

United States
Rambam Health Care Campus
Schneider Children's Hospital

Unknown

Controlled Ceasing of Colchicine Therapy in Familial Mediterranean Fever (FMF) Patients With Single MEFV (Mediterranean Fever) Gene Mutation

Familial Mediterranean Fever

Israel
michal roll

Unknown

Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis

FAP-Familial Adenomatous Polyposis

Israel
Sociedad Española de Arteriosclerosis
Universidad de Zaragoza; Hospital Miguel Servet

Unknown

Cardiovascular Disease in FH Heterozygous

Familial Hypercholesterolemia

Spain
Pamlab, Inc.
InfoMedics, Inc.

Completed

Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support)

Major Depressive Disorder

United States
Danish Breast Cancer Cooperative Group

Unknown

National Screening in Denmark With MR Versus Mammography and Ultrasound of Women With BRCA1 or BRCA2 Mutations (MR BRCA)

Breast Cancer

Denmark
GlaxoSmithKline

Completed

A Study of GSK2118436 in BRAF Mutant Metastatic Melanoma to the Brain (Break MB)

Melanoma and Brain Metastases

Australia, Germany, United States, Canada, Italy, France
National Taiwan University Hospital
National Cheng-Kung University Hospital

Unknown

Mitochondrial nt3243 A>G Mutation in Taiwan

MELAS Syndrome | Noninsulin-dependent Diabetes Mellitus With Deafness

Taiwan
AstraZeneca

Completed

Diagnosis and Treatment Strategies in Patients With NSCLC With or Without EGFR Mutations. (IDENTIFY)

Non-Small Cell Lung Cancer | Stage IIIB/IV

Argentina
Taipei Veterans General Hospital, Taiwan
National Taiwan University Hospital; China Medical University Hospital; Tri-Service... and other collaborators

Unknown

Genius Study Study to Compare Efficacy and Safety of Gefitinib/ Pemetrexed With Pemetrexed Alone as Maintenance Therapy in Patients With Stage IV EGFR Mutation Negative or T790M Single Mutation Who Respond to Pemetrexed/ Platinum as First-line Therapy

NSCLC

Taiwan
National Cancer Institute (NCI)

Terminated

Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific | Adenocarcinoma of the Pancreas | Recurrent Pancreatic Cancer | Stage IV Pancreatic Cancer | Stage IV Breast Cancer | Stage IV Ovarian Epithelial Cancer | Stage IV Ovarian Germ Cell Tumor | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB... and other conditions

United States
GlaxoSmithKline

Completed

Study to Determine the Effectiveness of GSK1120212 in BRAF Mutation-positive Melanoma Previously Treated With or Without a BRAF Inhibitor

Cancer

Australia, United States
AstraZeneca

Completed

A Non-interventional Survey on the EGFR (Epidermal Growth Factor Receptor) Mutation Status in Completely Resected Chinese Non-Small Cell Lung Cancer (NSCLC) Patients With Adenocarcinoma Histology (ICAN)

Non-Small Cell Lung Cancer

China
US Oncology Research
Quintiles, Inc.

Completed

Biomarker Analysis for Patients With Metastatic Colorectal Cancer (MCC)

Colorectal Neoplasms | Advanced Metastatic Colorectal Cancer

United States
University Hospital, Angers
University Hospital, Rouen; Central Hospital, Nancy, France; University Hospital... and other collaborators

Unknown

Theranostic Tool During Erlotinib Treatment in Non-small Cell Lung Cancer Patient (FLT-THERA)

Non-small Cell Lung Cancer Metastatic or Non-small Cell Lung Cancer Recurrent | No EGFR Activating Mutation

France
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Second Affiliated Hospital...

Unknown

Intermittent and Maintenance of Erlotinib in Combination With Pemetrexed/Carboplatin in Ⅲb/IV Non Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation

Lung, Carcinoma
Yonsei University

Completed

Registry and Prevalence of Gene Mutation in Korean Patients With Familial Hypertrophic Cardiomyopathy

Familial Hypertrophic Cardiomyopathy

Korea, Republic of
Betta Pharmaceuticals Co., Ltd.

Completed

Icotinib Combined With WBRT For NSCLC Patients With Brain Metastases and EGFR Mutation

Non-small Cell Lung Cancer | Brain Metastases

China
Samsung Medical Center

Completed

Prognostic Molecular Markers in Patients With Myelodysplastic Syndrome

Myelodysplastic Syndrome

Korea, Republic of
Associação Fundo de Incentivo à Pesquisa

Completed

Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene (CCHS)

Congenital Central Hypoventilation Syndrome

Brazil
Yonsei University
Bristol-Myers Squibb; Chonbuk National University Hospital; Seoul St. Mary's... and other collaborators

Unknown

Antiviral Efficacy of Switching to ETV Plus TDF

Chronic Hepatitis B
GlobeImmune
Memorial Sloan Kettering Cancer Center

Completed

A Pilot Phase 2 Trial of the Immunogenicity, and Safety of GI-4000; an Inactivated Recombinant S. Cerevisiae Expressing Mutant Ras Protein, as Consolidation Therapy Following Curative Treatment for Stage I-III Non-Small Cell Lung Cancer (NSCLC) With Tumor Sequence Confirmation of K-ras Mutation

NSCLC

United States
AstraZeneca

Completed

Gefitinib Usage and Outcomes in Routine Treatment

Lung Cancer

United Kingdom
National University Hospital, Singapore

Unknown

A Retrospective Study of C-kit Mutation Status in Asian Patients With Advanced Gastro-intestinal Stromal Tumors (GIST) Treated With Imatinib.

Asian Patients With Advanced Gastro-intestinal Stromal Tumors (GIST) Treated With Imatinib

Singapore
Peking Union Medical College Hospital
Stanford University

Unknown

Circulating Cell-free DNA as a Predictive Biomarker for Hepatocelluar Carcinoma.

Hepatocellular Carcinoma

United States, China
Seoul St. Mary's Hospital
Novartis

Unknown

Prospective Investigation of Dynamics of ABL Mutations in Imatinib Failed CML Patients Treated With Nilotinib (AMICAN)

Chronic Myeloid Leukemia

Korea, Republic of
Seoul St. Mary's Hospital
Bristol-Myers Squibb

Unknown

Patterns of ABL Mutation in Asian With Imatinib Resistant Chronic Myeloid Leukemia and Ph Positive Acute Lymphocytc Leuekmia Patients (AMICA)

Chronic Myeloid Leukemia or Ph Positive ALL

Korea, Republic of
Abramson Cancer Center of the University of Pennsylvania
National Cancer Institute (NCI)

Unknown

Sunitinib Before and After Surgery in Treating Patients With Stage IV Kidney Cancer

Kidney Cancer

United States
University Hospital Birmingham

Unknown

Different Factors Affecting Patients With Newly Diagnosed Bladder Cancer

Bladder Cancer

United Kingdom
Memorial Sloan Kettering Cancer Center
Boehringer Ingelheim; National Comprehensive Cancer Network

Withdrawn

Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With EGFR-Mutant Lung Cancers Undergoing Definitive Chemoradiation

Non-small Cell Lung Cancer
Medical Research Council

Completed

Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer

Colorectal Cancer

United Kingdom
Sidney Kimmel Cancer Center at Thomas Jefferson...
National Cancer Institute (NCI)

Unknown

Gene Expression in Predicting Response to Paclitaxel in Patients With Breast Cancer

Breast Cancer
University of Sheffield

Unknown

Genes That Affect Disease Outcome in Patients With Metastatic Colorectal Cancer

Colorectal Cancer
Ulsan University Hospital
AstraZeneca

Unknown

Efficacy of EGFR TKIs in Patients With Rare EGFR-mutated NSCLC

Lung Neoplasms

Korea, Republic of
National University Hospital, Singapore

Unknown

A Retrospective Molecular Epidemiology Study in Singapore Patients With Advanced Non Small Cell Lung Cancer (NSCLC) of Adenocarcinoma Histology to Assess Epidermal Growth Factor Receptor (EGFR) Mutation Status

NSCLC

Singapore
National University Hospital, Singapore

Completed

Detection of EGFR Mutations in the Blood of Patients With Non-small Cell Lung Cancer: a Feasibility Study

Non Small Cell Lung Cancer

Singapore
Xinjiang Medical University

Unknown

Erlotinib Intercalated With Chemotherapy Versus Erlotinib as First Line Treatment in Stage IIIB/IV NSCLC Patients With EGFR Mutation

Non-Small Cell Lung Cancer

China
National Taiwan University Hospital

Unknown

Gene Mutations in Non-Small Cell Lung Cancer Cells

Carcinoma, Non-Small-Cell Lung

Taiwan
Assistance Publique - Hôpitaux de Paris

Completed

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (DVDA)

Cardiomyopathy | Arrhythmogenic Right Ventricular Dysplasia

France
Assistance Publique - Hôpitaux de Paris
Institut Pasteur

Completed

Prolactin Receptor and Breast Diseases (Prolacsein)

Breast Cancer | Benign Breast Disease

France
Sheba Medical Center

Completed

Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers

Hereditary Breast and Ovarian Cancer Syndrome

Israel
National Taiwan University Hospital

Unknown

A Pilot Study on ALK Gene Mutations in Neuroblastoma

Neuroblastoma

Taiwan
AstraZeneca

Completed

Retrospective Study in a NSCLC M+ p (Ca_Pulmon)

EGFR Mutated Non-small Cell Lung Cancer Patients

Spain
AstraZeneca

Completed

Epidemiological and Scientific Evaluation of EGFR Mutation Status in Patients With Newly Diagnosed Locally Advanced or m (REASON)

Newly Diagnosed Locally Advanced or Metastatic Non-small Cell Lung Cancer

Germany
Centre Hospitalier Universitaire Dijon

Unknown

Clinical and Molecular Characterisation of Orofaciodigital Syndromes and Other Clinical Phenotypes Secondary to Mutations in the OFD1 Gene (OFD1)

Orofaciodigital Syndromes

France
Jin Il Kim
Korean College of Helicobacter and Upper Gastrointestinal Research

Completed

Clarithromycin Resistant Tailored Therapy

Peptic Ulcer | Helicobacter Pylori Infection

Korea, Republic of

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