Search clinical trials for: 2nd-line,

Total 6262 results

Université Catholique de Louvain

Completed

Mulligan Concept in the Treatment of Ankle Sprains

Ankle Sprain 1St Degree | Ankle Sprain 2Nd Degree

Belgium
Johns Hopkins University

Terminated

Cell-Based Approaches For Modeling and Treating Ataxia-Telangiectasia

Ataxia-Telangiectasia (A-T)

United States
Heuron Inc.

Completed

Evaluation of Clinical Decision Support System for Large Vessel Occlusion Using Brain CT Images

Ischemic Stroke

Korea, Republic of
Kirby Institute
Merck Sharp & Dohme LLC; amfAR, The Foundation for AIDS Research; Abbott

Completed

A Trial of 2 Options for Second Line Combination Antiretroviral Therapy Following Virological Failure of a Standard Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)+2N(t)RTI First Line Regimen (SECOND-LINE)

HIV Infections

Taiwan, Australia, Argentina, Singapore, India, France, South Africa, Chile, Germany, Hong Kong, Ireland, Malaysia, Mexico, New Zealand, Nigeria, Peru, United Kingdom
Swinburne University of Technology
US Department of Veterans Affairs

Terminated

Evaluation of Online Video Counselling

Videoconferencing

Australia
Affiliated 2 Hospital of Nantong University
National Natural Science Foundation of China

Recruiting

Laminoplasty for Multilevel Cervical Spondylotic Myelopathy Guided by Modified K-line and Modified SC-line in MRI

Modified K-line and Modified SC-line in MRI

China
Glaukos Corporation

Completed

Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG) (SL)

Glaucoma | Glaucoma, Open-Angle | Eye Diseases

Spain, France, Austria, Italy, Armenia, Germany, Greece, Poland, United Kingdom
Prevent Age Resort "Pervaya Liniya"

Recruiting

First Line Prevent Age Study (FLIPS)

Healthy Aging | Healthy Diet | Healthy Lifestyle

Russian Federation
Liverpool Heart and Chest Hospital NHS Foundation...
Biolife LLC

Not yet recruiting

Statseal® for Central Venous Catheter Insertion Sites in Critical Care (SCENIC)

Vascular Access | Critical Care | Central Venous Catheter | Central Line | Hemostatic

United Kingdom
University of Chicago

Completed

Trial Comparing Routine Intraoperative Transesophageal Echocardiography During Radical Cystectomy to Standard of Care

Cardiac and Pulmonary Complications. Central Venous Line Insertion. Gastrointestinal Recovery
PDC*line Pharma SAS

Active, not recruiting

Safety, Immunogenicity and Preliminary Clinical Activity Study of PDC*lung01 Cancer Vaccine in NSCLC

Non Small Cell Lung Cancer

Belgium, France, Netherlands, Germany, Poland
Line Kessel

Completed

Study for Optimizing Anti-inflammatory Prophylaxis (SOAP)

Irvine-Gass Syndrome | Postoperative Cystoid Macular Edema

Denmark
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Withdrawn

S095033 in Combination With Paclitaxel as 2nd- or 3rd-line Treatment in Participants With Advanced or Metastatic ESCC

Esophageal Squamous Cell Carcinoma
ERYtech Pharma

Completed

Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone as 2nd-Line Treatment in PAC (Trybeca-1)

Pancreatic Adenocarcinoma

United States, United Kingdom, France
Hanmi Pharmaceutical Company Limited

Terminated

Phase II Trial of HM61713 for the Treatment of ≥2nd Line T790M Mutation Positive Adenocarcinoma of the Lung

Non Small Cell Lung Cancer

United States, Australia, Italy, Korea, Republic of, Spain, Germany, Malaysia, Taiwan, Canada, Philippines
Achieve Life Sciences

Completed

Evaluation of Safety and Feasibility of OGX-011 in Combination With 2nd-line Chemotherapy in Patients With HRPC

Prostate Cancer

Canada
VA Office of Research and Development

Completed

Developing an Online Therapeutic Intervention for Chronic Pain in Veterans

Chronic Pain

United States
Bispebjerg Hospital
University of Copenhagen; Copenhagen Academy for Medical Education and Simulation

Recruiting

Learning Effect of Onsite vs. Online Education in a Medical Context

Online Learning

Denmark
Seoul St. Mary's Hospital
Boehringer Ingelheim

Active, not recruiting

Retrospective Multi-cohort Study of Frontline Afatinib Followed by 2nd Line Therapy Including Osimertinib, Chemotherapy or Other Therapy

NSCLC

Korea, Republic of
Achieve Life Sciences

Completed

Comparison of Cabazitaxel/Prednisone Alone or in Combination With Custirsen for 2nd Line Chemotherapy in Prostate Cancer (AFFINITY)

Prostate Cancer

France, United States, Canada, Australia, Hungary, Czech Republic, Russian Federation, United Kingdom
AstraZeneca

Completed

Comparing Efficacy Between Anti-microtubule and Non-anti-microtubule as 3th Therapy After 2nd Line EGFR-TKI Therapy

Cancer

Taiwan
Royal Holloway University
National Health Service, United Kingdom

Completed

Guided Self-help Following Sexual Assault - SCED

Sexual Dysfunction | Sexual Assault | Sex Disorder

United Kingdom
Roxane Laboratories

Completed

Bioequivalency Study of Levetiracetam 750 mg Tablets Under Fed Conditions

Seizures

United States
Ziv Hospital

Unknown

Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO)

Asthma | Primary Ciliary Dyskinesia

Israel
University of Manitoba

Completed

EEG Monitoring to Assess Emergence From Neuroanesthesia

Cerebral Aneurysm | Trigeminal Neuralgia

Canada
Soroka University Medical Center

Completed

Sequential Therapy Versus Quadruple Therapy as Second Line Treatment After Failure of the Standard Triple Therapy for H Pylori Infection

Optimization of Second Line Treatment Protocol for H Pylori Eradication

Israel
Millennium Pharmaceuticals, Inc.
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Completed

VELCADE/Melphalan/Prednisone Versus Melphalan/Prednisone in Patients With Previously Untreated Multiple Myeloma

Multiple Myeloma

United States
Hamad Medical Corporation

Completed

Arterial Line Patency in ICU Bound COVID-19 Patients

SARS-CoV-2 ICU Bound

Qatar
Novartis Pharmaceuticals

Active, not recruiting

A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment (RIBANNA)

Breast Cancer

Germany
Cairo University

Completed

Ultrasonographic Fetal Soft Markers and Aneuploidy

Soft Markers

Egypt
UCB Pharma

Completed

Pharmacovigilance Study of Keppra. SPAIN - SKATE : Safety of Keppra as Adjunctive Therapy in Epilepsy

Epilepsy, Partial
Rabin Medical Center

Recruiting

CLABSI Prevention With Tissue Adhesive (Cya-No-CLABSI)

Central-line Associated Blood Stream Infections (CLABSI)

Israel
Istanbul University - Cerrahpasa (IUC)
Scientific Research Project Coordination Unit of Istanbul University-Cerrahpasa

Active, not recruiting

LINE-1 and Alu Methylation Levels Among Middle Aged Women With Low Cardiovascular Risk Profile in Respect of Menopausal Hot Flashes

Cardiovascular Diseases | Hot Flashes | Sleep | Menopause | Epigenetics | DNA Methylation

Turkey
China National Biotec Group Company Limited
Beijing Institute of Biological Products Co Ltd.; Sichuan Center for Disease... and other collaborators

Completed

Evaluation of Immunogenicity and Safety of Combined Immunization of COVID-19 Vaccine (Produced in Beijing) and PPV23 / IIV4

Covid19 | Pneumonia, Pneumococcal | Influenza, Human

China
China National Biotec Group Company Limited
Wuhan Institute of Biological Products Co., Ltd; Henan Center for Disease Control... and other collaborators

Active, not recruiting

Evaluation of Immunogenicity and Safety of Combined Immunization of COVAX (Produced in Wuhan) and PPV23 / IIV4

Pneumonia, Pneumococcal | Influenza, Human | COVID-19 Pneumonia

China
Universitat Jaume I
Ministerio de Economía y Competitividad, Spain

Unknown

Development and Validation of an Online Treatment Program for Adjustment Disorders (TAO)

Online Computerized Program Group | Waiting List Control Group

Spain
University Hospital, Montpellier
Ministry of Health, France

Completed

Tolerance of "on Line" Hemodiafiltration in Chronic Renal Failure Patients (on-line-HDF)

Cardiovascular Disease

France
Chinese University of Hong Kong

Active, not recruiting

Efficacy of Guided and Unguided Online Self-help Psychological Intervention

Depression | Anxiety | Online Self-help Transdiagnostic Psychological Intervention

Hong Kong
University of Milano Bicocca

Recruiting

Retrospective Study of 2nd-line Therapies After CDK4/6i + Hormonal Therapy in HR+/HER2- Advanced Breast Cancer (HERMIONE-13)

Advanced Breast Cancer | Hormone Receptor Positive Breast Carcinoma | HER2-negative Breast Cancer

Italy
Tianjin Medical University Cancer Institute and...

Unknown

Apatinib Plus Docetaxel as 2nd Line Treatment in Patients With Advanced Non-squamous and Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Eli Lilly and Company

Completed

A Single Arm Phase 2 Study of Pemetrexed as 2nd-Line Treatment of Advanced Non-Small Cell Lung Cancer

Carcinoma, Non-Small Cell Lung

China, Taiwan, Australia, Korea, Republic of, Egypt, Romania, India, Turkey
Alcyone Lifesciences, Inc.

Completed

Quantitative Characterization of Safe Irrigation for Ventricular Shunt Catheters

Hydrocephaly

United States
Xin-Ning Lee

Not yet recruiting

RCT How an Online Escape Room Game Enhances Nurses' Learning Outcomes Regarding ESW Signs.

Early Goal-Directed Therapy
Main Line Center for Laser Surgery

Recruiting

TCA 15% Chemical Peel for Improvement in Hand Lentigines

Lentigo | Photoaging

United States
Eric Bernstein, MD
Novoxel Ltd.

Active, not recruiting

Evaluating the Safety and Effectiveness of the Tixel Fractional System in the Treatment of Photodamage at Low Settings

Wrinkle

United States
Cutera Inc.

Completed

Treatment of Lower Extremity Spider Veins With Excel V

Telangiectasis | Spider Veins

United States
Inonu University

Unknown

The Effect of Compression Time for Secure Stapling With a Linear Stapler in Laparoscopic Gastric Bypass Surgery

Bleeding of the Staple Line

Turkey
Hunan University
Central South University

Not yet recruiting

An Evaluation on a Mental Health Art Exhibition's Impact on Reducing Stigma

Mental Health Issue
Okan University
Yuksek Ihtisas University

Completed

Impact of COVID-19 Pandemic on Depression and Quality of Life

Depression | Quality of Life | Covid 19 | Social Isolation

Turkey
Columbia University

Completed

Impact of Cyanoacrylate Glue on PICC Line Dressing Care

Central Line Complication | Neonatal Disease

United States

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