TCA 15% Chemical Peel for Improvement in Hand Lentigines

March 14, 2025 updated by: Kachiu Lee, MD, Main Line Center for Laser Surgery

Use of TCA 15% + 3% Glycolic Acid Chemical Peel for Improvement in Hand Lentigines

This study will evaluate the efficacy of the a 15% trichloroacetic acid + 3% glycolic acid peel combination for treatment of lentigines on the hands. This peel combination is sold over the counter. Patients will receive 3 treatments (spaced 4 weeks).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This clinical investigation is a prospective study consisting of a screening visit, 3 treatment visits, and 1 follow-up visit. Baseline and post-treatment photos will be graded and compared.

A total of 20 patients will be recruited. Following informed consent and screening, subjects' dorsal hands will be photographed.

Patients will receive 3 treatments with the 15% TCA + 3% glycolic acid peel every 4-6 weeks on the dorsal hands. Post-treatment, patients will be instructed to apply Aquaphor to the treated area twice daily for 5 days. Patients' hands will be photographed at each visit.

Four to six weeks after their final treatment, subjects will return for photography.

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Pennsylvania
      • Ardmore, Pennsylvania, United States, 19003
        • Main Line Center for Laser Surgery

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

22 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Age >21
  • No laser, chemical peel, neuromodulator, filler treatment to the hands in >3 months
  • At least 5 lentigines on each hand

Exclusion Criteria:

  • Pregnancy
  • Breastfeeding
  • Allergy to trichloroacetic acid
  • Allergy to glycolic acid
  • Open wounds on treatment area (hands)
  • Active inflammatory disease on treatment area such as atopic dermatitis, psoriasis, dermatomyositis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Treatment
Treatment of hand lentigines with 15% trichloroacetic acid + 3% glycolic acid
Drug: 15% Trichloroacetic acid + 3% glycolic acid
Treatment of the hand with an over-the-counter chemical peel containing 15% trichloroacetic acid + 3% glycolic acid
Other Names:
  • 15% TCA + 3% GA

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Improvement in hand lentigines on a 5-point scale
Time Frame: 4-6 weeks after last treatment
Photos will be graded on a 5 point scale (0=no change, 1=1-25% change, 2=26-50% change, 3=51-75% change, 4=76-100% change)
4-6 weeks after last treatment

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Improvement in hand lentigines using the Global Aesthetic Improvement Scale
Time Frame: 4-6 weeks after last treatment
The GAIS is a validated scale assessing overall change after aesthetic procedures
4-6 weeks after last treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Main Line Center for Laser Surgery

Investigators

  • Principal Investigator: Kachiu Lee, MD, Main Line Center for Laser Surgery

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 15, 2023

Primary Completion (Actual)

December 30, 2023

Study Completion (Actual)

December 1, 2024

Study Registration Dates

First Submitted

July 21, 2022

First Submitted That Met QC Criteria

July 21, 2022

First Posted (Actual)

July 25, 2022

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

March 14, 2025

Last Verified

March 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SC20220721

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Lentigo

Clinical Trials on 15% Trichloroacetic acid + 3% glycolic acid

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Qatar

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe