Search clinical trials for: Glucokinase Activator

Total 587 results

Bausch Health Americas, Inc.

Completed

A Postmarketing Study of Plecanatide in Breast Milk of Lactating Women Treated With TRULANCE®

Chronic Idiopathic Constipation

United States
University of Medicine and Pharmacy at Ho Chi Minh...

Unknown

Efficacy of Intravenous Tissue-type Plasminogen Activator on Acute Ischemic Stroke Patients With Large Vessel Occlusions

Stroke, Ischemic | Stroke, Acute

Vietnam
Angde Biotech Pharmaceutical Co., Ltd.

Unknown

Injection of Recombinant Human Tissue-type Plasminogen Activator Derivative for Acute Pulmonary Embolism(rPA) (rPA)

Acute Pulmonary Embolism
Bausch Health Americas, Inc.

Completed

An Efficacy and Safety Study of Plecanatide in Adolescents 12 to <18 Years of Age With Chronic Idiopathic Constipation

Chronic Idiopathic Constipation

United States
Cedars-Sinai Medical Center

Withdrawn

Liraglutide Actions on the Liver: Effects on Glucose Phosphorylation

Type 2 Diabetes

United States
Johns Hopkins University
National Institute of Neurological Disorders and Stroke (NINDS); Genentech,... and other collaborators

Completed

Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III (MISTIE-III)

Intracerebral Hemorrhage

United States, Australia, Germany, China, Spain, Canada, Israel, Hungary, United Kingdom
Dinesh Khanna, MD, MS
Bayer

Completed

Riociguat in Scleroderma Associated Digital Ulcers (RESCUE)

Scleroderma | Digital Ulcers

United States
NHS Greater Glasgow and Clyde
National Institute for Health Research, United Kingdom; University of Glasgow

Completed

A Trial of Low-dose Adjunctive alTeplase During prIMary PCI (T-TIME)

Myocardial Infarction

United Kingdom
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation

Irritable Bowel Syndrome With Constipation | Chronic Idiopathic Constipation

United States
University of California, San Diego
Mayo Clinic; University of British Columbia; New York University; The Cleveland... and other collaborators

Completed

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

Nephrolithiasis | Urinary Tract Infections

United States, Canada
University of Arizona

Unknown

Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH

Pulmonary Arterial Hypertension

United States
Boehringer Ingelheim

Completed

Safety and Efficacy of Alteplase When Administered in Chinese Patients With Acute Ischemic Hemispheric Stroke Where Thrombolysis is Initiated Between 3 and 4.5 Hours After Stroke Onset

Stroke

China
Angde Biotech Pharmaceutical Co., Ltd.
Beijing Tiantan Hospital

Unknown

A PhaseⅡ of Injection for Recombinant Human Tissue Plasminogen Kinase Derivative in Treatment of Acute Ischemic Stroke.

Acute Ischemic Stroke

China
University of Iowa

Completed

Thrombolytic Care During Inter-hospital Transfer

Stroke

United States
Chippewa Valley Eye Clinic
TA-Sciences

Completed

Telomerase Activator and Retinal Amyloid

Alzheimer Disease

United States
Bausch Health Americas, Inc.
Syneos Health

Completed

Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)

Chronic Idiopathic Constipation

United States, Canada
TriHealth Inc.

Terminated

Efficacy of Linaclotide to Senna for CIC

Chronic Idiopathic Constipation

United States
VakgroepBewegingsEnSportwetenschappen
University Ghent

Completed

Reducing Older Adults' Sedentary Behavior by Self-monitoring

Sedentary Lifestyle

Belgium
The Hospital for Sick Children

Terminated

Safety and Efficacy of the Use of Tissue Plasminogen Activator (tPA) in Intra-Abdominal Collections in Children - A Prospective Study

Intra-abdominal Abscess

Canada
General Hospital of Shenyang Military Region

Withdrawn

Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China

Ischemic Stroke

China
Cyclerion Therapeutics

Completed

A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Praliciguat in Healthy Male Volunteers

Healthy Volunteers

United States
Bayer

Completed

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension (EXPERT)

Hypertension, Pulmonary

Turkey, Austria, Czechia, Russian Federation, Slovakia, Switzerland, Italy, Germany, United Kingdom, France, Belgium, Canada, Colombia, Greece, Luxembourg, Netherlands, Spain, Taiwan, Denmark, Sweden, Argentina, Portugal, Saudi Arabia, Austral... and more
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)

Functional Constipation in Children Ages 6-17 Years

United States, Canada
Bausch Health Americas, Inc.

Completed

Second Plecanatide Study In Irritable Bowel Syndrome With Constipation (IBS-C) (IBS-C)

Irritable Bowel Syndrome Characterized by Constipation

United States
Bausch Health Americas, Inc.

Completed

The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C) (IBS-C)

Irritable Bowel Syndrome Characterized by Constipation

United States
Bausch Health Americas, Inc.

Completed

The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C) (CIBS)

Irritable Bowel Syndrome Characterized by Constipation

United States
Bausch Health Americas, Inc.
Parexel

Completed

The Plecanatide Chronic Idiopathic Constipation (CIC) Study

Chronic Idiopathic Constipation

United States
Bausch Health Americas, Inc.

Completed

12-Week Study of Plecanatide for CIC (The National CIC3 Study) (CIC)

Chronic Idiopathic Constipation

United States
Bausch Health Americas, Inc.

Completed

Single Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of SP-333 Tablets in Healthy Adult Subjects

Exposure

United States
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain

Opioid-Induced Constipation

United States
Cereno Scientific AB

Completed

Study Investigation Pharmacokinetics and Pharmacodynamics of CS1

Thrombosis

Sweden
Cyclerion Therapeutics

Completed

Trial of IW-1973 (A Stimulator of Soluble Guanylate Cyclase (sGC)) in Healthy Volunteers

Healthy

United States
Cyclerion Therapeutics

Completed

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of Praliciguat (IW-1973) in Healthy Volunteers

Healthy

United States
Rabin Medical Center

Terminated

Thrombolysis in Ischemic Spinal Cord Stroke

Motor Weakness in Two or Four Limbs | Damage in the Anterior Spinal Artery (ASA) | Temperature and Superficial Sensation | Urinary Retention or Bowel Disorder

Israel
University of Rijeka

Completed

Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA

Brain Injuries | Intraventricular Hemorrhage | Hypertensive Intracerebral Hemorrhage
Bayer

Completed

Riociguat Clinical Effects Studied in Patients With Insufficient Treatment Response to Phosphodiesterase-5 Inhibitor (RESPITE)

Hypertension, Pulmonary

Belgium, United States, Switzerland, Canada, France, Germany, Italy, United Kingdom, Czechia
Rajavithi Hospital
Lumpang Hospital

Completed

Low-dose Versus Standard Dose Alteplase in Acute Ischemic Stroke , 4 Monthes Prospective Study

Acute Stroke

Thailand
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation

Irritable Bowel Syndrome With Constipation | Chronic Constipation

United States, Canada
Vanderbilt University Medical Center
National Center for Research Resources (NCRR)

Completed

Diurnal Variation of Plasminogen Activator Inhibitor-1

Metabolic Syndrome X

United States
Pulse Therapeutics

Suspended

Magnetically Enhanced Diffusion for Acute Ischaemic Stroke (MEDIS) Trial (MEDIS)

Cerebrovascular Disorders | Neurologic Disorder | Infarction, Middle Cerebral Artery | Stroke, Ischemic | Stroke, Acute | Intracranial Embolism and Thrombosis | Strokes Thrombotic

United Kingdom
Cairo University

Completed

Tissue Plasminogen Activator & Plasminogen Activator Inhibitor Type-1 In Gingival Tissues Of Chronic Periodontitis

Chronic Periodontitis

Egypt
National Cerebral and Cardiovascular Center
Japan Agency for Medical Research and Development; Charitable Trust Mihara...

Unknown

THrombolysis for Acute Wake-up and Unclear-onset Strokes With Alteplase at 0.6 mg/kg Trial (THAWS) (THAWS)

Stroke

Japan
Astellas Pharma Inc

Completed

A Study to Evaluate Dose Responses of Efficacy and Safety of ASP0456 in Patient With Chronic Constipation

Chronic Constipation

Japan
Astellas Pharma Inc

Completed

A Study of Oral Dosing of ASP0456 in Patients With Chronic Constipation

Chronic Constipation

Japan
Johns Hopkins University
National Institute of Neurological Disorders and Stroke (NINDS); Genentech,... and other collaborators

Completed

Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III)

Intraventricular Hemorrhage

United States, Spain, Germany, Canada, Israel, Brazil, Hungary, United Kingdom, Switzerland
Cerevast Medical, Inc.

Unknown

Aureva Transcranial Ultrasound Device With tPA in Patients With Acute Ischemic Stroke (TRUST)

Acute Ischemic Stroke

United States
Hui-Sheng Chen

Terminated

Argatroban Plus r-tPA for Posterior Circulation Infarction（AR-PCI）

Argatroban, Rt-PA

China
Universitätsklinikum Hamburg-Eppendorf

Completed

Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke (WAKE-UP)

Stroke

Germany, United Kingdom, Belgium, Denmark, France, Spain
University of Connecticut

Completed

Effects of TA-65, a Telomerase Activator on Metabolic Syndrome

Metabolic Syndrome X

United States
Pfizer
PRA Health Sciences

Terminated

Safety, Tolerability and Efficacy of Ceftaroline in Paediatrics With Late-Onset Sepsis

Late-onset Sepsis

United States, Hungary

Search clinical trials for: Glucokinase Activator

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