Search clinical trials for: Maximum Observed Plasma Concentration (Cmax)

Total 9618 results

Shane Burch
Eli Lilly and Company

Completed

Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion

Lumbar Spondylolisthesis | Lumbar Spondylosis | Adult Degenerative Lumbar Scoliosis

United States
University Hospital, Basel, Switzerland
University of Basel

Completed

Bioavailability Mechanistic Study of Hot-Melt Extruded Amorphous Solid Dispersions (BEAD)

Biological Availability | Amorphous Solid Dispersions

Switzerland
Spero Therapeutics
Clinartis

Completed

Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers

Healthy Volunteers

United States
Kunming Medical University
National Natural Science Foundation of China

Completed

5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia

Early-onset Schizophrenia

China
Hiroaki Sato, MD., PhD.

Unknown

Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose

Ischemic Heart Disease | Aortic Aneurysm

Canada
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Phase 1, Open-Label Study of Latanoprost Acid Plasma Concentrations in Pediatric and Adult Glaucoma Patients Treated With Latanoprost.

Ocular Hypertension | Glaucoma

United States, Spain, Italy, Denmark, Portugal, South Africa
McGill University

Completed

The Effects of Cricket- and Beef-derived Protein on Plasma Amino Acid Concentrations and Appetite Responses

Appetitive Behavior | Aminoacidemia

Canada
Institut Bergonié
Novartis

Terminated

Phase III Trial Evaluating the Effectiveness of a Dose Adjustment of Imatinib Mesylate on the Molecular Response (MIM)

Leukemia, Myeloid, Chronic-Phase

France
University Hospital, Toulouse

Completed

Association Between Side Effects Occurrence and Concentrations of Ibrutinib and Idelalisib (PK-E3I)

Hematological Malignancies

France
Novartis Pharmaceuticals

Completed

A Phase I-Ib/II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 Alone and in Combination With Bortezomib, With or Without Dexamethasone, in Patients With Relapsed or Refractory Multiple Myeloma.

Relapsed or Refractory Multiple Myeloma

Germany, Spain, Singapore, United States, Australia
Radboud University Medical Center
University Medical Center Groningen; Maastricht University Medical Center; UMC... and other collaborators

Completed

Evaluation of RIBAvirin Plasma COncentrations in Patients With Chronic Hepatitis C Infection Routinely Treated With Modern DAA Regimens (RIBACOP)

Hepatitis C | HCV Coinfection

Netherlands
Pfizer

Completed

A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease

Alzheimer's Disease

United States, Canada, Chile, Czechia
University Hospital, Grenoble

Completed

Determining of Normal Values and Conformity Assessment of the Dosage of a Plasmatic Marker of the Cellular Captation of Glucose: the IRAP Protein (IRAP)

Insulin Resistance

France
PepsiCo Global R&D

Completed

Comparison of Plasma Caffeine Concentration After Oral Consumption of Caffeinated Beverages With Varied Bioactive Compounds in Healthy Volunteers

Plasma Caffeine Concentration

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Ropivacaine Plasma Concentration With or Without Epinephrine for Posterior Quadratus Lumborum Block

Anesthesia, Local | Local Anesthetic Systemic Toxicity

Italy
Teva Pharmaceuticals USA

Withdrawn

An Open-Label, Single-Center Study to Evaluate the Exposure-Response Relationship Between the Plasma Drug Concentrations and the Change From Baseline in QTc at Steady State Following Once-daily Administration of CASSIPA® in Opioid Dependent Subjects.

Evaluation of QTc Interval
Cairo University

Unknown

Metformin Versus Vildagliptin in Reducing Risk of Metabolic Syndrome Complications Progression

Metabolic Syndrome | Kidney Insufficiency | Diabete Type 2

Egypt
Purdue University

Completed

Protein Source on Plasma Amino Acid Concentrations

Protein Deposition

United States
Hopital Foch
Institut National de la Santé Et de la Recherche Médicale Rouen U1096

Completed

Impact of Cold Ischemia on Pulmonary Endothelial Dysfunction in Ex-vivo Pulmonary Reconditioning (Endoth-Exvivo)

Lung Transplant

France
University Hospital, Clermont-Ferrand

Unknown

Plasma Concentrations of Amoxicillin Administered in High-doses During the First Week of Treatment (MAX-AMOX) (MAX-AMOX)

Infection, Bacterial

France
University Hospital, Bordeaux

Completed

Correlation Between Sorafenib Plasma Concentrations, Toxicity and Disease Control Rate in Patients Treated by Sorafenib for Hepatocellular Carcinoma (ACTES)

Hepatocellular Carcinoma (HCC)

France
Celgene
Multiple Myeloma Research Consortium

Completed

Study to Determine the Maximum Tolerated Dose for the Combination of Pomalidomide, Bortezomib and Low-Dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma

United States
Mahidol University

Completed

Plasma Concentrations of Prophylactic Cefazolin in Pediatric Patients Undergoing Cardiac Surgery With CPB

Surgical Site Infection

Thailand
Xuzhou Medical University

Completed

POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Postoperative Cognitive Dysfunction

China
The University of Texas Health Science Center at...

Terminated

The Effect of TLR4 Inhibition in Obese and Type 2 Diabetic Subjects (Eritoran2)

Insulin Sensitivity

United States
University Women's Hospital Tübingen

Unknown

Plasma Concentrations of Calcium, Phosphate, FGF23, Klotho, 25 (OH) D3 and 1,25 (OH) 2D3 From Patients Who Wants to Have Children

Infertility, Female

Germany
University of Monastir

Completed

Clinical and Genetic Influencing Factors on Clozapine Pharmacokinetics

Schizophrenia | Clozapine | CYP1A2 Polymorphism | CYP2C19 Polymorphism

Tunisia
Astellas Pharma Inc

Completed

ASP1517 Pharmacokinetics Study in Anemia Patients on Hemodialysis

Anemia | Hemodialysis | Renal Impairment

Japan
Karolinska University Hospital

Completed

Meropenem and Piperacillin Plasma Concentrations During CRRT (ABC2)

Sepsis | Hemolysis | Renal Replacement Therapy | Infection | Antibiotic

Sweden
Germans Trias i Pujol Hospital
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la...

Completed

Pilot Study to Compare the Pharmacokinetics Parameters in Plasma and Intracellular of Raltegravir Administered Once a Day in Adult Patients Infected With HIV

HIV Infections

Spain
Celgene

Terminated

A Phase I/II Study to Determine the Maximum Tolerated Dose (MTD) and Safety of CC-4047 (Pomalidomide) Administered in Conjunction With Cisplatin and Etoposide

Carcinoma, Small Cell

United States, Canada
Oslo University Hospital

Unknown

Correlation Between Exhaled Propofol Concentration With Plasma Concentration in Children

Eye Diseases

Norway
The University of Texas Health Science Center at...

Completed

The Role of TLR4 on Lipid-induced Insulin Resistance (Eritoran1)

Insulin Sensitivity

United States
University Hospital, Limoges

Completed

Description of the Evolution of Plasma and Urinary Concentrations of Iohexol in a Cirrhotic Patient Population (DFG HEP)

Cirrhosis Renal

France
Turku University Hospital
Helsinki University Central Hospital

Completed

NOAC Plasma Concentration and Blood Coagulation in Healthy Volunteers (EdoRot)

Blood Coagulation Disorder

Finland
King's College London

Completed

Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

Healthy Men | Raised Fasting Plasma Triacylglycerol Concentrations

United Kingdom
Xinhua Hospital, Shanghai Jiao Tong University...

Completed

Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins

Acute Lung Injury

China
Astellas Pharma Inc

Completed

Comparison of Plasma Concentration Changes Between Two Types of Tablets of FK949E Administration to Patients With Major Depressive Disorder

Major Depressive Disorder

Japan
Medical University of Vienna
Aprofol AG

Completed

A Study to Assess the Effect of a 3-month Folate Supplementation on Systemic Homocysteine Plasma Concentration and Ocular Blood Flow in Patients With Diabetes

Diabetes

Austria
Seoul National University Hospital

Completed

Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients

OCD

Korea, Republic of
Indonesian Cardiovascular Research Center

Completed

Association of Plasma PTX3 Concentration and Outcomes of STEMI

STEMI | Coronary; Ischemic

Indonesia
Boehringer Ingelheim

Completed

Study to Investigate the Pharmacokinetics (PK) and Pharmacodynamics (PD) of Idarucizumab in Chinese Healthy Male and Female Volunteers Who Had Taken Dabigatran Etexilate and Whose Plasma Concentrations of Dabigatran Were at or Close to Steady State

Healthy Volunteers

China
University Hospital, Grenoble

Completed

Influence of a Combined Pharmacogenetic Score on Through Plasma Voriconazole Concentrations in Haematological Patients (VORIGENE)

Invasive Aspergillosis | Voriconazole | Haematological Cancer Patients

France
Oslo University Hospital

Unknown

Expiratory and Plasma Propofol Concentration in Gastrological Surgery Patients

Bariatric Surgery Candidate | Cholecystectomy

Norway
Alison Gernand
Penn State University

Completed

Cyclic Variation in Micronutrient Concentrations and Plasma Volume

Menstrual Cycle | Plasma Volume | Micronutrients

United States
The Cleveland Clinic

Completed

Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock

Septic Shock

United States
Centre Hospitalier Universitaire de Nīmes

Completed

Free DNA and Nucleosome Concentrations in Pathological Pregnancies

Venous Thrombosis | Pregnancy | Eclampsia | Pre-Eclampsia | Hypertension, Pregnancy-Induced | Pulmonary Embolism | HELLP Syndrome | Fetal Death | Placental Insufficiency

France
Pfizer

Terminated

A Four-Way Cross-Over Study To Compare The Plasma Concentrations Of PF-02413873 After Oral Administration Of Several Doses As Suspension And As Tablets.

Healthy

Singapore
Astellas Pharma Inc

Completed

Examination of Plasma Concentrations and Safety in Chronic Kidney Disease Patients Undergoing Hemodialysis

Patients on Stable Chronic Maintenance Dialysis Who Are Receiving Hemodialysis Therapy | Pharmacodynamics of ASP7991 | Pharmacokinetics of ASP7991

Japan
Ain Shams Maternity Hospital

Unknown

Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .

Placenta Accreta | Placenta Previa | Placenta Percreta | Placenta Increta

Egypt

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